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UniProtKB - O75607 (NPM3_HUMAN)
Protein
Nucleoplasmin-3
Gene
NPM3
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning (PubMed:22362753, PubMed:20073534).
Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM (PubMed:22362753).
Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM (PubMed:15596447).
3 PublicationsGO - Molecular functioni
- chromatin binding Source: GO_Central
- histone binding Source: GO_Central
- RNA binding Source: UniProtKB
GO - Biological processi
- chromatin remodeling Source: GO_Central
- rRNA processing Source: Ensembl
- rRNA transcription Source: Ensembl
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
PathwayCommonsi | O75607 |
SignaLinki | O75607 |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleoplasmin-3 |
Gene namesi | Name:NPM3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7931, NPM3 |
MIMi | 606456, gene |
neXtProti | NX_O75607 |
VEuPathDBi | HostDB:ENSG00000107833 |
Subcellular locationi
Cytoskeleton
- actin cytoskeleton Source: HPA
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10360 |
OpenTargetsi | ENSG00000107833 |
PharmGKBi | PA31733 |
Miscellaneous databases
Pharosi | O75607, Tbio |
Genetic variation databases
BioMutai | NPM3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000219489 | 2 – 178 | Nucleoplasmin-3Add BLAST | 177 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 13 | PhosphoserineCombined sources | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 27 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 147 | PhosphoserineCombined sources | 1 | |
Modified residuei | 151 | PhosphoserineCombined sources | 1 | |
Modified residuei | 158 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated.Curated
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | O75607 |
jPOSTi | O75607 |
MassIVEi | O75607 |
MaxQBi | O75607 |
PaxDbi | O75607 |
PeptideAtlasi | O75607 |
PRIDEi | O75607 |
ProteomicsDBi | 50116 |
TopDownProteomicsi | O75607 |
PTM databases
GlyGeni | O75607, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O75607 |
PhosphoSitePlusi | O75607 |
Expressioni
Tissue specificityi
Ubiquitous.1 Publication
Gene expression databases
Bgeei | ENSG00000107833, Expressed in oocyte and 188 other tissues |
Genevisiblei | O75607, HS |
Organism-specific databases
HPAi | ENSG00000107833, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
O75607
With | #Exp. | IntAct |
---|---|---|
NPM2 [Q86SE8] | 5 | EBI-721544,EBI-6658150 |
UPRT [Q96BW1] | 3 | EBI-721544,EBI-742943 |
tat [P04608] from Human immunodeficiency virus type 1 group M subtype B (isolate HXB2). | 2 | EBI-721544,EBI-6164389 |
GO - Molecular functioni
- histone binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 115640, 235 interactors |
IntActi | O75607, 43 interactors |
MINTi | O75607 |
STRINGi | 9606.ENSP00000359128 |
Miscellaneous databases
RNActi | O75607, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 141 – 178 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 146 – 164 | Acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the nucleoplasmin family.Curated
Phylogenomic databases
eggNOGi | ENOG502S1E6, Eukaryota |
GeneTreei | ENSGT00940000158796 |
HOGENOMi | CLU_058838_1_0_1 |
InParanoidi | O75607 |
OMAi | TEDYFWG |
OrthoDBi | 1485080at2759 |
PhylomeDBi | O75607 |
TreeFami | TF327704 |
Family and domain databases
InterProi | View protein in InterPro IPR004301, Nucleoplasmin IPR024057, Nucleoplasmin_core_dom IPR036824, Nucleoplasmin_core_dom_sf |
PANTHERi | PTHR22747, PTHR22747, 1 hit |
Pfami | View protein in Pfam PF03066, Nucleoplasmin, 1 hit |
SUPFAMi | SSF69203, SSF69203, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O75607-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAGTAAALA FLSQESRTRA GGVGGLRVPA PVTMDSFFFG CELSGHTRSF
