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Entry version 192 (17 Jun 2020)
Sequence version 4 (23 Jan 2007)
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Protein

Serine/threonine-protein kinase 16

Gene

STK16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei49ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei148Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi26 – 34ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.1 2681

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O75716

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase 16 (EC:2.7.11.1)
Alternative name(s):
Myristoylated and palmitoylated serine/threonine-protein kinase
Short name:
MPSK
Protein kinase PKL12
TGF-beta-stimulated factor 1
Short name:
TSF-1
Tyrosine-protein kinase STK16 (EC:2.7.10.2)
hPSK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STK16
Synonyms:MPSK1, PKL12, TSF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000115661.13

Human Gene Nomenclature Database

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HGNCi
HGNC:11394 STK16

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604719 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O75716

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2G → A: Loss of myristoylation. 1 Publication1
Mutagenesisi6C → S: Loss of palmitoylation. 1 Publication1
Mutagenesisi8C → S: Loss of palmitoylation. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
8576

Open Targets

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OpenTargetsi
ENSG00000115661

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36202

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75716 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3938

Drug and drug target database

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DrugBanki
DB12010 Fostamatinib

DrugCentral

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DrugCentrali
O75716

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2213

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STK16

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000867012 – 305Serine/threonine-protein kinase 16Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
Lipidationi6S-palmitoyl cysteine1 Publication1
Lipidationi8S-palmitoyl cysteine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei185Phosphothreonine; by autocatalysis1 Publication1
Modified residuei197Phosphoserine; by autocatalysis1 Publication1
Modified residuei198Phosphotyrosine; by autocatalysis1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-198.1 Publication
It is uncertain whether palmitoylation is on Cys-6 and/or Cys-8.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75716

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75716

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O75716

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75716

PeptideAtlas

More...
PeptideAtlasi
O75716

PRoteomics IDEntifications database

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PRIDEi
O75716

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
50174

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75716

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75716

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O75716

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed at very low levels.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000115661 Expressed in blood and 141 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75716 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75716 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000115661 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts with DRG1 (via its N-terminal); the interaction phosphorylates DRG1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O75716
With#Exp.IntAct
ADAMTSL4 [Q6UY14]3EBI-749295,EBI-742002
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-749295,EBI-10173507
AGR2 [O95994]3EBI-749295,EBI-712648
ARNT2 [A0A087WVE9]3EBI-749295,EBI-12808086
ATP23 [Q9Y6H3]3EBI-749295,EBI-12811889
BHLHA9 [Q7RTU4]3EBI-749295,EBI-17508719
CALCOCO2 [Q13137]3EBI-749295,EBI-739580
CBX3 [Q13185]3EBI-749295,EBI-78176
CFP [P27918]3EBI-749295,EBI-9038570
CRX [O43186]3EBI-749295,EBI-748171
CSKMT [A8MUP2]3EBI-749295,EBI-12842046
CYSRT1 [A8MQ03]3EBI-749295,EBI-3867333
DDIT4L [Q96D03]3EBI-749295,EBI-742054
DNAJA3 - isoform 2 [Q96EY1-2]3EBI-749295,EBI-3952284
DRG1 [Q9Y295]3EBI-749295,EBI-719554
EFEMP2 [O95967]6EBI-749295,EBI-743414
EFHC2 [Q5JST6]3EBI-749295,EBI-2349927
FLACC1 [Q96Q35]3EBI-749295,EBI-750451
FRS3 [O43559]3EBI-749295,EBI-725515
FXR1 - isoform 2 [P51114-2]3EBI-749295,EBI-11022345
GABPA [Q06546]3EBI-749295,EBI-638925
IKZF3 [Q9UKT9]3EBI-749295,EBI-747204
INCA1 [Q0VD86]6EBI-749295,EBI-6509505
KCTD14 [Q9BQ13]4EBI-749295,EBI-10189448
KCTD14 - isoform 3b [Q9BQ13-2]3EBI-749295,EBI-12278688
KCTD17 [Q8N5Z5]9EBI-749295,EBI-743960
KCTD17 - isoform 2 [Q8N5Z5-2]3EBI-749295,EBI-10189368
KLHL20 [Q9BS75]3EBI-749295,EBI-10693436
KPRP [Q5T749]3EBI-749295,EBI-10981970
KRT31 [Q15323]3EBI-749295,EBI-948001
KRTAP1-1 [Q07627]3EBI-749295,EBI-11959885
KRTAP10-5 [P60370]3EBI-749295,EBI-10172150
KRTAP10-7 [P60409]3EBI-749295,EBI-10172290
KRTAP10-8 [P60410]6EBI-749295,EBI-10171774
KRTAP10-9 [P60411]3EBI-749295,EBI-10172052
KRTAP11-1 [Q8IUC1]3EBI-749295,EBI-1052037
KRTAP13-2 [Q52LG2]3EBI-749295,EBI-11953846
KRTAP26-1 [Q6PEX3]3EBI-749295,EBI-3957672
MEOX2 [P50222]3EBI-749295,EBI-748397
MIER3 - isoform 2 [Q7Z3K6-2]3EBI-749295,EBI-12224671
MIIP [Q5JXC2]4EBI-749295,EBI-2801965
MTUS2 [Q5JR59]3EBI-749295,EBI-742948
NAA80 - isoform 2 [Q93015-2]5EBI-749295,EBI-12126220
NIF3L1 [Q9GZT8]3EBI-749295,EBI-740897
NOTCH2NLA [Q7Z3S9]3EBI-749295,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-749295,EBI-22310682
PCSK5 [Q92824]3EBI-749295,EBI-751290
PKNOX2 [Q96KN3]3EBI-749295,EBI-2692890
PLA2G10 [O15496]3EBI-749295,EBI-726466
PLSCR1 [O15162]3EBI-749295,EBI-740019
PLSCR3 [Q9NRY6]6EBI-749295,EBI-750734
PRDM6 [Q9NQX0]3EBI-749295,EBI-11320284
PRKAR1B [P31321]3EBI-749295,EBI-2805516
PTH1R [Q03431]3EBI-749295,EBI-2860297
REL [Q04864]3EBI-749295,EBI-307352
REL - isoform 2 [Q04864-2]3EBI-749295,EBI-10829018
RFX6 [Q8HWS3]3EBI-749295,EBI-746118
RPIA [P49247]4EBI-749295,EBI-744831
RSPO4 [Q2I0M5]3EBI-749295,EBI-12821217
SAXO1 [Q8IYX7]6EBI-749295,EBI-3957636
SKIL [P12757]3EBI-749295,EBI-2902468
SOCS2 [O14508]3EBI-749295,EBI-617737
SPRY2 [O43597]3EBI-749295,EBI-742487
TCF12 [Q99081]3EBI-749295,EBI-722877
TCF4 [P15884]3EBI-749295,EBI-533224
TLE5 [Q08117]3EBI-749295,EBI-717810
TNFAIP1 [Q13829]3EBI-749295,EBI-2505861
TRAF3IP2 [O43734]3EBI-749295,EBI-744798
TRIM27 [P14373]3EBI-749295,EBI-719493
TRIM42 [Q8IWZ5]6EBI-749295,EBI-5235829
TRIP6 [Q15654]3EBI-749295,EBI-742327
USP54 - isoform 6 [Q70EL1-9]3EBI-749295,EBI-11975223
ZNF330 [Q9Y3S2]6EBI-749295,EBI-373456
ZNF343 [Q6P1L6]3EBI-749295,EBI-10252492
ZNF774 [Q6NX45]3EBI-749295,EBI-10251462
Drg1 [P32233] from Mus musculus.4EBI-749295,EBI-8429215
tir [Q7DB77] from Escherichia coli O157:H7.3EBI-749295,EBI-6480811

