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UniProtKB - O75628 (REM1_HUMAN)
Protein
GTP-binding protein REM 1
Gene
REM1
Organism
Homo sapiens (Human)
Status
Functioni
Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca2+ signaling.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 87 – 94 | GTPBy similarity | 8 | |
Nucleotide bindingi | 195 – 198 | GTPBy similarity | 4 |
GO - Molecular functioni
- calcium channel regulator activity Source: GO_Central
- calmodulin binding Source: UniProtKB-KW
- GTPase activity Source: InterPro
- GTP binding Source: GO_Central
GO - Biological processi
- negative regulation of high voltage-gated calcium channel activity Source: InterPro
Keywordsi
Molecular function | Calmodulin-binding |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O75628 |
SignaLinki | O75628 |
Names & Taxonomyi
Protein namesi | Recommended name: GTP-binding protein REM 1Alternative name(s): GTPase-regulating endothelial cell sprouting Rad and Gem-like GTP-binding protein 1 |
Gene namesi | Name:REM1 Synonyms:GES, REM |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15922, REM1 |
MIMi | 610388, gene |
neXtProti | NX_O75628 |
VEuPathDBi | HostDB:ENSG00000088320 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 94 | T → N: No endothelial cell sprouting. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 28954 |
OpenTargetsi | ENSG00000088320 |
PharmGKBi | PA34324 |
Miscellaneous databases
Pharosi | O75628, Tbio |
Genetic variation databases
BioMutai | REM1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000122481 | 1 – 298 | GTP-binding protein REM 1Add BLAST | 298 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 51 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O75628 |
MassIVEi | O75628 |
PaxDbi | O75628 |
PeptideAtlasi | O75628 |
PRIDEi | O75628 |
ProteomicsDBi | 50127 |
PTM databases
iPTMneti | O75628 |
PhosphoSitePlusi | O75628 |
Expressioni
Tissue specificityi
Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate.
Gene expression databases
Bgeei | ENSG00000088320, Expressed in lymph node and 199 other tissues |
Genevisiblei | O75628, HS |
Organism-specific databases
HPAi | ENSG00000088320, Tissue enhanced (cervix) |
Interactioni
Subunit structurei
In vitro, interacts with calmodulin in a calcium-dependent manner.
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 118781, 7 interactors |
STRINGi | 9606.ENSP00000201979 |
Miscellaneous databases
RNActi | O75628, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O75628 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O75628 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 73 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 268 – 287 | Calmodulin-bindingBy similarityAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 31 – 55 | Polar residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000160613 |
HOGENOMi | CLU_041217_3_2_1 |
InParanoidi | O75628 |
OMAi | ACAMVFD |
OrthoDBi | 679855at2759 |
PhylomeDBi | O75628 |
TreeFami | TF314379 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR017358, RGK IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
PIRSFi | PIRSF038017, GTP-binding_GEM, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
i Sequence
Sequence statusi: Complete.
