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Protein

PR domain zinc finger protein 1

Gene

PRDM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri575 – 597C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 653C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri659 – 681C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Methyltransferase, Repressor, Transferase
Biological processAdaptive immunity, Immunity, Innate immunity, Transcription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6804754 Regulation of TP53 Expression

SIGNOR Signaling Network Open Resource

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SIGNORi
O75626

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PR domain zinc finger protein 1 (EC:2.1.1.-)
Alternative name(s):
BLIMP-1
Beta-interferon gene positive regulatory domain I-binding factor
PR domain-containing protein 1
Positive regulatory domain I-binding factor 1
Short name:
PRDI-BF1
Short name:
PRDI-binding factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRDM1
Synonyms:BLIMP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000057657.14

Human Gene Nomenclature Database

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HGNCi
HGNC:9346 PRDM1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603423 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O75626

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
639

Open Targets

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OpenTargetsi
ENSG00000057657

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33707

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRDM1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477571 – 825PR domain zinc finger protein 1Add BLAST825

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki816Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication
Cross-linki816Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation.1 Publication
Ubiquitinated by the SCF(FBXO11) complex, leading to its degradation by the proteasome.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75626

MaxQB - The MaxQuant DataBase

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MaxQBi
O75626

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O75626

PeptideAtlas

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PeptideAtlasi
O75626

PRoteomics IDEntifications database

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PRIDEi
O75626

ProteomicsDB human proteome resource

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ProteomicsDBi
50124
50125 [O75626-2]
50126 [O75626-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75626

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75626

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000057657 Expressed in 179 organ(s), highest expression level in ectocervix

CleanEx database of gene expression profiles

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CleanExi
HS_PRDM1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75626 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75626 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA030033

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRMT5 (By similarity). Interacts with FBXO10 (PubMed:24613396). Interacts with FBXO11 (PubMed:24613396, PubMed:24968003).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107108, 32 interactors

Protein interaction database and analysis system

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IntActi
O75626, 7 interactors

Molecular INTeraction database

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MINTi
O75626

STRING: functional protein association networks

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STRINGi
9606.ENSP00000358092

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1825
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DALX-ray1.65A/B38-223[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75626

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75626

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O75626

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini84 – 201SETPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni527 – 574Interaction with PIAS1Add BLAST48

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri575 – 597C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 653C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri659 – 681C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2461 Eukaryota
ENOG410ZFVU LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154798

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000059670

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053670

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75626

Identification of Orthologs from Complete Genome Data

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OMAi
HCHKSYI

Database of Orthologous Groups

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OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75626

TreeFam database of animal gene trees

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TreeFami
TF316545

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00856 SET, 1 hit
PF00096 zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75626-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLDICLEKRV GTTLAAPKCN SSTVRFQGLA EGTKGTMKMD MEDADMTLWT
60 70 80 90 100
EAEFEEKCTY IVNDHPWDSG ADGGTSVQAE ASLPRNLLFK YATNSEEVIG
110 120 130 140 150
VMSKEYIPKG TRFGPLIGEI YTNDTVPKNA NRKYFWRIYS RGELHHFIDG
160 170 180 190 200
FNEEKSNWMR YVNPAHSPRE QNLAACQNGM NIYFYTIKPI PANQELLVWY
210 220 230 240 250
CRDFAERLHY PYPGELTMMN LTQTQSSLKQ PSTEKNELCP KNVPKREYSV
260 270 280 290 300
KEILKLDSNP SKGKDLYRSN ISPLTSEKDL DDFRRRGSPE MPFYPRVVYP
310 320 330 340 350
IRAPLPEDFL KASLAYGIER PTYITRSPIP SSTTPSPSAR SSPDQSLKSS
360 370 380 390 400
SPHSSPGNTV SPVGPGSQEH RDSYAYLNAS YGTEGLGSYP GYAPLPHLPP
410 420 430 440 450
AFIPSYNAHY PKFLLPPYGM NCNGLSAVSS MNGINNFGLF PRLCPVYSNL
460 470 480 490 500
LGGGSLPHPM LNPTSLPSSL PSDGARRLLQ PEHPREVLVP APHSAFSFTG
510 520 530 540 550
AAASMKDKAC SPTSGSPTAG TAATAEHVVQ PKATSAAMAA PSSDEAMNLI
560 570 580 590 600
KNKRNMTGYK TLPYPLKKQN GKIKYECNVC AKTFGQLSNL KVHLRVHSGE
610 620 630 640 650
RPFKCQTCNK GFTQLAHLQK HYLVHTGEKP HECQVCHKRF SSTSNLKTHL
660 670 680 690 700
RLHSGEKPYQ CKVCPAKFTQ FVHLKLHKRL HTRERPHKCS QCHKNYIHLC
710 720 730 740 750
SLKVHLKGNC AAAPAPGLPL EDLTRINEEI EKFDISDNAD RLEDVEDDIS
760 770 780 790 800
VISVVEKEIL AVVRKEKEET GLKVSLQRNM GNGLLSSGCS LYESSDLPLM
810 820
KLPPSNPLPL VPVKVKQETV EPMDP
Length:825
Mass (Da):91,771
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07B389BACCD6172F
GO
Isoform 2 (identifier: O75626-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:789
Mass (Da):87,991
Checksum:i6A1FEBEAD309BC7D
GO
Isoform 3 (identifier: O75626-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MLD → MEK
     4-137: Missing.