60 70 80 90 100
TFKVEEEDDA EHVLALTMLC LTEGAKDECN VVEVVARNHD HQEIAVPVAN
110 120 130 140 150
LKLSCQPMLS LDDFQLQPPV TFRLKSGSGP VRITGRHQIV TMSNDVSEEE
160 170
SEEEEEDSDE EEVELCPILP AKKQGGRP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 – 62 | EH → DD in AAD51496 (Ref. 3) Curated | 2 | |
Sequence conflicti | 83 | E → K in AAD51496 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050410 | 16 | S → N. Corresponds to variant dbSNP:rs34376117Ensembl. | 1 | |
Natural variantiVAR_050411 | 80 | N → I1 PublicationCorresponds to variant dbSNP:rs2735420Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY049737 mRNA Translation: AAL12172.1 AF081280 mRNA Translation: AAC31609.1 AF079325 Genomic DNA Translation: AAD51496.1 BC041067 mRNA Translation: AAH41067.1 BC054868 mRNA Translation: AAH54868.1 |
CCDSi | CCDS7519.1 |
RefSeqi | NP_008924.1, NM_006993.2 |
Genome annotation databases
Ensembli | ENST00000370110.5; ENSP00000359128.5; ENSG00000107833.10 |
GeneIDi | 10360 |
KEGGi | hsa:10360 |
UCSCi | uc001ktt.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY049737 mRNA Translation: AAL12172.1 AF081280 mRNA Translation: AAC31609.1 AF079325 Genomic DNA Translation: AAD51496.1 BC041067 mRNA Translation: AAH41067.1 BC054868 mRNA Translation: AAH54868.1 |
CCDSi | CCDS7519.1 |
RefSeqi | NP_008924.1, NM_006993.2 |
3D structure databases
AlphaFoldDBi | O75607 |
SMRi | O75607 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115640, 235 interactors |
IntActi | O75607, 43 interactors |
MINTi | O75607 |
STRINGi | 9606.ENSP00000359128 |
PTM databases
GlyGeni | O75607, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O75607 |
PhosphoSitePlusi | O75607 |
Genetic variation databases
BioMutai | NPM3 |
Proteomic databases
EPDi | O75607 |
jPOSTi | O75607 |
MassIVEi | O75607 |
MaxQBi | O75607 |
PaxDbi | O75607 |
PeptideAtlasi | O75607 |
PRIDEi | O75607 |
ProteomicsDBi | 50116 |
TopDownProteomicsi | O75607 |
Protocols and materials databases
Antibodypediai | 31335, 120 antibodies from 20 providers |
DNASUi | 10360 |
Genome annotation databases
Ensembli | ENST00000370110.5; ENSP00000359128.5; ENSG00000107833.10 |
GeneIDi | 10360 |
KEGGi | hsa:10360 |
UCSCi | uc001ktt.3, human |
Organism-specific databases
CTDi | 10360 |
DisGeNETi | 10360 |
GeneCardsi | NPM3 |
HGNCi | HGNC:7931, NPM3 |
HPAi | ENSG00000107833, Low tissue specificity |
MIMi | 606456, gene |
neXtProti | NX_O75607 |
OpenTargetsi | ENSG00000107833 |
PharmGKBi | PA31733 |
VEuPathDBi | HostDB:ENSG00000107833 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1E6, Eukaryota |
GeneTreei | ENSGT00940000158796 |
HOGENOMi | CLU_058838_1_0_1 |
InParanoidi | O75607 |
OMAi | TEDYFWG |
OrthoDBi | 1485080at2759 |
PhylomeDBi | O75607 |
TreeFami | TF327704 |
Enzyme and pathway databases
PathwayCommonsi | O75607 |
SignaLinki | O75607 |
Miscellaneous databases
BioGRID-ORCSi | 10360, 68 hits in 1081 CRISPR screens |
ChiTaRSi | NPM3, human |
GeneWikii | NPM3 |
GenomeRNAii | 10360 |
Pharosi | O75607, Tbio |
PROi | PR:O75607 |
RNActi | O75607, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000107833, Expressed in oocyte and 188 other tissues |
Genevisiblei | O75607, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004301, Nucleoplasmin IPR024057, Nucleoplasmin_core_dom IPR036824, Nucleoplasmin_core_dom_sf |
PANTHERi | PTHR22747, PTHR22747, 1 hit |
Pfami | View protein in Pfam PF03066, Nucleoplasmin, 1 hit |
SUPFAMi | SSF69203, SSF69203, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NPM3_HUMAN | |
Accessioni | O75607Primary (citable) accession number: O75607 Secondary accession number(s): Q9UNY6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families