O75628-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLNTEQEAK TPLHRRASTP LPLSPRGHQP GRLSTVPSTQ SQHPRLGQSA
60 70 80 90 100
SLNPPTQKPS PAPDDWSSES SDSEGSWEAL YRVVLLGDPG VGKTSLASLF
110 120 130 140 150
AGKQERDLHE QLGEDVYERT LTVDGEDTTL VVVDTWEAEK LDKSWSQESC
160 170 180 190 200
LQGGSAYVIV YSIADRGSFE SASELRIQLR RTHQADHVPI ILVGNKADLA
210 220 230 240 250
RCREVSVEEG RACAVVFDCK FIETSATLQH NVAELFEGVV RQLRLRRRDS
260 270 280 290
AAKEPPAPRR PASLAQRARR FLARLTARSA RRRALKARSK SCHNLAVL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 209 | E → V in AAC33132 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049498 | 28 | H → R2 PublicationsCorresponds to variant dbSNP:rs1006459Ensembl. | 1 | |
Natural variantiVAR_061232 | 45 | R → W. Corresponds to variant dbSNP:rs59730832Ensembl. | 1 | |
Natural variantiVAR_049499 | 59 | P → A. Corresponds to variant dbSNP:rs2233829Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF084465 mRNA Translation: AAC33132.1 AF152863 mRNA Translation: AAF74212.1 BT020078 mRNA Translation: AAV38881.1 BT020079 mRNA Translation: AAV38882.1 AK313060 mRNA Translation: BAG35890.1 AL121751 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76439.1 CH471077 Genomic DNA Translation: EAW76440.1 CH471077 Genomic DNA Translation: EAW76442.1 BC039813 mRNA Translation: AAH39813.1 |
CCDSi | CCDS13181.1 |
RefSeqi | NP_054731.2, NM_014012.5 |
Genome annotation databases
Ensembli | ENST00000201979; ENSP00000201979; ENSG00000088320 |
GeneIDi | 28954 |
KEGGi | hsa:28954 |
MANE-Selecti | ENST00000201979.3; ENSP00000201979.2; NM_014012.6; NP_054731.2 |
UCSCi | uc002wwa.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF084465 mRNA Translation: AAC33132.1 AF152863 mRNA Translation: AAF74212.1 BT020078 mRNA Translation: AAV38881.1 BT020079 mRNA Translation: AAV38882.1 AK313060 mRNA Translation: BAG35890.1 AL121751 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76439.1 CH471077 Genomic DNA Translation: EAW76440.1 CH471077 Genomic DNA Translation: EAW76442.1 BC039813 mRNA Translation: AAH39813.1 |
CCDSi | CCDS13181.1 |
RefSeqi | NP_054731.2, NM_014012.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2NZJ | X-ray | 2.50 | A/B/C/D | 79-251 | [»] | |
SMRi | O75628 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118781, 7 interactors |
STRINGi | 9606.ENSP00000201979 |
PTM databases
iPTMneti | O75628 |
PhosphoSitePlusi | O75628 |
Genetic variation databases
BioMutai | REM1 |
Proteomic databases
jPOSTi | O75628 |
MassIVEi | O75628 |
PaxDbi | O75628 |
PeptideAtlasi | O75628 |
PRIDEi | O75628 |
ProteomicsDBi | 50127 |
Protocols and materials databases
Antibodypediai | 10156, 107 antibodies from 27 providers |
DNASUi | 28954 |
Genome annotation databases
Ensembli | ENST00000201979; ENSP00000201979; ENSG00000088320 |
GeneIDi | 28954 |
KEGGi | hsa:28954 |
MANE-Selecti | ENST00000201979.3; ENSP00000201979.2; NM_014012.6; NP_054731.2 |
UCSCi | uc002wwa.5, human |
Organism-specific databases
CTDi | 28954 |
DisGeNETi | 28954 |
GeneCardsi | REM1 |
HGNCi | HGNC:15922, REM1 |
HPAi | ENSG00000088320, Tissue enhanced (cervix) |
MIMi | 610388, gene |
neXtProti | NX_O75628 |
OpenTargetsi | ENSG00000088320 |
PharmGKBi | PA34324 |
VEuPathDBi | HostDB:ENSG00000088320 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000160613 |
HOGENOMi | CLU_041217_3_2_1 |
InParanoidi | O75628 |
OMAi | ACAMVFD |
OrthoDBi | 679855at2759 |
PhylomeDBi | O75628 |
TreeFami | TF314379 |
Enzyme and pathway databases
PathwayCommonsi | O75628 |
SignaLinki | O75628 |
Miscellaneous databases
BioGRID-ORCSi | 28954, 18 hits in 1037 CRISPR screens |
EvolutionaryTracei | O75628 |
GenomeRNAii | 28954 |
Pharosi | O75628, Tbio |
PROi | PR:O75628 |
RNActi | O75628, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000088320, Expressed in lymph node and 199 other tissues |
Genevisiblei | O75628, HS |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR017358, RGK IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
PIRSFi | PIRSF038017, GTP-binding_GEM, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | REM1_HUMAN | |
Accessioni | O75628Primary (citable) accession number: O75628 Secondary accession number(s): E1P5L1 Q9NP57 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 7, 2003 |
Last sequence update: | November 7, 2003 | |
Last modified: | February 23, 2022 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families