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Protein

Peptidoglycan recognition protein 1

Gene

PGLYRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.2 Publications

GO - Molecular functioni

  • N-acetylmuramoyl-L-alanine amidase activity Source: GO_Central
  • peptidoglycan binding Source: UniProtKB
  • peptidoglycan receptor activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial
Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan recognition protein 1
Alternative name(s):
Peptidoglycan recognition protein short
Short name:
PGRP-S
Gene namesi
Name:PGLYRP1
Synonyms:PGLYRP, PGRP, TNFSF3L
ORF Names:SBBI68, UNQ639/PRO1269
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000008438.4
HGNCiHGNC:8904 PGLYRP1
MIMi604963 gene
neXtProtiNX_O75594

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8993
OpenTargetsiENSG00000008438
PharmGKBiPA33241

Polymorphism and mutation databases

BioMutaiPGLYRP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002390122 – 196Peptidoglycan recognition protein 1Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi30 ↔ 1541 Publication
Disulfide bondi46 ↔ 911 Publication
Disulfide bondi67 ↔ 731 Publication
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated. N-glycosylation is required for bactericidal activity.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiO75594
PeptideAtlasiO75594
PRIDEiO75594
ProteomicsDBi50104

PTM databases

iPTMnetiO75594
PhosphoSitePlusiO75594

Expressioni

Tissue specificityi

Highly expressed in bone marrow. Weak expression found in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils.2 Publications

Gene expression databases

BgeeiENSG00000008438 Expressed in 79 organ(s), highest expression level in bone marrow
CleanExiHS_PGLYRP1
GenevisibleiO75594 HS

Organism-specific databases

HPAiHPA045702

Interactioni

Subunit structurei

Homodimer; disulfide-linked.2 Publications

Protein-protein interaction databases

BioGridi114474, 3 interactors
IntActiO75594, 1 interactor
MINTiO75594
STRINGi9606.ENSP00000008938

Structurei

Secondary structure

1196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75594
SMRiO75594
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75594

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 180N-acetylmuramoyl-L-alanine amidaseSequence analysisAdd BLAST128

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYTD Eukaryota
ENOG4111PQD LUCA
GeneTreeiENSGT00390000016833
HOGENOMiHOG000267017
HOVERGENiHBG007406
InParanoidiO75594
KOiK01446
OMAiIQNWPHY
OrthoDBiEOG091G0O6Z
PhylomeDBiO75594
TreeFamiTF323898

Family and domain databases

CDDicd06583 PGRP, 1 hit
Gene3Di3.40.80.10, 1 hit
InterProiView protein in InterPro
IPR036505 Amidase/PGRP_sf
IPR002502 Amidase_domain
IPR017331 Peptidoglycan_recognition
IPR015510 PGRP
IPR006619 PGRP_domain_met/bac
PANTHERiPTHR11022 PTHR11022, 1 hit
PfamiView protein in Pfam
PF01510 Amidase_2, 1 hit
PIRSFiPIRSF037945 PGRPs, 1 hit
SMARTiView protein in SMART
SM00644 Ami_2, 1 hit
SM00701 PGRP, 1 hit
SUPFAMiSSF55846 SSF55846, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75594-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRSMLLAW ALPSLLRLGA AQETEDPACC SPIVPRNEWK ALASECAQHL
60 70 80 90 100
SLPLRYVVVS HTAGSSCNTP ASCQQQARNV QHYHMKTLGW CDVGYNFLIG
110 120 130 140 150
EDGLVYEGRG WNFTGAHSGH LWNPMSIGIS FMGNYMDRVP TPQAIRAAQG
160 170 180 190
LLACGVAQGA LRSNYVLKGH RDVQRTLSPG NQLYHLIQNW PHYRSP
Length:196
Mass (Da):21,731
Last modified:November 1, 1998 - v1
Checksum:iD954C51440DC27DC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05049734V → G. Corresponds to variant dbSNP:rs34180629Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076483 mRNA Translation: AAC31822.1
AF242517 mRNA Translation: AAF99598.1
AY358936 mRNA Translation: AAQ89295.1
AC007785 Genomic DNA Translation: AAD38243.1
BC096154 mRNA Translation: AAH96154.1
BC096155 mRNA Translation: AAH96155.1
BC096156 mRNA Translation: AAH96156.1
BC096157 mRNA Translation: AAH96157.1
BC101845 mRNA Translation: AAI01846.1
BC101847 mRNA Translation: AAI01848.1
CCDSiCCDS12680.1
RefSeqiNP_005082.1, NM_005091.2
UniGeneiHs.137583

Genome annotation databases

EnsembliENST00000008938; ENSP00000008938; ENSG00000008438
GeneIDi8993
KEGGihsa:8993
UCSCiuc002pdx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076483 mRNA Translation: AAC31822.1
AF242517 mRNA Translation: AAF99598.1
AY358936 mRNA Translation: AAQ89295.1
AC007785 Genomic DNA Translation: AAD38243.1
BC096154 mRNA Translation: AAH96154.1
BC096155 mRNA Translation: AAH96155.1
BC096156 mRNA Translation: AAH96156.1
BC096157 mRNA Translation: AAH96157.1
BC101845 mRNA Translation: AAI01846.1
BC101847 mRNA Translation: AAI01848.1
CCDSiCCDS12680.1
RefSeqiNP_005082.1, NM_005091.2
UniGeneiHs.137583

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YCKX-ray1.70A22-196[»]
ProteinModelPortaliO75594
SMRiO75594
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114474, 3 interactors
IntActiO75594, 1 interactor
MINTiO75594
STRINGi9606.ENSP00000008938

PTM databases

iPTMnetiO75594
PhosphoSitePlusiO75594

Polymorphism and mutation databases

BioMutaiPGLYRP1

Proteomic databases

PaxDbiO75594
PeptideAtlasiO75594
PRIDEiO75594
ProteomicsDBi50104

Protocols and materials databases

DNASUi8993
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000008938; ENSP00000008938; ENSG00000008438
GeneIDi8993
KEGGihsa:8993
UCSCiuc002pdx.4 human

Organism-specific databases

CTDi8993
DisGeNETi8993
EuPathDBiHostDB:ENSG00000008438.4
GeneCardsiPGLYRP1
HGNCiHGNC:8904 PGLYRP1
HPAiHPA045702
MIMi604963 gene
neXtProtiNX_O75594
OpenTargetsiENSG00000008438
PharmGKBiPA33241
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYTD Eukaryota
ENOG4111PQD LUCA
GeneTreeiENSGT00390000016833
HOGENOMiHOG000267017
HOVERGENiHBG007406
InParanoidiO75594
KOiK01446
OMAiIQNWPHY
OrthoDBiEOG091G0O6Z
PhylomeDBiO75594
TreeFamiTF323898

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-6803157 Antimicrobial peptides

Miscellaneous databases

EvolutionaryTraceiO75594
GeneWikiiPGLYRP1
GenomeRNAii8993
PROiPR:O75594
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000008438 Expressed in 79 organ(s), highest expression level in bone marrow
CleanExiHS_PGLYRP1
GenevisibleiO75594 HS

Family and domain databases

CDDicd06583 PGRP, 1 hit
Gene3Di3.40.80.10, 1 hit
InterProiView protein in InterPro
IPR036505 Amidase/PGRP_sf
IPR002502 Amidase_domain
IPR017331 Peptidoglycan_recognition
IPR015510 PGRP
IPR006619 PGRP_domain_met/bac
PANTHERiPTHR11022 PTHR11022, 1 hit
PfamiView protein in Pfam
PF01510 Amidase_2, 1 hit
PIRSFiPIRSF037945 PGRPs, 1 hit
SMARTiView protein in SMART
SM00644 Ami_2, 1 hit
SM00701 PGRP, 1 hit
SUPFAMiSSF55846 SSF55846, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGRP1_HUMAN
AccessioniPrimary (citable) accession number: O75594
Secondary accession number(s): Q4VB36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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