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Protein

Small subunit processome component 20 homolog

Gene

UTP20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processrRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Small subunit processome component 20 homolog
Alternative name(s):
Down-regulated in metastasis protein
Novel nucleolar protein 73
Short name:
NNP73
Protein Key-1A6
Gene namesi
Name:UTP20
Synonyms:DRIM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000120800.4
HGNCiHGNC:17897 UTP20
MIMi612822 gene
neXtProtiNX_O75691

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2744 – 2746KKK → AAA: Inhibits nucleolar but not nuclear localization. 1 Publication3
Mutagenesisi2744K → A: Does not decrease nucleolar localization. 1 Publication1
Mutagenesisi2745K → A: Does not decrease nucleolar localization. 1 Publication1
Mutagenesisi2746K → A: Decreases nucleolar localization. 1 Publication1
Mutagenesisi2748 – 2749KK → AA: Inhibits nucleolar but not nuclear localization. 1 Publication2
Mutagenesisi2748K → A: Does not decrease nucleolar localization. 1 Publication1
Mutagenesisi2749K → A: Decreases nucleolar localization. 1 Publication1
Mutagenesisi2751K → A: Does not decrease nucleolar localization. 1 Publication1
Mutagenesisi2753K → A: Does not decrease nucleolar localization. 1 Publication1
Mutagenesisi2757 – 2760KKRK → AAAA: Inhibits nucleolar localization and decreases nuclear localization. 1 Publication4
Mutagenesisi2757K → A: Does not decrease nucleolar localization. 1 Publication1
Mutagenesisi2758K → A: Does not decrease nucleolar localization. 1 Publication1
Mutagenesisi2760K → A: Does not decrease nucleolar localization. 1 Publication1

Organism-specific databases

DisGeNETi27340
OpenTargetsiENSG00000120800
PharmGKBiPA143485666

Polymorphism and mutation databases

BioMutaiUTP20

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000800111 – 2785Small subunit processome component 20 homologAdd BLAST2785

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei788PhosphoserineCombined sources1
Modified residuei1741PhosphothreonineCombined sources1
Modified residuei2601PhosphoserineCombined sources1
Modified residuei2637PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75691
MaxQBiO75691
PaxDbiO75691
PeptideAtlasiO75691
PRIDEiO75691
ProteomicsDBi50164

2D gel databases

SWISS-2DPAGEiO75691

PTM databases

CarbonylDBiO75691
iPTMnetiO75691
PhosphoSitePlusiO75691
SwissPalmiO75691

Expressioni

Tissue specificityi

Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.1 Publication

Gene expression databases

BgeeiENSG00000120800 Expressed in 172 organ(s), highest expression level in minor salivary gland
CleanExiHS_UTP20
GenevisibleiO75691 HS

Organism-specific databases

HPAiHPA049341

Interactioni

Subunit structurei

Interacts with FBL and PPP1R26.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1R26Q5T8A74EBI-356062,EBI-308500

Protein-protein interaction databases

BioGridi118152, 113 interactors
IntActiO75691, 9 interactors
MINTiO75691
STRINGi9606.ENSP00000261637

Structurei

3D structure databases

ProteinModelPortaliO75691
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati165 – 202HEAT 1Add BLAST38
Repeati1841 – 1878HEAT 2Add BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2688 – 2765Sequence analysisAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2744 – 2775Nuclear localization signalAdd BLAST32
Motifi2744 – 2761Nucleolar localization signalAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1319 – 1324Poly-Lys6

Sequence similaritiesi

Belongs to the UTP20 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1823 Eukaryota
ENOG410XSRE LUCA
GeneTreeiENSGT00390000016813
HOGENOMiHOG000168315
HOVERGENiHBG094143
InParanoidiO75691
KOiK14772
OMAiFCYEVIQ
OrthoDBiEOG091G005G
PhylomeDBiO75691
TreeFamiTF105652

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011430 DRIM
PfamiView protein in Pfam
PF07539 DRIM, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

