Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WD repeat and HMG-box DNA-binding protein 1

Gene

WDHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1016 – 1079HMG boxPROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • DNA binding Source: ProtInc
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

SignaLinkiO75717

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and HMG-box DNA-binding protein 1
Alternative name(s):
Acidic nucleoplasmic DNA-binding protein 1
Short name:
And-1
Gene namesi
Name:WDHD1
Synonyms:AND1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000198554.11
HGNCiHGNC:23170 WDHD1
MIMi608126 gene
neXtProtiNX_O75717

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11169
OpenTargetsiENSG00000198554
PharmGKBiPA134988782

Polymorphism and mutation databases

BioMutaiWDHD1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513381 – 1129WD repeat and HMG-box DNA-binding protein 1Add BLAST1129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei333PhosphoserineCombined sources1
Modified residuei374PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Cross-linki397Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei671N6-acetyllysineBy similarity1
Modified residuei824PhosphothreonineCombined sources1
Modified residuei826PhosphothreonineCombined sources1
Modified residuei868PhosphoserineCombined sources1
Modified residuei917PhosphoserineCombined sources1
Modified residuei919PhosphoserineCombined sources1
Modified residuei932PhosphoserineCombined sources1
Modified residuei962N6-acetyllysineCombined sources1
Modified residuei984PhosphoserineCombined sources1
Modified residuei1041PhosphoserineCombined sources1
Modified residuei1090PhosphoserineCombined sources1
Cross-linki1127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO75717
MaxQBiO75717
PaxDbiO75717
PeptideAtlasiO75717
PRIDEiO75717
ProteomicsDBi50175

PTM databases

iPTMnetiO75717
PhosphoSitePlusiO75717

Expressioni

Gene expression databases

BgeeiENSG00000198554 Expressed in 130 organ(s), highest expression level in testis
CleanExiHS_WDHD1
ExpressionAtlasiO75717 baseline and differential
GenevisibleiO75717 HS

Organism-specific databases

HPAiHPA001122

Interactioni

Subunit structurei

Interacts with the polymerase alpha catalytic subunit POLA1. Interacts with MCM10. Interacts with DNA2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KAT2AQ928305EBI-3951691,EBI-477622

Protein-protein interaction databases

BioGridi116340, 51 interactors
CORUMiO75717
IntActiO75717, 10 interactors
MINTiO75717
STRINGi9606.ENSP00000353793

Structurei

Secondary structure

11129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75717
SMRiO75717
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75717

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 50WD 1Add BLAST40
Repeati52 – 91WD 2Add BLAST40
Repeati92 – 131WD 3Add BLAST40
Repeati134 – 173WD 4Add BLAST40
Repeati184 – 223WD 5Add BLAST40
Repeati228 – 267WD 6Add BLAST40
Repeati271 – 310WD 7Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi829 – 836Glu-rich (acidic)8
Compositional biasi862 – 878Asp/Glu-rich (acidic)Add BLAST17

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1274 Eukaryota
ENOG410XSJV LUCA
GeneTreeiENSGT00390000002030
HOGENOMiHOG000015160
HOVERGENiHBG074190
InParanoidiO75717
KOiK11274
OMAiNAWFPIC
OrthoDBiEOG091G084W
PhylomeDBiO75717
TreeFamiTF105988

