UniProtKB - O75679 (RFPL3_HUMAN)
Protein
Ret finger protein-like 3
Gene
RFPL3
Organism
Homo sapiens (Human)
Status
Functioni
(Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 40 – 82 | RING-typePROSITE-ProRule annotationAdd BLAST | 43 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin-protein transferase activity Source: GO_Central
GO - Biological processi
- positive regulation of transcription, DNA-templated Source: GO_Central
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O75679 |
Names & Taxonomyi
Protein namesi | Recommended name: Ret finger protein-like 3 |
Gene namesi | Name:RFPL3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000128276.10 |
HGNCi | HGNC:9980, RFPL3 |
MIMi | 605970, gene |
neXtProti | NX_O75679 |
Subcellular locationi
Nucleus
- nucleoplasm Source: GO_Central
Other locations
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10738 |
OpenTargetsi | ENSG00000128276 |
PharmGKBi | PA34349 |
Miscellaneous databases
Pharosi | O75679, Tbio |
Polymorphism and mutation databases
BioMutai | RFPL3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056032 | 1 – 317 | Ret finger protein-like 3Add BLAST | 317 |
Proteomic databases
PaxDbi | O75679 |
PeptideAtlasi | O75679 |
PRIDEi | O75679 |
ProteomicsDBi | 173 50155 [O75679-1] |
PTM databases
iPTMneti | O75679 |
PhosphoSitePlusi | O75679 |
Expressioni
Tissue specificityi
Expressed during neurogenesis in differentiating human embryonic stem cells and in the developing human neocortex.1 Publication
Gene expression databases
Bgeei | ENSG00000128276, Expressed in buccal mucosa cell and 84 other tissues |
Genevisiblei | O75679, HS |
Organism-specific databases
HPAi | ENSG00000128276, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Hide detailsO75679
Protein-protein interaction databases
BioGRIDi | 115961, 17 interactors |
IntActi | O75679, 15 interactors |
STRINGi | 9606.ENSP00000249007 |
Miscellaneous databases
RNActi | O75679, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 107 – 301 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 195 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 40 – 82 | RING-typePROSITE-ProRule annotationAdd BLAST | 43 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000163408 |
HOGENOMi | CLU_013137_7_1_1 |
InParanoidi | O75679 |
OMAi | RSGCIRH |
OrthoDBi | 1139938at2759 |
PhylomeDBi | O75679 |
TreeFami | TF317532 |
Family and domain databases
CDDi | cd15821, SPRY_PRY_RFPL, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR022723, RDM_domain_RFPL IPR038908, RFPL IPR037960, SPRY/PRY_RFPL IPR003877, SPRY_dom IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR24103:SF587, PTHR24103:SF587, 1 hit |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF11002, RDM, 1 hit PF00622, SPRY, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00589, PRY, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50089, ZF_RING_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O75679-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKRLSLVTTN RLSPQGNFLP LCTFPLAVDM AALFQEASSC PVCSDYLEKP
60 70 80 90 100
MSLECGCTVC LKCINSLQKE PHGEDLLCCC CSMVSQRNKI RPNRQLERLV
110 120 130 140 150
SHIKELEPKL KKILQMNPRM RKFQVDMTLD ADTANNFLLI SDDLRSVRSG
160 170 180 190 200
LITQNRQDLA ERFDVSVCIL GSPRFTCGRH YWEVDVGTST EWDLGVCRES
210 220 230 240 250
VHCKGKIQLT TELGFWTVSL RDGSRLSAST VPLTFLLVDR KLQRVGIFLD
260 270 280 290 300
MGMQNVSFFD AESGSHVYTF RSVSAEEPLR PFLAPSIPPN GDQGVLSICP
310
LMNSGTTDAP VRPGEAK
Sequence cautioni
The sequence CAA09046 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052091 | 83 | M → T. Corresponds to variant dbSNP:rs16987625Ensembl. | 1 | |
Natural variantiVAR_052092 | 110 | L → M1 PublicationCorresponds to variant dbSNP:rs9621427Ensembl. | 1 | |
