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Entry version 179 (29 Sep 2021)
Sequence version 2 (04 Jan 2005)
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Protein

GTPase Era, mitochondrial

Gene

ERAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi120 – 127GTPSequence analysis8
Nucleotide bindingi167 – 171GTPSequence analysis5
Nucleotide bindingi236 – 239GTPSequence analysis4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding, rRNA-binding
Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O75616

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5368286, Mitochondrial translation initiation
R-HSA-5389840, Mitochondrial translation elongation
R-HSA-5419276, Mitochondrial translation termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTPase Era, mitochondrial
Short name:
H-ERA
Short name:
hERA
Alternative name(s):
Conserved ERA-like GTPase
Short name:
CEGA
ERA-W
ERA-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERAL1
Synonyms:HERA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3424, ERAL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607435, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75616

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000132591

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Perrault syndrome 6 (PRLTS6)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of Perrault syndrome, a sex-influenced disorder characterized by sensorineural deafness in both males and females, and ovarian dysgenesis in females. Affected females have primary amenorrhea, streak gonads, and infertility, whereas affected males show normal pubertal development and are fertile. PRLTS6 inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079209236N → I in PRLTS6; decreased protein abundance; reduced assembly of the mitochondrial ribosomal small subunit. 1 PublicationCorresponds to variant dbSNP:rs1131692170EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease variant

Organism-specific databases

DisGeNET

More...
DisGeNETi
26284

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
ERAL1

MalaCards human disease database

More...
MalaCardsi
ERAL1
MIMi617565, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000132591

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2855, Perrault syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27843

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75616, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ERAL1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 43MitochondrionSequence analysisAdd BLAST43
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000018008144 – 437GTPase Era, mitochondrialAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei173PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75616

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75616

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O75616

MaxQB - The MaxQuant DataBase

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MaxQBi
O75616

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75616

PeptideAtlas

More...
PeptideAtlasi
O75616

PRoteomics IDEntifications database

More...
PRIDEi
O75616

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
50120 [O75616-1]
50121 [O75616-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
O75616, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75616

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75616

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132591, Expressed in heart left ventricle and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75616, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75616, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000132591, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
117666, 172 interactors

Protein interaction database and analysis system

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IntActi
O75616, 56 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000254928

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O75616, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 330Era-type GPROSITE-ProRule annotationAdd BLAST219
Domaini360 – 437KH type-2Add BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni120 – 127G1PROSITE-ProRule annotation8
Regioni146 – 150G2PROSITE-ProRule annotation5
Regioni167 – 170G3PROSITE-ProRule annotation4
Regioni236 – 239G4PROSITE-ProRule annotation4
Regioni271 – 290DisorderedSequence analysisAdd BLAST20
Regioni308 – 310G5PROSITE-ProRule annotation3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1423, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000013800

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_038009_2_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75616

Identification of Orthologs from Complete Genome Data

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OMAi
WAEVDVI

Database of Orthologous Groups

More...
OrthoDBi
586738at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75616

TreeFam database of animal gene trees

More...
TreeFami
TF321650

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04163, Era, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.300.20, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00367, GTPase_Era, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030388, G_ERA_dom
IPR006073, GTP-bd
IPR005662, GTP-bd_Era
IPR015946, KH_dom-like_a/b
IPR009019, KH_sf_prok-type
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom

The PANTHER Classification System

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PANTHERi
PTHR42698, PTHR42698, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01926, MMR_HSR1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00326, GTP1OBG

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF54814, SSF54814, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00231, small_GTP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51713, G_ERA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform HERA-A (identifier: O75616-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPSWRGAR LVQSVLRVWQ VGPHVARERV IPFSSLLGFQ RRCVSCVAGS
60 70 80 90 100
AFSGPRLASA SRSNGQGSAL DHFLGFSQPD SSVTPCVPAV SMNRDEQDVL
110 120 130 140 150
LVHHPDMPEN SRVLRVVLLG APNAGKSTLS NQLLGRKVFP VSRKVHTTRC
160 170 180 190 200
QALGVITEKE TQVILLDTPG IISPGKQKRH HLELSLLEDP WKSMESADLV
210 220 230 240 250
VVLVDVSDKW TRNQLSPQLL RCLTKYSQIP SVLVMNKVDC LKQKSVLLEL
260 270 280 290 300
TAALTEGVVN GKKLKMRQAF HSHPGTHCPS PAVKDPNTQS VGNPQRIGWP
310 320 330 340 350
HFKEIFMLSA LSQEDVKTLK QYLLTQAQPG PWEYHSAVLT SQTPEEICAN
360 370 380 390 400
IIREKLLEHL PQEVPYNVQQ KTAVWEEGPG GELVIQQKLL VPKESYVKLL
410 420 430
IGPKGHVISQ IAQEAGHDLM DIFLCDVDIR LSVKLLK
Length:437
Mass (Da):48,350
Last modified:January 4, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C2454A1D9AFF5AA
GO
Isoform HERA-B (identifier: O75616-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-437: GVVNGKKLKM...DIRLSVKLLK → AIPSDTGPARALGVPQCSPH

