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Protein

Surfeit locus protein 6

Gene

SURF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • ribosomal large subunit biogenesis Source: GO_Central
  • ribosomal small subunit biogenesis Source: GO_Central

Keywordsi

Molecular functionDNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 6
Gene namesi
Name:SURF6
Synonyms:SURF-6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148296.6
HGNCiHGNC:11478 SURF6
MIMi185642 gene
neXtProtiNX_O75683

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6838
OpenTargetsiENSG00000148296
PharmGKBiPA36263

Polymorphism and mutation databases

BioMutaiSURF6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209691 – 361Surfeit locus protein 6Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei229PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75683
MaxQBiO75683
PaxDbiO75683
PeptideAtlasiO75683
PRIDEiO75683
ProteomicsDBi50156

PTM databases

iPTMnetiO75683
PhosphoSitePlusiO75683

Expressioni

Gene expression databases

BgeeiENSG00000148296 Expressed in 194 organ(s), highest expression level in quadriceps femoris
CleanExiHS_SURF6
GenevisibleiO75683 HS

Organism-specific databases

HPAiHPA023608
HPA074622

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CSNK2A1P684002EBI-2691252,EBI-347804

Protein-protein interaction databases

BioGridi112705, 46 interactors
IntActiO75683, 23 interactors
STRINGi9606.ENSP00000361092

Structurei

3D structure databases

ProteinModelPortaliO75683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 49Nuclear localization signalSequence analysis5
Motifi154 – 158Nuclear localization signalSequence analysis5

Sequence similaritiesi

Belongs to the SURF6 family.Curated

Phylogenomic databases

eggNOGiKOG2885 Eukaryota
ENOG4111G0Y LUCA
GeneTreeiENSGT00390000006980
HOGENOMiHOG000133097
HOVERGENiHBG054998
InParanoidiO75683
OMAiDEDRPWY
OrthoDBiEOG091G0O75
PhylomeDBiO75683
TreeFamiTF321608

Family and domain databases

InterProiView protein in InterPro
IPR029190 Rrp14/SURF6_C
IPR007019 SURF6
PANTHERiPTHR14369 PTHR14369, 1 hit
PfamiView protein in Pfam
PF04935 SURF6, 1 hit

Sequencei

Sequence statusi: Complete.

O75683-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK
60 70 80 90 100
TQKKFRKREE KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP
110 120 130 140 150
ADGLATEPES VFALDVLRQR LHEKIQEARG QGSAKELSPA ALEKRRRRKQ
160 170 180 190 200
ERDRKKRKRK ELRAKEKARK AEEATEAQEV VEATPEGACT EPREPPGLIF
210 220 230 240 250
NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL ERLQARQSRL
260 270 280 290 300
DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR
310 320 330 340 350
AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI
360
LPQDLERAGL V
Length:361
Mass (Da):41,450
Last modified:June 6, 2002 - v3
Checksum:i34F63992E3E82797
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6A → T in CAA12054 (PubMed:11891058).Curated1
Sequence conflicti102D → N in AAD56587 (PubMed:10675619).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014532163R → W. Corresponds to variant dbSNP:rs886090Ensembl.1
Natural variantiVAR_014533175T → M. Corresponds to variant dbSNP:rs886089Ensembl.1
Natural variantiVAR_052199193R → Q. Corresponds to variant dbSNP:rs34657219Ensembl.1
Natural variantiVAR_052200201N → H. Corresponds to variant dbSNP:rs35316446Ensembl.1
Natural variantiVAR_014534311T → M. Corresponds to variant dbSNP:rs1800867Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186772 Genomic DNA Translation: AAD56587.1
AL158826 Genomic DNA Translation: CAI12825.1
CH471090 Genomic DNA Translation: EAW88055.1
BC003001 mRNA Translation: AAH03001.1
BC006197 mRNA Translation: AAH06197.1
BC014878 mRNA Translation: AAH14878.1
AJ224639 Genomic DNA Translation: CAA12054.1
CCDSiCCDS6962.1
RefSeqiNP_001265871.1, NM_001278942.1
NP_006744.2, NM_006753.5
UniGeneiHs.274430

Genome annotation databases

EnsembliENST00000372022; ENSP00000361092; ENSG00000148296
ENST00000629980; ENSP00000485909; ENSG00000281309
GeneIDi6838
KEGGihsa:6838
UCSCiuc004cdb.6 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186772 Genomic DNA Translation: AAD56587.1
AL158826 Genomic DNA Translation: CAI12825.1
CH471090 Genomic DNA Translation: EAW88055.1
BC003001 mRNA Translation: AAH03001.1
BC006197 mRNA Translation: AAH06197.1
BC014878 mRNA Translation: AAH14878.1
AJ224639 Genomic DNA Translation: CAA12054.1
CCDSiCCDS6962.1
RefSeqiNP_001265871.1, NM_001278942.1
NP_006744.2, NM_006753.5
UniGeneiHs.274430

3D structure databases

ProteinModelPortaliO75683
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112705, 46 interactors
IntActiO75683, 23 interactors
STRINGi9606.ENSP00000361092

PTM databases

iPTMnetiO75683
PhosphoSitePlusiO75683

Polymorphism and mutation databases

BioMutaiSURF6

Proteomic databases

EPDiO75683
MaxQBiO75683
PaxDbiO75683
PeptideAtlasiO75683
PRIDEiO75683
ProteomicsDBi50156

Protocols and materials databases

DNASUi6838
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372022; ENSP00000361092; ENSG00000148296
ENST00000629980; ENSP00000485909; ENSG00000281309
GeneIDi6838
KEGGihsa:6838
UCSCiuc004cdb.6 human

Organism-specific databases

CTDi6838
DisGeNETi6838
EuPathDBiHostDB:ENSG00000148296.6
GeneCardsiSURF6
HGNCiHGNC:11478 SURF6
HPAiHPA023608
HPA074622
MIMi185642 gene
neXtProtiNX_O75683
OpenTargetsiENSG00000148296
PharmGKBiPA36263
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2885 Eukaryota
ENOG4111G0Y LUCA
GeneTreeiENSGT00390000006980
HOGENOMiHOG000133097
HOVERGENiHBG054998
InParanoidiO75683
OMAiDEDRPWY
OrthoDBiEOG091G0O75
PhylomeDBiO75683
TreeFamiTF321608

Miscellaneous databases

ChiTaRSiSURF6 human
GeneWikiiSURF6
GenomeRNAii6838
PROiPR:O75683
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148296 Expressed in 194 organ(s), highest expression level in quadriceps femoris
CleanExiHS_SURF6
GenevisibleiO75683 HS

Family and domain databases

InterProiView protein in InterPro
IPR029190 Rrp14/SURF6_C
IPR007019 SURF6
PANTHERiPTHR14369 PTHR14369, 1 hit
PfamiView protein in Pfam
PF04935 SURF6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSURF6_HUMAN
AccessioniPrimary (citable) accession number: O75683
Secondary accession number(s): Q5T8U1
, Q9BRK9, Q9BTZ5, Q9UK24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 6, 2002
Last modified: November 7, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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