RFPL1

Functionⁱ

Negatively regulates the G2-M phase transition, possibly by promoting cyclin B1/CCNB1 and CDK1 proteasomal degradation and thereby preventing their accumulation during interphase.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	40 – 82	RING-typePROSITE-ProRule annotationAdd BLAST		43

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ret finger protein-like 1 Alternative name(s): RING finger protein 78
Gene namesⁱ	Name:RFPL1 Synonyms:RFPL1L, RNF78
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128250.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9977 RFPL1
MIMⁱ	605968 gene
neXtProtⁱ	NX_O75677

Subcellular locationⁱ

UniProt annotation

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	65 – 124	Missing : Increased cell proliferation. 1 PublicationAdd BLAST	60
Mutagenesisⁱ	200	S → A: Reduced phosphorylation by PKC, increased cell proliferation, reduced apoptosis and lack of cyclin B1/CCNB1 and CDK1 degradation. 1 Publication	1
Mutagenesisⁱ	200	S → E: No effect on cell proliferation. 1 Publication	1
Mutagenesisⁱ	287	S → E: Increased cell proliferation, reduced apoptosis and lack of cyclin B1/CCNB1 and CDK1 degradation. 1 Publication	1
Mutagenesisⁱ	287	S → G: Reduced phosphorylation by CDK1. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5988
Open Targets More...OpenTargetsⁱ	ENSG00000128250
PharmGKBⁱ	PA34346

Polymorphism and mutation databases

BioMutaⁱ	RFPL1

BioMutaⁱ

RFPL1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056030	1 – 317	Ret finger protein-like 1Add BLAST		317

Post-translational modificationⁱ

Phosphorylated by PKC and CDK1 (PubMed:20725088). The antiproliferative effect seems to be positively regulated by PKC phosphorylation and negatively by CDK1 phosphorylation (PubMed:20725088).1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	O75677
PeptideAtlas More...PeptideAtlasⁱ	O75677
PRIDEⁱ	O75677
ProteomicsDBⁱ	50151

PTM databases

iPTMnetⁱ	O75677
PhosphoSitePlusⁱ	O75677

Expressionⁱ

Tissue specificityⁱ

Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal kidney.

Gene expression databases

Bgeeⁱ	ENSG00000128250 Expressed in 47 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_RFPL1
Genevisibleⁱ	O75677 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048320 HPA072380

HPAⁱ

HPA048320
HPA072380

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	111920, 1 interactor
STRINGⁱ	9606.ENSP00000346342

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75677
SMRⁱ	O75677
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	107 – 301	B30.2/SPRYPROSITE-ProRule annotationAdd BLAST		195

Domainⁱ

The B30.2/SPRY domain is required for the negative regulation of cell proliferation.1 Publication

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	40 – 82	RING-typePROSITE-ProRule annotationAdd BLAST		43

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2177 Eukaryota ENOG4111G04 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118993
HOGENOMⁱ	HOG000230861
HOVERGENⁱ	HBG061854
InParanoidⁱ	O75677
OMAⁱ	CATSIEC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G5I
PhylomeDBⁱ	O75677
TreeFamⁱ	TF317532

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15821 SPRY_PRY_RFPL, 1 hit
Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR006574 PRY IPR022723 RDM_domain_RFPL IPR038908 RFPL IPR037960 SPRY/PRY_RFPL IPR003877 SPRY_dom IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR25462 PTHR25462, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13765 PRY, 1 hit PF11002 RDM, 1 hit PF00622 SPRY, 1 hit
PRINTSⁱ	PR01407 BUTYPHLNCDUF
SMARTⁱ	View protein in SMART SM00589 PRY, 1 hit SM00449 SPRY, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50089 ZF_RING_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O75677-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKRLSLVTTN RLSPHGNFLP LCTFPLAVDM AALFQEASSC PVCSDYLEKP 
        60         70         80         90        100
MSLECGCAVC FKCINSLQKE PHGEDLLCCC CSMVSQKNKI RPSWQLERLA 
       110        120        130        140        150
SHIKELEPKL KKILQMNPRM RKFQVDMTLD ADTANNFLLI SDDLRSVRSG 
       160        170        180        190        200
CITQNRQDLA ERFDVSICIL GSPRFTCGRH YWEVDVGTST EWDLGVCRES 
       210        220        230        240        250
VHRKGRIHLT TERGFWTVSL RDGSRLSAST VPLTFLFVDR KLQRVGIFLD 
       260        270        280        290        300
MGMQNVSFFD AEGGSHVYTF RSVSAEEPLH LFFAPPSPPN GDKSVLSICP 
       310 
VINPGTTDAP VHPGEAK

Length:317

Mass (Da):35,491

Last modified:March 15, 2005 - v2

Checksum:ⁱ75FDDED7BF51B8CA

GO

Sequence cautionⁱ

The sequence CAA09043 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAA09044 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	289	P → S in CAG30448 (PubMed:15461802).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_039572	94	W → R. Corresponds to variant dbSNP:rs16987627Ensembl.	1
Natural variantⁱVAR_020115	127	M → T3 PublicationsCorresponds to variant dbSNP:rs3804076Ensembl.	1
Natural variantⁱVAR_039573	139	Missing 3 Publications	1
Natural variantⁱVAR_080854	148 – 317	Missing Increased cell proliferation. 1 PublicationCorresponds to variant dbSNP:rs16987628Add BLAST	170
Natural variantⁱVAR_080855	243 – 317	Missing 1 PublicationCorresponds to variant dbSNP:rs12484086Add BLAST	75

