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Protein

Solute carrier family 22 member 3

Gene

SLC22A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-2161517 Abacavir transmembrane transport
R-HSA-549127 Organic cation transport

Protein family/group databases

TCDBi2.A.1.19.24 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 3
Alternative name(s):
Extraneuronal monoamine transporter
Short name:
EMT
Organic cation transporter 3
Gene namesi
Name:SLC22A3
Synonyms:EMTH, OCT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146477.5
HGNCiHGNC:10967 SLC22A3
MIMi604842 gene
neXtProtiNX_O75751

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6581
OpenTargetsiENSG00000146477
PharmGKBiPA330

Chemistry databases

ChEMBLiCHEMBL2073673
DrugBankiDB00718 Adefovir Dipivoxil
DB08838 Agmatine
DB00182 Amphetamine
DB00122 Choline
DB00501 Cimetidine
DB00575 Clonidine
DB01394 Colchicine
DB01151 Desipramine
DB00988 Dopamine
DB00783 Estradiol
DB00536 Guanidine
DB05381 Histamine
DB00458 Imipramine
DB00762 Irinotecan
DB00709 Lamivudine
DB01042 Melphalan
DB00331 Metformin
DB01577 Methamphetamine
DB00184 Nicotine
DB00368 Norepinephrine
DB00526 Oxaliplatin
DB00925 Phenoxybenzamine
DB00457 Prazosin
DB01035 Procainamide
DB00396 Progesterone
DB00624 Testosterone
DB08837 Tetraethylammonium
DB08841 Tyramine
DB00541 Vincristine
GuidetoPHARMACOLOGYi1021

Polymorphism and mutation databases

BioMutaiSLC22A3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205031 – 556Solute carrier family 22 member 3Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75751
PeptideAtlasiO75751
PRIDEiO75751
ProteomicsDBi50179

PTM databases

iPTMnetiO75751
PhosphoSitePlusiO75751

Expressioni

Tissue specificityi

Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.3 Publications

Gene expression databases

BgeeiENSG00000146477 Expressed in 139 organ(s), highest expression level in thoracic aorta
CleanExiHS_SLC22A3
GenevisibleiO75751 HS

Organism-specific databases

HPAiHPA029750

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005192EBI-1752674,EBI-375543

Protein-protein interaction databases

BioGridi112468, 1 interactor
IntActiO75751, 2 interactors
STRINGi9606.ENSP00000275300

Chemistry databases

BindingDBiO75751

Structurei

3D structure databases

ProteinModelPortaliO75751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE Eukaryota
ENOG410XSRI LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234568
HOVERGENiHBG061545
InParanoidiO75751
KOiK08200
OMAiWSPEEEW
OrthoDBiEOG091G05AC
PhylomeDBiO75751
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequencei

Sequence statusi: Complete.

O75751-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSFDEALQR VGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGTQPDHYW
60 70 80 90 100
CRGPSAAALA ERCGWSPEEE WNRTAPASRG PEPPERRGRC QRYLLEAAND
110 120 130 140 150
SASATSALSC ADPLAAFPNR SAPLVPCRGG WRYAQAHSTI VSEFDLVCVN
160 170 180 190 200
AWMLDLTQAI LNLGFLTGAF TLGYAADRYG RIVIYLLSCL GVGVTGVVVA
210 220 230 240 250
FAPNFPVFVI FRFLQGVFGK GTWMTCYVIV TEIVGSKQRR IVGIVIQMFF
260 270 280 290 300
TLGIIILPGI AYFIPNWQGI QLAITLPSFL FLLYYWVVPE SPRWLITRKK
310 320 330 340 350
GDKALQILRR IAKCNGKYLS SNYSEITVTD EEVSNPSFLD LVRTPQMRKC
360 370 380 390 400
TLILMFAWFT SAVVYQGLVM RLGIIGGNLY IDFFISGVVE LPGALLILLT
410 420 430 440 450
IERLGRRLPF AASNIVAGVA CLVTAFLPEG IAWLRTTVAT LGRLGITMAF
460 470 480 490 500
EIVYLVNSEL YPTTLRNFGV SLCSGLCDFG GIIAPFLLFR LAAVWLELPL
510 520 530 540 550
IIFGILASIC GGLVMLLPET KGIALPETVD DVEKLGSPHS CKCGRNKKTP

