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Protein

Left-right determination factor 1

Gene

LEFTY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor

Enzyme and pathway databases

ReactomeiR-HSA-1181150 Signaling by NODAL
R-HSA-1433617 Regulation of signaling by NODAL
SIGNORiO75610

Names & Taxonomyi

Protein namesi
Recommended name:
Left-right determination factor 1
Alternative name(s):
Left-right determination factor B
Protein lefty-1
Protein lefty-B
Gene namesi
Name:LEFTY1
Synonyms:LEFTB, LEFTYB
ORF Names:UNQ278/PRO317
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000243709.1
HGNCiHGNC:6552 LEFTY1
MIMi603037 gene
neXtProtiNX_O75610

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10637
OpenTargetsiENSG00000243709
PharmGKBiPA30332

Polymorphism and mutation databases

BioMutaiLEFTY1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000003381022 – 76Or 135Sequence analysisAdd BLAST55
ChainiPRO_000003381177 – 366Left-right determination factor 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi251 ↔ 264By similarity
Disulfide bondi263 ↔ 316By similarity
Disulfide bondi293 ↔ 351By similarity
Disulfide bondi297 ↔ 353By similarity

Post-translational modificationi

The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO75610
PaxDbiO75610
PeptideAtlasiO75610
PRIDEiO75610
ProteomicsDBi50119

PTM databases

iPTMnetiO75610
PhosphoSitePlusiO75610

Miscellaneous databases

PMAP-CutDBiO75610

Expressioni

Gene expression databases

BgeeiENSG00000243709
CleanExiHS_LEFTY1
ExpressionAtlasiO75610 baseline and differential
GenevisibleiO75610 HS

Organism-specific databases

HPAiHPA047883
HPA056210

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115881, 2 interactors
STRINGi9606.ENSP00000272134

Structurei

3D structure databases

ProteinModelPortaliO75610
SMRiO75610
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00390000010056
HOGENOMiHOG000113317
HOVERGENiHBG074429
InParanoidiO75610
KOiK04668
OMAiMAIPTHV
OrthoDBiEOG091G09EN
PhylomeDBiO75610
TreeFamiTF106462

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR003942 LRDF
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PIRSFiPIRSF037402 TGFb4, 1 hit
PRINTSiPR01427 TGFBETA4
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPLWLCWAL WVLPLASPGA ALTGEQLLGS LLRQLQLKEV PTLDRADMEE
60 70 80 90 100
LVIPTHVRAQ YVALLQRSHG DRSRGKRFSQ SFREVAGRFL ALEASTHLLV
110 120 130 140 150
FGMEQRLPPN SELVQAVLRL FQEPVPKAAL HRHGRLSPRS ARARVTVEWL
160 170 180 190 200
RVRDDGSNRT SLIDSRLVSV HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ
210 220 230 240 250
VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL DLGDYGAQGD
260 270 280 290 300
CDPEAPMTEG TRCCRQEMYI DLQGMKWAEN WVLEPPGFLA YECVGTCRQP
310 320 330 340 350
PEALAFKWPF LGPRQCIASE TDSLPMIVSI KEGGRTRPQV VSLPNMRVQK
360
CSCASDGALV PRRLQP
Length:366
Mass (Da):40,880
Last modified:November 1, 1998 - v1
Checksum:iBCF900C71ED9AA2A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05256757V → M. Corresponds to variant dbSNP:rs35273824Ensembl.1
Natural variantiVAR_07088892L → S2 PublicationsCorresponds to variant dbSNP:rs145431393Ensembl.1
Natural variantiVAR_070889142R → Q2 PublicationsCorresponds to variant dbSNP:rs191758097Ensembl.1
Natural variantiVAR_024231322D → A. Corresponds to variant dbSNP:rs360057Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081507
, AF081504, AF081505, AF081506 Genomic DNA Translation: AAC33967.1
AF081512 mRNA Translation: AAD48144.1
AY358873 mRNA Translation: AAQ89232.1
AK313115 mRNA Translation: BAG35937.1
AK222714 mRNA Translation: BAD96434.1
AL117348 Genomic DNA No translation available.
BC027883 mRNA Translation: AAH27883.1
CCDSiCCDS1548.1
RefSeqiNP_066277.1, NM_020997.3
UniGeneiHs.656214

Genome annotation databases

EnsembliENST00000272134; ENSP00000272134; ENSG00000243709
GeneIDi10637
KEGGihsa:10637
UCSCiuc001hpo.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLFTY1_HUMAN
AccessioniPrimary (citable) accession number: O75610
Secondary accession number(s): B2R7U0, Q53H67, Q5TE94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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