LEFTY1

Functionⁱ

Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
growth factor activity Source: UniProtKB-KW
transforming growth factor beta receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
determination of left/right symmetry Source: BHF-UCL
heart morphogenesis Source: BHF-UCL
negative regulation of transcription by RNA polymerase II Source: BHF-UCL
positive regulation of pathway-restricted SMAD protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of apoptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of MAPK cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SMAD protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transforming growth factor beta receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10053005

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine, Developmental protein, Growth factor

Molecular function

Cytokine, Developmental protein, Growth factor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1181150 Signaling by NODAL R-HSA-1433617 Regulation of signaling by NODAL
SIGNORⁱ	O75610

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Left-right determination factor 1 Alternative name(s): Left-right determination factor B Protein lefty-1 Protein lefty-B
Gene namesⁱ	Name:LEFTY1 Synonyms:LEFTB, LEFTYB ORF Names:UNQ278/PRO317
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000243709.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6552 LEFTY1
MIMⁱ	603037 gene
neXtProtⁱ	NX_O75610

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10637
Open Targets More...OpenTargetsⁱ	ENSG00000243709
PharmGKBⁱ	PA30332

Polymorphism and mutation databases

BioMutaⁱ	LEFTY1

BioMutaⁱ

LEFTY1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST	21
PropeptideⁱPRO_0000033810	22 – 76	Or 135Sequence analysisAdd BLAST	55
ChainⁱPRO_0000033811	77 – 366	Left-right determination factor 1Add BLAST	290

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	158	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	251 ↔ 264	By similarity
Disulfide bondⁱ	263 ↔ 316	By similarity
Disulfide bondⁱ	293 ↔ 351	By similarity
Disulfide bondⁱ	297 ↔ 353	By similarity

Post-translational modificationⁱ

The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	O75610
PaxDbⁱ	O75610
PeptideAtlas More...PeptideAtlasⁱ	O75610
PRIDEⁱ	O75610
ProteomicsDBⁱ	50119

PTM databases

iPTMnetⁱ	O75610
PhosphoSitePlusⁱ	O75610

Miscellaneous databases

PMAP-CutDBⁱ	O75610

PMAP-CutDBⁱ

O75610

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000243709 Expressed in 81 organ(s), highest expression level in transverse colon
CleanExⁱ	HS_LEFTY1
ExpressionAtlasⁱ	O75610 baseline and differential
Genevisibleⁱ	O75610 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047883 HPA056210

HPAⁱ

HPA047883
HPA056210

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
growth factor activity Source: UniProtKB-KW
transforming growth factor beta receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115881, 2 interactors
STRINGⁱ	9606.ENSP00000272134

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75610
SMRⁱ	O75610
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TGF-beta family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3900 Eukaryota ENOG410XT8Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010056
HOGENOMⁱ	HOG000113317
HOVERGENⁱ	HBG074429
InParanoidⁱ	O75610
KEGG Orthology (KO) More...KOⁱ	K04668
OMAⁱ	MAIPTHV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09EN
PhylomeDBⁱ	O75610
TreeFamⁱ	TF106462

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR003942 LRDF IPR001839 TGF-b_C IPR001111 TGF-b_propeptide IPR015615 TGF-beta-rel IPR017948 TGFb_CS
PANTHERⁱ	PTHR11848 PTHR11848, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00019 TGF_beta, 1 hit PF00688 TGFb_propeptide, 1 hit
PIRSFⁱ	PIRSF037402 TGFb4, 1 hit
PRINTSⁱ	PR01427 TGFBETA4
SMARTⁱ	View protein in SMART SM00204 TGFB, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00250 TGF_BETA_1, 1 hit PS51362 TGF_BETA_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O75610-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQPLWLCWAL WVLPLASPGA ALTGEQLLGS LLRQLQLKEV PTLDRADMEE 
        60         70         80         90        100
LVIPTHVRAQ YVALLQRSHG DRSRGKRFSQ SFREVAGRFL ALEASTHLLV 
       110        120        130        140        150
FGMEQRLPPN SELVQAVLRL FQEPVPKAAL HRHGRLSPRS ARARVTVEWL 
       160        170        180        190        200
RVRDDGSNRT SLIDSRLVSV HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ 
       210        220        230        240        250
VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL DLGDYGAQGD 
       260        270        280        290        300
CDPEAPMTEG TRCCRQEMYI DLQGMKWAEN WVLEPPGFLA YECVGTCRQP 
       310        320        330        340        350
PEALAFKWPF LGPRQCIASE TDSLPMIVSI KEGGRTRPQV VSLPNMRVQK 
       360 
CSCASDGALV PRRLQP

