UniProtKB - O75570 (RF1M_HUMAN)
Protein
Peptide chain release factor 1, mitochondrial
Gene
MTRF1
Organism
Homo sapiens (Human)
Status
Functioni
Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.
GO - Molecular functioni
- translation release factor activity Source: ProtInc
GO - Biological processi
- mitochondrial translational termination Source: GO_Central
- regulation of translational termination Source: ProtInc
Keywordsi
Biological process | Protein biosynthesis |
Enzyme and pathway databases
PathwayCommonsi | O75570 |
Names & Taxonomyi
Protein namesi | Recommended name: Peptide chain release factor 1, mitochondrialShort name: MRF-1 Short name: MtRF-1 |
Gene namesi | Name:MTRF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7469, MTRF1 |
MIMi | 604601, gene |
neXtProti | NX_O75570 |
VEuPathDBi | HostDB:ENSG00000120662.15 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Mitochondrion
- mitochondrion Source: GO_Central
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 9617 |
OpenTargetsi | ENSG00000120662 |
PharmGKBi | PA31273 |
Miscellaneous databases
Pharosi | O75570, Tbio |
Genetic variation databases
BioMutai | MTRF1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | MitochondrionSequence analysis | ||
ChainiPRO_0000030333 | ? – 445 | Peptide chain release factor 1, mitochondrial |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 313 | N5-methylglutamineBy similarity | 1 |
Post-translational modificationi
Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity
Keywords - PTMi
MethylationProteomic databases
EPDi | O75570 |
jPOSTi | O75570 |
MassIVEi | O75570 |
MaxQBi | O75570 |
PaxDbi | O75570 |
PeptideAtlasi | O75570 |
PRIDEi | O75570 |
ProteomicsDBi | 4093 50091 [O75570-1] |
PTM databases
iPTMneti | O75570 |
PhosphoSitePlusi | O75570 |
SwissPalmi | O75570 |
Expressioni
Gene expression databases
Bgeei | ENSG00000120662, Expressed in body of pancreas and 216 other tissues |
ExpressionAtlasi | O75570, baseline and differential |
Genevisiblei | O75570, HS |
Organism-specific databases
HPAi | ENSG00000120662, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 114978, 27 interactors |
IntActi | O75570, 3 interactors |
STRINGi | 9606.ENSP00000368793 |
Miscellaneous databases
RNActi | O75570, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the prokaryotic/mitochondrial release factor family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2726, Eukaryota |
GeneTreei | ENSGT00940000156877 |
HOGENOMi | CLU_036856_0_3_1 |
InParanoidi | O75570 |
OMAi | FLCGEKC |
OrthoDBi | 1313171at2759 |
PhylomeDBi | O75570 |
TreeFami | TF313720 |
Family and domain databases
InterProi | View protein in InterPro IPR005139, PCRF IPR000352, Pep_chain_release_fac_I |
Pfami | View protein in Pfam PF03462, PCRF, 1 hit PF00472, RF-1, 1 hit |
SMARTi | View protein in SMART SM00937, PCRF, 1 hit |
PROSITEi | View protein in PROSITE PS00745, RF_PROK_I, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O75570-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNRHLCVWLF RHPSLNGYLQ CHIQLHSHQF RQIHLDTRLQ VFRQNRNCIL
60 70 80 90 100
HLLSKNWSRR YCHQDTKMLW KHKALQKYME NLSKEYQTLE QCLQHIPVNE
110 120 130 140 150
ENRRSLNRRH AELAPLAAIY QEIQETEQAI EELESMCKSL NKQDEKQLQE
160 170 180 190 200
LALEERQTID QKINMLYNEL FQSLVPKEKY DKNDVILEVT AGRTTGGDIC
210 220 230 240 250
QQFTREIFDM YQNYSCYKHW QFELLNYTPA DYGGLHHAAA RISGDGVYKH
260 270 280 290 300
LKYEGGIHRV QRIPEVGLSS RMQRIHTGTM SVIVLPQPDE VDVKLDPKDL
310 320 330 340 350
RIDTFRAKGA GGQHVNKTDS AVRLVHIPTG LVVECQQERS QIKNKEIAFR
360 370 380 390 400
VLRARLYQQI IEKDKRQQQS ARKLQVGTRA QSERIRTYNF TQDRVSDHRI
410 420 430 440
AYEVRDIKEF LCGGKGLDQL IQRLLQSADE EAIAELLDEH LKSAK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketX6RFD4 | X6RFD4_HUMAN | Peptide chain release factor 1, mit... | MTRF1 | 226 | Annotation score: | ||
A0A087WZ41 | A0A087WZ41_HUMAN | Peptide chain release factor 1, mit... | MTRF1 | 137 | Annotation score: | ||
Q8N6Z2 | Q8N6Z2_HUMAN | MTRF1 protein | MTRF1 hCG_32761 | 151 | Annotation score: | ||