Natural variantiVAR_052093 | 126 | D → N. Corresponds to variant dbSNP:rs9619258Ensembl. | 1 | |
Natural variantiVAR_059814 | 181 | Y → C. Corresponds to variant dbSNP:rs5749408Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045651 | 1 – 29 | Missing in isoform 2. 1 PublicationAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ010232 mRNA Translation: CAA09046.1 Different initiation. CR456564 mRNA Translation: CAG30450.1 AL021937 Genomic DNA No translation available. BC031689 mRNA Translation: AAH31689.1 BC069753 mRNA Translation: AAH69753.2 |
CCDSi | CCDS13904.1 [O75679-2] CCDS43011.1 [O75679-1] |
RefSeqi | NP_001092005.1, NM_001098535.1 [O75679-1] NP_006595.1, NM_006604.2 [O75679-2] |
Genome annotation databases
Ensembli | ENST00000249007; ENSP00000249007; ENSG00000128276 [O75679-1] ENST00000397468; ENSP00000380609; ENSG00000128276 [O75679-2] |
GeneIDi | 10738 |
KEGGi | hsa:10738 |
UCSCi | uc003amj.3, human [O75679-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ010232 mRNA Translation: CAA09046.1 Different initiation. CR456564 mRNA Translation: CAG30450.1 AL021937 Genomic DNA No translation available. BC031689 mRNA Translation: AAH31689.1 BC069753 mRNA Translation: AAH69753.2 |
CCDSi | CCDS13904.1 [O75679-2] CCDS43011.1 [O75679-1] |
RefSeqi | NP_001092005.1, NM_001098535.1 [O75679-1] NP_006595.1, NM_006604.2 [O75679-2] |
3D structure databases
SMRi | O75679 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115961, 17 interactors |
IntActi | O75679, 15 interactors |
STRINGi | 9606.ENSP00000249007 |
PTM databases
iPTMneti | O75679 |
PhosphoSitePlusi | O75679 |
Polymorphism and mutation databases
BioMutai | RFPL3 |
Proteomic databases
PaxDbi | O75679 |
PeptideAtlasi | O75679 |
PRIDEi | O75679 |
ProteomicsDBi | 173 50155 [O75679-1] |
Protocols and materials databases
Antibodypediai | 11237, 170 antibodies |
DNASUi | 10738 |
Genome annotation databases
Ensembli | ENST00000249007; ENSP00000249007; ENSG00000128276 [O75679-1] ENST00000397468; ENSP00000380609; ENSG00000128276 [O75679-2] |
GeneIDi | 10738 |
KEGGi | hsa:10738 |
UCSCi | uc003amj.3, human [O75679-1] |
Organism-specific databases
CTDi | 10738 |
DisGeNETi | 10738 |
EuPathDBi | HostDB:ENSG00000128276.10 |
GeneCardsi | RFPL3 |
HGNCi | HGNC:9980, RFPL3 |
HPAi | ENSG00000128276, Tissue enriched (testis) |
MIMi | 605970, gene |
neXtProti | NX_O75679 |
OpenTargetsi | ENSG00000128276 |
PharmGKBi | PA34349 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000163408 |
HOGENOMi | CLU_013137_7_1_1 |
InParanoidi | O75679 |
OMAi | RSGCIRH |
OrthoDBi | 1139938at2759 |
PhylomeDBi | O75679 |
TreeFami | TF317532 |
Enzyme and pathway databases
PathwayCommonsi | O75679 |
Miscellaneous databases
BioGRID-ORCSi | 10738, 2 hits in 816 CRISPR screens |
GenomeRNAii | 10738 |
Pharosi | O75679, Tbio |
PROi | PR:O75679 |
RNActi | O75679, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000128276, Expressed in buccal mucosa cell and 84 other tissues |
Genevisiblei | O75679, HS |
Family and domain databases
CDDi | cd15821, SPRY_PRY_RFPL, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR022723, RDM_domain_RFPL IPR038908, RFPL IPR037960, SPRY/PRY_RFPL IPR003877, SPRY_dom IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR24103:SF587, PTHR24103:SF587, 1 hit |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF11002, RDM, 1 hit PF00622, SPRY, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00589, PRY, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RFPL3_HUMAN | |
Accessioni | O75679Primary (citable) accession number: O75679 Secondary accession number(s): A2A279 Q8N5R4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | March 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations