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Protein

Carboxylic ester hydrolase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • lipase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation

Protein family/group databases

ESTHERihuman-CEL Cholesterol_esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiO75612

Structurei

3D structure databases

ProteinModelPortaliO75612
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 522COesteraseInterPro annotationAdd BLAST517

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
HOGENOMiHOG000091866
HOVERGENiHBG008839
KOiK12298

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR033560 BAL
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PANTHERiPTHR43903:SF1 PTHR43903:SF1, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Fragment.

O75612-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AKLGAVYTEG GFVEGVNKKL GLLGDSVDIF KGIPFAAPTK ALENPQPHPG
60 70 80 90 100
WQGTLKAKNF KKRCLQATIT QDSTYGDEDC LYLNIWVPQG RKQVSRDLPV
110 120 130 140 150
MIWIYGGAFL MGSGHGANFL NNYLYDGEEI ATRGNVIVVT FNYRVGPLGF
160 170 180 190 200
LSTGDANLPG NYGLRDQHMA IAWVKRNIAA FGGDPNNITL FGESAGGASV
210 220 230 240 250
SLQTLSPYNK GLIRRAISQS GVALSPWVIQ KNPLFWAKKV AEKVGCPVGD
260 270 280 290 300
AARMAQCLKV TDPRALTLAY KVPLAGLEYP MLHYVGFVPV IDGDFIPADP
310 320 330 340 350
INLYANAADI DYIAGTNNMD GHIFASIDMP AINKGNKKVT EEDFYKLVSE
360 370 380 390 400
FTITKGLRGA KTTFDVYTES WAQDPSQENK KKTVVDFETD VLFLVPTEIA
410 420 430 440 450
LAQHRANAKS AKTYAYLFSH PSRMPVYPKW VGADHADDIQ YVFGKPFATP
460 470 480 490 500
TGYRPQDRTV SKAMIAYWTN FAKTGDPNMG DSAVPTHWEP YTTENSGYLE
510 520 530 540 550
ITKKMGSSSM KRSLRTNFLR YWTLTYLALP TVTDQEATPV PPTGDSEATP
560 570 580 590 600
VPPTGDSETA PVPPTGDSGA PPVPPTGDSG APPVPPTGDS EAAPVPPTGD
610
SKEAQMPAVI RF
Length:612
Mass (Da):66,363
Last modified:November 1, 1998 - v1
Checksum:iA5E9092D19390B26
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081673 mRNA Translation: AAC71012.1
RefSeqiNP_001798.2, NM_001807.4
UniGeneiHs.533258

Genome annotation databases

GeneIDi1056
KEGGihsa:1056

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081673 mRNA Translation: AAC71012.1
RefSeqiNP_001798.2, NM_001807.4
UniGeneiHs.533258

3D structure databases

ProteinModelPortaliO75612
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERihuman-CEL Cholesterol_esterase

Proteomic databases

PeptideAtlasiO75612

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1056
KEGGihsa:1056

Organism-specific databases

CTDi1056

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
HOGENOMiHOG000091866
HOVERGENiHBG008839
KOiK12298

Miscellaneous databases

GenomeRNAii1056

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR033560 BAL
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PANTHERiPTHR43903:SF1 PTHR43903:SF1, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO75612_HUMAN
AccessioniPrimary (citable) accession number: O75612
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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