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:276
Mass (Da):30,040
Checksum:i4D0A9F7F0D657072
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRV9J3QRV9_HUMAN
ERA-like protein 1
ERAL1
284Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSB2J3QSB2_HUMAN
ERA-like protein 1
ERAL1
276Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQJ8K7EQJ8_HUMAN
GTPase Era, mitochondrial
ERAL1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QT61J3QT61_HUMAN
GTPase Era, mitochondrial
ERAL1
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG12978 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → V in AAC31603 (PubMed:10945472).Curated1
Sequence conflicti1M → V in AAC31604 (PubMed:10945472).Curated1
Sequence conflicti15V → A in AAC31603 (PubMed:10945472).Curated1
Sequence conflicti15V → A in AAC31604 (PubMed:10945472).Curated1
Sequence conflicti17 – 18RV → KI in AAG12978 (Ref. 3) Curated2
Sequence conflicti190P → T in BAB56112 (PubMed:11733036).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079209236N → I in PRLTS6; decreased protein abundance; reduced assembly of the mitochondrial ribosomal small subunit. 1 PublicationCorresponds to variant dbSNP:rs1131692170EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001453257 – 437GVVNG…VKLLK → AIPSDTGPARALGVPQCSPH in isoform HERA-B. 1 PublicationAdd BLAST181

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF082657 mRNA Translation: AAC31603.1
AF082658 mRNA Translation: AAC31604.1
AB049388 mRNA Translation: BAB56112.1
AY007435 mRNA Translation: AAG12978.1 Different initiation.
AK023342 mRNA Translation: BAG51183.1
AC024267 Genomic DNA No translation available.
CH471159 Genomic DNA Translation: EAW51147.1
BC019094 mRNA Translation: AAH19094.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11244.1 [O75616-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001304914.1, NM_001317985.1
NP_001304915.1, NM_001317986.1
NP_005693.1, NM_005702.3 [O75616-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000254928; ENSP00000254928; ENSG00000132591 [O75616-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26284

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:26284

UCSC genome browser

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UCSCi
uc002hcy.2, human [O75616-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082657 mRNA Translation: AAC31603.1
AF082658 mRNA Translation: AAC31604.1
AB049388 mRNA Translation: BAB56112.1
AY007435 mRNA Translation: AAG12978.1 Different initiation.
AK023342 mRNA Translation: BAG51183.1
AC024267 Genomic DNA No translation available.
CH471159 Genomic DNA Translation: EAW51147.1
BC019094 mRNA Translation: AAH19094.1
CCDSiCCDS11244.1 [O75616-1]
RefSeqiNP_001304914.1, NM_001317985.1
NP_001304915.1, NM_001317986.1
NP_005693.1, NM_005702.3 [O75616-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117666, 172 interactors
IntActiO75616, 56 interactors
STRINGi9606.ENSP00000254928

PTM databases

GlyGeniO75616, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO75616
PhosphoSitePlusiO75616

Genetic variation databases

BioMutaiERAL1

Proteomic databases

EPDiO75616
jPOSTiO75616
MassIVEiO75616
MaxQBiO75616
PaxDbiO75616
PeptideAtlasiO75616
PRIDEiO75616
ProteomicsDBi50120 [O75616-1]
50121 [O75616-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
14896, 217 antibodies

The DNASU plasmid repository

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DNASUi
26284

Genome annotation databases

EnsembliENST00000254928; ENSP00000254928; ENSG00000132591 [O75616-1]
GeneIDi26284
KEGGihsa:26284
UCSCiuc002hcy.2, human [O75616-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26284
DisGeNETi26284

GeneCards: human genes, protein and diseases

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GeneCardsi
ERAL1
GeneReviewsiERAL1
HGNCiHGNC:3424, ERAL1
HPAiENSG00000132591, Low tissue specificity
MalaCardsiERAL1
MIMi607435, gene
617565, phenotype
neXtProtiNX_O75616
OpenTargetsiENSG00000132591
Orphaneti2855, Perrault syndrome
PharmGKBiPA27843
VEuPathDBiHostDB:ENSG00000132591

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1423, Eukaryota
GeneTreeiENSGT00390000013800
HOGENOMiCLU_038009_2_1_1
InParanoidiO75616
OMAiWAEVDVI
OrthoDBi586738at2759
PhylomeDBiO75616
TreeFamiTF321650

Enzyme and pathway databases

PathwayCommonsiO75616
ReactomeiR-HSA-5368286, Mitochondrial translation initiation
R-HSA-5389840, Mitochondrial translation elongation
R-HSA-5419276, Mitochondrial translation termination

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
26284, 226 hits in 1030 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ERAL1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26284
PharosiO75616, Tbio

Protein Ontology

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PROi
PR:O75616
RNActiO75616, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000132591, Expressed in heart left ventricle and 218 other tissues
ExpressionAtlasiO75616, baseline and differential
GenevisibleiO75616, HS

Family and domain databases

CDDicd04163, Era, 1 hit
Gene3Di3.30.300.20, 1 hit
HAMAPiMF_00367, GTPase_Era, 1 hit
InterProiView protein in InterPro
IPR030388, G_ERA_dom
IPR006073, GTP-bd
IPR005662, GTP-bd_Era
IPR015946, KH_dom-like_a/b
IPR009019, KH_sf_prok-type
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
PANTHERiPTHR42698, PTHR42698, 1 hit
PfamiView protein in Pfam
PF01926, MMR_HSR1, 1 hit
PRINTSiPR00326, GTP1OBG
SUPFAMiSSF52540, SSF52540, 1 hit
SSF54814, SSF54814, 1 hit
TIGRFAMsiTIGR00231, small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51713, G_ERA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERAL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75616
Secondary accession number(s): B3KN21
, C9JEC6, O75617, Q8WUY4, Q96LE2, Q96TC0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 4, 2005
Last modified: September 29, 2021
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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