VSRSHL
Length:556
Mass (Da):61,280
Last modified:November 1, 1998 - v1
Checksum:iC3CA2D77DD21C658
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02035144T → M. Corresponds to variant dbSNP:rs8187715Ensembl.1
Natural variantiVAR_020352116A → S. Corresponds to variant dbSNP:rs8187717Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001417 mRNA Translation: CAA04751.1
AK314590 mRNA Translation: BAG37164.1
AL591069 Genomic DNA No translation available.
AL355506 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47599.1
AF078749 mRNA Translation: AAD20977.1
CCDSiCCDS5277.1
RefSeqiNP_068812.1, NM_021977.3
UniGeneiHs.567337

Genome annotation databases

EnsembliENST00000275300; ENSP00000275300; ENSG00000146477
GeneIDi6581
KEGGihsa:6581
UCSCiuc003qti.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001417 mRNA Translation: CAA04751.1
AK314590 mRNA Translation: BAG37164.1
AL591069 Genomic DNA No translation available.
AL355506 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47599.1
AF078749 mRNA Translation: AAD20977.1
CCDSiCCDS5277.1
RefSeqiNP_068812.1, NM_021977.3
UniGeneiHs.567337

3D structure databases

ProteinModelPortaliO75751
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112468, 1 interactor
IntActiO75751, 2 interactors
STRINGi9606.ENSP00000275300

Chemistry databases

BindingDBiO75751
ChEMBLiCHEMBL2073673
DrugBankiDB00718 Adefovir Dipivoxil
DB08838 Agmatine
DB00182 Amphetamine
DB00122 Choline
DB00501 Cimetidine
DB00575 Clonidine
DB01394 Colchicine
DB01151 Desipramine
DB00988 Dopamine
DB00783 Estradiol
DB00536 Guanidine
DB05381 Histamine
DB00458 Imipramine
DB00762 Irinotecan
DB00709 Lamivudine
DB01042 Melphalan
DB00331 Metformin
DB01577 Methamphetamine
DB00184 Nicotine
DB00368 Norepinephrine
DB00526 Oxaliplatin
DB00925 Phenoxybenzamine
DB00457 Prazosin
DB01035 Procainamide
DB00396 Progesterone
DB00624 Testosterone
DB08837 Tetraethylammonium
DB08841 Tyramine
DB00541 Vincristine
GuidetoPHARMACOLOGYi1021

Protein family/group databases

TCDBi2.A.1.19.24 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiO75751
PhosphoSitePlusiO75751

Polymorphism and mutation databases

BioMutaiSLC22A3

Proteomic databases

PaxDbiO75751
PeptideAtlasiO75751
PRIDEiO75751
ProteomicsDBi50179

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275300; ENSP00000275300; ENSG00000146477
GeneIDi6581
KEGGihsa:6581
UCSCiuc003qti.5 human

Organism-specific databases

CTDi6581
DisGeNETi6581
EuPathDBiHostDB:ENSG00000146477.5
GeneCardsiSLC22A3
HGNCiHGNC:10967 SLC22A3
HPAiHPA029750
MIMi604842 gene
neXtProtiNX_O75751
OpenTargetsiENSG00000146477
PharmGKBiPA330
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRIE Eukaryota
ENOG410XSRI LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234568
HOVERGENiHBG061545
InParanoidiO75751
KOiK08200
OMAiWSPEEEW
OrthoDBiEOG091G05AC
PhylomeDBiO75751
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-HSA-2161517 Abacavir transmembrane transport
R-HSA-549127 Organic cation transport

Miscellaneous databases

ChiTaRSiSLC22A3 human
GeneWikiiSLC22A3
GenomeRNAii6581
PROiPR:O75751
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146477 Expressed in 139 organ(s), highest expression level in thoracic aorta
CleanExiHS_SLC22A3
GenevisibleiO75751 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS22A3_HUMAN
AccessioniPrimary (citable) accession number: O75751
Secondary accession number(s): Q5SYN6, Q9UP02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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