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Entry version 153 (12 Aug 2020)
Sequence version 1 (01 Nov 1998)
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Protein

Protein CREG1

Gene

CREG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processGrowth regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O75629

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein CREG1
Alternative name(s):
Cellular repressor of E1A-stimulated genes 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CREG1
Synonyms:CREG
ORF Names:UNQ727/PRO1409
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143162.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2351, CREG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618055, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75629

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8804

Open Targets

More...
OpenTargetsi
ENSG00000143162

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26869

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75629, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CREG1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 311 PublicationAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000620332 – 220Protein CREG1Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi160N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi193N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi216N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1487

Encyclopedia of Proteome Dynamics

More...
EPDi
O75629

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75629

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O75629

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75629

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75629

PeptideAtlas

More...
PeptideAtlasi
O75629

PRoteomics IDEntifications database

More...
PRIDEi
O75629

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50128

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1653, 13 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O75629, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75629

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75629

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143162, Expressed in mammalian vulva and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75629, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75629, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000143162, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with IGF2R; the interaction is dependent on glycosylation.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114332, 16 interactors

Protein interaction database and analysis system

More...
IntActi
O75629, 6 interactors

Molecular INTeraction database

More...
MINTi
O75629

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359540

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O75629, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75629

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O75629

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CREG family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3374, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005914

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_083635_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75629

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAHIIFV

Database of Orthologous Groups

More...
OrthoDBi
1252017at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75629

TreeFam database of animal gene trees

More...
TreeFami
TF324680

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014631, CREG
IPR012349, Split_barrel_FMN-bd

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036911, CREG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O75629-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGLSRGSAR ALLAALLAST LLALLVSPAR GRGGRDHGDW DEASRLPPLP
60 70 80 90 100
PREDAARVAR FVTHVSDWGA LATISTLEAV RGRPFADVLS LSDGPPGAGS
110 120 130 140 150
GVPYFYLSPL QLSVSNLQEN PYATLTMTLA QTNFCKKHGF DPQSPLCVHI
160 170 180 190 200
MLSGTVTKVN ETEMDIAKHS LFIRHPEMKT WPSSHNWFFA KLNITNIWVL
210 220
DYFGGPKIVT PEEYYNVTVQ
Length:220
Mass (Da):24,075
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DB95A1E4149CD7C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IRL2A0A3B3IRL2_HUMAN
Cellular repressor of E1A-stimulate...
CREG1 hCG_41319
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52 – 59Missing in BAC04550 (PubMed:16710414).Curated8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF084523 mRNA Translation: AAC34861.1
AY359071 mRNA Translation: AAQ89430.1
AK095456 mRNA Translation: BAC04550.1
AK315497 mRNA Translation: BAG37881.1
AL031733 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90795.1
BC006786 mRNA Translation: AAH06786.1
BC008628 mRNA Translation: AAH08628.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1262.1

NCBI Reference Sequences

More...
RefSeqi
NP_003842.1, NM_003851.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370509; ENSP00000359540; ENSG00000143162

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8804

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8804

UCSC genome browser

More...
UCSCi
uc001gel.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084523 mRNA Translation: AAC34861.1
AY359071 mRNA Translation: AAQ89430.1
AK095456 mRNA Translation: BAC04550.1
AK315497 mRNA Translation: BAG37881.1
AL031733 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90795.1
BC006786 mRNA Translation: AAH06786.1
BC008628 mRNA Translation: AAH08628.1
CCDSiCCDS1262.1
RefSeqiNP_003842.1, NM_003851.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XHNX-ray1.95A/B/C/D49-220[»]
SMRiO75629
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114332, 16 interactors
IntActiO75629, 6 interactors
MINTiO75629
STRINGi9606.ENSP00000359540

PTM databases

GlyConnecti1653, 13 N-Linked glycans (3 sites)
GlyGeniO75629, 4 sites
iPTMnetiO75629
PhosphoSitePlusiO75629

Polymorphism and mutation databases

BioMutaiCREG1

Proteomic databases

CPTACiCPTAC-1487
EPDiO75629
jPOSTiO75629
MassIVEiO75629
MaxQBiO75629
PaxDbiO75629
PeptideAtlasiO75629
PRIDEiO75629
ProteomicsDBi50128

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
20531, 304 antibodies

The DNASU plasmid repository

More...
DNASUi
8804

Genome annotation databases

EnsembliENST00000370509; ENSP00000359540; ENSG00000143162
GeneIDi8804
KEGGihsa:8804
UCSCiuc001gel.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8804
DisGeNETi8804
EuPathDBiHostDB:ENSG00000143162.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CREG1
HGNCiHGNC:2351, CREG1
HPAiENSG00000143162, Low tissue specificity
MIMi618055, gene
neXtProtiNX_O75629
OpenTargetsiENSG00000143162
PharmGKBiPA26869

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3374, Eukaryota
GeneTreeiENSGT00390000005914
HOGENOMiCLU_083635_3_1_1
InParanoidiO75629
OMAiCAHIIFV
OrthoDBi1252017at2759
PhylomeDBiO75629
TreeFamiTF324680

Enzyme and pathway databases

PathwayCommonsiO75629
ReactomeiR-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8804, 4 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CREG1, human
EvolutionaryTraceiO75629

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CREG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8804
PharosiO75629, Tbio

Protein Ontology

More...
PROi
PR:O75629
RNActiO75629, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143162, Expressed in mammalian vulva and 249 other tissues
ExpressionAtlasiO75629, baseline and differential
GenevisibleiO75629, HS

Family and domain databases

Gene3Di2.30.110.10, 1 hit
InterProiView protein in InterPro
IPR014631, CREG
IPR012349, Split_barrel_FMN-bd
PIRSFiPIRSF036911, CREG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCREG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75629
Secondary accession number(s): B2RDD4, Q8N9A3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 1, 1998
Last modified: August 12, 2020
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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