UniProtKB - O75582 (KS6A5_HUMAN)
Ribosomal protein S6 kinase alpha-5
RPS6KA5
Functioni
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047).
Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047).
Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904).
In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924).
In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138).
Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367).
Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469).
Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393).
May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393).
Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393).
In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity).
Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity).
Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity).
Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810).
By similarity10 PublicationsMiscellaneous
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 81 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 177 | Proton acceptorBy similarity | 1 | |
Binding sitei | 455 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 544 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 55 – 63 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 432 – 440 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- magnesium ion binding Source: InterPro
- protein kinase activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- axon guidance Source: Reactome
- epidermal growth factor receptor signaling pathway Source: UniProtKB
- histone H2A-S1 phosphorylation Source: UniProtKB
- histone H3-S10 phosphorylation Source: UniProtKB
- histone H3-S28 phosphorylation Source: UniProtKB
- histone phosphorylation Source: UniProtKB
- inflammatory response Source: UniProtKB-KW
- interleukin-1-mediated signaling pathway Source: BHF-UCL
- intracellular signal transduction Source: UniProtKB
- negative regulation of cytokine production Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- peptidyl-serine phosphorylation Source: GO_Central
- positive regulation of CREB transcription factor activity Source: UniProtKB
- positive regulation of histone acetylation Source: BHF-UCL
- positive regulation of histone phosphorylation Source: BHF-UCL
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- protein phosphorylation Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Inflammatory response, Stress response |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O75582 |
Reactomei | R-HSA-198753, ERK/MAPK targets R-HSA-199920, CREB phosphorylation R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-437239, Recycling pathway of L1 R-HSA-5621575, CD209 (DC-SIGN) signaling |
SABIO-RKi | O75582 |
SignaLinki | O75582 |
SIGNORi | O75582 |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosomal protein S6 kinase alpha-5 (EC:2.7.11.1)Short name: S6K-alpha-5 Alternative name(s): 90 kDa ribosomal protein S6 kinase 5 Nuclear mitogen- and stress-activated protein kinase 1 RSK-like protein kinase Short name: RSKL |
Gene namesi | Name:RPS6KA5 Synonyms:MSK1 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10434, RPS6KA5 |
MIMi | 603607, gene |
neXtProti | NX_O75582 |
VEuPathDBi | HostDB:ENSG00000100784 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 195 | D → A: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 212 | S → A: Inactivates the N-terminal kinase domain. 1 Publication | 1 | |
Mutagenesisi | 360 | S → A: Decreases kinase activity by 60% in response to PMA and UV-C. 1 Publication | 1 | |
Mutagenesisi | 376 | S → A: Loss of kinase activity, and decreases the phosphorylation of S-360 and T-581. 1 Publication | 1 | |
Mutagenesisi | 565 | D → A: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 581 | T → A: Loss of kinase activity, and blocks phosphorylation of S-212; S-376 and S-381 in response to PMA and UV-C. 1 Publication | 1 | |
Mutagenesisi | 700 | T → A or D: Strongly reduces phosphorylation of T-581 in response to PMA and UV-C. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9252 |
OpenTargetsi | ENSG00000100784 |
PharmGKBi | PA34849 |
Miscellaneous databases
Pharosi | O75582, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4237 |
DrugCentrali | O75582 |
GuidetoPHARMACOLOGYi | 1523 |
Genetic variation databases
BioMutai | RPS6KA5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086207 | 1 – 802 | Ribosomal protein S6 kinase alpha-5Add BLAST | 802 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 212 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 360 | Phosphoserine; by MAPK1, MAPK3 and MAPK141 Publication | 1 | |
Modified residuei | 376 | Phosphoserine; by autocatalysisCombined sources1 Publication | 1 | |
Modified residuei | 381 | Phosphoserine; by autocatalysisCombined sources1 Publication | 1 | |
Modified residuei | 581 | Phosphothreonine; by MAPK1, MAPK3 and MAPK141 Publication | 1 | |
Modified residuei | 647 | Phosphoserine1 Publication | 1 | |
Modified residuei | 657 | Phosphoserine1 Publication | 1 | |
Modified residuei | 691 | PhosphoserineBy similarity | 1 | |
Modified residuei | 695 | Phosphoserine1 Publication | 1 | |
Modified residuei | 700 | Phosphothreonine; by MAPK1, MAPK3 and MAPK141 Publication | 1 | |
Modified residuei | 750 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 752 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 758 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 798 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O75582 |
jPOSTi | O75582 |
MassIVEi | O75582 |
MaxQBi | O75582 |
PaxDbi | O75582 |
PeptideAtlasi | O75582 |
PRIDEi | O75582 |
ProteomicsDBi | 50098 [O75582-1] 50099 [O75582-2] 6477 |
PTM databases
GlyGeni | O75582, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O75582 |
PhosphoSitePlusi | O75582 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000100784, Expressed in caudate nucleus and 249 other tissues |
ExpressionAtlasi | O75582, baseline and differential |
Genevisiblei | O75582, HS |
Organism-specific databases
HPAi | ENSG00000100784, Low tissue specificity |
Interactioni
Subunit structurei
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.