Family and domain databases

Gene3Di1.10.30.10, 1 hit
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR022100 Mcl1_mid
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF12341 Mcl1_mid, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF47095 SSF47095, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75717-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPATRKPMRY GHTEGHTEVC FDDSGSFIVT CGSDGDVRIW EDLDDDDPKF
60 70 80 90 100
INVGEKAYSC ALKSGKLVTA VSNNTIQVHT FPEGVPDGIL TRFTTNANHV
110 120 130 140 150
VFNGDGTKIA AGSSDFLVKI VDVMDSSQQK TFRGHDAPVL SLSFDPKDIF
160 170 180 190 200
LASASCDGSV RVWQISDQTC AISWPLLQKC NDVINAKSIC RLAWQPKSGK
210 220 230 240 250
LLAIPVEKSV KLYRRESWSH QFDLSDNFIS QTLNIVTWSP CGQYLAAGSI
260 270 280 290 300
NGLIIVWNVE TKDCMERVKH EKGYAICGLA WHPTCGRISY TDAEGNLGLL
310 320 330 340 350
ENVCDPSGKT SSSKVSSRVE KDYNDLFDGD DMSNAGDFLN DNAVEIPSFS
360 370 380 390 400
KGIINDDEDD EDLMMASGRP RQRSHILEDD ENSVDISMLK TGSSLLKEEE
410 420 430 440 450
EDGQEGSIHN LPLVTSQRPF YDGPMPTPRQ KPFQSGSTPL HLTHRFMVWN
460 470 480 490 500
SIGIIRCYND EQDNAIDVEF HDTSIHHATH LSNTLNYTIA DLSHEAILLA
510 520 530 540 550
CESTDELASK LHCLHFSSWD SSKEWIIDLP QNEDIEAICL GQGWAAAATS
560 570 580 590 600
ALLLRLFTIG GVQKEVFSLA GPVVSMAGHG EQLFIVYHRG TGFDGDQCLG
610 620 630 640 650
VQLLELGKKK KQILHGDPLP LTRKSYLAWI GFSAEGTPCY VDSEGIVRML
660 670 680 690 700
NRGLGNTWTP ICNTREHCKG KSDHYWVVGI HENPQQLRCI PCKGSRFPPT
710 720 730 740 750
LPRPAVAILS FKLPYCQIAT EKGQMEEQFW RSVIFHNHLD YLAKNGYEYE
760 770 780 790 800
ESTKNQATKE QQELLMKMLA LSCKLEREFR CVELADLMTQ NAVNLAIKYA
810 820 830 840 850
SRSRKLILAQ KLSELAVEKA AELTATQVEE EEEEEDFRKK LNAGYSNTAT
860 870 880 890 900
EWSQPRFRNQ VEEDAEDSGE ADDEEKPEIH KPGQNSFSKS TNSSDVSAKS
910 920 930 940 950
GAVTFSSQGR VNPFKVSASS KEPAMSMNSA RSTNILDNMG KSSKKSTALS
960 970 980 990 1000
RTTNNEKSPI IKPLIPKPKP KQASAASYFQ KRNSQTNKTE EVKEENLKNV
1010 1020 1030 1040 1050
LSETPAICPP QNTENQRPKT GFQMWLEENR SNILSDNPDF SDEADIIKEG
1060 1070 1080 1090 1100
MIRFRVLSTE ERKVWANKAK GETASEGTEA KKRKRVVDES DETENQEEKA
1110 1120
KENLNLSKKQ KPLDFSTNQK LSAFAFKQE
Length:1,129
Mass (Da):125,967
Last modified:November 1, 1998 - v1
Checksum:iDD3E3613CA6AE70A
GO
Isoform 2 (identifier: O75717-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:1,006
Mass (Da):112,705
Checksum:i430FD72EAB983984
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYB3C9JYB3_HUMAN
WD repeat and HMG-box DNA-binding p...
WDHD1
168Annotation score:
H3BSQ1H3BSQ1_HUMAN
WD repeat and HMG-box DNA-binding p...
WDHD1
64Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti612Q → K in AAH43349 (PubMed:15489334).Curated1
Sequence conflicti612Q → K in AAH00622 (PubMed:15489334).Curated1
Sequence conflicti613I → K in AAH00622 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053422338F → L. Corresponds to variant dbSNP:rs8020032Ensembl.1
Natural variantiVAR_053423411L → P. Corresponds to variant dbSNP:rs17128116Ensembl.1
Natural variantiVAR_0621001102E → K. Corresponds to variant dbSNP:rs41309252Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547751 – 123Missing in isoform 2. CuratedAdd BLAST123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006266 mRNA Translation: CAA06932.1
AL160471 Genomic DNA No translation available.
BC000622 mRNA Translation: AAH00622.1
BC043349 mRNA Translation: AAH43349.1
BC063041 mRNA Translation: AAH63041.1
CCDSiCCDS41955.1 [O75717-2]
CCDS9721.1 [O75717-1]
RefSeqiNP_001008397.1, NM_001008396.2 [O75717-2]
NP_009017.1, NM_007086.3 [O75717-1]
UniGeneiHs.385998