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ010228 mRNA Translation: CAA09043.1 Different initiation. AJ010229 mRNA Translation: CAA09044.1 Different initiation. CR456562 mRNA Translation: CAG30448.1 BC104768 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13857.2
NCBI Reference Sequences More...RefSeqⁱ	NP_066306.2, NM_021026.2 XP_011528600.1, XM_011530298.2 XP_011528601.1, XM_011530299.2 XP_016884389.1, XM_017028900.1 XP_016884390.1, XM_017028901.1 XP_016884391.1, XM_017028902.1
UniGeneⁱ	Hs.648249

Genome annotation databases

Ensemblⁱ	ENST00000354373; ENSP00000346342; ENSG00000128250
GeneIDⁱ	5988
KEGGⁱ	hsa:5988
UCSC genome browser More...UCSCⁱ	uc003afn.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O75677	Uncharacterized protein		PANTR		348	UniRef90_O75677
UPI0000133801		HUMAN		288
RFPL3 isoform 1 (Fragment)		PANTR		289
UPI0000E25AC7		PANTR		319

Protein	Similar proteins		Species	Score	Length	Source
O75677	Ret finger protein-like 3		HUMAN		317	UniRef50_O75677
Uncharacterized protein		PANTR		348
Uncharacterized protein		SAIBB		331
Uncharacterized protein		CALJA		307
Uncharacterized protein		PONAB		318
+87

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ010228 mRNA Translation: CAA09043.1 Different initiation. AJ010229 mRNA Translation: CAA09044.1 Different initiation. CR456562 mRNA Translation: CAG30448.1 BC104768 mRNA No translation available.
CCDSⁱ	CCDS13857.2
RefSeqⁱ	NP_066306.2, NM_021026.2 XP_011528600.1, XM_011530298.2 XP_011528601.1, XM_011530299.2 XP_016884389.1, XM_017028900.1 XP_016884390.1, XM_017028901.1 XP_016884391.1, XM_017028902.1
UniGeneⁱ	Hs.648249

3D structure databases

ProteinModelPortalⁱ	O75677
SMRⁱ	O75677
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111920, 1 interactor
STRINGⁱ	9606.ENSP00000346342

PTM databases

iPTMnetⁱ	O75677
PhosphoSitePlusⁱ	O75677

Polymorphism and mutation databases

BioMutaⁱ	RFPL1

BioMutaⁱ

RFPL1

Proteomic databases

PaxDbⁱ	O75677
PeptideAtlasⁱ	O75677
PRIDEⁱ	O75677
ProteomicsDBⁱ	50151

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5988
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000354373; ENSP00000346342; ENSG00000128250
GeneIDⁱ	5988
KEGGⁱ	hsa:5988
UCSCⁱ	uc003afn.3 human

Organism-specific databases

CTDⁱ	5988
DisGeNETⁱ	5988
EuPathDBⁱ	HostDB:ENSG00000128250.5
GeneCardsⁱ	RFPL1
HGNCⁱ	HGNC:9977 RFPL1
HPAⁱ	HPA048320 HPA072380
MIMⁱ	605968 gene
neXtProtⁱ	NX_O75677
OpenTargetsⁱ	ENSG00000128250
PharmGKBⁱ	PA34346
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2177 Eukaryota ENOG4111G04 LUCA
GeneTreeⁱ	ENSGT00760000118993
HOGENOMⁱ	HOG000230861
HOVERGENⁱ	HBG061854
InParanoidⁱ	O75677
OMAⁱ	CATSIEC
OrthoDBⁱ	EOG091G0G5I
PhylomeDBⁱ	O75677
TreeFamⁱ	TF317532

Miscellaneous databases

GenomeRNAiⁱ	5988
Protein Ontology More...PROⁱ	PR:O75677
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000128250 Expressed in 47 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_RFPL1
Genevisibleⁱ	O75677 HS

Family and domain databases

CDDⁱ	cd15821 SPRY_PRY_RFPL, 1 hit
Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR006574 PRY IPR022723 RDM_domain_RFPL IPR038908 RFPL IPR037960 SPRY/PRY_RFPL IPR003877 SPRY_dom IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR25462 PTHR25462, 1 hit
Pfamⁱ	View protein in Pfam PF13765 PRY, 1 hit PF11002 RDM, 1 hit PF00622 SPRY, 1 hit
PRINTSⁱ	PR01407 BUTYPHLNCDUF
SMARTⁱ	View protein in SMART SM00589 PRY, 1 hit SM00449 SPRY, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RFPL1_HUMAN
Accessionⁱ	O75677Primary (citable) accession number: O75677 Secondary accession number(s): Q6IC06, Q9UJ97
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
	Last sequence update:	March 15, 2005
	Last modified:	October 10, 2018
	This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O75677 (RFPL1_HUMAN)

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Ret finger protein-like 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