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Protein

TOM1-like protein 1

Gene

TOM1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • clathrin binding Source: UniProtKB
  • protein kinase activator activity Source: InterPro
  • protein kinase binding Source: UniProtKB
  • SH3 domain binding Source: UniProtKB-KW
  • ubiquitin binding Source: HGNC

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
O75674

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
O75674 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TOM1-like protein 1
Alternative name(s):
Src-activating and signaling molecule protein
Target of Myb-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOM1L1
Synonyms:SRCASM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000141198.13

Human Gene Nomenclature Database

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HGNCi
HGNC:11983 TOM1L1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604701 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O75674

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10040

Open Targets

More...
OpenTargetsi
ENSG00000141198

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36667

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TOM1L1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000725661 – 476TOM1-like protein 1Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei171PhosphoserineBy similarity1
Modified residuei314PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei460PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosines by FYN and LYN.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75674

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75674

MaxQB - The MaxQuant DataBase

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MaxQBi
O75674

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O75674

PeptideAtlas

More...
PeptideAtlasi
O75674

PRoteomics IDEntifications database

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PRIDEi
O75674

ProteomicsDB human proteome resource

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ProteomicsDBi
50148

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75674

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75674

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000141198 Expressed in 195 organ(s), highest expression level in jejunal mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_TOM1L1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75674 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75674 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA022916

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. Interacts with LYN.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115352, 63 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
O75674

Protein interaction database and analysis system

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IntActi
O75674, 34 interactors

Molecular INTeraction database

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MINTi
O75674

STRING: functional protein association networks

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STRINGi
9606.ENSP00000460823

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RRUX-ray3.00A/B9-150[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75674

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75674

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 154VHSPROSITE-ProRule annotationAdd BLAST133
Domaini200 – 288GATPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni392 – 395Interaction with GRB2By similarity4
Regioni442 – 445Interaction with PIK3R1By similarity4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi421 – 425SH3-bindingBy similarity5
Motifi460 – 463SH2-bindingBy similarity4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TOM1 family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1087 Eukaryota
ENOG410Y26G LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160240

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000285970

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG025068

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75674

Identification of Orthologs from Complete Genome Data

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OMAi
KGAQSHS

Database of Orthologous Groups

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OrthoDBi
594067at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75674

TreeFam database of animal gene trees

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TreeFami
TF314105

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.58.160, 1 hit
1.25.40.90, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008942 ENTH_VHS
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR014645 TOM1
IPR027428 TOM1L1
IPR002014 VHS_dom

The PANTHER Classification System

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PANTHERi
PTHR13856:SF28 PTHR13856:SF28, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF036948 TOM1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00288 VHS, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48464 SSF48464, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFGKSHRDP YATSVGHLIE KATFAGVQTE DWGQFMHICD IINTTQDGPK
60 70 80 90 100
DAVKALKKRI SKNYNHKEIQ LTLSLIDMCV QNCGPSFQSL IVKKEFVKEN
110 120 130 140 150
LVKLLNPRYN LPLDIQNRIL NFIKTWSQGF PGGVDVSEVK EVYLDLVKKG
160 170 180 190 200
VQFPPSEAEA ETARQETAQI SSNPPTSVPT APALSSVIAP KNSTVTLVPE
210 220 230 240 250
QIGKLHSELD MVKMNVRVMS AILMENTPGS ENHEDIELLQ KLYKTGREMQ
260 270 280 290 300
ERIMDLLVVV ENEDVTVELI QVNEDLNNAI LGYERFTRNQ QRILEQNKNQ
310 320 330 340 350
KEATNTTSEP SAPSQDLLDL SPSPRMPRAT LGELNTMNNQ LSGLNFSLPS
360 370 380 390 400
SDVTNNLKPS LHPQMNLLAL ENTEIPPFAQ RTSQNLTSSH AYDNFLEHSN
410 420 430 440 450
SVFLQPVSLQ TIAAAPSNQS LPPLPSNHPA MTKSDLQPPN YYEVMEFDPL
460 470
APAVTTEAIY EEIDAHQHKG AQNDGD
Length:476
Mass (Da):52,989
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47ED5FA1F40144C0
GO
Isoform 2 (identifier: O75674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-346: NF → SK
     347-476: Missing.

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):38,713
Checksum:i414DC8AEA1AB415F
GO
Isoform 3 (identifier: O75674-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Note: No experimental confirmation available.
Show »
Length:399
Mass (Da):44,334
Checksum:iF1E782419B262E59
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQU4J3KQU4_HUMAN
TOM1-like protein 1
TOM1L1 hCG_32771
465Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4I4I3L4I4_HUMAN
TOM1-like protein 1
TOM1L1
469Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3T4I3L3T4_HUMAN
TOM1-like protein 1
TOM1L1
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3NI44I3NI44_HUMAN
TOM1-like protein 1
TOM1L1
326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L367I3L367_HUMAN
TOM1-like protein 1
TOM1L1
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4N3I3L4N3_HUMAN
TOM1-like protein 1
TOM1L1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3M3I3L3M3_HUMAN
TOM1-like protein 1
TOM1L1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4G0I3L4G0_HUMAN
TOM1-like protein 1
TOM1L1
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1G1I3L1G1_HUMAN
TOM1-like protein 1
TOM1L1
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0N2I3L0N2_HUMAN
TOM1-like protein 1
TOM1L1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48G → A in CAA08993 (PubMed:10329004).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047469108R → S. Corresponds to variant dbSNP:rs16955377Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0574241 – 77Missing in isoform 3. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_056852345 – 346NF → SK in isoform 2. 1 Publication2
Alternative sequenceiVSP_056853347 – 476Missing in isoform 2. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ010071 mRNA Translation: CAA08993.1
AK315039 mRNA Translation: BAG37522.1
AK315907 mRNA Translation: BAH14278.1
AK223125 mRNA Translation: BAD96845.1
AC007485 Genomic DNA No translation available.
AC090824 Genomic DNA No translation available.
KC877665 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94551.1
CH471109 Genomic DNA Translation: EAW94553.1
BC029396 mRNA Translation: AAH29396.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11582.1 [O75674-1]
CCDS82160.1 [O75674-2]
CCDS82161.1 [O75674-3]