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114144, 71 interactors

Database of interacting proteins

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DIPi
DIP-29598N

Protein interaction database and analysis system

More...
IntActi
O75716, 86 interactors

Molecular INTeraction database

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MINTi
O75716

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386928

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O75716

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O75716 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1305
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75716

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O75716

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 293Protein kinasePROSITE-ProRule annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni166 – 202Activation loopAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2345 Eukaryota
ENOG410YN06 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00550000075037

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75716

KEGG Orthology (KO)

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KOi
K08856

Database of Orthologous Groups

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OrthoDBi
831026at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75716

TreeFam database of animal gene trees

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TreeFami
TF350433

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

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Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O75716-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGHALCVCSR GTVIIDNKRY LFIQKLGEGG FSYVDLVEGL HDGHFYALKR
60 70 80 90 100
ILCHEQQDRE EAQREADMHR LFNHPNILRL VAYCLRERGA KHEAWLLLPF
110 120 130 140 150
FKRGTLWNEI ERLKDKGNFL TEDQILWLLL GICRGLEAIH AKGYAHRDLK
160 170 180 190 200
PTNILLGDEG QPVLMDLGSM NQACIHVEGS RQALTLQDWA AQRCTISYRA
210 220 230 240 250
PELFSVQSHC VIDERTDVWS LGCVLYAMMF GEGPYDMVFQ KGDSVALAVQ
260 270 280 290 300
NQLSIPQSPR HSSALRQLLN SMMTVDPHQR PHIPLLLSQL EALQPPAPGQ

