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Entry version 182 (13 Feb 2019)
Sequence version 1 (01 Nov 1998)
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Protein

GRB2-related adapter protein 2

Gene

GRAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-202433 Generation of second messenger molecules
R-HSA-2424491 DAP12 signaling
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-389356 CD28 co-stimulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O75791

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRB2-related adapter protein 2
Alternative name(s):
Adapter protein GRID
GRB-2-like protein
Short name:
GRB2L
GRBLG
GRBX
Grf40 adapter protein
Short name:
Grf-40
Growth factor receptor-binding protein
Hematopoietic cell-associated adapter protein GrpL
P38
Protein GADS
SH3-SH2-SH3 adapter Mona
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRAP2
Synonyms:GADS, GRB2L, GRID
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100351.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4563 GRAP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604518 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75791

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Endosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9402

Open Targets

More...
OpenTargetsi
ENSG00000100351

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28959

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GRAP2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000882081 – 330GRB2-related adapter protein 2Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei45PhosphotyrosineCombined sources1
Modified residuei106N6-acetyllysineCombined sources1
Modified residuei187PhosphoserineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei262PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75791

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75791

PeptideAtlas

More...
PeptideAtlasi
O75791

PRoteomics IDEntifications database

More...
PRIDEi
O75791

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50196

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75791

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75791

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
O75791

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100351 Expressed in 86 organ(s), highest expression level in leukocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75791 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75791 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022073
HPA005788

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23.By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114799, 79 interactors

Database of interacting proteins

More...
DIPi
DIP-38435N

Protein interaction database and analysis system

More...
IntActi
O75791, 66 interactors

Molecular INTeraction database

More...
MINTi
O75791

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339186

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GJHX-ray1.20A/C58-155[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75791

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75791

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 56SH3 1PROSITE-ProRule annotationAdd BLAST56
Domaini58 – 149SH2PROSITE-ProRule annotationAdd BLAST92
Domaini271 – 330SH3 2PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3601 Eukaryota
ENOG410XR1G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157307

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000251625

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005404

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75791

KEGG Orthology (KO)

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KOi
K07366

Identification of Orthologs from Complete Genome Data

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OMAi
AKFDFMA

Database of Orthologous Groups

More...
OrthoDBi
1024179at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75791

TreeFam database of animal gene trees

More...
TreeFami
TF354288

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11950 SH3_GRAP2_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035646 GRAP2_C_SH3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401 SH2DOMAIN
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75791-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAVAKFDFT ASGEDELSFH TGDVLKILSN QEEWFKAELG SQEGYVPKNF
60 70 80 90 100
IDIQFPKWFH EGLSRHQAEN LLMGKEVGFF IIRASQSSPG DFSISVRHED
110 120 130 140 150
DVQHFKVMRD NKGNYFLWTE KFPSLNKLVD YYRTNSISRQ KQIFLRDRTR
160 170 180 190 200
EDQGHRGNSL DRRSQGGPHL SGAVGEEIRP SMNRKLSDHP PTLPLQQHQH
210 220 230 240 250
QPQPPQYAPA PQQLQQPPQQ RYLQHHHFHQ ERRGGSLDIN DGHCGTGLGS
260 270 280 290 300
EMNAALMHRR HTDPVQLQAA GRVRWARALY DFEALEDDEL GFHSGEVVEV
310 320 330
LDSSNPSWWT GRLHNKLGLF PANYVAPMTR
Length:330
Mass (Da):37,909
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74F4C8D0EBB56D55
GO
Isoform 2 (identifier: O75791-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: MEAVAKFDFT...NQEEWFKAEL → MVSRRPLSTP...ELPRGLLHLC
     40-152: Missing.

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):24,382
Checksum:iEC20AF61B4EFCD49
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AH86B1AH86_HUMAN
GRB2-related adapter protein 2
GRAP2
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012079319L → F1 PublicationCorresponds to variant dbSNP:rs12759Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0552341 – 39MEAVA…FKAEL → MVSRRPLSTPGRELTHGQGG WLLHHPGQPELPRGLLHLC in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_05523540 – 152Missing in isoform 2. 1 PublicationAdd BLAST113

