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Protein

Ficolin-3

Gene

FCN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi237CalciumCombined sources1 Publication1
Metal bindingi239CalciumCombined sources1 Publication1
Metal bindingi241Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi243Calcium; via carbonyl oxygenCombined sources1 Publication1

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • carbohydrate binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

Keywordsi

Biological processComplement activation lectin pathway, Immunity, Innate immunity
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement
R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface

Protein family/group databases

UniLectiniO75636

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-3
Alternative name(s):
Collagen/fibrinogen domain-containing lectin 3 p35
Collagen/fibrinogen domain-containing protein 3
Hakata antigen
Gene namesi
Name:FCN3
Synonyms:FCNH, HAKA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142748.12
HGNCiHGNC:3625 FCN3
MIMi604973 gene
neXtProtiNX_O75636

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Ficolin 3 deficiency (FCN3D)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine.
See also OMIM:613860

Organism-specific databases

DisGeNETi8547
MalaCardsiFCN3
MIMi613860 phenotype
OpenTargetsiENSG00000142748
Orphaneti331190 Immunodeficiency due to ficolin3 deficiency
PharmGKBiPA28071

Polymorphism and mutation databases

BioMutaiFCN3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000914224 – 299Ficolin-3Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50Hydroxyproline1 Publication1
Modified residuei53Hydroxyproline1 Publication1
Modified residuei59Hydroxyproline1 Publication1
Modified residuei65Hydroxyproline1 Publication1
Modified residuei68Hydroxyproline1 Publication1
Modified residuei77Hydroxyproline1 Publication1
Disulfide bondi86 ↔ 110Combined sources1 Publication
Disulfide bondi93 ↔ 121Combined sources1 Publication
Glycosylationi189N-linked (GlcNAc...) (complex) asparagine3 Publications1
Disulfide bondi245 ↔ 258Combined sources1 Publication

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiO75636
PeptideAtlasiO75636
PRIDEiO75636
ProteomicsDBi50132
50133 [O75636-2]

PTM databases

GlyConnecti1247
iPTMnetiO75636
PhosphoSitePlusiO75636

Expressioni

Tissue specificityi

Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells.1 Publication

Gene expression databases

BgeeiENSG00000142748 Expressed in 106 organ(s), highest expression level in right lung
CleanExiHS_FCN3
ExpressionAtlasiO75636 baseline and differential
GenevisibleiO75636 HS

Organism-specific databases

HPAiCAB025945

Interactioni

Subunit structurei

Homotrimer (PubMed:17215869). May form an octadecamer consisting of an elementary trimer unit. Does not interact with fibronectin, elastin or zymosan. Interacts with MASP1 and MASP2.2 Publications

Protein-protein interaction databases

BioGridi114117, 1 interactor
IntActiO75636, 1 interactor
STRINGi9606.ENSP00000270879

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75636
SMRiO75636
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75636

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 80Collagen-likeAdd BLAST33
Domaini84 – 299Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST216

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni258 – 259Carbohydrate binding1 Publication2

Sequence similaritiesi

Belongs to the ficolin lectin family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150813
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiO75636
KOiK10104
OMAiRPWSSYK
OrthoDBiEOG091G03M1
PhylomeDBiO75636
TreeFamiTF351983

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O75636-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLLWILPSL WLLLLGGPAC LKTQEHPSCP GPRELEASKV VLLPSCPGAP
60 70 80 90 100
GSPGEKGAPG PQGPPGPPGK MGPKGEPGDP VNLLRCQEGP RNCRELLSQG
110 120 130 140 150
ATLSGWYHLC LPEGRALPVF CDMDTEGGGW LVFQRRQDGS VDFFRSWSSY
160 170 180 190 200
RAGFGNQESE FWLGNENLHQ LTLQGNWELR VELEDFNGNR TFAHYATFRL
210 220 230 240 250
LGEVDHYQLA LGKFSEGTAG DSLSLHSGRP FTTYDADHDS SNSNCAVIVH
260 270 280 290
GAWWYASCYR SNLNGRYAVS EAAAHKYGID WASGRGVGHP YRRVRMMLR
Length:299
Mass (Da):32,903
Last modified:March 7, 2006 - v2
Checksum:i5CB8A7D3668FA364
GO
Isoform 2 (identifier: O75636-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-89: Missing.