Length:366

Mass (Da):40,880

Last modified:November 1, 1998 - v1

Checksum:ⁱBCF900C71ED9AA2A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087WW09	A0A087WW09_HUMAN		Left-right determination factor 1 Left-right determination factor 1	LEFTY1	64	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_052567	57	V → M. Corresponds to variant dbSNP:rs35273824Ensembl.	1
Natural variantⁱVAR_070888	92	L → S2 PublicationsCorresponds to variant dbSNP:rs145431393Ensembl.	1
Natural variantⁱVAR_070889	142	R → Q2 PublicationsCorresponds to variant dbSNP:rs191758097Ensembl.	1
Natural variantⁱVAR_024231	322	D → A. Corresponds to variant dbSNP:rs360057Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF081507 , AF081504, AF081505, AF081506 Genomic DNA Translation: AAC33967.1 AF081512 mRNA Translation: AAD48144.1 AY358873 mRNA Translation: AAQ89232.1 AK313115 mRNA Translation: BAG35937.1 AK222714 mRNA Translation: BAD96434.1 AL117348 Genomic DNA No translation available. BC027883 mRNA Translation: AAH27883.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1548.1
NCBI Reference Sequences More...RefSeqⁱ	NP_066277.1, NM_020997.3
UniGeneⁱ	Hs.656214

Genome annotation databases

Ensemblⁱ	ENST00000272134; ENSP00000272134; ENSG00000243709
GeneIDⁱ	10637
KEGGⁱ	hsa:10637
UCSC genome browser More...UCSCⁱ	uc001hpo.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75610	Left-right determination factor 2		HUMAN		366	UniRef90_O00292
Left-right determination factor		PANTR		366
Left-right determination factor		PANPA		366
Left-right determination factor		PONAB		366
Left-right determination factor		SAIBB		366
+37

Protein	Similar proteins		Species	Score	Length	Source
O75610	Left-right determination factor 2		HUMAN		366	UniRef50_O00292
Left-right determination factor 2		MOUSE		368
Left-right determination factor		PANTR		366
Left-right determination factor		PANPA		366
Left-right determination factor		CERAT		366
+158

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF081507 , AF081504, AF081505, AF081506 Genomic DNA Translation: AAC33967.1 AF081512 mRNA Translation: AAD48144.1 AY358873 mRNA Translation: AAQ89232.1 AK313115 mRNA Translation: BAG35937.1 AK222714 mRNA Translation: BAD96434.1 AL117348 Genomic DNA No translation available. BC027883 mRNA Translation: AAH27883.1
CCDSⁱ	CCDS1548.1
RefSeqⁱ	NP_066277.1, NM_020997.3
UniGeneⁱ	Hs.656214

3D structure databases

ProteinModelPortalⁱ	O75610
SMRⁱ	O75610
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115881, 2 interactors
STRINGⁱ	9606.ENSP00000272134

PTM databases

iPTMnetⁱ	O75610
PhosphoSitePlusⁱ	O75610

Polymorphism and mutation databases

BioMutaⁱ	LEFTY1

BioMutaⁱ

LEFTY1

Proteomic databases

EPDⁱ	O75610
PaxDbⁱ	O75610
PeptideAtlasⁱ	O75610
PRIDEⁱ	O75610
ProteomicsDBⁱ	50119

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10637
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000272134; ENSP00000272134; ENSG00000243709
GeneIDⁱ	10637
KEGGⁱ	hsa:10637
UCSCⁱ	uc001hpo.3 human

Organism-specific databases

CTDⁱ	10637
DisGeNETⁱ	10637
EuPathDBⁱ	HostDB:ENSG00000243709.1
GeneCardsⁱ	LEFTY1
HGNCⁱ	HGNC:6552 LEFTY1
HPAⁱ	HPA047883 HPA056210
MIMⁱ	603037 gene
neXtProtⁱ	NX_O75610
OpenTargetsⁱ	ENSG00000243709
PharmGKBⁱ	PA30332
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3900 Eukaryota ENOG410XT8Z LUCA
GeneTreeⁱ	ENSGT00390000010056
HOGENOMⁱ	HOG000113317
HOVERGENⁱ	HBG074429
InParanoidⁱ	O75610
KOⁱ	K04668
OMAⁱ	MAIPTHV
OrthoDBⁱ	EOG091G09EN
PhylomeDBⁱ	O75610
TreeFamⁱ	TF106462

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1181150 Signaling by NODAL R-HSA-1433617 Regulation of signaling by NODAL
SIGNORⁱ	O75610

Miscellaneous databases

ChiTaRSⁱ	LEFTY1 human
GenomeRNAiⁱ	10637
PMAP-CutDBⁱ	O75610
Protein Ontology More...PROⁱ	PR:O75610
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000243709 Expressed in 81 organ(s), highest expression level in transverse colon
CleanExⁱ	HS_LEFTY1
ExpressionAtlasⁱ	O75610 baseline and differential
Genevisibleⁱ	O75610 HS

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR003942 LRDF IPR001839 TGF-b_C IPR001111 TGF-b_propeptide IPR015615 TGF-beta-rel IPR017948 TGFb_CS
PANTHERⁱ	PTHR11848 PTHR11848, 1 hit
Pfamⁱ	View protein in Pfam PF00019 TGF_beta, 1 hit PF00688 TGFb_propeptide, 1 hit
PIRSFⁱ	PIRSF037402 TGFb4, 1 hit
PRINTSⁱ	PR01427 TGFBETA4
SMARTⁱ	View protein in SMART SM00204 TGFB, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00250 TGF_BETA_1, 1 hit PS51362 TGF_BETA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LFTY1_HUMAN
Accessionⁱ	O75610Primary (citable) accession number: O75610 Secondary accession number(s): B2R7U0, Q53H67, Q5TE94
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O75610 (LFTY1_HUMAN)

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Left-right determination factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