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Protein

Surfeit locus protein 6

Gene

SURF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • ribosomal large subunit biogenesis Source: GO_Central
  • ribosomal small subunit biogenesis Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Surfeit locus protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SURF6
Synonyms:SURF-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000148296.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11478 SURF6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
185642 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75683

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6838

Open Targets

More...
OpenTargetsi
ENSG00000148296

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36263

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SURF6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002209691 – 361Surfeit locus protein 6Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei74PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei229PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75683

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75683

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75683

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75683

PeptideAtlas

More...
PeptideAtlasi
O75683

PRoteomics IDEntifications database

More...
PRIDEi
O75683

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50156

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75683

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75683

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148296 Expressed in 194 organ(s), highest expression level in quadriceps femoris

CleanEx database of gene expression profiles

More...
CleanExi
HS_SURF6

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75683 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023608
HPA074622

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CSNK2A1P684002EBI-2691252,EBI-347804

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112705, 47 interactors

Protein interaction database and analysis system

More...
IntActi
O75683, 23 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361092

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75683

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi45 – 49Nuclear localization signalSequence analysis5
Motifi154 – 158Nuclear localization signalSequence analysis5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SURF6 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2885 Eukaryota
ENOG4111G0Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006980

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000133097

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054998

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75683

Identification of Orthologs from Complete Genome Data

More...
OMAi
DEDRPWY

Database of Orthologous Groups

More...
OrthoDBi
1153190at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75683

TreeFam database of animal gene trees

More...
TreeFami
TF321608

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029190 Rrp14/SURF6_C
IPR007019 SURF6

The PANTHER Classification System

More...
PANTHERi
PTHR14369 PTHR14369, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04935 SURF6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O75683-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK
60 70 80 90 100
TQKKFRKREE KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP
110 120 130 140 150
ADGLATEPES VFALDVLRQR LHEKIQEARG QGSAKELSPA ALEKRRRRKQ
160 170 180 190 200
ERDRKKRKRK ELRAKEKARK AEEATEAQEV VEATPEGACT EPREPPGLIF
210 220 230 240 250
NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL ERLQARQSRL
260 270 280 290 300
DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR
310 320 330 340 350
AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI
360
LPQDLERAGL V
Length:361
Mass (Da):41,450
Last modified:June 6, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34F63992E3E82797
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6A → T in CAA12054 (PubMed:11891058).Curated1
Sequence conflicti102D → N in AAD56587 (PubMed:10675619).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014532163R → W. Corresponds to variant dbSNP:rs886090Ensembl.1
Natural variantiVAR_014533175T → M. Corresponds to variant dbSNP:rs886089Ensembl.1
Natural variantiVAR_052199193R → Q. Corresponds to variant dbSNP:rs34657219Ensembl.1
Natural variantiVAR_052200201N → H. Corresponds to variant dbSNP:rs35316446Ensembl.1
Natural variantiVAR_014534311T → M. Corresponds to variant dbSNP:rs1800867Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF186772 Genomic DNA Translation: AAD56587.1
AL158826 Genomic DNA Translation: CAI12825.1
CH471090 Genomic DNA Translation: EAW88055.1
BC003001 mRNA Translation: AAH03001.1
BC006197 mRNA Translation: AAH06197.1
BC014878 mRNA Translation: AAH14878.1
AJ224639 Genomic DNA Translation: CAA12054.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6962.1

NCBI Reference Sequences

More...
RefSeqi
NP_001265871.1, NM_001278942.1
NP_006744.2, NM_006753.5

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.274430

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372022; ENSP00000361092; ENSG00000148296
ENST00000629980; ENSP00000485909; ENSG00000281309

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6838

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6838

UCSC genome browser

More...
UCSCi
uc004cdb.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186772 Genomic DNA Translation: AAD56587.1
AL158826 Genomic DNA Translation: CAI12825.1
CH471090 Genomic DNA Translation: EAW88055.1
BC003001 mRNA Translation: AAH03001.1
BC006197 mRNA Translation: AAH06197.1
BC014878 mRNA Translation: AAH14878.1
AJ224639 Genomic DNA Translation: CAA12054.1
CCDSiCCDS6962.1
RefSeqiNP_001265871.1, NM_001278942.1
NP_006744.2, NM_006753.5
UniGeneiHs.274430

3D structure databases

ProteinModelPortaliO75683
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112705, 47 interactors
IntActiO75683, 23 interactors
STRINGi9606.ENSP00000361092

PTM databases

iPTMnetiO75683
PhosphoSitePlusiO75683

Polymorphism and mutation databases

BioMutaiSURF6

Proteomic databases

EPDiO75683
jPOSTiO75683
MaxQBiO75683
PaxDbiO75683
PeptideAtlasiO75683
PRIDEiO75683
ProteomicsDBi50156

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6838
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372022; ENSP00000361092; ENSG00000148296
ENST00000629980; ENSP00000485909; ENSG00000281309
GeneIDi6838
KEGGihsa:6838
UCSCiuc004cdb.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6838
DisGeNETi6838
EuPathDBiHostDB:ENSG00000148296.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SURF6
HGNCiHGNC:11478 SURF6
HPAiHPA023608
HPA074622
MIMi185642 gene
neXtProtiNX_O75683
OpenTargetsiENSG00000148296
PharmGKBiPA36263

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2885 Eukaryota
ENOG4111G0Y LUCA
GeneTreeiENSGT00390000006980
HOGENOMiHOG000133097
HOVERGENiHBG054998
InParanoidiO75683
OMAiDEDRPWY
OrthoDBi1153190at2759
PhylomeDBiO75683
TreeFamiTF321608

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SURF6 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SURF6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6838

Protein Ontology

More...
PROi
PR:O75683

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148296 Expressed in 194 organ(s), highest expression level in quadriceps femoris
CleanExiHS_SURF6
GenevisibleiO75683 HS

Family and domain databases

InterProiView protein in InterPro
IPR029190 Rrp14/SURF6_C
IPR007019 SURF6
PANTHERiPTHR14369 PTHR14369, 1 hit
PfamiView protein in Pfam
PF04935 SURF6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSURF6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75683
Secondary accession number(s): Q5T8U1
, Q9BRK9, Q9BTZ5, Q9UK24
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 6, 2002
Last modified: January 16, 2019
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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