RFPL3

Functionⁱ

(Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	40 – 82	RING-typePROSITE-ProRule annotationAdd BLAST		43

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ret finger protein-like 3
Gene namesⁱ	Name:RFPL3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128276.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9980 RFPL3
MIMⁱ	605970 gene
neXtProtⁱ	NX_O75679

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000128276
PharmGKBⁱ	PA34349

Polymorphism and mutation databases

BioMutaⁱ	RFPL3

BioMutaⁱ

RFPL3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056032	1 – 317	Ret finger protein-like 3Add BLAST		317

Proteomic databases

PaxDbⁱ	O75679
PeptideAtlas More...PeptideAtlasⁱ	O75679
PRIDEⁱ	O75679
ProteomicsDBⁱ	50155

PTM databases

iPTMnetⁱ	O75679
PhosphoSitePlusⁱ	O75679

Expressionⁱ

Tissue specificityⁱ

Expressed during neurogenesis in differentiating human embryonic stem cells and in the developing human neocortex.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000128276 Expressed in 74 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_RFPL3
Genevisibleⁱ	O75679 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048320 HPA072380

HPAⁱ

HPA048320
HPA072380

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LNX1	Q8TBB1	3	EBI-10188956,EBI-739832
UBE2I	Q7KZS0	3	EBI-10188956,EBI-10180829

Protein-protein interaction databases

BioGridⁱ	115961, 8 interactors
IntActⁱ	O75679, 10 interactors
STRINGⁱ	9606.ENSP00000249007

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75679
SMRⁱ	O75679
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	107 – 301	B30.2/SPRYPROSITE-ProRule annotationAdd BLAST		195

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	40 – 82	RING-typePROSITE-ProRule annotationAdd BLAST		43

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2177 Eukaryota ENOG4111G04 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118993
HOGENOMⁱ	HOG000230861
HOVERGENⁱ	HBG061854
InParanoidⁱ	O75679
OMAⁱ	RFDMSIC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G5I
PhylomeDBⁱ	O75679
TreeFamⁱ	TF317532

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15821 SPRY_PRY_RFPL, 1 hit
Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR006574 PRY IPR022723 RDM_domain_RFPL IPR038908 RFPL IPR037960 SPRY/PRY_RFPL IPR003877 SPRY_dom IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR25462 PTHR25462, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13765 PRY, 1 hit PF11002 RDM, 1 hit PF00622 SPRY, 1 hit
PRINTSⁱ	PR01407 BUTYPHLNCDUF
SMARTⁱ	View protein in SMART SM00589 PRY, 1 hit SM00449 SPRY, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50089 ZF_RING_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: O75679-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRLSLVTTN RLSPQGNFLP LCTFPLAVDM AALFQEASSC PVCSDYLEKP 
        60         70         80         90        100
MSLECGCTVC LKCINSLQKE PHGEDLLCCC CSMVSQRNKI RPNRQLERLV 
       110        120        130        140        150
SHIKELEPKL KKILQMNPRM RKFQVDMTLD ADTANNFLLI SDDLRSVRSG 
       160        170        180        190        200
LITQNRQDLA ERFDVSVCIL GSPRFTCGRH YWEVDVGTST EWDLGVCRES 
       210        220        230        240        250
VHCKGKIQLT TELGFWTVSL RDGSRLSAST VPLTFLLVDR KLQRVGIFLD 
       260        270        280        290        300
MGMQNVSFFD AESGSHVYTF RSVSAEEPLR PFLAPSIPPN GDQGVLSICP 
       310 
LMNSGTTDAP VRPGEAK

Length:317

Mass (Da):35,386

Last modified:March 15, 2005 - v2

Checksum:ⁱ6C27D4829924D2FB

GO

Isoform 2 (identifier: O75679-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-29: Missing.

« Hide

        10         20         30         40         50
MAALFQEASS CPVCSDYLEK PMSLECGCTV CLKCINSLQK EPHGEDLLCC 
        60         70         80         90        100
CCSMVSQRNK IRPNRQLERL VSHIKELEPK LKKILQMNPR MRKFQVDMTL 
       110        120        130        140        150
DADTANNFLL ISDDLRSVRS GLITQNRQDL AERFDVSVCI LGSPRFTCGR 
       160        170        180        190        200
HYWEVDVGTS TEWDLGVCRE SVHCKGKIQL TTELGFWTVS LRDGSRLSAS 
       210        220        230        240        250
TVPLTFLLVD RKLQRVGIFL DMGMQNVSFF DAESGSHVYT FRSVSAEEPL 
       260        270        280 
RPFLAPSIPP NGDQGVLSIC PLMNSGTTDA PVRPGEAK

Note: No experimental confirmation available.

Show »

Length:288

Mass (Da):32,171

Checksum:ⁱE1FB99D29C010E3E

GO

Sequence cautionⁱ

The sequence CAA09046 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_052091	83	M → T. Corresponds to variant dbSNP:rs16987625Ensembl.	1
Natural variantⁱVAR_052092	110	L → M1 PublicationCorresponds to variant dbSNP:rs9621427Ensembl.	1
Natural variantⁱVAR_052093	126	D → N. Corresponds to variant dbSNP:rs9619258Ensembl.	1
Natural variantⁱVAR_059814	181	Y → C. Corresponds to variant dbSNP:rs5749408Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045651	1 – 29	Missing in isoform 2. 1 PublicationAdd BLAST		29

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ010232 mRNA Translation: CAA09046.1 Different initiation. CR456564 mRNA Translation: CAG30450.1 AL021937 Genomic DNA No translation available. BC031689 mRNA Translation: AAH31689.1 BC069753 mRNA Translation: AAH69753.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13904.1 [O75679-2] CCDS43011.1 [O75679-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001092005.1, NM_001098535.1 [O75679-1] NP_006595.1, NM_006604.2 [O75679-2]
UniGeneⁱ	Hs.558455

Genome annotation databases

Ensemblⁱ	ENST00000249007; ENSP00000249007; ENSG00000128276 [O75679-1] ENST00000397468; ENSP00000380609; ENSG00000128276 [O75679-2]
GeneIDⁱ	10738
KEGGⁱ	hsa:10738
UCSC genome browser More...UCSCⁱ	uc003amj.3 human [O75679-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75679	Isoform 2 of Ret finger protein-like 3		HUMAN		288	UniRef90_O75679
Uncharacterized protein		RHIBE		362
Uncharacterized protein		MACFA		328
Uncharacterized protein		MANLE		328
Uncharacterized protein		MACNE		328
+22

Protein	Similar proteins		Species	Score	Length	Source
O75679	Ret finger protein-like 1		HUMAN		317	UniRef50_O75679
Uncharacterized protein		RHIBE		362
Ret finger protein-like 1 (Predicted)		PAPAN		328
Uncharacterized protein		MACNE		328
Uncharacterized protein		MACFA		328
+83

Entry informationⁱ

Entry nameⁱ	RFPL3_HUMAN
Accessionⁱ	O75679Primary (citable) accession number: O75679 Secondary accession number(s): A2A279 , Q6IC03, Q6IC04, Q6NSX3, Q8N5R4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
	Last sequence update:	March 15, 2005
	Last modified:	September 12, 2018
	This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O75679 (RFPL3_HUMAN)

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Ret finger protein-like 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