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Protein

Epididymal secretory glutathione peroxidase

Gene

GPX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73By similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: Reactome
  • lipid metabolic process Source: ProtInc

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Enzyme and pathway databases

BRENDAi1.11.1.9 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species

Protein family/group databases

PeroxiBasei3604 HsGPx05-A
3629 HsGPx05-B

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal secretory glutathione peroxidase (EC:1.11.1.9)
Alternative name(s):
Epididymis-specific glutathione peroxidase-like protein
Short name:
EGLP
Glutathione peroxidase 5
Short name:
GPx-5
Short name:
GSHPx-5
Gene namesi
Name:GPX5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000224586.6
HGNCiHGNC:4557 GPX5
MIMi603435 gene
neXtProtiNX_O75715

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2880
OpenTargetsiENSG00000224586
PharmGKBiPA28953

Chemistry databases

DrugBankiDB00143 Glutathione

Polymorphism and mutation databases

BioMutaiGPX5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001307622 – 221Epididymal secretory glutathione peroxidaseAdd BLAST200

Proteomic databases

PaxDbiO75715
PeptideAtlasiO75715
PRIDEiO75715
ProteomicsDBi50172
50173 [O75715-2]

PTM databases

iPTMnetiO75715
PhosphoSitePlusiO75715

Expressioni

Tissue specificityi

Epididymis.

Gene expression databases

BgeeiENSG00000224586 Expressed in 20 organ(s), highest expression level in caput epididymis
CleanExiHS_GPX5
ExpressionAtlasiO75715 baseline and differential
GenevisibleiO75715 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000392398

Structurei

Secondary structure

1221
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75715
SMRiO75715
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75715

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277055
HOVERGENiHBG101716
InParanoidiO75715
KOiK00432
OMAiKHISWEP
OrthoDBiEOG091G10LN
PhylomeDBiO75715
TreeFamiTF105318

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O75715-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTQLRVVHL LPLLLACFVQ TSPKQEKMKM DCHKDEKGTI YDYEAIALNK
60 70 80 90 100
NEYVSFKQYV GKHILFVNVA TYCGLTAQYP ELNALQEELK PYGLVVLGFP
110 120 130 140 150
CNQFGKQEPG DNKEILPGLK YVRPGGGFVP SFQLFEKGDV NGEKEQKVFS
160 170 180 190 200
FLKHSCPHPS EILGTFKSIS WDPVKVHDIR WNFEKFLVGP DGIPVMRWSH
210 220
RATVSSVKTD ILAYLKQFKT K
Length:221
Mass (Da):25,202
Last modified:November 1, 1998 - v1
Checksum:iCE3E7BFD53CE979F
GO
Isoform 2 (identifier: O75715-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-221: ELNALQEELK...LAYLKQFKTK → GMSVQGEDLYLVSSFLRKGM

Note: No experimental confirmation available.
Show »
Length:100
Mass (Da):11,429
Checksum:i04BFE67B6E77684F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06120685L → P. Corresponds to variant dbSNP:rs58554303Ensembl.1
Natural variantiVAR_01204085L → V1 PublicationCorresponds to variant dbSNP:rs769188Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04304681 – 221ELNAL…QFKTK → GMSVQGEDLYLVSSFLRKGM in isoform 2. 1 PublicationAdd BLAST141

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005277 mRNA Translation: CAA06463.1
AY882013 Genomic DNA Translation: AAW56939.1
AL049543 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03168.1
BC128159 mRNA Translation: AAI28160.1
BC128160 mRNA Translation: AAI28161.1
CCDSiCCDS4652.1 [O75715-1]
CCDS4653.1 [O75715-2]
RefSeqiNP_001500.1, NM_001509.2 [O75715-1]
NP_003987.2, NM_003996.3 [O75715-2]
UniGeneiHs.248129

Genome annotation databases

EnsembliENST00000412168; ENSP00000392398; ENSG00000224586 [O75715-1]
ENST00000469384; ENSP00000419935; ENSG00000224586 [O75715-2]
ENST00000550775; ENSP00000450365; ENSG00000257770 [O75715-1]
ENST00000551639; ENSP00000449271; ENSG00000257770 [O75715-2]
GeneIDi2880
KEGGihsa:2880
UCSCiuc003nlm.3 human [O75715-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005277 mRNA Translation: CAA06463.1
AY882013 Genomic DNA Translation: AAW56939.1
AL049543 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03168.1
BC128159 mRNA Translation: AAI28160.1
BC128160 mRNA Translation: AAI28161.1
CCDSiCCDS4652.1 [O75715-1]
CCDS4653.1 [O75715-2]
RefSeqiNP_001500.1, NM_001509.2 [O75715-1]
NP_003987.2, NM_003996.3 [O75715-2]
UniGeneiHs.248129

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I3YX-ray2.00A28-220[»]
ProteinModelPortaliO75715
SMRiO75715
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000392398

Chemistry databases

DrugBankiDB00143 Glutathione

Protein family/group databases

PeroxiBasei3604 HsGPx05-A
3629 HsGPx05-B

PTM databases

iPTMnetiO75715
PhosphoSitePlusiO75715

Polymorphism and mutation databases

BioMutaiGPX5

Proteomic databases

PaxDbiO75715
PeptideAtlasiO75715
PRIDEiO75715
ProteomicsDBi50172
50173 [O75715-2]

Protocols and materials databases

DNASUi2880
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412168; ENSP00000392398; ENSG00000224586 [O75715-1]
ENST00000469384; ENSP00000419935; ENSG00000224586 [O75715-2]
ENST00000550775; ENSP00000450365; ENSG00000257770 [O75715-1]
ENST00000551639; ENSP00000449271; ENSG00000257770 [O75715-2]
GeneIDi2880
KEGGihsa:2880
UCSCiuc003nlm.3 human [O75715-1]

Organism-specific databases

CTDi2880
DisGeNETi2880
EuPathDBiHostDB:ENSG00000224586.6
GeneCardsiGPX5
HGNCiHGNC:4557 GPX5
MIMi603435 gene
neXtProtiNX_O75715
OpenTargetsiENSG00000224586
PharmGKBiPA28953
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277055
HOVERGENiHBG101716
InParanoidiO75715
KOiK00432
OMAiKHISWEP
OrthoDBiEOG091G10LN
PhylomeDBiO75715
TreeFamiTF105318

Enzyme and pathway databases

BRENDAi1.11.1.9 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species

Miscellaneous databases

EvolutionaryTraceiO75715
GeneWikiiGPX5
GenomeRNAii2880
PROiPR:O75715
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000224586 Expressed in 20 organ(s), highest expression level in caput epididymis
CleanExiHS_GPX5
ExpressionAtlasiO75715 baseline and differential
GenevisibleiO75715 HS

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPX5_HUMAN
AccessioniPrimary (citable) accession number: O75715
Secondary accession number(s): A1A4Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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