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Protein

TOM1-like protein 1

Gene

TOM1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).By similarity

GO - Molecular functioni

  • clathrin binding Source: UniProtKB
  • protein kinase activator activity Source: InterPro
  • protein kinase binding Source: UniProtKB
  • SH3 domain binding Source: UniProtKB-KW
  • ubiquitin binding Source: HGNC

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

SIGNORiO75674

Protein family/group databases

MoonDBiO75674 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
TOM1-like protein 1
Alternative name(s):
Src-activating and signaling molecule protein
Target of Myb-like protein 1
Gene namesi
Name:TOM1L1
Synonyms:SRCASM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141198.13
HGNCiHGNC:11983 TOM1L1
MIMi604701 gene
neXtProtiNX_O75674

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10040
OpenTargetsiENSG00000141198
PharmGKBiPA36667

Polymorphism and mutation databases

BioMutaiTOM1L1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725661 – 476TOM1-like protein 1Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphoserineBy similarity1
Modified residuei314PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei460PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosines by FYN and LYN.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75674
MaxQBiO75674
PaxDbiO75674
PeptideAtlasiO75674
PRIDEiO75674
ProteomicsDBi50148

PTM databases

iPTMnetiO75674
PhosphoSitePlusiO75674

Expressioni

Gene expression databases

BgeeiENSG00000141198 Expressed in 195 organ(s), highest expression level in jejunal mucosa
CleanExiHS_TOM1L1
ExpressionAtlasiO75674 baseline and differential
GenevisibleiO75674 HS

Organism-specific databases

HPAiHPA022916

Interactioni

Subunit structurei

Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. Interacts with LYN.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115352, 63 interactors
ELMiO75674
IntActiO75674, 34 interactors
MINTiO75674
STRINGi9606.ENSP00000460823

Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75674
SMRiO75674
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 154VHSPROSITE-ProRule annotationAdd BLAST133
Domaini200 – 288GATPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni392 – 395Interaction with GRB2By similarity4
Regioni442 – 445Interaction with PIK3R1By similarity4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi421 – 425SH3-bindingBy similarity5
Motifi460 – 463SH2-bindingBy similarity4

Sequence similaritiesi

Belongs to the TOM1 family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG1087 Eukaryota
ENOG410Y26G LUCA
GeneTreeiENSGT00930000150885
HOGENOMiHOG000285970
HOVERGENiHBG025068
InParanoidiO75674
OMAiKGAQSHS
OrthoDBiEOG091G08M1
PhylomeDBiO75674
TreeFamiTF314105

Family and domain databases

Gene3Di1.20.58.160, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR014645 TOM1
IPR027428 TOM1L1
IPR002014 VHS_dom
PANTHERiPTHR13856:SF28 PTHR13856:SF28, 1 hit
PfamiView protein in Pfam
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit
PIRSFiPIRSF036948 TOM1, 1 hit
SMARTiView protein in SMART
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFGKSHRDP YATSVGHLIE KATFAGVQTE DWGQFMHICD IINTTQDGPK
60 70 80 90 100
DAVKALKKRI SKNYNHKEIQ LTLSLIDMCV QNCGPSFQSL IVKKEFVKEN
110 120 130 140 150
LVKLLNPRYN LPLDIQNRIL NFIKTWSQGF PGGVDVSEVK EVYLDLVKKG
160 170 180 190 200
VQFPPSEAEA ETARQETAQI SSNPPTSVPT APALSSVIAP KNSTVTLVPE
210 220 230 240 250
QIGKLHSELD MVKMNVRVMS AILMENTPGS ENHEDIELLQ KLYKTGREMQ
260 270 280 290 300
ERIMDLLVVV ENEDVTVELI QVNEDLNNAI LGYERFTRNQ QRILEQNKNQ
310 320 330 340 350
KEATNTTSEP SAPSQDLLDL SPSPRMPRAT LGELNTMNNQ LSGLNFSLPS
360 370 380 390 400
SDVTNNLKPS LHPQMNLLAL ENTEIPPFAQ RTSQNLTSSH AYDNFLEHSN
410 420 430 440 450
SVFLQPVSLQ TIAAAPSNQS LPPLPSNHPA MTKSDLQPPN YYEVMEFDPL
460 470
APAVTTEAIY EEIDAHQHKG AQNDGD
Length:476
Mass (Da):52,989
Last modified:November 25, 2008 - v2
Checksum:i47ED5FA1F40144C0
GO
Isoform 2 (identifier: O75674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-346: NF → SK
     347-476: Missing.

