ADAP1

Functionⁱ

GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).1 PublicationCurated1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	21 – 44	C4-typePROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

GTPase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10333475
- 10448098
inositol 1,3,4,5 tetrakisphosphate binding
Source: UniProtKB
Traceable author statementⁱ
- 12018390
metal ion binding Source: UniProtKB-KW
phosphatidylinositol-3,4,5-trisphosphate binding Source: Ensembl
phosphatidylinositol bisphosphate binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10333475
regulation of GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10333475

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	O75689

SIGNORⁱ

O75689

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arf-GAP with dual PH domain-containing protein 1 Alternative name(s): Centaurin-alpha-1 Short name: Cnt-a1 Putative MAPK-activating protein PM25
Gene namesⁱ	Name:ADAP1 Synonyms:CENTA1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105963.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16486 ADAP1
MIMⁱ	608114 gene
neXtProtⁱ	NX_O75689

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	21	C → A: Loss of GTPase-activating activity. 1 Publication	1
Mutagenesisⁱ	24	C → A: Loss of GTPase-activating activity. 1 Publication	1
Mutagenesisⁱ	149	R → C: 40-45% reduction in PtdInsP2 3-kinase dependent membrane localization. Almost complete loss of PtdInsP2 3-kinase dependent membrane localization; when associated with C-273. 2 Publications	1
Mutagenesisⁱ	273	R → C: 70% reduction in PtdInsP2 3-kinase dependent membrane localization. Almost complete loss of PtdInsP2 3-kinase dependent membrane localization; when associated with C-149. 2 Publications	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11033
Open Targets More...OpenTargetsⁱ	ENSG00000105963
PharmGKBⁱ	PA26404

Polymorphism and mutation databases

BioMutaⁱ	ADAP1

BioMutaⁱ

ADAP1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000074205	1 – 374	Arf-GAP with dual PH domain-containing protein 1Add BLAST		374

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	87	Phosphoserine; by PKC1 Publication	1
Modified residueⁱ	272	N6-acetyllysineCombined sources	1
Modified residueⁱ	276	Phosphothreonine; by PKC1 Publication	1

Post-translational modificationⁱ

Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O75689
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75689
PaxDbⁱ	O75689
PeptideAtlas More...PeptideAtlasⁱ	O75689
PRIDEⁱ	O75689
ProteomicsDBⁱ	50162

PTM databases

iPTMnetⁱ	O75689
PhosphoSitePlusⁱ	O75689

Expressionⁱ

Tissue specificityⁱ

Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000105963 Expressed in 92 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_ADAP1
ExpressionAtlasⁱ	O75689 baseline and differential
Genevisibleⁱ	O75689 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007033 HPA012049

HPAⁱ

HPA007033
HPA012049

Interactionⁱ

Subunit structureⁱ

Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
DVL3	Q92997	3	EBI-714732,EBI-739789
GOLGA2	Q08379	3	EBI-714732,EBI-618309
KIF13B	Q9NQT8	6	EBI-714732,EBI-766408
SDCBP2	Q9H190	3	EBI-714732,EBI-742426

Protein-protein interaction databases

BioGridⁱ	116222, 18 interactors
Database of interacting proteins More...DIPⁱ	DIP-41731N
IntActⁱ	O75689, 11 interactors
Molecular INTeraction database More...MINTⁱ	O75689
STRINGⁱ	9606.ENSP00000265846

