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Protein

Nuclear pore complex protein Nup155

Gene

NUP155

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.By similarity

GO - Molecular functioni

  • structural constituent of nuclear pore Source: GO_Central
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup155
Alternative name(s):
155 kDa nucleoporin
Nucleoporin Nup155
Gene namesi
Name:NUP155
Synonyms:KIAA0791
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113569.15
HGNCiHGNC:8063 NUP155
MIMi606694 gene
neXtProtiNX_O75694

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Involvement in diseasei

Atrial fibrillation, familial, 15 (ATFB15)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.
See also OMIM:615770
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071762391R → H in ATFB15; fails to accumulate at various foci of the nuclear envelope and is diffusely distributed in the cytoplasm; shows significantly reduced permeability of the nuclear envelope compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs587777339EnsemblClinVar.1

Keywords - Diseasei

Atrial fibrillation, Disease mutation

Organism-specific databases

DisGeNETi9631
MalaCardsiNUP155
MIMi615770 phenotype
OpenTargetsiENSG00000113569
Orphaneti334 Familial atrial fibrillation
PharmGKBiPA31849

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002048442 – 1391Nuclear pore complex protein Nup155Add BLAST1390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi526O-linked (GlcNAc) serineBy similarity1
Cross-linki740Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1057PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).By similarity
Disulfide-linked to NUP62. The the inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO75694
MaxQBiO75694
PaxDbiO75694
PeptideAtlasiO75694
PRIDEiO75694
ProteomicsDBi50165
50166 [O75694-2]

PTM databases

CarbonylDBiO75694
iPTMnetiO75694
PhosphoSitePlusiO75694
SwissPalmiO75694

Expressioni

Tissue specificityi

Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiENSG00000113569
CleanExiHS_NUP155
ExpressionAtlasiO75694 baseline and differential
GenevisibleiO75694 HS

Organism-specific databases

HPAiHPA037775

Interactioni

Subunit structurei

Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro. Forms a complex with NUP35, NUP93, NUP205 and lamin B.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EFSO432813EBI-1050769,EBI-718488

Protein-protein interaction databases

BioGridi114990, 58 interactors
CORUMiO75694
IntActiO75694, 40 interactors
MINTiO75694
STRINGi9606.ENSP00000231498

Structurei

3D structure databases

ProteinModelPortaliO75694
SMRiO75694
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi585 – 655Pro-richAdd BLAST71

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1900 Eukaryota
COG5308 LUCA
GeneTreeiENSGT00390000016532
HOGENOMiHOG000043927
HOVERGENiHBG052680
InParanoidiO75694
KOiK14312
OMAiTRYVENP
OrthoDBiEOG091G00T9
PhylomeDBiO75694
TreeFamiTF105951