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):38,713
Checksum:i414DC8AEA1AB415F
GO
Isoform 3 (identifier: O75674-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Note: No experimental confirmation available.
Show »
Length:399
Mass (Da):44,334
Checksum:iF1E782419B262E59
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQU4J3KQU4_HUMAN
TOM1-like protein 1
TOM1L1 hCG_32771
465Annotation score:
I3L4I4I3L4I4_HUMAN
TOM1-like protein 1
TOM1L1
469Annotation score:
I3L3T4I3L3T4_HUMAN
TOM1-like protein 1
TOM1L1
225Annotation score:
I3NI44I3NI44_HUMAN
TOM1-like protein 1
TOM1L1
326Annotation score:
I3L367I3L367_HUMAN
TOM1-like protein 1
TOM1L1
229Annotation score:
I3L3M3I3L3M3_HUMAN
TOM1-like protein 1
TOM1L1
92Annotation score:
I3L4N3I3L4N3_HUMAN
TOM1-like protein 1
TOM1L1
122Annotation score:
I3L4G0I3L4G0_HUMAN
TOM1-like protein 1
TOM1L1
199Annotation score:
I3L1G1I3L1G1_HUMAN
TOM1-like protein 1
TOM1L1
252Annotation score:
I3L0N2I3L0N2_HUMAN
TOM1-like protein 1
TOM1L1
63Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48G → A in CAA08993 (PubMed:10329004).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047469108R → S. Corresponds to variant dbSNP:rs16955377Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0574241 – 77Missing in isoform 3. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_056852345 – 346NF → SK in isoform 2. 1 Publication2
Alternative sequenceiVSP_056853347 – 476Missing in isoform 2. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010071 mRNA Translation: CAA08993.1
AK315039 mRNA Translation: BAG37522.1
AK315907 mRNA Translation: BAH14278.1
AK223125 mRNA Translation: BAD96845.1
AC007485 Genomic DNA No translation available.
AC090824 Genomic DNA No translation available.
KC877665 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94551.1
CH471109 Genomic DNA Translation: EAW94553.1
BC029396 mRNA Translation: AAH29396.1
CCDSiCCDS11582.1 [O75674-1]
CCDS82160.1 [O75674-2]
CCDS82161.1 [O75674-3]
RefSeqiNP_001308102.1, NM_001321173.1 [O75674-2]
NP_001308103.1, NM_001321174.1 [O75674-3]
NP_001308104.1, NM_001321175.1 [O75674-3]
NP_001308105.1, NM_001321176.1 [O75674-3]
NP_005477.2, NM_005486.2 [O75674-1]
XP_016879491.1, XM_017024002.1 [O75674-3]
UniGeneiHs.153504