O75691-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTKPVSHKT ENTYRFLTFA ERLGNVNIDI IHRIDRTASY EEEVETYFFE
60 70 80 90 100
GLLKWRELNL TEHFGKFYKE VIDKCQSFNQ LVYHQNEIVQ SLKTHLQVKN
110 120 130 140 150
SFAYQPLLDL VVQLARDLQM DFYPHFPEFF LTITSILETQ DTELLEWAFT
160 170 180 190 200
SLSYLYKYLW RLMVKDMSSI YSMYSTLLAH KKLHIRNFAA ESFTFLMRKV
210 220 230 240 250
SDKNALFNLM FLDLDKHPEK VEGVGQLLFE MCKGVRNMFH SCTGQAVKLI
260 270 280 290 300
LRKLGPVTET ETQLPWMLIG ETLKNMVKST VSYISKEHFG TFFECLQESL
310 320 330 340 350
LDLHTKVTKT NCCESSEQIK RLLETYLILV KHGSGTKIPT PADVCKVLSQ
360 370 380 390 400
TLQVASLSTS CWETLLDVIS ALILGENVSL PETLIKETIE KIFESRFEKR
410 420 430 440 450
LIFSFSEVMF AMKQFEQLFL PSFLSYIVNC FLIDDAVVKD EALAILAKLI
460 470 480 490 500
LNKAAPPTAG SMAIEKYPLV FSPQMVGFYI KQKKTRSKGR NEQFPVLDHL
510 520 530 540 550
LSIIKLPPNK DTTYLSQSWA ALVVLPHIRP LEKEKVIPLV TGFIEALFMT
560 570 580 590 600
VDKGSFGKGN LFVLCQAVNT LLSLEESSEL LHLVPVERVK NLVLTFPLEP
610 620 630 640 650
SVLLLTDLYY QRLALCGCKG PLSQEALMEL FPKLQANIST GVSKIRLLTI
660 670 680 690 700
RILNHFDVQL PESMEDDGLS ERQSVFAILR QAELVPATVN DYREKLLHLR
710 720 730 740 750
KLRHDVVQTA VPDGPLQEVP LRYLLGMLYI NFSALWDPVI ELISSHAHEM
760 770 780 790 800
ENKQFWKVYY EHLEKAATHA EKELQNDMTD EKSVGDESWE QTQEGDVGAL
810 820 830 840 850
YHEQLALKTD CQERLDHTNF RFLLWRALTK FPERVEPRSR ELSPLFLRFI
860 870 880 890 900
NNEYYPADLQ VAPTQDLRRK GKGMVAEEIE EEPAAGDDEE LEEEAVPQDE
910 920 930 940 950
SSQKKKTRRA AAKQLIAHLQ VFSKFSNPRA LYLESKLYEL YLQLLLHQDQ
960 970 980 990 1000
MVQKITLDCI MTYKHPHVLP YRENLQRLLE DRSFKEEIVH FSISEDNAVV
1010 1020 1030 1040 1050
KTAHRADLFP ILMRILYGRM KNKTGSKTQG KSASGTRMAI VLRFLAGTQP
1060 1070 1080 1090 1100
EEIQIFLDLL FEPVRHFKNG ECHSAVIQAV EDLDLSKVLP LGRQHGILNS
1110 1120 1130 1140 1150
LEIVLKNISH LISAYLPKIL QILLCMTATV SHILDQREKI QLRFINPLKN
1160 1170 1180 1190 1200
LRRLGIKMVT DIFLDWESYQ FRTEEIDAVF HGAVWPQISR LGSESQYSPT
1210 1220 1230 1240 1250
PLLKLISIWS RNARYFPLLA KQKPGHPECD ILTNVFAILS AKNLSDATAS
1260 1270 1280 1290 1300
IVMDIVDDLL NLPDFEPTET VLNLLVTGCV YPGIAENIGE SITIGGRLIL
1310 1320 1330 1340 1350
PHVPAILQYL SKTTISAEKV KKKKNRAQVS KELGILSKIS KFMKDKEQSS
1360 1370 1380 1390 1400
VLITLLLPFL HRGNIAEDTE VDILVTVQNL LKHCVDPTSF LKPIAKLFSV
1410 1420 1430 1440 1450
IKNKLSRKLL CTVFETLSDF ESGLKYITDV VKLNAFDQRH LDDINFDVRF
1460 1470 1480 1490 1500
ETFQTITSYI KEMQIVDVNY LIPVMHNCFY NLELGDMSLS DNASMCLMSI
1510 1520 1530 1540 1550
IKKLAALNVT EKDYREIIHR SLLEKLRKGL KSQTESIQQD YTTILSCLIQ
1560 1570 1580 1590 1600
TFPNQLEFKD LVQLTHYHDP EMDFFENMKH IQIHRRARAL KKLAKQLMEG
1610 1620 1630 1640 1650
KVVLSSKSLQ NYIMPYAMTP IFDEKMLKHE NITTAATEII GAICKHLSWS
1660 1670 1680 1690 1700
AYMYYLKHFI HVLQTGQINQ KLGVSLLVIV LEAFHFDHKT LEEQMGKIEN
1710 1720 1730 1740 1750
EENAIEAIEL PEPEAMELER VDEEEKEYTC KSLSDNGQPG TPDPADSGGT
1760 1770 1780 1790 1800
SAKESECITK PVSFLPQNKE EIERTIKNIQ GTITGDILPR LHKCLASTTK
1810 1820 1830 1840 1850
REEEHKLVKS KVVNDEEVVR VPLAFAMVKL MQSLPQEVME ANLPSILLKV
1860 1870 1880 1890 1900
CALLKNRAQE IRDIARSTLA KIIEDLGVHF LLYVLKELQT TLVRGYQVHV
1910 1920 1930 1940 1950
LTFTVHMLLQ GLTNKLQVGD LDSCLDIMIE IFNHELFGAV AEEKEVKQIL
1960 1970 1980 1990 2000
SKVMEARRSK SYDSYEILGK FVGKDQVTKL ILPLKEILQN TTSLKLARKV
2010 2020 2030 2040 2050
HETLRRITVG LIVNQEMTAE SILLLSYGLI SENLPLLTEK EKNPVAPAPD
2060 2070 2080 2090 2100
PRLPPQSCLL LPPTPVRGGQ KAVVSRKTNM HIFIESGLRL LHLSLKTSKI
2110 2120 2130 2140 2150
KSSGECVLEM LDPFVSLLID CLGSMDVKVI TGALQCLIWV LRFPLPSIET
2160 2170 2180 2190 2200
KAEQLTKHLF LLLKDYAKLG AARGQNFHLV VNCFKCVTIL VKKVKSYQIT
2210 2220 2230 2240 2250
EKQLQVLLAY AEEDIYDTSR QATAFGLLKA ILSRKLLVPE IDEVMRKVSK
2260 2270 2280 2290 2300
LAVSAQSEPA RVQCRQVFLK YILDYPLGDK LRPNLEFMLA QLNYEHETGR
2310 2320 2330 2340 2350
ESTLEMIAYL FDTFPQGLLH ENCGMFFIPL CLMTINDDSA TCKKMASMTI
2360 2370 2380 2390 2400
KSLLGKISLE KKDWLFDMVT TWFGAKKRLN RQLAALICGL FVESEGVDFE
2410 2420 2430 2440 2450
KRLGTVLPVI EKEIDPENFK DIMEETEEKA ADRLLFSFLT LITKLIKECN
2460 2470 2480 2490 2500
IIQFTKPAET LSKIWSHVHS HLRHPHNWVW LTAAQIFGLL FASCQPEELI
2510 2520 2530 2540 2550
QKWNTKKTKK HLPEPVAIKF LASDLDQKMK SISLASCHQL HSKFLDQSLG
2560 2570 2580 2590 2600
EQVVKNLLFA AKVLYLLELY CEDKQSKIKE DLEEQEALED GVACADEKAE
2610 2620 2630 2640 2650
SDGEEKEEVK EELGRPATLL WLIQKLSRIA KLEAAYSPRN PLKRTCIFKF
2660 2670 2680 2690 2700
LGAVAMDLGI DKVKPYLPMI IAPLFRELNS TYSEQDPLLK NLSQEIIELL
2710 2720 2730 2740 2750
KKLVGLESFS LAFASVQKQA NEKRALRKKR KALEFVTNPD IAAKKKMKKH
2760 2770 2780
KNKSEAKKRK IEFLRPGYKA KRQKSHSLKD LAMVE
Length:2,785
Mass (Da):318,385
Last modified:May 18, 2010 - v3
Checksum:i0CE63611C8440E0D
GO

