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UniProtKB - O75747 (P3C2G_HUMAN)
Protein
Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
Gene
PIK3C2G
Organism
Homo sapiens (Human)
Status
Functioni
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (By similarity).
May play a role in SDF1A-stimulated chemotaxis (By similarity).
By similarityCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H+By similarityEC:2.7.1.154By similarityThis reaction proceeds in the forwardBy similarity direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H+By similarityEC:2.7.1.137By similarityThis reaction proceeds in the forwardBy similarity direction.
GO - Molecular functioni
- 1-phosphatidylinositol-3-kinase activity Source: UniProtKB
- 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- phosphatidylinositol binding Source: InterPro
- phosphatidylinositol kinase activity Source: GO_Central
- phosphatidylinositol phosphate kinase activity Source: UniProtKB
GO - Biological processi
- cell migration Source: GO_Central
- chemotaxis Source: UniProtKB-KW
- phosphatidylinositol 3-kinase signaling Source: GO_Central
- phosphatidylinositol-3-phosphate biosynthetic process Source: UniProtKB
- phosphatidylinositol-mediated signaling Source: GO_Central
- phosphatidylinositol phosphate biosynthetic process Source: GO_Central
- viral RNA genome replication Source: ParkinsonsUK-UCL
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Chemotaxis, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.1.137, 2681 2.7.1.154, 2681 |
PathwayCommonsi | O75747 |
Reactomei | R-HSA-1660499, Synthesis of PIPs at the plasma membrane R-HSA-1660514, Synthesis of PIPs at the Golgi membrane |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PIK3C2G |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8973, PIK3C2G |
MIMi | 609001, gene |
neXtProti | NX_O75747 |
VEuPathDBi | HostDB:ENSG00000139144 |
Subcellular locationi
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- extrinsic component of membrane Source: UniProtKB
- membrane Source: GO_Central
- phosphatidylinositol 3-kinase complex Source: GO_Central
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5288 |
MalaCardsi | PIK3C2G |
OpenTargetsi | ENSG00000139144 |
PharmGKBi | PA33306 |
Miscellaneous databases
Pharosi | O75747, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1163120 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | O75747 |
GuidetoPHARMACOLOGYi | 2288 |
Genetic variation databases
BioMutai | PIK3C2G |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088799 | 1 – 1445 | Phosphatidylinositol 3-kinase C2 domain-containing subunit gammaAdd BLAST | 1445 |
Proteomic databases
MassIVEi | O75747 |
PaxDbi | O75747 |
PeptideAtlasi | O75747 |
PRIDEi | O75747 |
ProteomicsDBi | 50178 |
PTM databases
iPTMneti | O75747 |
PhosphoSitePlusi | O75747 |
Expressioni
Tissue specificityi
Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000139144, Expressed in stomach and 114 other tissues |
ExpressionAtlasi | O75747, baseline and differential |
Genevisiblei | O75747, HS |
Organism-specific databases
HPAi | ENSG00000139144, Tissue enhanced (epididymis, stomach) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 111306, 2 interactors |
STRINGi | 9606.ENSP00000445381 |
Chemistry databases
BindingDBi | O75747 |
Miscellaneous databases
RNActi | O75747, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O75747 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O75747 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 285 – 371 | PI3K-RBDPROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 453 – 628 | C2 PI3K-typePROSITE-ProRule annotationAdd BLAST | 176 | |