A0A087X1S1 | A0A087X1S1_HUMAN | Peptide chain release factor 1, mit... | MTRF1 | 153 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 63 | H → L in AAD12759 (PubMed:9838146).Curated | 1 | |
Sequence conflicti | 71 | K → N in AAD12759 (PubMed:9838146).Curated | 1 | |
Sequence conflicti | 102 | N → S in AAD12759 (PubMed:9838146).Curated | 1 | |
Sequence conflicti | 123 | I → T in AAD12759 (PubMed:9838146).Curated | 1 | |
Sequence conflicti | 134 | E → G in AAD12759 (PubMed:9838146).Curated | 1 | |
Sequence conflicti | 143 | Q → R in AAD12759 (PubMed:9838146).Curated | 1 | |
Sequence conflicti | 149 | Q → L in AAD12759 (PubMed:9838146).Curated | 1 | |
Sequence conflicti | 224 | L → P in AAD12759 (PubMed:9838146).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024603 | 2 | N → S. Corresponds to variant dbSNP:rs9532758Ensembl. | 1 | |
Natural variantiVAR_034447 | 324 | L → V. Corresponds to variant dbSNP:rs9566725Ensembl. | 1 | |
Natural variantiVAR_051789 | 407 | I → V. Corresponds to variant dbSNP:rs9315812Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055858 | 1 | M → MGNGEVVLFSDAEM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_055859 | 409 – 445 | EFLCG…LKSAK → AQSHSTGGSRDPAHSTFLSL DSVRSPGILIMTSSVRNFYV VGRAWIS in isoform 2. 1 PublicationAdd BLAST | 37 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000379477; ENSP00000368790; ENSG00000120662 [O75570-1] ENST00000379480; ENSP00000368793; ENSG00000120662 [O75570-1] |
GeneIDi | 9617 |
KEGGi | hsa:9617 |
UCSCi | uc001uxx.4, human [O75570-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | O75570 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114978, 27 interactors |
IntActi | O75570, 3 interactors |
STRINGi | 9606.ENSP00000368793 |
PTM databases
iPTMneti | O75570 |
PhosphoSitePlusi | O75570 |
SwissPalmi | O75570 |
Genetic variation databases
BioMutai | MTRF1 |
Proteomic databases
EPDi | O75570 |
jPOSTi | O75570 |
MassIVEi | O75570 |
MaxQBi | O75570 |
PaxDbi | O75570 |
PeptideAtlasi | O75570 |
PRIDEi | O75570 |
ProteomicsDBi | 4093 50091 [O75570-1] |
Protocols and materials databases
Antibodypediai | 23394, 143 antibodies |
Genome annotation databases
Ensembli | ENST00000379477; ENSP00000368790; ENSG00000120662 [O75570-1] ENST00000379480; ENSP00000368793; ENSG00000120662 [O75570-1] |
GeneIDi | 9617 |
KEGGi | hsa:9617 |
UCSCi | uc001uxx.4, human [O75570-1] |
Organism-specific databases
CTDi | 9617 |
DisGeNETi | 9617 |
GeneCardsi | MTRF1 |
HGNCi | HGNC:7469, MTRF1 |
HPAi | ENSG00000120662, Low tissue specificity |
MIMi | 604601, gene |
neXtProti | NX_O75570 |
OpenTargetsi | ENSG00000120662 |
PharmGKBi | PA31273 |
VEuPathDBi | HostDB:ENSG00000120662.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2726, Eukaryota |
GeneTreei | ENSGT00940000156877 |
HOGENOMi | CLU_036856_0_3_1 |
InParanoidi | O75570 |
OMAi | FLCGEKC |
OrthoDBi | 1313171at2759 |
PhylomeDBi | O75570 |
TreeFami | TF313720 |
Enzyme and pathway databases
PathwayCommonsi | O75570 |
Miscellaneous databases
BioGRID-ORCSi | 9617, 40 hits in 878 CRISPR screens |
ChiTaRSi | MTRF1, human |
GeneWikii | MTRF1 |
GenomeRNAii | 9617 |
Pharosi | O75570, Tbio |
PROi | PR:O75570 |
RNActi | O75570, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000120662, Expressed in body of pancreas and 216 other tissues |
ExpressionAtlasi | O75570, baseline and differential |
Genevisiblei | O75570, HS |
Family and domain databases
InterProi | View protein in InterPro IPR005139, PCRF IPR000352, Pep_chain_release_fac_I |
Pfami | View protein in Pfam PF03462, PCRF, 1 hit PF00472, RF-1, 1 hit |
SMARTi | View protein in SMART SM00937, PCRF, 1 hit |
PROSITEi | View protein in PROSITE PS00745, RF_PROK_I, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RF1M_HUMAN | |
Accessioni | O75570Primary (citable) accession number: O75570 Secondary accession number(s): B4DG01, Q5T6Y5, Q8IUQ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | April 12, 2005 | |
Last modified: | February 10, 2021 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants