NPM3

Functionⁱ

May act as a chaperone.

GO - Molecular functionⁱ

chromatin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
histone binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromatin remodeling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
rRNA processing Source: Ensembl
rRNA transcription Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone

Molecular function

Chaperone

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nucleoplasmin-3
Gene namesⁱ	Name:NPM3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000107833.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7931 NPM3
MIMⁱ	606456 gene
neXtProtⁱ	NX_O75607

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10360
Open Targets More...OpenTargetsⁱ	ENSG00000107833
PharmGKBⁱ	PA31733

Polymorphism and mutation databases

BioMutaⁱ	NPM3

BioMutaⁱ

NPM3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000219489	2 – 178	Nucleoplasmin-3Add BLAST		177

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	13	PhosphoserineCombined sources	1
Modified residueⁱ	16	PhosphoserineCombined sources	1
Modified residueⁱ	27	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	147	PhosphoserineCombined sources	1
Modified residueⁱ	151	PhosphoserineCombined sources	1
Modified residueⁱ	158	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated.Curated

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	O75607
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75607
PaxDbⁱ	O75607
PeptideAtlas More...PeptideAtlasⁱ	O75607
PRIDEⁱ	O75607
ProteomicsDBⁱ	50116
TopDownProteomicsⁱ	O75607

PTM databases

iPTMnetⁱ	O75607
PhosphoSitePlusⁱ	O75607

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000107833 Expressed in 173 organ(s), highest expression level in oocyte
CleanExⁱ	HS_NPM3
Genevisibleⁱ	O75607 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036295 HPA036296

HPAⁱ

HPA036295
HPA036296

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NPM2	Q86SE8	3	EBI-721544,EBI-6658150
tat	P04608	2	EBI-721544,EBI-6164389	From Human immunodeficiency virus type 1 group M subtype B (isolate HXB2).

GO - Molecular functionⁱ

histone binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115640, 32 interactors
IntActⁱ	O75607, 15 interactors
Molecular INTeraction database More...MINTⁱ	O75607
STRINGⁱ	9606.ENSP00000359128

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75607
SMRⁱ	O75607
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	2 – 10	Ala-rich	9
Compositional biasⁱ	145 – 164	Asp/Glu-rich (highly acidic)Add BLAST	20
Compositional biasⁱ	148 – 156	Poly-Glu	9

Sequence similaritiesⁱ

Belongs to the nucleoplasmin family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IZ8K Eukaryota ENOG41120H8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000034554
HOGENOMⁱ	HOG000030911
HOVERGENⁱ	HBG045601
InParanoidⁱ	O75607
KEGG Orthology (KO) More...KOⁱ	K11278
OMAⁱ	KVPFYTF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MSK
PhylomeDBⁱ	O75607
TreeFamⁱ	TF327704

Family and domain databases

InterProⁱ	View protein in InterPro IPR004301 Nucleoplasmin IPR024057 Nucleoplasmin_core_dom IPR036824 Nucleoplasmin_core_dom_sf
PANTHERⁱ	PTHR22747 PTHR22747, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03066 Nucleoplasmin, 1 hit
SUPFAMⁱ	SSF69203 SSF69203, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O75607-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAGTAAALA FLSQESRTRA GGVGGLRVPA PVTMDSFFFG CELSGHTRSF 
        60         70         80         90        100
TFKVEEEDDA EHVLALTMLC LTEGAKDECN VVEVVARNHD HQEIAVPVAN 
       110        120        130        140        150
LKLSCQPMLS LDDFQLQPPV TFRLKSGSGP VRITGRHQIV TMSNDVSEEE 
       160        170 
SEEEEEDSDE EEVELCPILP AKKQGGRP

Length:178

Mass (Da):19,344

Last modified:January 23, 2007 - v3

Checksum:ⁱ8C899DE8C3CD61FA

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	61 – 62	EH → DD in AAD51496 (Ref. 3) Curated		2
Sequence conflictⁱ	83	E → K in AAD51496 (Ref. 3) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050410	16	S → N. Corresponds to variant dbSNP:rs34376117Ensembl.		1
Natural variantⁱVAR_050411	80	N → I1 PublicationCorresponds to variant dbSNP:rs2735420Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY049737 mRNA Translation: AAL12172.1 AF081280 mRNA Translation: AAC31609.1 AF079325 Genomic DNA Translation: AAD51496.1 BC041067 mRNA Translation: AAH41067.1 BC054868 mRNA Translation: AAH54868.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7519.1
NCBI Reference Sequences More...RefSeqⁱ	NP_008924.1, NM_006993.2
UniGeneⁱ	Hs.90691