Domaini | 643 – 819 | PIK helicalPROSITE-ProRule annotationAdd BLAST | 177 | |
Domaini | 888 – 1166 | PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST | 279 | |
Domaini | 1199 – 1311 | PXPROSITE-ProRule annotationAdd BLAST | 113 | |
Domaini | 1328 – 1445 | C2PROSITE-ProRule annotationAdd BLAST | 118 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 894 – 900 | G-loopPROSITE-ProRule annotation | 7 | |
Regioni | 1030 – 1038 | Catalytic loopPROSITE-ProRule annotation | 9 | |
Regioni | 1049 – 1075 | Activation loopPROSITE-ProRule annotationAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0905, Eukaryota |
GeneTreei | ENSGT00940000159982 |
InParanoidi | O75747 |
OrthoDBi | 204282at2759 |
PhylomeDBi | O75747 |
TreeFami | TF102031 |
Family and domain databases
CDDi | cd05177, PI3Kc_C2_gamma, 1 hit |
Gene3Di | 1.10.1070.11, 1 hit 1.25.40.70, 1 hit 2.60.40.150, 2 hits 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR000008, C2_dom IPR035892, C2_domain_sf IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR037707, PI3K-C2-gamma_dom IPR002420, PI3K-type_C2_dom IPR001263, PI3K_accessory_dom IPR042236, PI3K_accessory_sf IPR000341, PI3K_Ras-bd_dom IPR015433, PI_Kinase IPR001683, PX_dom IPR036871, PX_dom_sf IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR10048, PTHR10048, 2 hits |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00454, PI3_PI4_kinase, 1 hit PF00794, PI3K_rbd, 1 hit PF00613, PI3Ka, 1 hit PF00787, PX, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00145, PI3Ka, 1 hit SM00146, PI3Kc, 1 hit SM00312, PX, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF49562, SSF49562, 2 hits SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS51547, C2_PI3K, 1 hit PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51546, PI3K_RBD, 1 hit PS51545, PIK_HELICAL, 1 hit PS50195, PX, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O75747-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAYSWQTDPN PNESHEKQYE HQEFLFVNQP HSSSQVSLGF DQIVDEISGK
60 70 80 90 100
IPHYESEIDE NTFFVPTAPK WDSTGHSLNE AHQISLNEFT SKSRELSWHQ
110 120 130 140 150
VSKAPAIGFS PSVLPKPQNT NKECSWGSPI GKHHGADDSR FSILAPSFTS
160 170 180 190 200
LDKINLEKEL ENENHNYHIG FESSIPPTNS SFSSDFMPKE ENKRSGHVNI
210 220 230 240 250
VEPSLMLLKG SLQPGMWEST WQKNIESIGC SIQLVEVPQS SNTSLASFCN
260 270 280 290 300
KVKKIRERYH AADVNFNSGK IWSTTTAFPY QLFSKTKFNI HIFIDNSTQP
310 320 330 340 350
LHFMPCANYL VKDLIAEILH FCTNDQLLPK DHILSVCGSE EFLQNDHCLG
360 370 380 390 400
SHKMFQKDKS VIQLHLQKSR EAPGKLSRKH EEDHSQFYLN QLLEFMHIWK
410 420 430 440 450
VSRQCLLTLI RKYDFHLKYL LKTQENVYNI IEEVKKICSV LGCVETKQIT
460 470 480 490 500
DAVNELSLIL QRKGENFYQS SETSAKGLIE KVTTELSTSI YQLINVYCNS
510 520 530 540 550
FYADFQPVNV PRCTSYLNPG LPSHLSFTVY AAHNIPETWV HRINFPLEIK
560 570 580 590 600
SLPRESMLTV KLFGIACATN NANLLAWTCL PLFPKEKSIL GSMLFSMTLQ
610 620 630 640 650
SEPPVEMITP GVWDVSQPSP VTLQIDFPAT GWEYMKPDSE ENRSNLEEPL
660 670 680 690 700
KECIKHIARL SQKQTPLLLS EEKKRYLWFY RFYCNNENCS LPLVLGSAPG
710 720 730 740 750
WDERTVSEMH TILRRWTFSQ PLEALGLLTS SFPDQEIRKV AVQQLDNLLN
760 770 780 790 800
DELLEYLPQL VQAVKFEWNL ESPLVQLLLH RSLQSIQVAH RLYWLLKNAE
810 820 830 840 850
NEAYFKSWYQ KLLAALQFCA GKALNDEFSK EQKLIKILGD IGERVKSASD
860 870 880 890 900
HQRQEVLKKE IGRLEEFFQD VNTCHLPLNP ALCIKGIDHD ACSYFTSNAL
910 920 930 940 950
PLKITFINAN PMGKNISIIF KAGDDLRQDM LVLQLIQVMD NIWLQEGLDM
960 970 980 990 1000
