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Protein

Protein phosphatase 1B

Gene

PPM1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi60Manganese 1By similarity1
Metal bindingi60Manganese 2Combined sources1 Publication1
Metal bindingi61Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi243Manganese 2Combined sources1 Publication1
Metal bindingi286Manganese 2Combined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • magnesium-dependent protein serine/threonine phosphatase activity Source: GO_Central
  • magnesium ion binding Source: InterPro
  • manganese ion binding Source: InterPro
  • protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169408 ISG15 antiviral mechanism

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O75688

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 1B (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform beta
Short name:
PP2C-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPM1B
Synonyms:PP2CB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138032.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9276 PPM1B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603770 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75688

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5495

MalaCards human disease database

More...
MalaCardsi
PPM1B

Open Targets

More...
OpenTargetsi
ENSG00000138032

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
163693 2p21 microdeletion syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33604

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2845

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPM1B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000577462 – 479Protein phosphatase 1BAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei386PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isgylation negatively regulates its activity.1 Publication
N-myristoylation is essential for the recognition of its substrates for dephosphorylation.By similarity

Keywords - PTMi

Isopeptide bond, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75688

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75688

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75688

PeptideAtlas

More...
PeptideAtlasi
O75688

PRoteomics IDEntifications database

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PRIDEi
O75688

ProteomicsDB human proteome resource

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ProteomicsDBi
50157
50158 [O75688-2]
50159 [O75688-3]
50160 [O75688-4]
50161 [O75688-5]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
O75688

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75688

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75688

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138032 Expressed in 235 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_PPM1B

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75688 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75688 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA016745

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (By similarity). Interacts with PAK6. Interacts with the phosphorylated form of IKBKB/IKKB.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111490, 98 interactors

Protein interaction database and analysis system

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IntActi
O75688, 33 interactors

Molecular INTeraction database

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MINTi
O75688

STRING: functional protein association networks

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STRINGi
9606.ENSP00000282412

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O75688

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1479
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P8EX-ray1.82A/B2-297[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75688

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75688

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O75688

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 295PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST273

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0697 Eukaryota
COG0631 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156070

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233895

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053647

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75688

KEGG Orthology (KO)

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KOi
K04461

Identification of Orthologs from Complete Genome Data

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OMAi
ARVSAHC

Database of Orthologous Groups

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OrthoDBi
957254at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75688

TreeFam database of animal gene trees

More...
TreeFami
TF313590

Family and domain databases

Conserved Domains Database

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CDDi
cd00143 PP2Cc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.430, 1 hit
3.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR012911 PP2C_C
IPR036580 PP2C_C_sf
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom

The PANTHER Classification System

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PANTHERi
PTHR13832 PTHR13832, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00481 PP2C, 1 hit
PF07830 PP2C_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00332 PP2Cc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF81601 SSF81601, 1 hit
SSF81606 SSF81606, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Beta-1 (identifier: O75688-1) [UniParc]FASTAAdd to basket
Also known as: Beta-X, PPM1B2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL
60 70 80 90 100
EDWSFFAVYD GHAGSRVANY CSTHLLEHIT TNEDFRAAGK SGSALELSVE
110 120 130 140 150
NVKNGIRTGF LKIDEYMRNF SDLRNGMDRS GSTAVGVMIS PKHIYFINCG
160 170 180 190 200
DSRAVLYRNG QVCFSTQDHK PCNPREKERI QNAGGSVMIQ RVNGSLAVSR
210 220 230 240 250
ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL ACDGIWDVMS
260 270 280 290 300
NEELCEYVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFSNAPK
310 320 330 340 350
VSDEAVKKDS ELDKHLESRV EEIMEKSGEE GMPDLAHVMR ILSAENIPNL
360 370 380 390 400
PPGGGLAGKR NVIEAVYSRL NPHRESDGAS DEAEESGSQG KLVEALRQMR
410 420 430 440 450
INHRGNYRQL LEEMLTSYRL AKVEGEESPA EPAATATSSN SDAGNPVTMQ
460 470
ESHTESESGL AELDSSNEDA GTKMSGEKI
Length:479
Mass (Da):52,643
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3A5797AD263DFBD
GO
Isoform Beta-2 (identifier: O75688-2) [UniParc]FASTAAdd to basket
Also known as: PPM1B1

The sequence of this isoform differs from the canonical sequence as follows:
     379-387: ASDEAEESG → GAGDLEDPW
     388-479: Missing.

Show »
Length:387
Mass (Da):42,771
Checksum:i56A644A4E5E2B12B
GO
Isoform Beta-X (identifier: O75688-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-287: Missing.

Show »
Length:192
Mass (Da):20,753
Checksum:i46FA14838483534F
GO
Isoform 4 (identifier: O75688-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     379-380: AS → QK
     381-387: Missing.
     388-479: Missing.

Show »
Length:380
Mass (Da):42,086
Checksum:iE5C00B5FF4278013
GO
Isoform 5 (identifier: O75688-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-327: EIMEKS → GKTNAF
     328-380: Missing.
     381-387: Missing.
     388-479: Missing.

