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UniProtKB - O75610 (LFTY1_HUMAN)
Protein
Left-right determination factor 1
Gene
LEFTY1
Organism
Homo sapiens (Human)
Status
Functioni
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: InterPro
GO - Biological processi
- BMP signaling pathway Source: GO_Central
- determination of left/right symmetry Source: BHF-UCL
- heart morphogenesis Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- SMAD protein signal transduction Source: GO_Central
- transforming growth factor beta receptor signaling pathway Source: ProtInc
Keywordsi
Molecular function | Cytokine, Developmental protein, Growth factor |
Enzyme and pathway databases
PathwayCommonsi | O75610 |
Reactomei | R-HSA-1181150, Signaling by NODAL R-HSA-1433617, Regulation of signaling by NODAL |
SignaLinki | O75610 |
SIGNORi | O75610 |
Names & Taxonomyi
Protein namesi | Recommended name: Left-right determination factor 1Alternative name(s): Left-right determination factor B Protein lefty-1 Protein lefty-B |
Gene namesi | Name:LEFTY1 Synonyms:LEFTB, LEFTYB ORF Names:UNQ278/PRO317 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6552, LEFTY1 |
MIMi | 603037, gene |
neXtProti | NX_O75610 |
VEuPathDBi | HostDB:ENSG00000243709 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 10637 |
OpenTargetsi | ENSG00000243709 |
PharmGKBi | PA30332 |
Miscellaneous databases
Pharosi | O75610, Tbio |
Genetic variation databases
BioMutai | LEFTY1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000033810 | 22 – 76 | Or 135Sequence analysisAdd BLAST | 55 | |
ChainiPRO_0000033811 | 77 – 366 | Left-right determination factor 1Add BLAST | 290 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 158 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 251 ↔ 264 | By similarity | ||
Disulfide bondi | 263 ↔ 316 | By similarity | ||
Disulfide bondi | 293 ↔ 351 | By similarity | ||
Disulfide bondi | 297 ↔ 353 | By similarity |
Post-translational modificationi
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | O75610 |
jPOSTi | O75610 |
MassIVEi | O75610 |
PaxDbi | O75610 |
PeptideAtlasi | O75610 |
PRIDEi | O75610 |
ProteomicsDBi | 50119 |
PTM databases
GlyGeni | O75610, 1 site |
iPTMneti | O75610 |
PhosphoSitePlusi | O75610 |
Expressioni
Gene expression databases
Bgeei | ENSG00000243709, Expressed in pancreas and 100 other tissues |
Genevisiblei | O75610, HS |
Organism-specific databases
HPAi | ENSG00000243709, Group enriched (intestine, pancreas) |
Interactioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 115881, 7 interactors |
IntActi | O75610, 2 interactors |
STRINGi | 9606.ENSP00000272134 |
Miscellaneous databases
RNActi | O75610, protein |
Structurei
3D structure databases
AlphaFoldDBi | O75610 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00390000010056 |
HOGENOMi | CLU_064098_0_0_1 |
InParanoidi | O75610 |
OMAi | AGSEVMM |
OrthoDBi | 751948at2759 |
PhylomeDBi | O75610 |
TreeFami | TF106462 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR003942, LRDF IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF037402, TGFb4, 1 hit |
PRINTSi | PR01427, TGFBETA4 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O75610-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPLWLCWAL WVLPLASPGA ALTGEQLLGS LLRQLQLKEV PTLDRADMEE
60 70 80 90 100
LVIPTHVRAQ YVALLQRSHG DRSRGKRFSQ SFREVAGRFL ALEASTHLLV
110 120 130 140 150
FGMEQRLPPN SELVQAVLRL FQEPVPKAAL HRHGRLSPRS ARARVTVEWL
160 170 180 190 200
RVRDDGSNRT SLIDSRLVSV HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ
210 220 230 240 250
VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL DLGDYGAQGD
260 270 280 290 300
CDPEAPMTEG TRCCRQEMYI DLQGMKWAEN WVLEPPGFLA YECVGTCRQP
310 320 330 340 350
PEALAFKWPF LGPRQCIASE TDSLPMIVSI KEGGRTRPQV VSLPNMRVQK
360
CSCASDGALV PRRLQP
