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Protein

Transcription elongation factor A protein 3

Gene

TCEA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri306 – 346TFIIS-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein 3
Alternative name(s):
Transcription elongation factor S-II protein 3
Transcription elongation factor TFIIS.h
Gene namesi
Name:TCEA3
Synonyms:TFIISH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000204219.9
HGNCiHGNC:11615 TCEA3
MIMi604128 gene
neXtProtiNX_O75764

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6920
OpenTargetsiENSG00000204219
PharmGKBiPA36374

Polymorphism and mutation databases

BioMutaiTCEA3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001214521 – 348Transcription elongation factor A protein 3Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75764
MaxQBiO75764
PaxDbiO75764
PeptideAtlasiO75764
PRIDEiO75764
ProteomicsDBi50182

PTM databases

iPTMnetiO75764
PhosphoSitePlusiO75764

Expressioni

Gene expression databases

BgeeiENSG00000204219
CleanExiHS_TCEA3
ExpressionAtlasiO75764 baseline and differential
GenevisibleiO75764 HS

Organism-specific databases

HPAiHPA044960
HPA055811

Interactioni

Protein-protein interaction databases

BioGridi112782, 1 interactor
IntActiO75764, 3 interactors
STRINGi9606.ENSP00000406293

Structurei

3D structure databases

ProteinModelPortaliO75764
SMRiO75764
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 82TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST78
Domaini187 – 303TFIIS centralPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi130 – 173Ser-richAdd BLAST44

Sequence similaritiesi

Belongs to the TFS-II family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri306 – 346TFIIS-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1105 Eukaryota
COG1594 LUCA
GeneTreeiENSGT00390000017794
HOGENOMiHOG000195015
HOVERGENiHBG055022
InParanoidiO75764
OMAiKGTDMKY
OrthoDBiEOG091G10EJ
PhylomeDBiO75764
TreeFamiTF314970

Family and domain databases

Gene3Di1.10.472.30, 1 hit
1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR035100 TF_IIS-typ
IPR003617 TFIIS/CRSP70_N_sub
IPR035441 TFIIS/LEDGF_dom_sf
IPR003618 TFIIS_cen_dom
IPR036575 TFIIS_cen_dom_sf
IPR017923 TFIIS_N
IPR006289 TFSII
IPR001222 Znf_TFIIS
PfamiView protein in Pfam
PF08711 Med26, 1 hit
PF01096 TFIIS_C, 1 hit
PF07500 TFIIS_M, 1 hit
PIRSFiPIRSF006704 TF_IIS, 1 hit
SMARTiView protein in SMART
SM00510 TFS2M, 1 hit
SM00509 TFS2N, 1 hit
SM00440 ZnF_C2C2, 1 hit
SUPFAMiSSF46942 SSF46942, 1 hit
SSF47676 SSF47676, 1 hit
TIGRFAMsiTIGR01385 TFSII, 1 hit
PROSITEiView protein in PROSITE
PS51321 TFIIS_CENTRAL, 1 hit
PS51319 TFIIS_N, 1 hit
PS00466 ZF_TFIIS_1, 1 hit
PS51133 ZF_TFIIS_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75764-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQEEELLRI AKKLEKMVAR KNTEGALDLL KKLHSCQMSI QLLQTTRIGV
60 70 80 90 100
AVNGVRKHCS DKEVVSLAKV LIKNWKRLLD SPGPPKGEKG EEREKAKKKE
110 120 130 140 150
KGLECSDWKP EAGLSPPRKK REDPKTRRDS VDSKSSASSS PKRPSVERSN
160 170 180 190 200
SSKSKAESPK TPSSPLTPTF ASSMCLLAPC YLTGDSVRDK CVEMLSAALK
210 220 230 240 250
ADDDYKDYGV NCDKMASEIE DHIYQELKST DMKYRNRVRS RISNLKDPRN
260 270 280 290 300
PGLRRNVLSG AISAGLIAKM TAEEMASDEL RELRNAMTQE AIREHQMAKT
310 320 330 340
GGTTTDLFQC SKCKKKNCTY NQVQTRSADE PMTTFVLCNE CGNRWKFC
Length:348
Mass (Da):38,972
Last modified:February 12, 2003 - v2
Checksum:i3D0A046B5096753D
GO
Isoform 2 (identifier: O75764-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-154: SNSSKS → ACSLMQ
     155-348: Missing.

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):17,258
Checksum:i0906A294B41EEFBF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056838149 – 154SNSSKS → ACSLMQ in isoform 2. 1 Publication6
Alternative sequenceiVSP_056839155 – 348Missing in isoform 2. 1 PublicationAdd BLAST194

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY540752 mRNA Translation: AAT44402.1
AK290272 mRNA Translation: BAF82961.1
AL109936 Genomic DNA No translation available.
AL357134 Genomic DNA No translation available.
BC041613 mRNA Translation: AAH41613.1
AJ223473 mRNA Translation: CAA11393.1
CCDSiCCDS44086.1 [O75764-1]
RefSeqiNP_003187.1, NM_003196.2 [O75764-1]
UniGeneiHs.446354

Genome annotation databases

EnsembliENST00000374601; ENSP00000363729; ENSG00000204219 [O75764-2]
ENST00000450454; ENSP00000406293; ENSG00000204219 [O75764-1]
ENST00000634832; ENSP00000488968; ENSG00000282941 [O75764-2]
ENST00000635035; ENSP00000489592; ENSG00000282941 [O75764-1]
GeneIDi6920
KEGGihsa:6920
UCSCiuc057dfl.1 human [O75764-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTCEA3_HUMAN
AccessioniPrimary (citable) accession number: O75764
Secondary accession number(s): A8K2K7, Q5DR83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: July 18, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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