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Protein

Mediator of RNA polymerase II transcription subunit 6

Gene

MED6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly Source: GO_Central
  • transcription coactivator activity Source: MGI
  • transcription factor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 6
Alternative name(s):
Activator-recruited cofactor 33 kDa component
Short name:
ARC33
Mediator complex subunit 6
Short name:
hMed6
Renal carcinoma antigen NY-REN-28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED6
Synonyms:ARC33
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000133997.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19970 MED6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602984 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75586

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000133997

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134868263

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MED6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000963881 – 246Mediator of RNA polymerase II transcription subunit 6Add BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei236N6-acetyllysineCombined sources1
Modified residuei241N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75586

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75586

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75586

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75586

PeptideAtlas

More...
PeptideAtlasi
O75586

PRoteomics IDEntifications database

More...
PRIDEi
O75586

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50100

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75586

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75586

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133997 Expressed in 207 organ(s), highest expression level in intestine

CleanEx database of gene expression profiles

More...
CleanExi
HS_MED6

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75586 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75586 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030764
HPA069039

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CTNNB1 and GLI3.9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115319, 59 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3227 Core mediator complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O75586

Database of interacting proteins

More...
DIPi
DIP-31456N

Protein interaction database and analysis system

More...
IntActi
O75586, 29 interactors

Molecular INTeraction database

More...
MINTi
O75586

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000256379

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75586

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75586

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 6 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3169 Eukaryota
COG5097 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017666

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000035127

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006825

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75586

KEGG Orthology (KO)

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KOi
K15128

Database of Orthologous Groups

More...
OrthoDBi
1251252at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75586

TreeFam database of animal gene trees

More...
TreeFami
TF313577

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.450.580, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038566 Med6_sf
IPR007018 Mediator_Med6
IPR016820 Mediator_Med6_met/pln

The PANTHER Classification System

More...
PANTHERi
PTHR13104 PTHR13104, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04934 Med6, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF023869 Mediator_MED6_meta/pln, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75586-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVDIRDNL LGISWVDSSW IPILNSGSVL DYFSERSNPF YDRTCNNEVV
60 70 80 90 100
KMQRLTLEHL NQMVGIEYIL LHAQEPILFI IRKQQRQSPA QVIPLADYYI
110 120 130 140 150
IAGVIYQAPD LGSVINSRVL TAVHGIQSAF DEAMSYCRYH PSKGYWWHFK
160 170 180 190 200
DHEEQDKVRP KAKRKEEPSS IFQRQRVDAL LLDLRQKFPP KFVQLKPGEK
210 220 230 240
PVPVDQTKKE AEPIPETVKP EEKETTKNVQ QTVSAKGPPE KRMRLQ
Length:246
Mass (Da):28,425
Last modified:February 28, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B173626F583B48B
GO
Isoform 2 (identifier: O75586-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-119: V → VSLFSFYK

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):29,298
Checksum:i3D89AD48C96C3CD7
GO
Isoform 3 (identifier: O75586-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-246: DKVRPKAKRK...GPPEKRMRLQ → AKAWRKACSSGSNKERGRTYTRNCKT

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):20,859
Checksum:i672B435005F9E984
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYL7A0A087WYL7_HUMAN
Mediator of RNA polymerase II trans...
MED6
257Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4A5G3V4A5_HUMAN
Mediator of RNA polymerase II trans...
MED6
249Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti151D → V in AAC26869 (PubMed:9734358).Curated1
Sequence conflicti156D → G in AAB84363 (PubMed:10508479).Curated1
Sequence conflicti203P → S in BAD97066 (Ref. 5) Curated1
Sequence conflicti224E → G in BAD96307 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054589119V → VSLFSFYK in isoform 2. 1 Publication1
Alternative sequenceiVSP_054590156 – 246DKVRP…RMRLQ → AKAWRKACSSGSNKERGRTY TRNCKT in isoform 3. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF074723 mRNA Translation: AAC26869.1
BT006831 mRNA Translation: AAP35477.1
CR541697 mRNA Translation: CAG46498.1
AK300460 mRNA Translation: BAG62179.1
AK304361 mRNA Translation: BAG65202.1
AK222587 mRNA Translation: BAD96307.1
AK223346 mRNA Translation: BAD97066.1
AL357153 Genomic DNA No translation available.
BC004106 mRNA Translation: AAH04106.1
U78082 mRNA Translation: AAB84363.1
AF155104 mRNA Translation: AAD42870.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS61483.1 [O75586-3]
CCDS61484.1 [O75586-2]
CCDS9805.1 [O75586-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001271138.1, NM_001284209.1 [O75586-2]
NP_001271139.1, NM_001284210.1 [O75586-3]
NP_001271140.1, NM_001284211.1
NP_005457.2, NM_005466.3 [O75586-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.497353