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052567 | 57 | V → M. Corresponds to variant dbSNP:rs35273824Ensembl. | 1 | |
Natural variantiVAR_070888 | 92 | L → S2 PublicationsCorresponds to variant dbSNP:rs145431393EnsemblClinVar. | 1 | |
Natural variantiVAR_070889 | 142 | R → Q2 PublicationsCorresponds to variant dbSNP:rs191758097EnsemblClinVar. | 1 | |
Natural variantiVAR_024231 | 322 | D → A. Corresponds to variant dbSNP:rs360057Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF081507 , AF081504, AF081505, AF081506 Genomic DNA Translation: AAC33967.1 AF081512 mRNA Translation: AAD48144.1 AY358873 mRNA Translation: AAQ89232.1 AK313115 mRNA Translation: BAG35937.1 AK222714 mRNA Translation: BAD96434.1 AL117348 Genomic DNA No translation available. BC027883 mRNA Translation: AAH27883.1 |
CCDSi | CCDS1548.1 |
RefSeqi | NP_066277.1, NM_020997.3 |
Genome annotation databases
Ensembli | ENST00000272134.5; ENSP00000272134.5; ENSG00000243709.1 |
GeneIDi | 10637 |
KEGGi | hsa:10637 |
MANE-Selecti | ENST00000272134.5; ENSP00000272134.5; NM_020997.4; NP_066277.1 |
UCSCi | uc001hpo.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF081507 , AF081504, AF081505, AF081506 Genomic DNA Translation: AAC33967.1 AF081512 mRNA Translation: AAD48144.1 AY358873 mRNA Translation: AAQ89232.1 AK313115 mRNA Translation: BAG35937.1 AK222714 mRNA Translation: BAD96434.1 AL117348 Genomic DNA No translation available. BC027883 mRNA Translation: AAH27883.1 |
CCDSi | CCDS1548.1 |
RefSeqi | NP_066277.1, NM_020997.3 |
3D structure databases
AlphaFoldDBi | O75610 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 115881, 7 interactors |
IntActi | O75610, 2 interactors |
STRINGi | 9606.ENSP00000272134 |
PTM databases
GlyGeni | O75610, 1 site |
iPTMneti | O75610 |
PhosphoSitePlusi | O75610 |
Genetic variation databases
BioMutai | LEFTY1 |
Proteomic databases
EPDi | O75610 |
jPOSTi | O75610 |
MassIVEi | O75610 |
PaxDbi | O75610 |
PeptideAtlasi | O75610 |
PRIDEi | O75610 |
ProteomicsDBi | 50119 |
Protocols and materials databases
Antibodypediai | 34775, 357 antibodies from 26 providers |
DNASUi | 10637 |
Genome annotation databases
Ensembli | ENST00000272134.5; ENSP00000272134.5; ENSG00000243709.1 |
GeneIDi | 10637 |
KEGGi | hsa:10637 |
MANE-Selecti | ENST00000272134.5; ENSP00000272134.5; NM_020997.4; NP_066277.1 |
UCSCi | uc001hpo.3, human |
Organism-specific databases
CTDi | 10637 |
DisGeNETi | 10637 |
GeneCardsi | LEFTY1 |
HGNCi | HGNC:6552, LEFTY1 |
HPAi | ENSG00000243709, Group enriched (intestine, pancreas) |
MIMi | 603037, gene |
neXtProti | NX_O75610 |
OpenTargetsi | ENSG00000243709 |
PharmGKBi | PA30332 |
VEuPathDBi | HostDB:ENSG00000243709 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00390000010056 |
HOGENOMi | CLU_064098_0_0_1 |
InParanoidi | O75610 |
OMAi | AGSEVMM |
OrthoDBi | 751948at2759 |
PhylomeDBi | O75610 |
TreeFami | TF106462 |
Enzyme and pathway databases
PathwayCommonsi | O75610 |
Reactomei | R-HSA-1181150, Signaling by NODAL R-HSA-1433617, Regulation of signaling by NODAL |
SignaLinki | O75610 |
SIGNORi | O75610 |
Miscellaneous databases
BioGRID-ORCSi | 10637, 10 hits in 1061 CRISPR screens |
ChiTaRSi | LEFTY1, human |
GenomeRNAii | 10637 |
Pharosi | O75610, Tbio |
PROi | PR:O75610 |
RNActi | O75610, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000243709, Expressed in pancreas and 100 other tissues |
Genevisiblei | O75610, HS |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR003942, LRDF IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF037402, TGFb4, 1 hit |
PRINTSi | PR01427, TGFBETA4 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LFTY1_HUMAN | |
Accessioni | O75610Primary (citable) accession number: O75610 Secondary accession number(s): B2R7U0, Q53H67, Q5TE94 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | November 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families