Genome annotation databases

Ensemblⁱ	ENST00000370110; ENSP00000359128; ENSG00000107833
GeneIDⁱ	10360
KEGGⁱ	hsa:10360
UCSC genome browser More...UCSCⁱ	uc001ktt.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75607	NPM3 isoform 1		PANTR		178	UniRef100_O75607
Uncharacterized protein		PANPA		178

Protein	Similar proteins		Species	Score	Length	Source
O75607	NPM3 isoform 1		PANTR		178	UniRef90_O75607
Uncharacterized protein		PANPA		178
Uncharacterized protein		MACMU		178
Uncharacterized protein		CALJA		178
Uncharacterized protein		Cebus capucinus imitator		178
+52

Protein	Similar proteins		Species	Score	Length	Source
O75607	Nucleoplasmin-3		PONAB		180	UniRef50_O75607
NPM3 isoform 1		PANTR		178
Uncharacterized protein		PANPA		178
Uncharacterized protein		CALJA		178
Uncharacterized protein		AOTNA		178
+88

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY049737 mRNA Translation: AAL12172.1 AF081280 mRNA Translation: AAC31609.1 AF079325 Genomic DNA Translation: AAD51496.1 BC041067 mRNA Translation: AAH41067.1 BC054868 mRNA Translation: AAH54868.1
CCDSⁱ	CCDS7519.1
RefSeqⁱ	NP_008924.1, NM_006993.2
UniGeneⁱ	Hs.90691

3D structure databases

ProteinModelPortalⁱ	O75607
SMRⁱ	O75607
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115640, 32 interactors
IntActⁱ	O75607, 15 interactors
MINTⁱ	O75607
STRINGⁱ	9606.ENSP00000359128

PTM databases

iPTMnetⁱ	O75607
PhosphoSitePlusⁱ	O75607

Polymorphism and mutation databases

BioMutaⁱ	NPM3

BioMutaⁱ

NPM3

Proteomic databases

EPDⁱ	O75607
MaxQBⁱ	O75607
PaxDbⁱ	O75607
PeptideAtlasⁱ	O75607
PRIDEⁱ	O75607
ProteomicsDBⁱ	50116
TopDownProteomicsⁱ	O75607

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10360
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000370110; ENSP00000359128; ENSG00000107833
GeneIDⁱ	10360
KEGGⁱ	hsa:10360
UCSCⁱ	uc001ktt.3 human

Organism-specific databases

CTDⁱ	10360
DisGeNETⁱ	10360
EuPathDBⁱ	HostDB:ENSG00000107833.10
GeneCardsⁱ	NPM3
HGNCⁱ	HGNC:7931 NPM3
HPAⁱ	HPA036295 HPA036296
MIMⁱ	606456 gene
neXtProtⁱ	NX_O75607
OpenTargetsⁱ	ENSG00000107833
PharmGKBⁱ	PA31733
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZ8K Eukaryota ENOG41120H8 LUCA
GeneTreeⁱ	ENSGT00440000034554
HOGENOMⁱ	HOG000030911
HOVERGENⁱ	HBG045601
InParanoidⁱ	O75607
KOⁱ	K11278
OMAⁱ	KVPFYTF
OrthoDBⁱ	EOG091G0MSK
PhylomeDBⁱ	O75607
TreeFamⁱ	TF327704

Miscellaneous databases

ChiTaRSⁱ	NPM3 human
GeneWikiⁱ	NPM3
GenomeRNAiⁱ	10360
Protein Ontology More...PROⁱ	PR:O75607
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107833 Expressed in 173 organ(s), highest expression level in oocyte
CleanExⁱ	HS_NPM3
Genevisibleⁱ	O75607 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004301 Nucleoplasmin IPR024057 Nucleoplasmin_core_dom IPR036824 Nucleoplasmin_core_dom_sf
PANTHERⁱ	PTHR22747 PTHR22747, 1 hit
Pfamⁱ	View protein in Pfam PF03066 Nucleoplasmin, 1 hit
SUPFAMⁱ	SSF69203 SSF69203, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NPM3_HUMAN
Accessionⁱ	O75607Primary (citable) accession number: O75607 Secondary accession number(s): Q9UNY6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O75607 (NPM3_HUMAN)

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Nucleoplasmin-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