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Protein

Ret finger protein-like 1

Gene

RFPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates the G2-M phase transition, possibly by promoting cyclin B1/CCNB1 and CDK1 proteasomal degradation and thereby preventing their accumulation during interphase.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri40 – 82RING-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

Keywordsi

Biological processCell cycle
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ret finger protein-like 1
Alternative name(s):
RING finger protein 78
Gene namesi
Name:RFPL1
Synonyms:RFPL1L, RNF78
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128250.5
HGNCiHGNC:9977 RFPL1
MIMi605968 gene
neXtProtiNX_O75677

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi65 – 124Missing : Increased cell proliferation. 1 PublicationAdd BLAST60
Mutagenesisi200S → A: Reduced phosphorylation by PKC, increased cell proliferation, reduced apoptosis and lack of cyclin B1/CCNB1 and CDK1 degradation. 1 Publication1
Mutagenesisi200S → E: No effect on cell proliferation. 1 Publication1
Mutagenesisi287S → E: Increased cell proliferation, reduced apoptosis and lack of cyclin B1/CCNB1 and CDK1 degradation. 1 Publication1
Mutagenesisi287S → G: Reduced phosphorylation by CDK1. 1 Publication1

Organism-specific databases

DisGeNETi5988
OpenTargetsiENSG00000128250
PharmGKBiPA34346

Polymorphism and mutation databases

BioMutaiRFPL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560301 – 317Ret finger protein-like 1Add BLAST317

Post-translational modificationi

Phosphorylated by PKC and CDK1 (PubMed:20725088). The antiproliferative effect seems to be positively regulated by PKC phosphorylation and negatively by CDK1 phosphorylation (PubMed:20725088).1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO75677
PeptideAtlasiO75677
PRIDEiO75677
ProteomicsDBi50151

PTM databases

iPTMnetiO75677
PhosphoSitePlusiO75677

Expressioni

Tissue specificityi

Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal kidney.

Gene expression databases

BgeeiENSG00000128250 Expressed in 47 organ(s), highest expression level in prostate gland
CleanExiHS_RFPL1
GenevisibleiO75677 HS

Organism-specific databases

HPAiHPA048320
HPA072380

Interactioni

Protein-protein interaction databases

BioGridi111920, 1 interactor
STRINGi9606.ENSP00000346342

Structurei

3D structure databases

ProteinModelPortaliO75677
SMRiO75677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 301B30.2/SPRYPROSITE-ProRule annotationAdd BLAST195

Domaini

The B30.2/SPRY domain is required for the negative regulation of cell proliferation.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri40 – 82RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118993
HOGENOMiHOG000230861
HOVERGENiHBG061854
InParanoidiO75677
OMAiCATSIEC
OrthoDBiEOG091G0G5I
PhylomeDBiO75677
TreeFamiTF317532

Family and domain databases

CDDicd15821 SPRY_PRY_RFPL, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR022723 RDM_domain_RFPL
IPR038908 RFPL
IPR037960 SPRY/PRY_RFPL
IPR003877 SPRY_dom
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR25462 PTHR25462, 1 hit
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF11002 RDM, 1 hit
PF00622 SPRY, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

O75677-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRLSLVTTN RLSPHGNFLP LCTFPLAVDM AALFQEASSC PVCSDYLEKP
60 70 80 90 100
MSLECGCAVC FKCINSLQKE PHGEDLLCCC CSMVSQKNKI RPSWQLERLA
110 120 130 140 150
SHIKELEPKL KKILQMNPRM RKFQVDMTLD ADTANNFLLI SDDLRSVRSG
160 170 180 190 200
CITQNRQDLA ERFDVSICIL GSPRFTCGRH YWEVDVGTST EWDLGVCRES
210 220 230 240 250
VHRKGRIHLT TERGFWTVSL RDGSRLSAST VPLTFLFVDR KLQRVGIFLD
260 270 280 290 300
MGMQNVSFFD AEGGSHVYTF RSVSAEEPLH LFFAPPSPPN GDKSVLSICP
310
VINPGTTDAP VHPGEAK
Length:317
Mass (Da):35,491
Last modified:March 15, 2005 - v2
Checksum:i75FDDED7BF51B8CA
GO