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 12	Combined sources	10
Helixⁱ	16 – 18	Combined sources	3
Turnⁱ	22 – 24	Combined sources	3
Beta strandⁱ	31 – 33	Combined sources	3
Turnⁱ	34 – 37	Combined sources	4
Beta strandⁱ	38 – 40	Combined sources	3
Helixⁱ	42 – 49	Combined sources	8
Turnⁱ	52 – 54	Combined sources	3
Beta strandⁱ	57 – 59	Combined sources	3
Turnⁱ	60 – 62	Combined sources	3
Helixⁱ	67 – 75	Combined sources	9
Helixⁱ	78 – 85	Combined sources	8
Turnⁱ	86 – 88	Combined sources	3
Helixⁱ	102 – 113	Combined sources	12
Turnⁱ	117 – 119	Combined sources	3
Helixⁱ	121 – 124	Combined sources	4
Helixⁱ	125 – 128	Combined sources	4
Beta strandⁱ	129 – 139	Combined sources	11
Beta strandⁱ	141 – 143	Combined sources	3
Beta strandⁱ	146 – 154	Combined sources	9
Turnⁱ	155 – 158	Combined sources	4
Beta strandⁱ	159 – 163	Combined sources	5
Beta strandⁱ	165 – 167	Combined sources	3
Beta strandⁱ	172 – 176	Combined sources	5
Helixⁱ	177 – 179	Combined sources	3
Beta strandⁱ	180 – 184	Combined sources	5
Helixⁱ	186 – 189	Combined sources	4
Beta strandⁱ	195 – 201	Combined sources	7
Beta strandⁱ	204 – 211	Combined sources	8
Helixⁱ	215 – 236	Combined sources	22
Beta strandⁱ	237 – 240	Combined sources	4
Helixⁱ	242 – 245	Combined sources	4
Helixⁱ	246 – 248	Combined sources	3
Beta strandⁱ	254 – 261	Combined sources	8
Beta strandⁱ	271 – 278	Combined sources	8
Beta strandⁱ	281 – 287	Combined sources	7
Beta strandⁱ	294 – 298	Combined sources	5
Helixⁱ	302 – 304	Combined sources	3
Beta strandⁱ	307 – 311	Combined sources	5
Beta strandⁱ	323 – 328	Combined sources	6
Beta strandⁱ	333 – 340	Combined sources	8
Helixⁱ	341 – 356	Combined sources	16
Helixⁱ	363 – 369	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	O75689
SMRⁱ	O75689
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O75689

EvolutionaryTraceⁱ

O75689

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	7 – 126	Arf-GAPPROSITE-ProRule annotationAdd BLAST	120
Domainⁱ	129 – 230	PH 1PROSITE-ProRule annotationAdd BLAST	102
Domainⁱ	252 – 356	PH 2PROSITE-ProRule annotationAdd BLAST	105

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	21 – 44	C4-typePROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0703 Eukaryota COG5347 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140892
HOGENOMⁱ	HOG000006719
HOVERGENⁱ	HBG050888
InParanoidⁱ	O75689
OMAⁱ	YEERVPP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0789
PhylomeDBⁱ	O75689
TreeFamⁱ	TF324540

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13252 PH1_ADAP, 1 hit cd01251 PH2_ADAP, 1 hit
Gene3Dⁱ	2.30.29.30, 2 hits 3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf IPR011993 PH-like_dom_sf IPR037849 PH1_ADAP IPR037851 PH2_ADAP IPR001849 PH_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01412 ArfGap, 1 hit PF00169 PH, 2 hits
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00105 ArfGap, 1 hit SM00233 PH, 2 hits
SUPFAMⁱ	SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50115 ARFGAP, 1 hit PS50003 PH_DOMAIN, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O75689-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKERRRAVL ELLQRPGNAR CADCGAPDPD WASYTLGVFI CLSCSGIHRN 
        60         70         80         90        100
IPQVSKVKSV RLDAWEEAQV EFMASHGNDA ARARFESKVP SFYYRPTPSD 
       110        120        130        140        150
CQLLREQWIR AKYERQEFIY PEKQEPYSAG YREGFLWKRG RDNGQFLSRK 
       160        170        180        190        200
FVLTEREGAL KYFNRNDAKE PKAVMKIEHL NATFQPAKIG HPHGLQVTYL 
       210        220        230        240        250
KDNSTRNIFI YHEDGKEIVD WFNALRAARF HYLQVAFPGA GDADLVPKLS 
       260        270        280        290        300
RNYLKEGYME KTGPKQTEGF RKRWFTMDDR RLMYFKDPLD AFARGEVFIG 
       310        320        330        340        350
SKESGYTVLH GFPPSTQGHH WPHGITIVTP DRKFLFACET ESDQREWVAA 
       360        370 
FQKAVDRPML PQEYAVEAHF KHKP

Length:374

Mass (Da):43,395

Last modified:November 25, 2008 - v2

Checksum:ⁱ38547281FB09D9B9

GO

Isoform 2 (identifier: O75689-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-27: MAKERRRAVLELLQRPGNARCADCGAP → MFQFVFSRVYCINPARRKWKEFEKMLGCAEEGHASLGR

« Hide

        10         20         30         40         50
MFQFVFSRVY CINPARRKWK EFEKMLGCAE EGHASLGRDP DWASYTLGVF 
        60         70         80         90        100
ICLSCSGIHR NIPQVSKVKS VRLDAWEEAQ VEFMASHGND AARARFESKV 
       110        120        130        140        150
PSFYYRPTPS DCQLLREQWI RAKYERQEFI YPEKQEPYSA GYREGFLWKR 
       160        170        180        190        200
GRDNGQFLSR KFVLTEREGA LKYFNRNDAK EPKAVMKIEH LNATFQPAKI 
       210        220        230        240        250
GHPHGLQVTY LKDNSTRNIF IYHEDGKEIV DWFNALRAAR FHYLQVAFPG 
       260        270        280        290        300
AGDADLVPKL SRNYLKEGYM EKTGPKQTEG FRKRWFTMDD RRLMYFKDPL 
       310        320        330        340        350
DAFARGEVFI GSKESGYTVL HGFPPSTQGH HWPHGITIVT PDRKFLFACE 
       360        370        380 
TESDQREWVA AFQKAVDRPM LPQEYAVEAH FKHKP

Show »

Length:385

Mass (Da):44,936

Checksum:ⁱ67ACBB2A85819D46

GO

Isoform 3 (identifier: O75689-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-72: Missing.

« Hide

        10         20         30         40         50
MASHGNDAAR ARFESKVPSF YYRPTPSDCQ LLREQWIRAK YERQEFIYPE 
        60         70         80         90        100
KQEPYSAGYR EGFLWKRGRD NGQFLSRKFV LTEREGALKY FNRNDAKEPK 
       110        120        130        140        150
AVMKIEHLNA TFQPAKIGHP HGLQVTYLKD NSTRNIFIYH EDGKEIVDWF 
       160        170        180        190        200
NALRAARFHY LQVAFPGAGD ADLVPKLSRN YLKEGYMEKT GPKQTEGFRK 
       210        220        230        240        250
RWFTMDDRRL MYFKDPLDAF ARGEVFIGSK ESGYTVLHGF PPSTQGHHWP 
       260        270        280        290        300
HGITIVTPDR KFLFACETES DQREWVAAFQ KAVDRPMLPQ EYAVEAHFKH 

KP

Show »

Length:302

Mass (Da):35,353

Checksum:ⁱ8197A42910488E1E

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y7Q1	H0Y7Q1_HUMAN	Arf-GAP with dual PH domain-contain... Arf-GAP with dual PH domain-containing protein 1	ADAP1	357	Annotation score:
H7C324	H7C324_HUMAN	Arf-GAP with dual PH domain-contain... Arf-GAP with dual PH domain-containing protein 1	ADAP1	245	Annotation score:
A0A087WTN6	A0A087WTN6_HUMAN	Arf-GAP with dual PH domain-contain... Arf-GAP with dual PH domain-containing protein 1	ADAP1	279	Annotation score:
H7BZT6	H7BZT6_HUMAN	Arf-GAP with dual PH domain-contain... Arf-GAP with dual PH domain-containing protein 1	ADAP1	192	Annotation score:
H7C4B3	H7C4B3_HUMAN	Arf-GAP with dual PH domain-contain... Arf-GAP with dual PH domain-containing protein 1	ADAP1	187	Annotation score:
H7C264	H7C264_HUMAN	Arf-GAP with dual PH domain-contain... Arf-GAP with dual PH domain-containing protein 1	ADAP1	207	Annotation score:
C9JN36	C9JN36_HUMAN	Arf-GAP with dual PH domain-contain... Arf-GAP with dual PH domain-containing protein 1	ADAP1	162	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	215	G → R in BAG52556 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_047470	241	G → S4 PublicationsCorresponds to variant dbSNP:rs10256887Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054793	1 – 72	Missing in isoform 3. 1 PublicationAdd BLAST		72
Alternative sequenceⁱVSP_054794	1 – 27	MAKER…DCGAP → MFQFVFSRVYCINPARRKWK EFEKMLGCAEEGHASLGR in isoform 2. 1 PublicationAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ006422 mRNA Translation: CAA07024.1 AF082324 mRNA Translation: AAD11414.1 AB097049 mRNA Translation: BAC77402.1 AK300999 mRNA Translation: BAG62618.1 AC073957 Genomic DNA No translation available. AK092471 mRNA Translation: BAG52556.1 CH236965 Genomic DNA Translation: EAL23709.1 CH471144 Genomic DNA Translation: EAW87183.1 CH471144 Genomic DNA Translation: EAW87184.1 BC033747 mRNA Translation: AAH33747.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5318.1 [O75689-1] CCDS64576.1 [O75689-3] CCDS64577.1 [O75689-2]
PIRⁱ	JC7091
NCBI Reference Sequences More...RefSeqⁱ	NP_001271237.1, NM_001284308.1 NP_001271238.1, NM_001284309.1 NP_001271239.1, NM_001284310.1 NP_001271240.1, NM_001284311.1 NP_006860.1, NM_006869.3
UniGeneⁱ	Hs.602573

Genome annotation databases

Ensemblⁱ	ENST00000265846; ENSP00000265846; ENSG00000105963 [O75689-1] ENST00000449296; ENSP00000407267; ENSG00000105963 [O75689-3] ENST00000539900; ENSP00000442682; ENSG00000105963 [O75689-2] ENST00000611167; ENSP00000481154; ENSG00000105963 [O75689-3]
GeneIDⁱ	11033
KEGGⁱ	hsa:11033
UCSC genome browser More...UCSCⁱ	uc003sjn.5 human [O75689-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75689	Arf-GAP with dual PH domain-containing protein 1		TUPCH		438	UniRef90_O75689
arf-GAP with dual PH domain-containing protein 1 isoform X1		Enhydra lutris kenyoni		374
Arf-GAP with dual PH domain-containing protein 1		NEOVI		374
Arf-GAP with dual PH domain-containing protein 1		CALJA		374
Uncharacterized protein		FELCA		374
+51
O75689-2	Arf-GAP with dual PH domain-containing protein 1 (Fragment)		HUMAN		162	UniRef90_O75689-2
ArfGAP with dual PH domains 1		SAIBB		385
Uncharacterized protein		CALJA		385
Uncharacterized protein		COLAP		385
Uncharacterized protein		AOTNA		385
+19
O75689-3	Isoform 2 of Arf-GAP with dual PH domain-containing protein 1		HUMAN		385	UniRef90_O75689-2
ArfGAP with dual PH domains 1		SAIBB		385
Uncharacterized protein		CALJA		385
Uncharacterized protein		COLAP		385
Uncharacterized protein		AOTNA		385
+19

Protein	Similar proteins		Species	Score	Length	Source
O75689	Arf-GAP with dual PH domain-containing protein 1		TUPCH		438	UniRef50_O75689
ArfGAP with dual PH domains 1		RAT		374
ArfGAP with dual PH domains 1		MOUSE		374
Uncharacterized protein		AOTNA		374
Uncharacterized protein		MACNE		374
+686

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ006422 mRNA Translation: CAA07024.1 AF082324 mRNA Translation: AAD11414.1 AB097049 mRNA Translation: BAC77402.1 AK300999 mRNA Translation: BAG62618.1 AC073957 Genomic DNA No translation available. AK092471 mRNA Translation: BAG52556.1 CH236965 Genomic DNA Translation: EAL23709.1 CH471144 Genomic DNA Translation: EAW87183.1 CH471144 Genomic DNA Translation: EAW87184.1 BC033747 mRNA Translation: AAH33747.1
CCDSⁱ	CCDS5318.1 [O75689-1] CCDS64576.1 [O75689-3] CCDS64577.1 [O75689-2]
PIRⁱ	JC7091
RefSeqⁱ	NP_001271237.1, NM_001284308.1 NP_001271238.1, NM_001284309.1 NP_001271239.1, NM_001284310.1 NP_001271240.1, NM_001284311.1 NP_006860.1, NM_006869.3
UniGeneⁱ	Hs.602573