Genome annotation databases

EnsembliENST00000360586; ENSP00000353793; ENSG00000198554 [O75717-1]
ENST00000420358; ENSP00000399349; ENSG00000198554 [O75717-2]
GeneIDi11169
KEGGihsa:11169
UCSCiuc001xbm.3 human [O75717-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006266 mRNA Translation: CAA06932.1
AL160471 Genomic DNA No translation available.
BC000622 mRNA Translation: AAH00622.1
BC043349 mRNA Translation: AAH43349.1
BC063041 mRNA Translation: AAH63041.1
CCDSiCCDS41955.1 [O75717-2]
CCDS9721.1 [O75717-1]
RefSeqiNP_001008397.1, NM_001008396.2 [O75717-2]
NP_009017.1, NM_007086.3 [O75717-1]
UniGeneiHs.385998

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D7LNMR-A1017-1084[»]
5GVAX-ray1.85A1-330[»]
5GVBX-ray2.75A416-850[»]
5OGSX-ray2.50A329-826[»]
ProteinModelPortaliO75717
SMRiO75717
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116340, 51 interactors
CORUMiO75717
IntActiO75717, 10 interactors
MINTiO75717
STRINGi9606.ENSP00000353793

PTM databases

iPTMnetiO75717
PhosphoSitePlusiO75717

Polymorphism and mutation databases

BioMutaiWDHD1

Proteomic databases

EPDiO75717
MaxQBiO75717
PaxDbiO75717
PeptideAtlasiO75717
PRIDEiO75717
ProteomicsDBi50175

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360586; ENSP00000353793; ENSG00000198554 [O75717-1]
ENST00000420358; ENSP00000399349; ENSG00000198554 [O75717-2]
GeneIDi11169
KEGGihsa:11169
UCSCiuc001xbm.3 human [O75717-1]

Organism-specific databases

CTDi11169
DisGeNETi11169
EuPathDBiHostDB:ENSG00000198554.11
GeneCardsiWDHD1
HGNCiHGNC:23170 WDHD1
HPAiHPA001122
MIMi608126 gene
neXtProtiNX_O75717
OpenTargetsiENSG00000198554
PharmGKBiPA134988782
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1274 Eukaryota
ENOG410XSJV LUCA
GeneTreeiENSGT00390000002030
HOGENOMiHOG000015160
HOVERGENiHBG074190
InParanoidiO75717
KOiK11274
OMAiNAWFPIC
OrthoDBiEOG091G084W
PhylomeDBiO75717
TreeFamiTF105988

Enzyme and pathway databases

SignaLinkiO75717

Miscellaneous databases

ChiTaRSiWDHD1 human
EvolutionaryTraceiO75717
GeneWikiiWDHD1
GenomeRNAii11169
PROiPR:O75717
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198554 Expressed in 130 organ(s), highest expression level in testis
CleanExiHS_WDHD1
ExpressionAtlasiO75717 baseline and differential
GenevisibleiO75717 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR022100 Mcl1_mid
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF12341 Mcl1_mid, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF47095 SSF47095, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDHD1_HUMAN
AccessioniPrimary (citable) accession number: O75717
Secondary accession number(s): C9JW18, F6W0U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again