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF102694 mRNA Translation: AAD04926.1
AF129476 mRNA Translation: AAD41782.1
AF042380 mRNA Translation: AAC69273.1
AF236119 mRNA Translation: AAF60319.1
AF236120 mRNA Translation: AAF60320.1
AF121002 mRNA Translation: AAF31758.1
AY069959 mRNA Translation: AAL58573.1
Y18051 mRNA Translation: CAA77021.1
AJ011736 mRNA Translation: CAA09757.1
AF090456 mRNA Translation: AAD13027.1
CR456498 mRNA Translation: CAG30384.1
AK303470 mRNA Translation: BAH13969.1
Z82206 Genomic DNA No translation available.
BC025692 mRNA Translation: AAH25692.1
BC026002 mRNA Translation: AAH26002.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13999.1 [O75791-1]

Protein sequence database of the Protein Information Resource

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PIRi
JE0376

NCBI Reference Sequences

More...
RefSeqi
NP_001278753.1, NM_001291824.1 [O75791-1]
NP_001278754.1, NM_001291825.1 [O75791-1]
NP_001278757.1, NM_001291828.1 [O75791-2]
NP_004801.1, NM_004810.3 [O75791-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.517499

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344138; ENSP00000339186; ENSG00000100351 [O75791-1]
ENST00000407075; ENSP00000385607; ENSG00000100351 [O75791-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9402

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9402

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102694 mRNA Translation: AAD04926.1
AF129476 mRNA Translation: AAD41782.1
AF042380 mRNA Translation: AAC69273.1
AF236119 mRNA Translation: AAF60319.1
AF236120 mRNA Translation: AAF60320.1
AF121002 mRNA Translation: AAF31758.1
AY069959 mRNA Translation: AAL58573.1
Y18051 mRNA Translation: CAA77021.1
AJ011736 mRNA Translation: CAA09757.1
AF090456 mRNA Translation: AAD13027.1
CR456498 mRNA Translation: CAG30384.1
AK303470 mRNA Translation: BAH13969.1
Z82206 Genomic DNA No translation available.
BC025692 mRNA Translation: AAH25692.1
BC026002 mRNA Translation: AAH26002.1
CCDSiCCDS13999.1 [O75791-1]
PIRiJE0376
RefSeqiNP_001278753.1, NM_001291824.1 [O75791-1]
NP_001278754.1, NM_001291825.1 [O75791-1]
NP_001278757.1, NM_001291828.1 [O75791-2]
NP_004801.1, NM_004810.3 [O75791-1]
UniGeneiHs.517499

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GJHX-ray1.20A/C58-155[»]
ProteinModelPortaliO75791
SMRiO75791
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114799, 79 interactors
DIPiDIP-38435N
IntActiO75791, 66 interactors
MINTiO75791
STRINGi9606.ENSP00000339186

PTM databases

iPTMnetiO75791
PhosphoSitePlusiO75791

Polymorphism and mutation databases

BioMutaiGRAP2

Proteomic databases

jPOSTiO75791
PaxDbiO75791
PeptideAtlasiO75791
PRIDEiO75791
ProteomicsDBi50196

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9402
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344138; ENSP00000339186; ENSG00000100351 [O75791-1]
ENST00000407075; ENSP00000385607; ENSG00000100351 [O75791-1]
GeneIDi9402
KEGGihsa:9402

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9402
DisGeNETi9402
EuPathDBiHostDB:ENSG00000100351.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GRAP2
HGNCiHGNC:4563 GRAP2
HPAiCAB022073
HPA005788
MIMi604518 gene
neXtProtiNX_O75791
OpenTargetsiENSG00000100351
PharmGKBiPA28959

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3601 Eukaryota
ENOG410XR1G LUCA
GeneTreeiENSGT00940000157307
HOGENOMiHOG000251625
HOVERGENiHBG005404
InParanoidiO75791
KOiK07366
OMAiAKFDFMA
OrthoDBi1024179at2759
PhylomeDBiO75791
TreeFamiTF354288

Enzyme and pathway databases

ReactomeiR-HSA-1433557 Signaling by SCF-KIT
R-HSA-202433 Generation of second messenger molecules
R-HSA-2424491 DAP12 signaling
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-389356 CD28 co-stimulation
SignaLinkiO75791

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GRAP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GRAP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9402
PMAP-CutDBiO75791

Protein Ontology

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PROi
PR:O75791

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000100351 Expressed in 86 organ(s), highest expression level in leukocyte
ExpressionAtlasiO75791 baseline and differential
GenevisibleiO75791 HS

Family and domain databases

CDDicd11950 SH3_GRAP2_C, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035646 GRAP2_C_SH3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRAP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75791
Secondary accession number(s): B7Z8I3, O43726, Q9NRB7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: February 13, 2019
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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