Show »
Length:691
Mass (Da):76,835
Checksum:i4C5A56D19255FE89
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2REA4B2REA4_HUMAN
PR domain zinc finger protein 1
PRDM1
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2REA5B2REA5_HUMAN
PR domain zinc finger protein 1
PRDM1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU23A0A3B3IU23_HUMAN
PR domain zinc finger protein 1
PRDM1
839Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO45623 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01998374G → S. Corresponds to variant dbSNP:rs2185379EnsemblClinVar.1
Natural variantiVAR_024221203D → E. Corresponds to variant dbSNP:rs811925EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0391881 – 36Missing in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0436461 – 3MLD → MEK in isoform 3. 2 Publications3
Alternative sequenceiVSP_0436474 – 137Missing in isoform 3. 2 PublicationsAdd BLAST134

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF084199 mRNA Translation: AAC33300.1
AY198414 mRNA Translation: AAO45623.1 Different initiation.
AY198415 mRNA Translation: AAO45624.1
AL358952 Genomic DNA No translation available.
AL022067 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48419.1
CH471051 Genomic DNA Translation: EAW48421.1
CH471051 Genomic DNA Translation: EAW48422.1
BC103832 mRNA Translation: AAI03833.1
BC103833 mRNA Translation: AAI03834.1
BC103834 mRNA Translation: AAI03835.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34505.1 [O75626-3]
CCDS5054.2 [O75626-1]

Protein sequence database of the Protein Information Resource

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PIRi
A39564

NCBI Reference Sequences

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RefSeqi
NP_001189.2, NM_001198.3 [O75626-1]
NP_878911.1, NM_182907.2 [O75626-3]
XP_011534365.1, XM_011536063.2 [O75626-2]
XP_016866676.1, XM_017011187.1 [O75626-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.436023

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000369089; ENSP00000358085; ENSG00000057657 [O75626-3]
ENST00000369091; ENSP00000358087; ENSG00000057657 [O75626-2]
ENST00000369096; ENSP00000358092; ENSG00000057657 [O75626-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
639

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:639

UCSC genome browser

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UCSCi
uc003prd.3 human [O75626-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084199 mRNA Translation: AAC33300.1
AY198414 mRNA Translation: AAO45623.1 Different initiation.
AY198415 mRNA Translation: AAO45624.1
AL358952 Genomic DNA No translation available.
AL022067 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48419.1
CH471051 Genomic DNA Translation: EAW48421.1
CH471051 Genomic DNA Translation: EAW48422.1
BC103832 mRNA Translation: AAI03833.1
BC103833 mRNA Translation: AAI03834.1
BC103834 mRNA Translation: AAI03835.1
CCDSiCCDS34505.1 [O75626-3]
CCDS5054.2 [O75626-1]
PIRiA39564
RefSeqiNP_001189.2, NM_001198.3 [O75626-1]
NP_878911.1, NM_182907.2 [O75626-3]
XP_011534365.1, XM_011536063.2 [O75626-2]
XP_016866676.1, XM_017011187.1 [O75626-2]
UniGeneiHs.436023

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DALX-ray1.65A/B38-223[»]
ProteinModelPortaliO75626
SMRiO75626
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107108, 32 interactors
IntActiO75626, 7 interactors
MINTiO75626
STRINGi9606.ENSP00000358092

PTM databases

iPTMnetiO75626
PhosphoSitePlusiO75626

Polymorphism and mutation databases

BioMutaiPRDM1

Proteomic databases

jPOSTiO75626
MaxQBiO75626
PaxDbiO75626
PeptideAtlasiO75626
PRIDEiO75626
ProteomicsDBi50124
50125 [O75626-2]
50126 [O75626-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
639
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369089; ENSP00000358085; ENSG00000057657 [O75626-3]
ENST00000369091; ENSP00000358087; ENSG00000057657 [O75626-2]
ENST00000369096; ENSP00000358092; ENSG00000057657 [O75626-1]
GeneIDi639
KEGGihsa:639
UCSCiuc003prd.3 human [O75626-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
639
DisGeNETi639
EuPathDBiHostDB:ENSG00000057657.14

GeneCards: human genes, protein and diseases

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GeneCardsi
PRDM1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0006099
HGNCiHGNC:9346 PRDM1
HPAiHPA030033
MIMi603423 gene
neXtProtiNX_O75626
OpenTargetsiENSG00000057657
PharmGKBiPA33707

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2461 Eukaryota
ENOG410ZFVU LUCA
GeneTreeiENSGT00940000154798
HOGENOMiHOG000059670
HOVERGENiHBG053670
InParanoidiO75626
OMAiHCHKSYI
OrthoDBi1318335at2759
PhylomeDBiO75626
TreeFamiTF316545

Enzyme and pathway databases

ReactomeiR-HSA-6804754 Regulation of TP53 Expression
SIGNORiO75626

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PRDM1 human
EvolutionaryTraceiO75626

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PRDM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
639

Protein Ontology

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PROi
PR:O75626

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000057657 Expressed in 179 organ(s), highest expression level in ectocervix
CleanExiHS_PRDM1
ExpressionAtlasiO75626 baseline and differential
GenevisibleiO75626 HS

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRDM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75626
Secondary accession number(s): B2REA6, E1P5E0, Q86WM7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 18, 2010
Last modified: January 16, 2019
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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