Genome annotation databases

EnsembliENST00000348161; ENSP00000343901; ENSG00000141198 [O75674-3]
ENST00000536554; ENSP00000443099; ENSG00000141198 [O75674-3]
ENST00000570371; ENSP00000458553; ENSG00000141198 [O75674-2]
ENST00000575333; ENSP00000458918; ENSG00000141198 [O75674-2]
ENST00000575882; ENSP00000460823; ENSG00000141198 [O75674-1]
GeneIDi10040
KEGGihsa:10040
UCSCiuc002iuc.4 human [O75674-1]
uc010dbz.3 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010071 mRNA Translation: CAA08993.1
AK315039 mRNA Translation: BAG37522.1
AK315907 mRNA Translation: BAH14278.1
AK223125 mRNA Translation: BAD96845.1
AC007485 Genomic DNA No translation available.
AC090824 Genomic DNA No translation available.
KC877665 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94551.1
CH471109 Genomic DNA Translation: EAW94553.1
BC029396 mRNA Translation: AAH29396.1
CCDSiCCDS11582.1 [O75674-1]
CCDS82160.1 [O75674-2]
CCDS82161.1 [O75674-3]
RefSeqiNP_001308102.1, NM_001321173.1 [O75674-2]
NP_001308103.1, NM_001321174.1 [O75674-3]
NP_001308104.1, NM_001321175.1 [O75674-3]
NP_001308105.1, NM_001321176.1 [O75674-3]
NP_005477.2, NM_005486.2 [O75674-1]
XP_016879491.1, XM_017024002.1 [O75674-3]
UniGeneiHs.153504

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RRUX-ray3.00A/B9-150[»]
ProteinModelPortaliO75674
SMRiO75674
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115352, 63 interactors
ELMiO75674
IntActiO75674, 34 interactors
MINTiO75674
STRINGi9606.ENSP00000460823

Protein family/group databases

MoonDBiO75674 Predicted

PTM databases

iPTMnetiO75674
PhosphoSitePlusiO75674

Polymorphism and mutation databases

BioMutaiTOM1L1

Proteomic databases

EPDiO75674
MaxQBiO75674
PaxDbiO75674
PeptideAtlasiO75674
PRIDEiO75674
ProteomicsDBi50148

Protocols and materials databases

DNASUi10040
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348161; ENSP00000343901; ENSG00000141198 [O75674-3]
ENST00000536554; ENSP00000443099; ENSG00000141198 [O75674-3]
ENST00000570371; ENSP00000458553; ENSG00000141198 [O75674-2]
ENST00000575333; ENSP00000458918; ENSG00000141198 [O75674-2]
ENST00000575882; ENSP00000460823; ENSG00000141198 [O75674-1]
GeneIDi10040
KEGGihsa:10040
UCSCiuc002iuc.4 human [O75674-1]
uc010dbz.3 human

Organism-specific databases

CTDi10040
DisGeNETi10040
EuPathDBiHostDB:ENSG00000141198.13
GeneCardsiTOM1L1
H-InvDBiHIX0014000
HGNCiHGNC:11983 TOM1L1
HPAiHPA022916
MIMi604701 gene
neXtProtiNX_O75674
OpenTargetsiENSG00000141198
PharmGKBiPA36667
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1087 Eukaryota
ENOG410Y26G LUCA
GeneTreeiENSGT00930000150885
HOGENOMiHOG000285970
HOVERGENiHBG025068
InParanoidiO75674
OMAiKGAQSHS
OrthoDBiEOG091G08M1
PhylomeDBiO75674
TreeFamiTF314105

Enzyme and pathway databases

SIGNORiO75674

Miscellaneous databases

ChiTaRSiTOM1L1 human
GeneWikiiTOM1L1
GenomeRNAii10040
PROiPR:O75674
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141198 Expressed in 195 organ(s), highest expression level in jejunal mucosa
CleanExiHS_TOM1L1
ExpressionAtlasiO75674 baseline and differential
GenevisibleiO75674 HS

Family and domain databases

Gene3Di1.20.58.160, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR014645 TOM1
IPR027428 TOM1L1
IPR002014 VHS_dom
PANTHERiPTHR13856:SF28 PTHR13856:SF28, 1 hit
PfamiView protein in Pfam
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit
PIRSFiPIRSF036948 TOM1, 1 hit
SMARTiView protein in SMART
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM1L1_HUMAN
AccessioniPrimary (citable) accession number: O75674
Secondary accession number(s): B7Z9E2, Q53G06, Q8N749
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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