QMIIYRCLST GKDQGLVQMV PDAVTLAKIH RHSGLIGPLK ENTIKKWFSQ
1010 1020 1030 1040 1050
HNHLKADYEK ALRNFFYSCA GWCVVTFILG VCDRHNDNIM LTKSGHMFHI
1060 1070 1080 1090 1100
DFGKFLGHAQ TFGGIKRDRA PFIFTSEMEY FITEGGKNPQ HFQDFVELCC
1110 1120 1130 1140 1150
RAYNIIRKHS QLLLNLLEMM LYAGLPELSG IQDLKYVYNN LRPQDTDLEA
1160 1170 1180 1190 1200
TSHFTKKIKE SLECFPVKLN NLIHTLAQMS AISPAKSTSQ TFPQESCLLS
1210 1220 1230 1240 1250
TTRSIERATI LGFSKKSSNL YLIQVTHSNN ETSLTEKSFE QFSKLHSQLQ
1260 1270 1280 1290 1300
KQFASLTLPE FPHWWHLPFT NSDHRRFRDL NHYMEQILNV SHEVTNSDCV
1310 1320 1330 1340 1350
LSFFLSEAVQ QTVEESSPVY LGEKFPDKKP KVQLVISYED VKLTILVKHM
1360 1370 1380 1390 1400
KNIHLPDGSA PSAHVEFYLL PYPSEVRRRK TKSVPKCTDP TYNEIVVYDE
1410 1420 1430 1440
VTELQGHVLM LIVKSKTVFV GAINIRLCSV PLDKEKWYPL GNSII
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H369 | F5H369_HUMAN | Phosphatidylinositol-4-phosphate 3-... | PIK3C2G | 1,486 | Annotation score: | ||
F5H7Y7 | F5H7Y7_HUMAN | Phosphatidylinositol 4-phosphate 3-... | PIK3C2G | 583 | Annotation score: | ||
A0A087WV31 | A0A087WV31_HUMAN | Phosphatidylinositol 4-phosphate 3-... | PIK3C2G | 187 | Annotation score: | ||
F5GWG6 | F5GWG6_HUMAN | Phosphatidylinositol 4-phosphate 3-... | PIK3C2G | 231 | Annotation score: |
Sequence cautioni
The sequence CAA03853 differs from that shown. Reason: Erroneous termination. Extended C-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 129 | Missing in EAW96387 (Ref. 3) Curated | 1 | |
Sequence conflicti | 129 | Missing in AAI30278 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 965 | G → R in CAA03853 (PubMed:9878262).Curated | 1 | |
Sequence conflicti | 1209 | Missing in CAA03853 (PubMed:9878262).Curated | 1 | |
Sequence conflicti | 1314 | Missing in CAA03853 (PubMed:9878262).Curated | 1 | |
Sequence conflicti | 1323 | E → EK in CAA03853 (PubMed:9878262).Curated | 1 | |
Sequence conflicti | 1377 | R → L in CAA03853 (PubMed:9878262).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056676 | 146 | P → L3 PublicationsCorresponds to variant dbSNP:rs11044004Ensembl. | 1 | |
Natural variantiVAR_056677 | 261 | A → E. Corresponds to variant dbSNP:rs7133666Ensembl. | 1 | |
Natural variantiVAR_060323 | 911 | P → L3 PublicationsCorresponds to variant dbSNP:rs12312266Ensembl. | 1 | |
Natural variantiVAR_060324 | 1290 | V → G. Corresponds to variant dbSNP:rs12099555Ensembl. | 1 | |
Natural variantiVAR_060325 | 1442 | N → T. Corresponds to variant dbSNP:rs12816860Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ000008 mRNA Translation: CAA03853.1 Sequence problems. AC087236 Genomic DNA No translation available. AC087240 Genomic DNA No translation available. AC091815 Genomic DNA No translation available. AC092851 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96387.1 BC130277 mRNA Translation: AAI30278.1 |
CCDSi | CCDS44839.1 |
PIRi | PC4347 |
RefSeqi | NP_001275701.1, NM_001288772.1 NP_001275703.1, NM_001288774.1 NP_004561.3, NM_004570.5 |
Genome annotation databases
Ensembli | ENST00000433979; ENSP00000404845; ENSG00000139144 |
GeneIDi | 5288 |
KEGGi | hsa:5288 |
UCSCi | uc001rdt.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ000008 mRNA Translation: CAA03853.1 Sequence problems. AC087236 Genomic DNA No translation available. AC087240 Genomic DNA No translation available. AC091815 Genomic DNA No translation available. AC092851 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96387.1 BC130277 mRNA Translation: AAI30278.1 |
CCDSi | CCDS44839.1 |
PIRi | PC4347 |