Sequence cautioni

The sequence CAA09043 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA09044 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289P → S in CAG30448 (PubMed:15461802).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03957294W → R. Corresponds to variant dbSNP:rs16987627Ensembl.1
Natural variantiVAR_020115127M → T3 PublicationsCorresponds to variant dbSNP:rs3804076Ensembl.1
Natural variantiVAR_039573139Missing 3 Publications1
Natural variantiVAR_080854148 – 317Missing Increased cell proliferation. 1 PublicationCorresponds to variant dbSNP:rs16987628Add BLAST170
Natural variantiVAR_080855243 – 317Missing 1 PublicationCorresponds to variant dbSNP:rs12484086Add BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010228 mRNA Translation: CAA09043.1 Different initiation.
AJ010229 mRNA Translation: CAA09044.1 Different initiation.
CR456562 mRNA Translation: CAG30448.1
BC104768 mRNA No translation available.
CCDSiCCDS13857.2
RefSeqiNP_066306.2, NM_021026.2
XP_011528600.1, XM_011530298.2
XP_011528601.1, XM_011530299.2
XP_016884389.1, XM_017028900.1
XP_016884390.1, XM_017028901.1
XP_016884391.1, XM_017028902.1
UniGeneiHs.648249

Genome annotation databases

EnsembliENST00000354373; ENSP00000346342; ENSG00000128250
GeneIDi5988
KEGGihsa:5988
UCSCiuc003afn.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010228 mRNA Translation: CAA09043.1 Different initiation.
AJ010229 mRNA Translation: CAA09044.1 Different initiation.
CR456562 mRNA Translation: CAG30448.1
BC104768 mRNA No translation available.
CCDSiCCDS13857.2
RefSeqiNP_066306.2, NM_021026.2
XP_011528600.1, XM_011530298.2
XP_011528601.1, XM_011530299.2
XP_016884389.1, XM_017028900.1
XP_016884390.1, XM_017028901.1
XP_016884391.1, XM_017028902.1
UniGeneiHs.648249

3D structure databases

ProteinModelPortaliO75677
SMRiO75677
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111920, 1 interactor
STRINGi9606.ENSP00000346342

PTM databases

iPTMnetiO75677
PhosphoSitePlusiO75677

Polymorphism and mutation databases

BioMutaiRFPL1

Proteomic databases

PaxDbiO75677
PeptideAtlasiO75677
PRIDEiO75677
ProteomicsDBi50151

Protocols and materials databases

DNASUi5988
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354373; ENSP00000346342; ENSG00000128250
GeneIDi5988
KEGGihsa:5988
UCSCiuc003afn.3 human

Organism-specific databases

CTDi5988
DisGeNETi5988
EuPathDBiHostDB:ENSG00000128250.5
GeneCardsiRFPL1
HGNCiHGNC:9977 RFPL1
HPAiHPA048320
HPA072380
MIMi605968 gene
neXtProtiNX_O75677
OpenTargetsiENSG00000128250
PharmGKBiPA34346
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118993
HOGENOMiHOG000230861
HOVERGENiHBG061854
InParanoidiO75677
OMAiCATSIEC
OrthoDBiEOG091G0G5I
PhylomeDBiO75677
TreeFamiTF317532

Miscellaneous databases

GenomeRNAii5988
PROiPR:O75677
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128250 Expressed in 47 organ(s), highest expression level in prostate gland
CleanExiHS_RFPL1
GenevisibleiO75677 HS

Family and domain databases

CDDicd15821 SPRY_PRY_RFPL, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR022723 RDM_domain_RFPL
IPR038908 RFPL
IPR037960 SPRY/PRY_RFPL
IPR003877 SPRY_dom
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR25462 PTHR25462, 1 hit
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF11002 RDM, 1 hit
PF00622 SPRY, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRFPL1_HUMAN
AccessioniPrimary (citable) accession number: O75677
Secondary accession number(s): Q6IC06, Q9UJ97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 15, 2005
Last modified: October 10, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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