HTTQI
Length:305
Mass (Da):34,656
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i593B2AEB8505009C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZI5B8ZZI5_HUMAN
Serine/threonine-protein kinase 16
STK16
273Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZN3B8ZZN3_HUMAN
Serine/threonine-protein kinase 16
STK16
350Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DPS1B4DPS1_HUMAN
Serine/threonine-protein kinase 16
STK16
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAV38392 differs from that shown. Reason: Frameshift.Curated
The sequence CAA06700 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti59R → L in AAV38392 (Ref. 6) Curated1
Sequence conflicti180S → P in BAF85383 (PubMed:14702039).Curated1
Sequence conflicti213D → G in CAA06700 (PubMed:9712705).Curated1
Sequence conflicti213D → G in CAA09387 (Ref. 4) Curated1
Sequence conflicti221L → F in AAC28337 (PubMed:10364453).Curated1
Sequence conflicti222G → S in CAA09387 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04114041H → R1 PublicationCorresponds to variant dbSNP:rs34799131Ensembl.1
Natural variantiVAR_04114155E → K1 PublicationCorresponds to variant dbSNP:rs35947471Ensembl.1
Natural variantiVAR_04114277I → V1 PublicationCorresponds to variant dbSNP:rs34282267Ensembl.1
Natural variantiVAR_041143266R → W3 PublicationsCorresponds to variant dbSNP:rs17849638Ensembl.1
Natural variantiVAR_041144277P → L1 PublicationCorresponds to variant dbSNP:rs35454203Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ005791 mRNA Translation: CAA06700.1 Frameshift.
AF060798 mRNA Translation: AAC28337.1
AB020739 mRNA Translation: BAB16311.1
AJ010872 mRNA Translation: CAA09387.1
AF203910 mRNA Translation: AAG23728.1
BT019585 mRNA Translation: AAV38392.1 Frameshift.
AK292694 mRNA Translation: BAF85383.1
CR407675 mRNA Translation: CAG28603.1
BC002618 mRNA Translation: AAH02618.1
BC053998 mRNA Translation: AAH53998.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42822.1

NCBI Reference Sequences

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RefSeqi
NP_001008910.1, NM_001008910.3
NP_001317142.1, NM_001330213.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000396738; ENSP00000379964; ENSG00000115661
ENST00000409638; ENSP00000386928; ENSG00000115661

Database of genes from NCBI RefSeq genomes

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GeneIDi
8576

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8576

UCSC genome browser

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UCSCi
uc002vko.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005791 mRNA Translation: CAA06700.1 Frameshift.
AF060798 mRNA Translation: AAC28337.1
AB020739 mRNA Translation: BAB16311.1
AJ010872 mRNA Translation: CAA09387.1
AF203910 mRNA Translation: AAG23728.1
BT019585 mRNA Translation: AAV38392.1 Frameshift.
AK292694 mRNA Translation: BAF85383.1
CR407675 mRNA Translation: CAG28603.1
BC002618 mRNA Translation: AAH02618.1
BC053998 mRNA Translation: AAH53998.1
CCDSiCCDS42822.1
RefSeqiNP_001008910.1, NM_001008910.3
NP_001317142.1, NM_001330213.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BUJX-ray2.60A/B13-305[»]
SMRiO75716
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114144, 71 interactors
DIPiDIP-29598N
IntActiO75716, 86 interactors
MINTiO75716
STRINGi9606.ENSP00000386928

Chemistry databases

BindingDBiO75716
ChEMBLiCHEMBL3938
DrugBankiDB12010 Fostamatinib
DrugCentraliO75716
GuidetoPHARMACOLOGYi2213

PTM databases

iPTMnetiO75716
PhosphoSitePlusiO75716
SwissPalmiO75716

Polymorphism and mutation databases

BioMutaiSTK16

Proteomic databases

EPDiO75716
jPOSTiO75716
MassIVEiO75716
PaxDbiO75716
PeptideAtlasiO75716
PRIDEiO75716
ProteomicsDBi50174

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
34316 272 antibodies

The DNASU plasmid repository

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DNASUi
8576

Genome annotation databases

EnsembliENST00000396738; ENSP00000379964; ENSG00000115661
ENST00000409638; ENSP00000386928; ENSG00000115661
GeneIDi8576
KEGGihsa:8576
UCSCiuc002vko.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8576
DisGeNETi8576
EuPathDBiHostDB:ENSG00000115661.13

GeneCards: human genes, protein and diseases

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GeneCardsi
STK16
HGNCiHGNC:11394 STK16
HPAiENSG00000115661 Low tissue specificity
MIMi604719 gene
neXtProtiNX_O75716
OpenTargetsiENSG00000115661
PharmGKBiPA36202

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2345 Eukaryota
ENOG410YN06 LUCA
GeneTreeiENSGT00550000075037
InParanoidiO75716
KOiK08856
OrthoDBi831026at2759
PhylomeDBiO75716
TreeFamiTF350433

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiO75716

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8576 1 hit in 816 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STK16 human
EvolutionaryTraceiO75716

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
STK16

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8576
PharosiO75716 Tchem

Protein Ontology

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PROi
PR:O75716
RNActiO75716 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115661 Expressed in blood and 141 other tissues
ExpressionAtlasiO75716 baseline and differential
GenevisibleiO75716 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTK16_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75716
Secondary accession number(s): A8K9H9
, Q5U0F8, Q96KI2, Q9BUH4, Q9UEN3, Q9UP78
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: June 17, 2020
This is version 192 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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