RefSeqi | NP_001275701.1, NM_001288772.1 NP_001275703.1, NM_001288774.1 NP_004561.3, NM_004570.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2WWE | X-ray | 1.25 | A | 1204-1307 | [»] | |
SMRi | O75747 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111306, 2 interactors |
STRINGi | 9606.ENSP00000445381 |
Chemistry databases
BindingDBi | O75747 |
ChEMBLi | CHEMBL1163120 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | O75747 |
GuidetoPHARMACOLOGYi | 2288 |
PTM databases
iPTMneti | O75747 |
PhosphoSitePlusi | O75747 |
Genetic variation databases
BioMutai | PIK3C2G |
Proteomic databases
MassIVEi | O75747 |
PaxDbi | O75747 |
PeptideAtlasi | O75747 |
PRIDEi | O75747 |
ProteomicsDBi | 50178 |
Protocols and materials databases
Antibodypediai | 23850, 118 antibodies from 28 providers |
DNASUi | 5288 |
Genome annotation databases
Ensembli | ENST00000433979; ENSP00000404845; ENSG00000139144 |
GeneIDi | 5288 |
KEGGi | hsa:5288 |
UCSCi | uc001rdt.4, human |
Organism-specific databases
CTDi | 5288 |
DisGeNETi | 5288 |
GeneCardsi | PIK3C2G |
HGNCi | HGNC:8973, PIK3C2G |
HPAi | ENSG00000139144, Tissue enhanced (epididymis, stomach) |
MalaCardsi | PIK3C2G |
MIMi | 609001, gene |
neXtProti | NX_O75747 |
OpenTargetsi | ENSG00000139144 |
PharmGKBi | PA33306 |
VEuPathDBi | HostDB:ENSG00000139144 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0905, Eukaryota |
GeneTreei | ENSGT00940000159982 |
InParanoidi | O75747 |
OrthoDBi | 204282at2759 |
PhylomeDBi | O75747 |
TreeFami | TF102031 |
Enzyme and pathway databases
BRENDAi | 2.7.1.137, 2681 2.7.1.154, 2681 |
PathwayCommonsi | O75747 |
Reactomei | R-HSA-1660499, Synthesis of PIPs at the plasma membrane R-HSA-1660514, Synthesis of PIPs at the Golgi membrane |
Miscellaneous databases
BioGRID-ORCSi | 5288, 5 hits in 1036 CRISPR screens |
ChiTaRSi | PIK3C2G, human |
EvolutionaryTracei | O75747 |
GeneWikii | PIK3C2G |
GenomeRNAii | 5288 |
Pharosi | O75747, Tchem |
PROi | PR:O75747 |
RNActi | O75747, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139144, Expressed in stomach and 114 other tissues |
ExpressionAtlasi | O75747, baseline and differential |
Genevisiblei | O75747, HS |
Family and domain databases
CDDi | cd05177, PI3Kc_C2_gamma, 1 hit |
Gene3Di | 1.10.1070.11, 1 hit 1.25.40.70, 1 hit 2.60.40.150, 2 hits 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR000008, C2_dom IPR035892, C2_domain_sf IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR037707, PI3K-C2-gamma_dom IPR002420, PI3K-type_C2_dom IPR001263, PI3K_accessory_dom IPR042236, PI3K_accessory_sf IPR000341, PI3K_Ras-bd_dom IPR015433, PI_Kinase IPR001683, PX_dom IPR036871, PX_dom_sf IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR10048, PTHR10048, 2 hits |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00454, PI3_PI4_kinase, 1 hit PF00794, PI3K_rbd, 1 hit PF00613, PI3Ka, 1 hit PF00787, PX, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00145, PI3Ka, 1 hit SM00146, PI3Kc, 1 hit SM00312, PX, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF49562, SSF49562, 2 hits SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS51547, C2_PI3K, 1 hit PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51546, PI3K_RBD, 1 hit PS51545, PIK_HELICAL, 1 hit PS50195, PX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | P3C2G_HUMAN | |
Accessioni | O75747Primary (citable) accession number: O75747 Secondary accession number(s): A1L3U0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 23, 2022 | |
This is version 192 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families