NCBI Reference Sequences

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RefSeqi
NP_001308102.1, NM_001321173.1 [O75674-2]
NP_001308103.1, NM_001321174.1 [O75674-3]
NP_001308104.1, NM_001321175.1 [O75674-3]
NP_001308105.1, NM_001321176.1 [O75674-3]
NP_005477.2, NM_005486.2 [O75674-1]
XP_016879491.1, XM_017024002.1 [O75674-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.153504

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000348161; ENSP00000343901; ENSG00000141198 [O75674-3]
ENST00000536554; ENSP00000443099; ENSG00000141198 [O75674-3]
ENST00000570371; ENSP00000458553; ENSG00000141198 [O75674-2]
ENST00000575333; ENSP00000458918; ENSG00000141198 [O75674-2]
ENST00000575882; ENSP00000460823; ENSG00000141198 [O75674-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10040

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10040

UCSC genome browser

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UCSCi
uc002iuc.4 human [O75674-1]
uc010dbz.3 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010071 mRNA Translation: CAA08993.1
AK315039 mRNA Translation: BAG37522.1
AK315907 mRNA Translation: BAH14278.1
AK223125 mRNA Translation: BAD96845.1
AC007485 Genomic DNA No translation available.
AC090824 Genomic DNA No translation available.
KC877665 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94551.1
CH471109 Genomic DNA Translation: EAW94553.1
BC029396 mRNA Translation: AAH29396.1
CCDSiCCDS11582.1 [O75674-1]
CCDS82160.1 [O75674-2]
CCDS82161.1 [O75674-3]
RefSeqiNP_001308102.1, NM_001321173.1 [O75674-2]
NP_001308103.1, NM_001321174.1 [O75674-3]
NP_001308104.1, NM_001321175.1 [O75674-3]
NP_001308105.1, NM_001321176.1 [O75674-3]
NP_005477.2, NM_005486.2 [O75674-1]
XP_016879491.1, XM_017024002.1 [O75674-3]
UniGeneiHs.153504

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RRUX-ray3.00A/B9-150[»]
ProteinModelPortaliO75674
SMRiO75674
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115352, 63 interactors
ELMiO75674
IntActiO75674, 34 interactors
MINTiO75674
STRINGi9606.ENSP00000460823

Protein family/group databases

MoonDBiO75674 Predicted

PTM databases

iPTMnetiO75674
PhosphoSitePlusiO75674

Polymorphism and mutation databases

BioMutaiTOM1L1

Proteomic databases

EPDiO75674
jPOSTiO75674
MaxQBiO75674
PaxDbiO75674
PeptideAtlasiO75674
PRIDEiO75674
ProteomicsDBi50148

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10040
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348161; ENSP00000343901; ENSG00000141198 [O75674-3]
ENST00000536554; ENSP00000443099; ENSG00000141198 [O75674-3]
ENST00000570371; ENSP00000458553; ENSG00000141198 [O75674-2]
ENST00000575333; ENSP00000458918; ENSG00000141198 [O75674-2]
ENST00000575882; ENSP00000460823; ENSG00000141198 [O75674-1]
GeneIDi10040
KEGGihsa:10040
UCSCiuc002iuc.4 human [O75674-1]
uc010dbz.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10040
DisGeNETi10040
EuPathDBiHostDB:ENSG00000141198.13

GeneCards: human genes, protein and diseases

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GeneCardsi
TOM1L1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0014000
HGNCiHGNC:11983 TOM1L1
HPAiHPA022916
MIMi604701 gene
neXtProtiNX_O75674
OpenTargetsiENSG00000141198
PharmGKBiPA36667

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1087 Eukaryota
ENOG410Y26G LUCA
GeneTreeiENSGT00940000160240
HOGENOMiHOG000285970
HOVERGENiHBG025068
InParanoidiO75674
OMAiKGAQSHS
OrthoDBi594067at2759
PhylomeDBiO75674
TreeFamiTF314105

Enzyme and pathway databases

SIGNORiO75674

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TOM1L1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TOM1L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10040

Protein Ontology

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PROi
PR:O75674

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141198 Expressed in 195 organ(s), highest expression level in jejunal mucosa
CleanExiHS_TOM1L1
ExpressionAtlasiO75674 baseline and differential
GenevisibleiO75674 HS

Family and domain databases

Gene3Di1.20.58.160, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR014645 TOM1
IPR027428 TOM1L1
IPR002014 VHS_dom
PANTHERiPTHR13856:SF28 PTHR13856:SF28, 1 hit
PfamiView protein in Pfam
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit
PIRSFiPIRSF036948 TOM1, 1 hit
SMARTiView protein in SMART
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM1L1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75674
Secondary accession number(s): B7Z9E2, Q53G06, Q8N749
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 25, 2008
Last modified: January 16, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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