Show »
Length:327
Mass (Da):36,313
Checksum:iE38A263FCF7F1692
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JIR6C9JIR6_HUMAN
Protein phosphatase 1B
PPM1B
378Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZF0B8ZZF0_HUMAN
Protein phosphatase 1B
PPM1B
303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0410851 – 287Missing in isoform Beta-X. 1 PublicationAdd BLAST287
Alternative sequenceiVSP_043641322 – 327EIMEKS → GKTNAF in isoform 5. 1 Publication6
Alternative sequenceiVSP_043642328 – 380Missing in isoform 5. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_005087379 – 387ASDEAEESG → GAGDLEDPW in isoform Beta-2. 4 Publications9
Alternative sequenceiVSP_043643379 – 380AS → QK in isoform 4. 1 Publication2
Alternative sequenceiVSP_043644381 – 387Missing in isoform 4 and isoform 5. 1 Publication7
Alternative sequenceiVSP_005088388 – 479Missing in isoform Beta-2, isoform 4 and isoform 5. 4 PublicationsAdd BLAST92

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ005801 mRNA Translation: CAA06704.1
AF294792 mRNA Translation: AAG02232.1
AJ271832 mRNA Translation: CAC27992.1
AJ271835 mRNA Translation: CAC27993.1
DQ023508 mRNA Translation: AAY89639.1
DQ023509 mRNA Translation: AAY89640.1
DQ023510 mRNA Translation: AAY89641.1
AF136972 mRNA Translation: AAG49433.1
AL833035 mRNA Translation: CAH56319.1
AC013717 Genomic DNA Translation: AAX88954.1
AC019129 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00282.1
CH471053 Genomic DNA Translation: EAX00283.1
BC012002 mRNA Translation: AAH12002.1
BC064381 mRNA Translation: AAH64381.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1816.1 [O75688-2]
CCDS1817.1 [O75688-1]
CCDS1818.1 [O75688-3]
CCDS46271.1 [O75688-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001028729.1, NM_001033557.2 [O75688-4]
NP_002697.1, NM_002706.5 [O75688-1]
NP_808907.1, NM_177968.3 [O75688-2]
NP_808908.1, NM_177969.3 [O75688-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.416769

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282412; ENSP00000282412; ENSG00000138032 [O75688-1]
ENST00000345249; ENSP00000326089; ENSG00000138032 [O75688-3]
ENST00000378551; ENSP00000367813; ENSG00000138032 [O75688-2]
ENST00000409432; ENSP00000387287; ENSG00000138032 [O75688-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5495

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5495

UCSC genome browser

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UCSCi
uc002rtt.4 human [O75688-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005801 mRNA Translation: CAA06704.1
AF294792 mRNA Translation: AAG02232.1
AJ271832 mRNA Translation: CAC27992.1
AJ271835 mRNA Translation: CAC27993.1
DQ023508 mRNA Translation: AAY89639.1
DQ023509 mRNA Translation: AAY89640.1
DQ023510 mRNA Translation: AAY89641.1
AF136972 mRNA Translation: AAG49433.1
AL833035 mRNA Translation: CAH56319.1
AC013717 Genomic DNA Translation: AAX88954.1
AC019129 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00282.1
CH471053 Genomic DNA Translation: EAX00283.1
BC012002 mRNA Translation: AAH12002.1
BC064381 mRNA Translation: AAH64381.1
CCDSiCCDS1816.1 [O75688-2]
CCDS1817.1 [O75688-1]
CCDS1818.1 [O75688-3]
CCDS46271.1 [O75688-4]
RefSeqiNP_001028729.1, NM_001033557.2 [O75688-4]
NP_002697.1, NM_002706.5 [O75688-1]
NP_808907.1, NM_177968.3 [O75688-2]
NP_808908.1, NM_177969.3 [O75688-3]
UniGeneiHs.416769

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P8EX-ray1.82A/B2-297[»]
ProteinModelPortaliO75688
SMRiO75688
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111490, 98 interactors
IntActiO75688, 33 interactors
MINTiO75688
STRINGi9606.ENSP00000282412

Chemistry databases

BindingDBiO75688
ChEMBLiCHEMBL2845

PTM databases

DEPODiO75688
iPTMnetiO75688
PhosphoSitePlusiO75688

Polymorphism and mutation databases

BioMutaiPPM1B

Proteomic databases

EPDiO75688
jPOSTiO75688
PaxDbiO75688
PeptideAtlasiO75688
PRIDEiO75688
ProteomicsDBi50157
50158 [O75688-2]
50159 [O75688-3]
50160 [O75688-4]
50161 [O75688-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5495
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282412; ENSP00000282412; ENSG00000138032 [O75688-1]
ENST00000345249; ENSP00000326089; ENSG00000138032 [O75688-3]
ENST00000378551; ENSP00000367813; ENSG00000138032 [O75688-2]
ENST00000409432; ENSP00000387287; ENSG00000138032 [O75688-4]
GeneIDi5495
KEGGihsa:5495
UCSCiuc002rtt.4 human [O75688-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5495
DisGeNETi5495
EuPathDBiHostDB:ENSG00000138032.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPM1B
HGNCiHGNC:9276 PPM1B
HPAiHPA016745
MalaCardsiPPM1B
MIMi603770 gene
neXtProtiNX_O75688
OpenTargetsiENSG00000138032
Orphaneti163693 2p21 microdeletion syndrome
PharmGKBiPA33604

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0697 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00940000156070
HOGENOMiHOG000233895
HOVERGENiHBG053647
InParanoidiO75688
KOiK04461
OMAiARVSAHC
OrthoDBi957254at2759
PhylomeDBiO75688
TreeFamiTF313590

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
SIGNORiO75688

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPM1B human
EvolutionaryTraceiO75688

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PPM1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5495

Protein Ontology

More...
PROi
PR:O75688

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138032 Expressed in 235 organ(s), highest expression level in secondary oocyte
CleanExiHS_PPM1B
ExpressionAtlasiO75688 baseline and differential
GenevisibleiO75688 HS

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di1.10.10.430, 1 hit
3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR012911 PP2C_C
IPR036580 PP2C_C_sf
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
PF07830 PP2C_C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81601 SSF81601, 1 hit
SSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPM1B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75688
Secondary accession number(s): Q461Q2
, Q4J6C1, Q4J6C2, Q658R4, Q96ER6, Q9HAY8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: January 16, 2019
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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