Show »
Length:288
Mass (Da):31,678
Checksum:i5027676AFCA39752
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271E → D in BAA32277 (PubMed:9694814).Curated1
Sequence conflicti271E → D in AAH20731 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00154179 – 89Missing in isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88587 mRNA Translation: BAA32277.1
AK075140 mRNA Translation: BAC11429.1
CR456808 mRNA Translation: CAG33089.1
AY756173 Genomic DNA Translation: AAU85296.1
FO393419 Genomic DNA No translation available.
BC020731 mRNA Translation: AAH20731.1
CCDSiCCDS300.1 [O75636-1]
CCDS301.1 [O75636-2]
RefSeqiNP_003656.2, NM_003665.3 [O75636-1]
NP_775628.1, NM_173452.2 [O75636-2]
UniGeneiHs.333383

Genome annotation databases

EnsembliENST00000270879; ENSP00000270879; ENSG00000142748 [O75636-1]
ENST00000354982; ENSP00000347077; ENSG00000142748 [O75636-2]
GeneIDi8547
KEGGihsa:8547
UCSCiuc001boa.4 human [O75636-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88587 mRNA Translation: BAA32277.1
AK075140 mRNA Translation: BAC11429.1
CR456808 mRNA Translation: CAG33089.1
AY756173 Genomic DNA Translation: AAU85296.1
FO393419 Genomic DNA No translation available.
BC020731 mRNA Translation: AAH20731.1
CCDSiCCDS300.1 [O75636-1]
CCDS301.1 [O75636-2]
RefSeqiNP_003656.2, NM_003665.3 [O75636-1]
NP_775628.1, NM_173452.2 [O75636-2]
UniGeneiHs.333383

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LA5model-A1-299[»]
2J5ZX-ray1.73A/B/C79-299[»]
2J60X-ray1.80A/B/C79-299[»]
2J64X-ray2.20A/B/C79-299[»]
ProteinModelPortaliO75636
SMRiO75636
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114117, 1 interactor
IntActiO75636, 1 interactor
STRINGi9606.ENSP00000270879

Protein family/group databases

UniLectiniO75636

PTM databases

GlyConnecti1247
iPTMnetiO75636
PhosphoSitePlusiO75636

Polymorphism and mutation databases

BioMutaiFCN3

Proteomic databases

PaxDbiO75636
PeptideAtlasiO75636
PRIDEiO75636
ProteomicsDBi50132
50133 [O75636-2]

Protocols and materials databases

DNASUi8547
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270879; ENSP00000270879; ENSG00000142748 [O75636-1]
ENST00000354982; ENSP00000347077; ENSG00000142748 [O75636-2]
GeneIDi8547
KEGGihsa:8547
UCSCiuc001boa.4 human [O75636-1]

Organism-specific databases

CTDi8547
DisGeNETi8547
EuPathDBiHostDB:ENSG00000142748.12
GeneCardsiFCN3
HGNCiHGNC:3625 FCN3
HPAiCAB025945
MalaCardsiFCN3
MIMi604973 gene
613860 phenotype
neXtProtiNX_O75636
OpenTargetsiENSG00000142748
Orphaneti331190 Immunodeficiency due to ficolin3 deficiency
PharmGKBiPA28071
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150813
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiO75636
KOiK10104
OMAiRPWSSYK
OrthoDBiEOG091G03M1
PhylomeDBiO75636
TreeFamiTF351983

Enzyme and pathway databases

ReactomeiR-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement
R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface

Miscellaneous databases

ChiTaRSiFCN3 human
EvolutionaryTraceiO75636
GeneWikiiFCN3
GenomeRNAii8547
PROiPR:O75636
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142748 Expressed in 106 organ(s), highest expression level in right lung
CleanExiHS_FCN3
ExpressionAtlasiO75636 baseline and differential
GenevisibleiO75636 HS

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCN3_HUMAN
AccessioniPrimary (citable) accession number: O75636
Secondary accession number(s): Q6IBJ5, Q8WW86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 187 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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