Interacts with CREBBP and EP300.
2 PublicationsBinary interactionsi
O75582
With | #Exp. | IntAct |
---|---|---|
CTNNA3 - isoform 2 [Q9UI47-2] | 3 | EBI-73869,EBI-11962928 |
KDM3A [Q9Y4C1] | 3 | EBI-73869,EBI-2515339 |
MAP3K20 [Q9NYL2] | 4 | EBI-73869,EBI-602273 |
Isoform 1 [O75582-1]
With | #Exp. | IntAct |
---|---|---|
KDM3A [Q9Y4C1] | 3 | EBI-16135973,EBI-2515339 |
Protein-protein interaction databases
BioGRIDi | 114676, 69 interactors |
DIPi | DIP-30894N |
ELMi | O75582 |
IntActi | O75582, 39 interactors |
MINTi | O75582 |
STRINGi | 9606.ENSP00000479667 |
Chemistry databases
BindingDBi | O75582 |
Miscellaneous databases
RNActi | O75582, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O75582 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O75582 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 318 | Protein kinase 1PROSITE-ProRule annotationAdd BLAST | 270 | |
Domaini | 319 – 387 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 426 – 687 | Protein kinase 2PROSITE-ProRule annotationAdd BLAST | 262 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 741 – 802 | DisorderedSequence analysisAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 752 – 802 | Polar residuesSequence analysisAdd BLAST | 51 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0603, Eukaryota |
GeneTreei | ENSGT00940000156886 |
InParanoidi | O75582 |
OMAi | MTPCFTL |
OrthoDBi | 181575at2759 |
PhylomeDBi | O75582 |
TreeFami | TF313438 |
Family and domain databases
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016239, Ribosomal_S6_kinase_II IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 2 hits PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000606, Ribsml_S6_kin_2, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 2 hits |
SUPFAMi | SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 2 hits PS50011, PROTEIN_KINASE_DOM, 2 hits PS00108, PROTEIN_KINASE_ST, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEEGGSSGG AAGTSADGGD GGEQLLTVKH ELRTANLTGH AEKVGIENFE
60 70 80 90 100
LLKVLGTGAY GKVFLVRKIS GHDTGKLYAM KVLKKATIVQ KAKTTEHTRT
110 120 130 140 150
ERQVLEHIRQ SPFLVTLHYA FQTETKLHLI LDYINGGELF THLSQRERFT
160 170 180 190 200
EHEVQIYVGE IVLALEHLHK LGIIYRDIKL ENILLDSNGH VVLTDFGLSK
210 220 230 240 250
EFVADETERA YSFCGTIEYM APDIVRGGDS GHDKAVDWWS LGVLMYELLT
260 270 280 290 300
GASPFTVDGE KNSQAEISRR ILKSEPPYPQ EMSALAKDLI QRLLMKDPKK
310 320 330 340 350
RLGCGPRDAD EIKEHLFFQK INWDDLAAKK VPAPFKPVIR DELDVSNFAE
360 370 380 390 400
EFTEMDPTYS PAALPQSSEK LFQGYSFVAP SILFKRNAAV IDPLQFHMGV
410 420 430 440 450
ERPGVTNVAR SAMMKDSPFY QHYDLDLKDK PLGEGSFSIC RKCVHKKSNQ
460 470 480 490 500
AFAVKIISKR MEANTQKEIT ALKLCEGHPN IVKLHEVFHD QLHTFLVMEL
510 520 530 540 550
LNGGELFERI KKKKHFSETE ASYIMRKLVS AVSHMHDVGV VHRDLKPENL
560 570 580 590 600
LFTDENDNLE IKIIDFGFAR LKPPDNQPLK TPCFTLHYAA PELLNQNGYD
610 620 630 640 650
ESCDLWSLGV ILYTMLSGQV PFQSHDRSLT CTSAVEIMKK IKKGDFSFEG
660 670 680 690 700
EAWKNVSQEA KDLIQGLLTV DPNKRLKMSG LRYNEWLQDG SQLSSNPLMT
710 720 730 740 750
PDILGSSGAA VHTCVKATFH AFNKYKREGF CLQNVDKAPL AKRRKMKKTS
760 770 780 790 800
TSTETRSSSS ESSHSSSSHS HGKTTPTKTL QPSNPADSNN PETLFQFSDS
VA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V2D1 | G3V2D1_HUMAN | Ribosomal protein S6 kinase alpha-5 | RPS6KA5 | 219 | Annotation score: | ||
A0A3B3ISL8 | A0A3B3ISL8_HUMAN | Ribosomal protein S6 kinase alpha-5 | RPS6KA5 | 207 | Annotation score: | ||
H0YJE1 | H0YJE1_HUMAN | Ribosomal protein S6 kinase alpha-5 | RPS6KA5 | 79 | Annotation score: | ||
G3V4D7 | G3V4D7_HUMAN | Ribosomal protein S6 kinase alpha-5 | RPS6KA5 | 83 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 452 – 453 | FA → LQ in AAC69577 (PubMed:10702687).Curated | 2 | |
Sequence conflicti | 532 | V → L in AAC69577 (PubMed:10702687).Curated | 1 | |
Sequence conflicti | 538 | V → L in AAC69577 (PubMed:10702687).Curated | 1 | |
Sequence conflicti | 757 – 758 | SS → RG in AAC69577 (PubMed:10702687).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051634 | 190 | H → R. Corresponds to variant dbSNP:rs34699345Ensembl. | 1 | |
Natural variantiVAR_040634 | 554 | D → N1 PublicationCorresponds to variant dbSNP:rs55911249Ensembl. | 1 | |
Natural variantiVAR_040635 | 574 | P → L1 PublicationCorresponds to variant dbSNP:rs34604933Ensembl. | 1 | |
Natural variantiVAR_040636 | 599 | Y → C1 PublicationCorresponds to variant dbSNP:rs55968863Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057410 | 1 – 79 | Missing in isoform 3. 1 PublicationAdd BLAST | 79 | |
Alternative sequenceiVSP_041837 | 549 | N → V in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_041838 | 550 – 802 | Missing in isoform 2. 1 PublicationAdd BLAST | 253 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF074393 mRNA Translation: AAC31171.1 AF080000 mRNA Translation: AAD23915.1 AF090421 mRNA Translation: AAC69577.1 Frameshift. AK295266 mRNA Translation: BAH12021.1 AL121784 Genomic DNA No translation available. AL133454 Genomic DNA No translation available. AL159191 Genomic DNA No translation available. BC017187 mRNA Translation: AAH17187.1 |
CCDSi | CCDS45149.1 [O75582-2] CCDS81839.1 [O75582-3] CCDS9893.1 [O75582-1] |
PIRi | T13149 |
RefSeqi | NP_001309164.1, NM_001322235.1 [O75582-3] NP_001309166.1, NM_001322237.1 [O75582-3] NP_004746.2, NM_004755.3 [O75582-1] NP_872198.1, NM_182398.2 [O75582-2] |
Genome annotation databases
Ensembli | ENST00000418736; ENSP00000402787; ENSG00000100784 [O75582-2] ENST00000536315; ENSP00000442803; ENSG00000100784 [O75582-3] ENST00000614987; ENSP00000479667; ENSG00000100784 |
GeneIDi | 9252 |
KEGGi | hsa:9252 |
MANE-Selecti | ENST00000614987.5; ENSP00000479667.1; NM_004755.4; NP_004746.2 |
UCSCi | uc001xys.4, human [O75582-1] uc010twi.3, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF074393 mRNA Translation: AAC31171.1 AF080000 mRNA Translation: AAD23915.1 AF090421 mRNA Translation: AAC69577.1 Frameshift. AK295266 mRNA Translation: BAH12021.1 AL121784 Genomic DNA No translation available. AL133454 Genomic DNA No translation available. AL159191 Genomic DNA No translation available. BC017187 mRNA Translation: AAH17187.1 |
CCDSi | CCDS45149.1 [O75582-2] CCDS81839.1 [O75582-3] CCDS9893.1 [O75582-1] |
PIRi | T13149 |
RefSeqi | NP_001309164.1, NM_001322235.1 [O75582-3] NP_001309166.1, NM_001322237.1 [O75582-3] NP_004746.2, NM_004755.3 [O75582-1] NP_872198.1, NM_182398.2 [O75582-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1VZO | X-ray | 1.80 | A | 2-348 | [»] | |
3KN5 | X-ray | 2.40 | A/B | 414-738 | [»] | |
3KN6 | X-ray | 2.00 | A/B | 414-738 | [»] | |