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000256379; ENSP00000256379; ENSG00000133997 [O75586-1]
ENST00000430055; ENSP00000413343; ENSG00000133997 [O75586-2]
ENST00000440435; ENSP00000394502; ENSG00000133997 [O75586-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10001

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10001

UCSC genome browser

More...
UCSCi
uc001xmf.5 human [O75586-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074723 mRNA Translation: AAC26869.1
BT006831 mRNA Translation: AAP35477.1
CR541697 mRNA Translation: CAG46498.1
AK300460 mRNA Translation: BAG62179.1
AK304361 mRNA Translation: BAG65202.1
AK222587 mRNA Translation: BAD96307.1
AK223346 mRNA Translation: BAD97066.1
AL357153 Genomic DNA No translation available.
BC004106 mRNA Translation: AAH04106.1
U78082 mRNA Translation: AAB84363.1
AF155104 mRNA Translation: AAD42870.1
CCDSiCCDS61483.1 [O75586-3]
CCDS61484.1 [O75586-2]
CCDS9805.1 [O75586-1]
RefSeqiNP_001271138.1, NM_001284209.1 [O75586-2]
NP_001271139.1, NM_001284210.1 [O75586-3]
NP_001271140.1, NM_001284211.1
NP_005457.2, NM_005466.3 [O75586-1]
UniGeneiHs.497353

3D structure databases

ProteinModelPortaliO75586
SMRiO75586
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115319, 59 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiO75586
DIPiDIP-31456N
IntActiO75586, 29 interactors
MINTiO75586
STRINGi9606.ENSP00000256379

PTM databases

iPTMnetiO75586
PhosphoSitePlusiO75586

Polymorphism and mutation databases

BioMutaiMED6

Proteomic databases

EPDiO75586
jPOSTiO75586
MaxQBiO75586
PaxDbiO75586
PeptideAtlasiO75586
PRIDEiO75586
ProteomicsDBi50100

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10001
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256379; ENSP00000256379; ENSG00000133997 [O75586-1]
ENST00000430055; ENSP00000413343; ENSG00000133997 [O75586-2]
ENST00000440435; ENSP00000394502; ENSG00000133997 [O75586-3]
GeneIDi10001
KEGGihsa:10001
UCSCiuc001xmf.5 human [O75586-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10001
EuPathDBiHostDB:ENSG00000133997.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MED6
HGNCiHGNC:19970 MED6
HPAiHPA030764
HPA069039
MIMi602984 gene
neXtProtiNX_O75586
OpenTargetsiENSG00000133997
PharmGKBiPA134868263

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3169 Eukaryota
COG5097 LUCA
GeneTreeiENSGT00390000017666
HOGENOMiHOG000035127
HOVERGENiHBG006825
InParanoidiO75586
KOiK15128
OrthoDBi1251252at2759
PhylomeDBiO75586
TreeFamiTF313577

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MED6 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MED6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10001

Protein Ontology

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PROi
PR:O75586

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000133997 Expressed in 207 organ(s), highest expression level in intestine
CleanExiHS_MED6
ExpressionAtlasiO75586 baseline and differential
GenevisibleiO75586 HS

Family and domain databases

Gene3Di3.10.450.580, 1 hit
InterProiView protein in InterPro
IPR038566 Med6_sf
IPR007018 Mediator_Med6
IPR016820 Mediator_Med6_met/pln
PANTHERiPTHR13104 PTHR13104, 1 hit
PfamiView protein in Pfam
PF04934 Med6, 1 hit
PIRSFiPIRSF023869 Mediator_MED6_meta/pln, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75586
Secondary accession number(s): B4DU17
, B4E2P0, O15401, Q53FE3, Q53HJ3, Q6FHQ4, Q9BTH1, Q9UHL1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: February 28, 2003
Last modified: January 16, 2019
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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