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Protein

Nucleoplasmin-3

Gene

NPM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a chaperone.

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • histone binding Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoplasmin-3
Gene namesi
Name:NPM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107833.10
HGNCiHGNC:7931 NPM3
MIMi606456 gene
neXtProtiNX_O75607

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10360
OpenTargetsiENSG00000107833
PharmGKBiPA31733

Polymorphism and mutation databases

BioMutaiNPM3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002194892 – 178Nucleoplasmin-3Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei13PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei27Omega-N-methylarginineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiO75607
MaxQBiO75607
PaxDbiO75607
PeptideAtlasiO75607
PRIDEiO75607
ProteomicsDBi50116
TopDownProteomicsiO75607

PTM databases

iPTMnetiO75607
PhosphoSitePlusiO75607

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000107833 Expressed in 173 organ(s), highest expression level in oocyte
CleanExiHS_NPM3
GenevisibleiO75607 HS

Organism-specific databases

HPAiHPA036295
HPA036296

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115640, 32 interactors
IntActiO75607, 15 interactors
MINTiO75607
STRINGi9606.ENSP00000359128

Structurei

3D structure databases

ProteinModelPortaliO75607
SMRiO75607
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 10Ala-rich9
Compositional biasi145 – 164Asp/Glu-rich (highly acidic)Add BLAST20
Compositional biasi148 – 156Poly-Glu9

Sequence similaritiesi

Belongs to the nucleoplasmin family.Curated

Phylogenomic databases

eggNOGiENOG410IZ8K Eukaryota
ENOG41120H8 LUCA
GeneTreeiENSGT00440000034554
HOGENOMiHOG000030911
HOVERGENiHBG045601
InParanoidiO75607
KOiK11278
OMAiKVPFYTF
OrthoDBiEOG091G0MSK
PhylomeDBiO75607
TreeFamiTF327704

Family and domain databases

InterProiView protein in InterPro
IPR004301 Nucleoplasmin
IPR024057 Nucleoplasmin_core_dom
IPR036824 Nucleoplasmin_core_dom_sf
PANTHERiPTHR22747 PTHR22747, 1 hit
PfamiView protein in Pfam
PF03066 Nucleoplasmin, 1 hit
SUPFAMiSSF69203 SSF69203, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75607-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGTAAALA FLSQESRTRA GGVGGLRVPA PVTMDSFFFG CELSGHTRSF
60 70 80 90 100
TFKVEEEDDA EHVLALTMLC LTEGAKDECN VVEVVARNHD HQEIAVPVAN
110 120 130 140 150
LKLSCQPMLS LDDFQLQPPV TFRLKSGSGP VRITGRHQIV TMSNDVSEEE
160 170
SEEEEEDSDE EEVELCPILP AKKQGGRP
Length:178
Mass (Da):19,344
Last modified:January 23, 2007 - v3
Checksum:i8C899DE8C3CD61FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61 – 62EH → DD in AAD51496 (Ref. 3) Curated2
Sequence conflicti83E → K in AAD51496 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05041016S → N. Corresponds to variant dbSNP:rs34376117Ensembl.1
Natural variantiVAR_05041180N → I1 PublicationCorresponds to variant dbSNP:rs2735420Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049737 mRNA Translation: AAL12172.1
AF081280 mRNA Translation: AAC31609.1
AF079325 Genomic DNA Translation: AAD51496.1
BC041067 mRNA Translation: AAH41067.1
BC054868 mRNA Translation: AAH54868.1
CCDSiCCDS7519.1
RefSeqiNP_008924.1, NM_006993.2
UniGeneiHs.90691

Genome annotation databases

EnsembliENST00000370110; ENSP00000359128; ENSG00000107833
GeneIDi10360
KEGGihsa:10360
UCSCiuc001ktt.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049737 mRNA Translation: AAL12172.1
AF081280 mRNA Translation: AAC31609.1
AF079325 Genomic DNA Translation: AAD51496.1
BC041067 mRNA Translation: AAH41067.1
BC054868 mRNA Translation: AAH54868.1
CCDSiCCDS7519.1
RefSeqiNP_008924.1, NM_006993.2
UniGeneiHs.90691

3D structure databases

ProteinModelPortaliO75607
SMRiO75607
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115640, 32 interactors
IntActiO75607, 15 interactors
MINTiO75607
STRINGi9606.ENSP00000359128

PTM databases

iPTMnetiO75607
PhosphoSitePlusiO75607

Polymorphism and mutation databases

BioMutaiNPM3

Proteomic databases

EPDiO75607
MaxQBiO75607
PaxDbiO75607
PeptideAtlasiO75607
PRIDEiO75607
ProteomicsDBi50116
TopDownProteomicsiO75607

Protocols and materials databases

DNASUi10360
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370110; ENSP00000359128; ENSG00000107833
GeneIDi10360
KEGGihsa:10360
UCSCiuc001ktt.3 human

Organism-specific databases

CTDi10360
DisGeNETi10360
EuPathDBiHostDB:ENSG00000107833.10
GeneCardsiNPM3
HGNCiHGNC:7931 NPM3
HPAiHPA036295
HPA036296
MIMi606456 gene
neXtProtiNX_O75607
OpenTargetsiENSG00000107833
PharmGKBiPA31733
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ8K Eukaryota
ENOG41120H8 LUCA
GeneTreeiENSGT00440000034554
HOGENOMiHOG000030911
HOVERGENiHBG045601
InParanoidiO75607
KOiK11278
OMAiKVPFYTF
OrthoDBiEOG091G0MSK
PhylomeDBiO75607
TreeFamiTF327704

Miscellaneous databases

ChiTaRSiNPM3 human
GeneWikiiNPM3
GenomeRNAii10360
PROiPR:O75607
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107833 Expressed in 173 organ(s), highest expression level in oocyte
CleanExiHS_NPM3
GenevisibleiO75607 HS

Family and domain databases

InterProiView protein in InterPro
IPR004301 Nucleoplasmin
IPR024057 Nucleoplasmin_core_dom
IPR036824 Nucleoplasmin_core_dom_sf
PANTHERiPTHR22747 PTHR22747, 1 hit
PfamiView protein in Pfam
PF03066 Nucleoplasmin, 1 hit
SUPFAMiSSF69203 SSF69203, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPM3_HUMAN
AccessioniPrimary (citable) accession number: O75607
Secondary accession number(s): Q9UNY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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