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3FEH	X-ray	1.90	A	3-370	[»]
	3FM8	X-ray	2.30	C/D	1-374	[»]
	3LJU	X-ray	1.70	X	3-370	[»]
	3MDB	X-ray	2.95	C/D	1-374	[»]
ProteinModelPortalⁱ	O75689
SMRⁱ	O75689
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116222, 18 interactors
DIPⁱ	DIP-41731N
IntActⁱ	O75689, 11 interactors
MINTⁱ	O75689
STRINGⁱ	9606.ENSP00000265846

PTM databases

iPTMnetⁱ	O75689
PhosphoSitePlusⁱ	O75689

Polymorphism and mutation databases

BioMutaⁱ	ADAP1

BioMutaⁱ

ADAP1

Proteomic databases

EPDⁱ	O75689
MaxQBⁱ	O75689
PaxDbⁱ	O75689
PeptideAtlasⁱ	O75689
PRIDEⁱ	O75689
ProteomicsDBⁱ	50162

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000265846; ENSP00000265846; ENSG00000105963 [O75689-1] ENST00000449296; ENSP00000407267; ENSG00000105963 [O75689-3] ENST00000539900; ENSP00000442682; ENSG00000105963 [O75689-2] ENST00000611167; ENSP00000481154; ENSG00000105963 [O75689-3]
GeneIDⁱ	11033
KEGGⁱ	hsa:11033
UCSCⁱ	uc003sjn.5 human [O75689-1]

Organism-specific databases

CTDⁱ	11033
DisGeNETⁱ	11033
EuPathDBⁱ	HostDB:ENSG00000105963.13
GeneCardsⁱ	ADAP1
HGNCⁱ	HGNC:16486 ADAP1
HPAⁱ	HPA007033 HPA012049
MIMⁱ	608114 gene
neXtProtⁱ	NX_O75689
OpenTargetsⁱ	ENSG00000105963
PharmGKBⁱ	PA26404
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0703 Eukaryota COG5347 LUCA
GeneTreeⁱ	ENSGT00900000140892
HOGENOMⁱ	HOG000006719
HOVERGENⁱ	HBG050888
InParanoidⁱ	O75689
OMAⁱ	YEERVPP
OrthoDBⁱ	EOG091G0789
PhylomeDBⁱ	O75689
TreeFamⁱ	TF324540

Enzyme and pathway databases

SIGNORⁱ	O75689

SIGNORⁱ

O75689

Miscellaneous databases

ChiTaRSⁱ	ADAP1 human
EvolutionaryTraceⁱ	O75689
GeneWikiⁱ	Centaurin,_alpha_1
GenomeRNAiⁱ	11033
Protein Ontology More...PROⁱ	PR:O75689
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105963 Expressed in 92 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_ADAP1
ExpressionAtlasⁱ	O75689 baseline and differential
Genevisibleⁱ	O75689 HS

Family and domain databases

CDDⁱ	cd13252 PH1_ADAP, 1 hit cd01251 PH2_ADAP, 1 hit
Gene3Dⁱ	2.30.29.30, 2 hits 3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf IPR011993 PH-like_dom_sf IPR037849 PH1_ADAP IPR037851 PH2_ADAP IPR001849 PH_domain
Pfamⁱ	View protein in Pfam PF01412 ArfGap, 1 hit PF00169 PH, 2 hits
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00105 ArfGap, 1 hit SM00233 PH, 2 hits
SUPFAMⁱ	SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50115 ARFGAP, 1 hit PS50003 PH_DOMAIN, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADAP1_HUMAN
Accessionⁱ	O75689Primary (citable) accession number: O75689 Secondary accession number(s): A4D2Q2 , B3KRZ4, B4DVA6, F6XZ68, H7C2Q4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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Proteomes

Annotation systems

Supporting data

UniProtKB - O75689 (ADAP1_HUMAN)

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Arf-GAP with dual PH domain-containing protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