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UniProtKB - O75570 (RF1M_HUMAN)

Entry version 165 (10 Feb 2021)
Sequence version 2 (12 Apr 2005)
Previous versions | rss
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Protein

Peptide chain release factor 1, mitochondrial

Gene

MTRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • translation release factor activity Source: ProtInc
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein biosynthesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75570

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptide chain release factor 1, mitochondrial
Short name:
MRF-1
Short name:
MtRF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTRF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7469, MTRF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604601, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75570

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000120662.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9617

Open Targets

More...OpenTargetsi		ENSG00000120662

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31273

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75570, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MTRF1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000030333? – 445Peptide chain release factor 1, mitochondrial

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei313N5-methylglutamineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75570

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75570

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75570

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75570

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75570

PeptideAtlas

More...PeptideAtlasi		O75570

PRoteomics IDEntifications database

More...PRIDEi		O75570

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4093
50091 [O75570-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75570

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75570

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O75570

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000120662, Expressed in body of pancreas and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75570, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75570, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000120662, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114978, 27 interactors

Protein interaction database and analysis system

More...IntActi		O75570, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000368793

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75570, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75570

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prokaryotic/mitochondrial release factor family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2726, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156877

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_036856_0_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75570

Identification of Orthologs from Complete Genome Data

More...OMAi		FLCGEKC

Database of Orthologous Groups

More...OrthoDBi		1313171at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75570

TreeFam database of animal gene trees

More...TreeFami		TF313720

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005139, PCRF
IPR000352, Pep_chain_release_fac_I

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03462, PCRF, 1 hit
PF00472, RF-1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00937, PCRF, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00745, RF_PROK_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75570-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNRHLCVWLF RHPSLNGYLQ CHIQLHSHQF RQIHLDTRLQ VFRQNRNCIL 
        60         70         80         90        100
HLLSKNWSRR YCHQDTKMLW KHKALQKYME NLSKEYQTLE QCLQHIPVNE 
       110        120        130        140        150
ENRRSLNRRH AELAPLAAIY QEIQETEQAI EELESMCKSL NKQDEKQLQE 
       160        170        180        190        200
LALEERQTID QKINMLYNEL FQSLVPKEKY DKNDVILEVT AGRTTGGDIC 
       210        220        230        240        250
QQFTREIFDM YQNYSCYKHW QFELLNYTPA DYGGLHHAAA RISGDGVYKH 
       260        270        280        290        300
LKYEGGIHRV QRIPEVGLSS RMQRIHTGTM SVIVLPQPDE VDVKLDPKDL 
       310        320        330        340        350
RIDTFRAKGA GGQHVNKTDS AVRLVHIPTG LVVECQQERS QIKNKEIAFR 
       360        370        380        390        400
VLRARLYQQI IEKDKRQQQS ARKLQVGTRA QSERIRTYNF TQDRVSDHRI 
       410        420        430        440 
AYEVRDIKEF LCGGKGLDQL IQRLLQSADE EAIAELLDEH LKSAK
Length:445
Mass (Da):52,306
Last modified:April 12, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3DC637D90F04C6F7
GO
Isoform 2 (identifier: O75570-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGNGEVVLFSDAEM
     409-445: EFLCGGKGLD...LLDEHLKSAK → AQSHSTGGSR...FYVVGRAWIS

Show »
Length:468
Mass (Da):54,622
Checksum:iC344E292BE468528
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RFD4X6RFD4_HUMAN
Peptide chain release factor 1, mit...
MTRF1
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ41A0A087WZ41_HUMAN
Peptide chain release factor 1, mit...
MTRF1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8N6Z2Q8N6Z2_HUMAN
MTRF1 protein
MTRF1 hCG_32761
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1S1A0A087X1S1_HUMAN
Peptide chain release factor 1, mit...
MTRF1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63H → L in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti71K → N in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti102N → S in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti123I → T in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti134E → G in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti143Q → R in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti149Q → L in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti224L → P in AAD12759 (PubMed:9838146).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0246032N → S. Corresponds to variant dbSNP:rs9532758Ensembl.1
Natural variantiVAR_034447324L → V. Corresponds to variant dbSNP:rs9566725Ensembl.1
Natural variantiVAR_051789407I → V. Corresponds to variant dbSNP:rs9315812Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0558581M → MGNGEVVLFSDAEM in isoform 2. 1 Publication1
Alternative sequenceiVSP_055859409 – 445EFLCG…LKSAK → AQSHSTGGSRDPAHSTFLSL DSVRSPGILIMTSSVRNFYV VGRAWIS in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF072934 mRNA Translation: AAD12759.1
AK294343 mRNA Translation: BAG57612.1
AL354696 Genomic DNA No translation available.
BC042196 mRNA Translation: AAH42196.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9378.1 [O75570-1]