SMRi | O75582 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114676, 69 interactors |
DIPi | DIP-30894N |
ELMi | O75582 |
IntActi | O75582, 39 interactors |
MINTi | O75582 |
STRINGi | 9606.ENSP00000479667 |
Chemistry databases
BindingDBi | O75582 |
ChEMBLi | CHEMBL4237 |
DrugCentrali | O75582 |
GuidetoPHARMACOLOGYi | 1523 |
PTM databases
GlyGeni | O75582, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O75582 |
PhosphoSitePlusi | O75582 |
Genetic variation databases
BioMutai | RPS6KA5 |
Proteomic databases
EPDi | O75582 |
jPOSTi | O75582 |
MassIVEi | O75582 |
MaxQBi | O75582 |
PaxDbi | O75582 |
PeptideAtlasi | O75582 |
PRIDEi | O75582 |
ProteomicsDBi | 50098 [O75582-1] 50099 [O75582-2] 6477 |
Protocols and materials databases
Antibodypediai | 83, 957 antibodies from 42 providers |
DNASUi | 9252 |
Genome annotation databases
Ensembli | ENST00000418736; ENSP00000402787; ENSG00000100784 [O75582-2] ENST00000536315; ENSP00000442803; ENSG00000100784 [O75582-3] ENST00000614987; ENSP00000479667; ENSG00000100784 |
GeneIDi | 9252 |
KEGGi | hsa:9252 |
MANE-Selecti | ENST00000614987.5; ENSP00000479667.1; NM_004755.4; NP_004746.2 |
UCSCi | uc001xys.4, human [O75582-1] uc010twi.3, human |
Organism-specific databases
CTDi | 9252 |
DisGeNETi | 9252 |
GeneCardsi | RPS6KA5 |
HGNCi | HGNC:10434, RPS6KA5 |
HPAi | ENSG00000100784, Low tissue specificity |
MIMi | 603607, gene |
neXtProti | NX_O75582 |
OpenTargetsi | ENSG00000100784 |
PharmGKBi | PA34849 |
VEuPathDBi | HostDB:ENSG00000100784 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0603, Eukaryota |
GeneTreei | ENSGT00940000156886 |
InParanoidi | O75582 |
OMAi | MTPCFTL |
OrthoDBi | 181575at2759 |
PhylomeDBi | O75582 |
TreeFami | TF313438 |
Enzyme and pathway databases
PathwayCommonsi | O75582 |
Reactomei | R-HSA-198753, ERK/MAPK targets R-HSA-199920, CREB phosphorylation R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-437239, Recycling pathway of L1 R-HSA-5621575, CD209 (DC-SIGN) signaling |
SABIO-RKi | O75582 |
SignaLinki | O75582 |
SIGNORi | O75582 |
Miscellaneous databases
BioGRID-ORCSi | 9252, 5 hits in 1076 CRISPR screens |
ChiTaRSi | RPS6KA5, human |
EvolutionaryTracei | O75582 |
GeneWikii | RPS6KA5 |
GenomeRNAii | 9252 |
Pharosi | O75582, Tchem |
PROi | PR:O75582 |
RNActi | O75582, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100784, Expressed in caudate nucleus and 249 other tissues |
ExpressionAtlasi | O75582, baseline and differential |
Genevisiblei | O75582, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016239, Ribosomal_S6_kinase_II IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 2 hits PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000606, Ribsml_S6_kin_2, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 2 hits |
SUPFAMi | SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 2 hits PS50011, PROTEIN_KINASE_DOM, 2 hits PS00108, PROTEIN_KINASE_ST, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KS6A5_HUMAN | |
Accessioni | O75582Primary (citable) accession number: O75582 Secondary accession number(s): B7Z2Y5, O95316, Q96AF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 24, 2003 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 210 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families