Sequence cautioni

The sequence AAG35208 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1505A → P in CAA07243 (PubMed:9673349).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055135120M → T. Corresponds to variant dbSNP:rs2290723Ensembl.1
Natural variantiVAR_022162502S → C. Corresponds to variant dbSNP:rs4764643Ensembl.1
Natural variantiVAR_0362741645K → I in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs140657361Ensembl.1
Natural variantiVAR_0551361882L → Q1 PublicationCorresponds to variant dbSNP:rs10082778Ensembl.1
Natural variantiVAR_0362752452I → F in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0221632612E → Q. Corresponds to variant dbSNP:rs1061436Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006778 mRNA Translation: CAA07243.1
AC063948 Genomic DNA No translation available.
AC063951 Genomic DNA No translation available.
AF072718 mRNA Translation: AAG35208.1 Different initiation.
CCDSiCCDS9081.1
RefSeqiNP_055318.2, NM_014503.2
UniGeneiHs.295732

Genome annotation databases

EnsembliENST00000261637; ENSP00000261637; ENSG00000120800
GeneIDi27340
KEGGihsa:27340
UCSCiuc001tia.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006778 mRNA Translation: CAA07243.1
AC063948 Genomic DNA No translation available.
AC063951 Genomic DNA No translation available.
AF072718 mRNA Translation: AAG35208.1 Different initiation.
CCDSiCCDS9081.1
RefSeqiNP_055318.2, NM_014503.2
UniGeneiHs.295732

3D structure databases

ProteinModelPortaliO75691
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118152, 113 interactors
IntActiO75691, 9 interactors
MINTiO75691
STRINGi9606.ENSP00000261637

PTM databases

CarbonylDBiO75691
iPTMnetiO75691
PhosphoSitePlusiO75691
SwissPalmiO75691

Polymorphism and mutation databases

BioMutaiUTP20

2D gel databases

SWISS-2DPAGEiO75691

Proteomic databases

EPDiO75691
MaxQBiO75691
PaxDbiO75691
PeptideAtlasiO75691
PRIDEiO75691
ProteomicsDBi50164

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261637; ENSP00000261637; ENSG00000120800
GeneIDi27340
KEGGihsa:27340
UCSCiuc001tia.2 human

Organism-specific databases

CTDi27340
DisGeNETi27340
EuPathDBiHostDB:ENSG00000120800.4
GeneCardsiUTP20
H-InvDBiHIX0010919
HGNCiHGNC:17897 UTP20
HPAiHPA049341
MIMi612822 gene
neXtProtiNX_O75691
OpenTargetsiENSG00000120800
PharmGKBiPA143485666
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1823 Eukaryota
ENOG410XSRE LUCA
GeneTreeiENSGT00390000016813
HOGENOMiHOG000168315
HOVERGENiHBG094143
InParanoidiO75691
KOiK14772
OMAiFCYEVIQ
OrthoDBiEOG091G005G
PhylomeDBiO75691
TreeFamiTF105652

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiUTP20 human
GeneWikiiUTP20
GenomeRNAii27340
PROiPR:O75691
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120800 Expressed in 172 organ(s), highest expression level in minor salivary gland
CleanExiHS_UTP20
GenevisibleiO75691 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011430 DRIM
PfamiView protein in Pfam
PF07539 DRIM, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiUTP20_HUMAN
AccessioniPrimary (citable) accession number: O75691
Secondary accession number(s): Q9H3H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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