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Entry version 138 (13 Feb 2019)
Sequence version 2 (01 Jan 1999)
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Protein

TIP41-like protein

Gene

TIPRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • DNA damage checkpoint Source: UniProtKB
  • negative regulation of phosphoprotein phosphatase activity Source: UniProtKB
  • signal transduction Source: GO_Central
  • TOR signaling Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TIP41-like protein
Alternative name(s):
Putative MAPK-activating protein PM10
Type 2A-interacting protein
Short name:
TIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TIPRL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143155.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30231 TIPRL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611807 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75663

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi71D → L: Abolishes interaction with PPP2CA, PPP2CB and PPP4C. 1 Publication1
Mutagenesisi79Y → H: Diminishes interaction with PPP2CA. 1 Publication1
Mutagenesisi136I → T: Abolishes interaction with PPP2CA, PPP2CB and PPP4C. 1 Publication1
Mutagenesisi196M → V: Abolishes interaction with PPP2CA, PPP2CB and PPP4C. 1 Publication1
Mutagenesisi198D → N: Abolishes interaction with PPP2CA, PPP2CB and PPP4C. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
261726

Open Targets

More...
OpenTargetsi
ENSG00000143155

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670811

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TIPRL

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003018531 – 272TIP41-like proteinAdd BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei106N6-acetyllysineCombined sources1
Modified residuei265PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75663

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75663

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75663

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75663

PeptideAtlas

More...
PeptideAtlasi
O75663

PRoteomics IDEntifications database

More...
PRIDEi
O75663

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50143
50144 [O75663-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75663

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75663

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143155 Expressed in 234 organ(s), highest expression level in amniotic fluid

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75663 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027995
HPA054282

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 interacts with PPP2CA. Isoform 2 does not interact with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2A PP2A(C):IGBP1 complex. Interacts with PPP4C and PPP4R2.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129283, 49 interactors

Protein interaction database and analysis system

More...
IntActi
O75663, 13 interactors

Molecular INTeraction database

More...
MINTi
O75663

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356807

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5D9GX-ray2.15A/B16-256[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75663

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75663

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni173 – 272Interaction with PPP2CAAdd BLAST100

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TIP41 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3224 Eukaryota
ENOG410XT96 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006659

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000213547

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053157

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75663

KEGG Orthology (KO)

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KOi
K17607

Identification of Orthologs from Complete Genome Data

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OMAi
TNPDEMQ

Database of Orthologous Groups

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OrthoDBi
1377237at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75663

TreeFam database of animal gene trees

More...
TreeFami
TF105943

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007303 TIP41-like

The PANTHER Classification System

More...
PANTHERi
PTHR21021:SF16 PTHR21021:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04176 TIP41, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O75663-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMIHGFQSSH RDFCFGPWKL TASKTHIMKS ADVEKLADEL HMPSLPEMMF
60 70 80 90 100
GDNVLRIQHG SGFGIEFNAT DALRCVNNYQ GMLKVACAEE WQESRTEGEH
110 120 130 140 150
SKEVIKPYDW TYTTDYKGTL LGESLKLKVV PTTDHIDTEK LKAREQIKFF
160 170 180 190 200
EEVLLFEDEL HDHGVSSLSV KIRVMPSSFF LLLRFFLRID GVLIRMNDTR
210 220 230 240 250
LYHEADKTYM LREYTSRESK ISSLMHVPPS LFTEPNEISQ YLPIKEAVCE
260 270
KLIFPERIDP NPADSQKSTQ VE
Length:272
Mass (Da):31,444
Last modified:January 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23B730E0BC27DCEA
GO
Isoform 2 (identifier: O75663-2) [UniParc]FASTAAdd to basket
Also known as: TIP_i2

The sequence of this isoform differs from the canonical sequence as follows:
     173-178: RVMPSS → PGGGHL
     179-272: Missing.

Show »
Length:178
Mass (Da):20,214
Checksum:i8016BC0DF3BF11F5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027883173 – 178RVMPSS → PGGGHL in isoform 2. 1 Publication6
Alternative sequenceiVSP_027884179 – 272Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL049670 mRNA Translation: CAB41244.1
AB097034 mRNA Translation: BAC77387.1
AK313520 mRNA Translation: BAG36300.1
AL021397 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90821.1
BC009506 mRNA Translation: AAH09506.1
BX648646 Transcribed RNA Translation: CAI46265.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1270.1 [O75663-1]
CCDS30935.1 [O75663-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001026970.1, NM_001031800.2 [O75663-2]
NP_690866.1, NM_152902.4 [O75663-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.209431

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367830; ENSP00000356804; ENSG00000143155 [O75663-2]
ENST00000367833; ENSP00000356807; ENSG00000143155 [O75663-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
261726

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:261726

UCSC genome browser

More...
UCSCi
uc001gff.5 human [O75663-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049670 mRNA Translation: CAB41244.1
AB097034 mRNA Translation: BAC77387.1
AK313520 mRNA Translation: BAG36300.1
AL021397 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90821.1
BC009506 mRNA Translation: AAH09506.1
BX648646 Transcribed RNA Translation: CAI46265.1
CCDSiCCDS1270.1 [O75663-1]
CCDS30935.1 [O75663-2]
RefSeqiNP_001026970.1, NM_001031800.2 [O75663-2]
NP_690866.1, NM_152902.4 [O75663-1]
UniGeneiHs.209431

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5D9GX-ray2.15A/B16-256[»]
ProteinModelPortaliO75663
SMRiO75663
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129283, 49 interactors
IntActiO75663, 13 interactors
MINTiO75663
STRINGi9606.ENSP00000356807

PTM databases

iPTMnetiO75663
PhosphoSitePlusiO75663

Polymorphism and mutation databases

BioMutaiTIPRL

Proteomic databases

EPDiO75663
jPOSTiO75663
MaxQBiO75663
PaxDbiO75663
PeptideAtlasiO75663
PRIDEiO75663
ProteomicsDBi50143
50144 [O75663-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367830; ENSP00000356804; ENSG00000143155 [O75663-2]
ENST00000367833; ENSP00000356807; ENSG00000143155 [O75663-1]
GeneIDi261726
KEGGihsa:261726
UCSCiuc001gff.5 human [O75663-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
261726
DisGeNETi261726
EuPathDBiHostDB:ENSG00000143155.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TIPRL
HGNCiHGNC:30231 TIPRL
HPAiHPA027995
HPA054282
MIMi611807 gene
neXtProtiNX_O75663
OpenTargetsiENSG00000143155
PharmGKBiPA142670811

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3224 Eukaryota
ENOG410XT96 LUCA
GeneTreeiENSGT00390000006659
HOGENOMiHOG000213547
HOVERGENiHBG053157
InParanoidiO75663
KOiK17607
OMAiTNPDEMQ
OrthoDBi1377237at2759
PhylomeDBiO75663
TreeFamiTF105943

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TIPRL human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
261726

Protein Ontology

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PROi
PR:O75663

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143155 Expressed in 234 organ(s), highest expression level in amniotic fluid
GenevisibleiO75663 HS

Family and domain databases

InterProiView protein in InterPro
IPR007303 TIP41-like
PANTHERiPTHR21021:SF16 PTHR21021:SF16, 1 hit
PfamiView protein in Pfam
PF04176 TIP41, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIPRL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75663
Secondary accession number(s): B2R8V3, Q5HYB2, Q8IZ86
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 1, 1999
Last modified: February 13, 2019
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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