Family and domain databases

InterProiView protein in InterPro
IPR007187 Nucleoporin_Nup133/Nup155_C
IPR014908 Nucleoporin_Nup133/Nup155_N
IPR004870 Nucleoporin_Nup155
PANTHERiPTHR10350 PTHR10350, 1 hit
PfamiView protein in Pfam
PF03177 Nucleoporin_C, 1 hit
PF08801 Nucleoporin_N, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75694-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSSLLGAAM PASTSAAALQ EALENAGRLI DRQLQEDRMY PDLSELLMVS
60 70 80 90 100
APNNPTVSGM SDMDYPLQGP GLLSVPNLPE ISSIRRVPLP PELVEQFGHM
110 120 130 140 150
QCNCMMGVFP PISRAWLTID SDIFMWNYED GGDLAYFDGL SETILAVGLV
160 170 180 190 200
KPKAGIFQPH VRHLLVLATP VDIVILGLSY ANLQTGSGVL NDSLSGGMQL
210 220 230 240 250
LPDPLYSLPT DNTYLLTITS TDNGRIFLAG KDGCLYEVAY QAEAGWFSQR
260 270 280 290 300
CRKINHSKSS LSFLVPSLLQ FTFSEDDPIL QIAIDNSRNI LYTRSEKGVI
310 320 330 340 350
QVYDLGQDGQ GMSRVASVSQ NAIVSAAGNI ARTIDRSVFK PIVQIAVIEN
360 370 380 390 400
SESLDCQLLA VTHAGVRLYF STCPFRQPLA RPNTLTLVHV RLPPGFSASS
410 420 430 440 450
TVEKPSKVHR ALYSKGILLM AASENEDNDI LWCVNHDTFP FQKPMMETQM
460 470 480 490 500
TAGVDGHSWA LSAIDELKVD KIITPLNKDH IPITDSPVVV QQHMLPPKKF
510 520 530 540 550
VLLSAQGSLM FHKLRPVDQL RHLLVSNVGG DGEEIERFFK LHQEDQACAT
560 570 580 590 600
CLILACSTAA CDREVSAWAT RAFFRYGGEA QMRFPTTLPP PSNVGPILGS
610 620 630 640 650
PVYSSSPVPS GSPYPNPSFL GTPSHGIQPP AMSTPVCALG NPATQATNMS
660 670 680 690 700
CVTGPEIVYS GKHNGICIYF SRIMGNIWDA SLVVERIFKS GNREITAIES
710 720 730 740 750
SVPCQLLESV LQELKGLQEF LDRNSQFAGG PLGNPNTTAK VQQRLIGFMR
760 770 780 790 800
PENGNPQQMQ QELQRKFHEA QLSEKISLQA IQQLVRKSYQ ALALWKLLCE
810 820 830 840 850
HQFTIIVAEL QKELQEQLKI TTFKDLVIRD KELTGALIAS LINCYIRDNA
860 870 880 890 900
AVDGISLHLQ DICPLLYSTD DAICSKANEL LQRSRQVQNK TEKERMLRES
910 920 930 940 950
LKEYQKISNQ VDLSNVCAQY RQVRFYEGVV ELSLTAAEKK DPQGLGLHFY
960 970 980 990 1000
KHGEPEEDIV GLQAFQERLN SYKCITDTLQ ELVNQSKAAP QSPSVPKKPG
1010 1020 1030 1040 1050
PPVLSSDPNM LSNEEAGHHF EQMLKLSQRS KDELFSIALY NWLIQVDLAD
1060 1070 1080 1090 1100
KLLQVASPFL EPHLVRMAKV DQNRVRYMDL LWRYYEKNRS FSNAARVLSR
1110 1120 1130 1140 1150
LADMHSTEIS LQQRLEYIAR AILSAKSSTA ISSIAADGEF LHELEEKMEV
1160 1170 1180 1190 1200
ARIQLQIQET LQRQYSHHSS VQDAVSQLDS ELMDITKLYG EFADPFKLAE
1210 1220 1230 1240 1250
CKLAIIHCAG YSDPILVQTL WQDIIEKELS DSVTLSSSDR MHALSLKIVL
1260 1270 1280 1290 1300
LGKIYAGTPR FFPLDFIVQF LEQQVCTLNW DVGFVIQTMN EIGVPLPRLL
1310 1320 1330 1340 1350
EVYDQLFKSR DPFWNRMKKP LHLLDCIHVL LIRYVENPSQ VLNCERRRFT
1360 1370 1380 1390
NLCLDAVCGY LVELQSMSSS VAVQAITGNF KSLQAKLERL H
Length:1,391
Mass (Da):155,199
Last modified:November 1, 1998 - v1
Checksum:i7F07A103AFF7EE1D
GO
Isoform 2 (identifier: O75694-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.
Show »
Length:1,332
Mass (Da):149,016
Checksum:iD84A93B75A3F66A6
GO

Sequence cautioni

The sequence AAD52966 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA34511 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071762391R → H in ATFB15; fails to accumulate at various foci of the nuclear envelope and is diffusely distributed in the cytoplasm; shows significantly reduced permeability of the nuclear envelope compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs587777339EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0144371 – 59Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007558 mRNA Translation: CAA07553.1
AF165926 Genomic DNA Translation: AAD52966.1 Sequence problems.
AB018334 mRNA Translation: BAA34511.2 Different initiation.
BC039257 mRNA Translation: AAH39257.1
AL117585 mRNA Translation: CAB56007.1
CCDSiCCDS3921.1 [O75694-1]
CCDS43310.1 [O75694-2]
PIRiT17317
RefSeqiNP_004289.1, NM_004298.3 [O75694-2]
NP_705618.1, NM_153485.2 [O75694-1]
UniGeneiHs.547696

Genome annotation databases

EnsembliENST00000231498; ENSP00000231498; ENSG00000113569 [O75694-1]
ENST00000381843; ENSP00000371265; ENSG00000113569 [O75694-2]
GeneIDi9631
KEGGihsa:9631
UCSCiuc003jkt.3 human [O75694-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNU155_HUMAN
AccessioniPrimary (citable) accession number: O75694
Secondary accession number(s): Q9UBE9, Q9UFL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 18, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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