NCBI Reference Sequences

More...RefSeqi		NP_004285.2, NM_004294.2 [O75570-1]
XP_005266656.1, XM_005266599.2
XP_006719960.1, XM_006719897.2
XP_006719961.1, XM_006719898.2 [O75570-1]
XP_006719963.1, XM_006719900.2 [O75570-1]
XP_011533620.1, XM_011535318.2 [O75570-1]
XP_011533622.1, XM_011535320.2 [O75570-1]
XP_011533623.1, XM_011535321.2 [O75570-1]
XP_011533625.1, XM_011535323.2 [O75570-1]
XP_011533627.1, XM_011535325.2 [O75570-1]
XP_016876351.1, XM_017020862.1
XP_016876352.1, XM_017020863.1
XP_016876353.1, XM_017020864.1
XP_016876354.1, XM_017020865.1 [O75570-1]
XP_016876355.1, XM_017020866.1 [O75570-1]
XP_016876356.1, XM_017020867.1 [O75570-1]
XP_016876357.1, XM_017020868.1 [O75570-1]
XP_016876358.1, XM_017020869.1 [O75570-1]
XP_016876362.1, XM_017020873.1
XP_016876363.1, XM_017020874.1 [O75570-1]
XP_016876364.1, XM_017020875.1 [O75570-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000379477; ENSP00000368790; ENSG00000120662 [O75570-1]
ENST00000379480; ENSP00000368793; ENSG00000120662 [O75570-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9617

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9617

UCSC genome browser

More...UCSCi		uc001uxx.4, human [O75570-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072934 mRNA Translation: AAD12759.1
AK294343 mRNA Translation: BAG57612.1
AL354696 Genomic DNA No translation available.
BC042196 mRNA Translation: AAH42196.1
CCDSiCCDS9378.1 [O75570-1]
RefSeqiNP_004285.2, NM_004294.2 [O75570-1]
XP_005266656.1, XM_005266599.2
XP_006719960.1, XM_006719897.2
XP_006719961.1, XM_006719898.2 [O75570-1]
XP_006719963.1, XM_006719900.2 [O75570-1]
XP_011533620.1, XM_011535318.2 [O75570-1]
XP_011533622.1, XM_011535320.2 [O75570-1]
XP_011533623.1, XM_011535321.2 [O75570-1]
XP_011533625.1, XM_011535323.2 [O75570-1]
XP_011533627.1, XM_011535325.2 [O75570-1]
XP_016876351.1, XM_017020862.1
XP_016876352.1, XM_017020863.1
XP_016876353.1, XM_017020864.1
XP_016876354.1, XM_017020865.1 [O75570-1]
XP_016876355.1, XM_017020866.1 [O75570-1]
XP_016876356.1, XM_017020867.1 [O75570-1]
XP_016876357.1, XM_017020868.1 [O75570-1]
XP_016876358.1, XM_017020869.1 [O75570-1]
XP_016876362.1, XM_017020873.1
XP_016876363.1, XM_017020874.1 [O75570-1]
XP_016876364.1, XM_017020875.1 [O75570-1]

3D structure databases

SMRiO75570
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114978, 27 interactors
IntActiO75570, 3 interactors
STRINGi9606.ENSP00000368793

PTM databases

iPTMnetiO75570
PhosphoSitePlusiO75570
SwissPalmiO75570

Genetic variation databases

BioMutaiMTRF1

Proteomic databases

EPDiO75570
jPOSTiO75570
MassIVEiO75570
MaxQBiO75570
PaxDbiO75570
PeptideAtlasiO75570
PRIDEiO75570
ProteomicsDBi4093
50091 [O75570-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23394, 143 antibodies

Genome annotation databases

EnsembliENST00000379477; ENSP00000368790; ENSG00000120662 [O75570-1]
ENST00000379480; ENSP00000368793; ENSG00000120662 [O75570-1]
GeneIDi9617
KEGGihsa:9617
UCSCiuc001uxx.4, human [O75570-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9617
DisGeNETi9617

GeneCards: human genes, protein and diseases

More...GeneCardsi		MTRF1
HGNCiHGNC:7469, MTRF1
HPAiENSG00000120662, Low tissue specificity
MIMi604601, gene
neXtProtiNX_O75570
OpenTargetsiENSG00000120662
PharmGKBiPA31273
VEuPathDBiHostDB:ENSG00000120662.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2726, Eukaryota
GeneTreeiENSGT00940000156877
HOGENOMiCLU_036856_0_3_1
InParanoidiO75570
OMAiFLCGEKC
OrthoDBi1313171at2759
PhylomeDBiO75570
TreeFamiTF313720

Enzyme and pathway databases

PathwayCommonsiO75570

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9617, 40 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MTRF1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MTRF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9617
PharosiO75570, Tbio

Protein Ontology

More...PROi		PR:O75570
RNActiO75570, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000120662, Expressed in body of pancreas and 216 other tissues
ExpressionAtlasiO75570, baseline and differential
GenevisibleiO75570, HS

Family and domain databases

InterProiView protein in InterPro
IPR005139, PCRF
IPR000352, Pep_chain_release_fac_I
PfamiView protein in Pfam
PF03462, PCRF, 1 hit
PF00472, RF-1, 1 hit
SMARTiView protein in SMART
SM00937, PCRF, 1 hit
PROSITEiView protein in PROSITE
PS00745, RF_PROK_I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRF1M_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75570
Secondary accession number(s): B4DG01, Q5T6Y5, Q8IUQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 12, 2005
Last modified: February 10, 2021
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with genetic variants
    List of human entries with genetic variants
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