UniProtKB - O75570 (RF1M_HUMAN)

BLAST

>sp|O75570|RF1M_HUMAN Peptide chain release factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=MTRF1 PE=1 SV=2
MNRHLCVWLFRHPSLNGYLQCHIQLHSHQFRQIHLDTRLQVFRQNRNCILHLLSKNWSRR
YCHQDTKMLWKHKALQKYMENLSKEYQTLEQCLQHIPVNEENRRSLNRRHAELAPLAAIY
QEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKINMLYNELFQSLVPKEKY
DKNDVILEVTAGRTTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAA
RISGDGVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDL
RIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQI
IEKDKRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKEFLCGGKGLDQL
IQRLLQSADEEAIAELLDEHLKSAK

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History
Entry version 148 (07 Nov 2018)
Sequence version 2 (12 Apr 2005)
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Protein

Peptide chain release factor 1, mitochondrial

Gene

MTRF1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.

GO - Molecular functionⁱ

translation release factor activity
Source: ProtInc
Traceable author statementⁱ
- 9838146

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial translational termination
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of translational termination
Source: ProtInc
Traceable author statementⁱ
- 9838146
translational termination
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein biosynthesis

Biological process

Protein biosynthesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peptide chain release factor 1, mitochondrial Short name: MRF-1 Short name: MtRF-1
Gene namesⁱ	Name:MTRF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000120662.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7469 MTRF1
MIMⁱ	604601 gene
neXtProtⁱ	NX_O75570

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9617
Open Targets More...OpenTargetsⁱ	ENSG00000120662
PharmGKBⁱ	PA31273

Polymorphism and mutation databases

BioMutaⁱ	MTRF1

BioMutaⁱ

MTRF1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000030333	? – 445	Peptide chain release factor 1, mitochondrial
Transit peptideⁱ	1 – ?	MitochondrionSequence analysis

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	313	N5-methylglutamineBy similarity		1

Post-translational modificationⁱ

Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

Keywords - PTMⁱ

Methylation

Proteomic databases

EPDⁱ	O75570
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75570
PaxDbⁱ	O75570
PeptideAtlas More...PeptideAtlasⁱ	O75570
PRIDEⁱ	O75570
ProteomicsDBⁱ	50091

PTM databases

iPTMnetⁱ	O75570
PhosphoSitePlusⁱ	O75570
SwissPalmⁱ	O75570

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000120662 Expressed in 202 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_MTRF1
ExpressionAtlasⁱ	O75570 baseline and differential
Genevisibleⁱ	O75570 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043316

HPAⁱ

HPA043316

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114978, 22 interactors
IntActⁱ	O75570, 2 interactors
STRINGⁱ	9606.ENSP00000368790

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75570
SMRⁱ	O75570
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the prokaryotic/mitochondrial release factor family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG2726 Eukaryota COG0216 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011879
HOGENOMⁱ	HOG000074815
HOVERGENⁱ	HBG017071
InParanoidⁱ	O75570
KEGG Orthology (KO) More...KOⁱ	K02835
OMAⁱ	FLCGEKC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O7T
PhylomeDBⁱ	O75570
TreeFamⁱ	TF313720

Family and domain databases

InterProⁱ	View protein in InterPro IPR005139 PCRF IPR000352 Pep_chain_release_fac_I_II
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03462 PCRF, 1 hit PF00472 RF-1, 1 hit
SMARTⁱ	View protein in SMART SM00937 PCRF, 1 hit
PROSITEⁱ	View protein in PROSITE PS00745 RF_PROK_I, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O75570-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRHLCVWLF RHPSLNGYLQ CHIQLHSHQF RQIHLDTRLQ VFRQNRNCIL 
        60         70         80         90        100
HLLSKNWSRR YCHQDTKMLW KHKALQKYME NLSKEYQTLE QCLQHIPVNE 
       110        120        130        140        150
ENRRSLNRRH AELAPLAAIY QEIQETEQAI EELESMCKSL NKQDEKQLQE 
       160        170        180        190        200
LALEERQTID QKINMLYNEL FQSLVPKEKY DKNDVILEVT AGRTTGGDIC 
       210        220        230        240        250
QQFTREIFDM YQNYSCYKHW QFELLNYTPA DYGGLHHAAA RISGDGVYKH 
       260        270        280        290        300
LKYEGGIHRV QRIPEVGLSS RMQRIHTGTM SVIVLPQPDE VDVKLDPKDL 
       310        320        330        340        350
RIDTFRAKGA GGQHVNKTDS AVRLVHIPTG LVVECQQERS QIKNKEIAFR 
       360        370        380        390        400
VLRARLYQQI IEKDKRQQQS ARKLQVGTRA QSERIRTYNF TQDRVSDHRI 
       410        420        430        440 
AYEVRDIKEF LCGGKGLDQL IQRLLQSADE EAIAELLDEH LKSAK

Length:445

Mass (Da):52,306

Last modified:April 12, 2005 - v2

Checksum:ⁱ3DC637D90F04C6F7

Isoform 2 (identifier: O75570-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MGNGEVVLFSDAEM
409-445: EFLCGGKGLD...LLDEHLKSAK → AQSHSTGGSR...FYVVGRAWIS

« Hide

        10         20         30         40         50
MGNGEVVLFS DAEMNRHLCV WLFRHPSLNG YLQCHIQLHS HQFRQIHLDT 
        60         70         80         90        100
RLQVFRQNRN CILHLLSKNW SRRYCHQDTK MLWKHKALQK YMENLSKEYQ 
       110        120        130        140        150
TLEQCLQHIP VNEENRRSLN RRHAELAPLA AIYQEIQETE QAIEELESMC 
       160        170        180        190        200
KSLNKQDEKQ LQELALEERQ TIDQKINMLY NELFQSLVPK EKYDKNDVIL 
       210        220        230        240        250
EVTAGRTTGG DICQQFTREI FDMYQNYSCY KHWQFELLNY TPADYGGLHH 
       260        270        280        290        300
AAARISGDGV YKHLKYEGGI HRVQRIPEVG LSSRMQRIHT GTMSVIVLPQ 
       310        320        330        340        350
PDEVDVKLDP KDLRIDTFRA KGAGGQHVNK TDSAVRLVHI PTGLVVECQQ 
       360        370        380        390        400
ERSQIKNKEI AFRVLRARLY QQIIEKDKRQ QQSARKLQVG TRAQSERIRT 
       410        420        430        440        450
YNFTQDRVSD HRIAYEVRDI KAQSHSTGGS RDPAHSTFLS LDSVRSPGIL 
       460 
IMTSSVRNFY VVGRAWIS

Note: No experimental confirmation available.

Show »

Length:468

Mass (Da):54,622

Checksum:ⁱC344E292BE468528

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

X6RFD4	X6RFD4_HUMAN	Peptide chain release factor 1, mit... Peptide chain release factor 1, mitochondrial	MTRF1	226	Annotation score:
A0A087WZ41	A0A087WZ41_HUMAN	Peptide chain release factor 1, mit... Peptide chain release factor 1, mitochondrial	MTRF1	137	Annotation score:
Q8N6Z2	Q8N6Z2_HUMAN	MTRF1 protein MTRF1 protein (Mitochondrial translational release factor 1, isoform CRA_b) (Peptide chain release factor 1, mitochondrial)	MTRF1 hCG_32761	151	Annotation score:
A0A087X1S1	A0A087X1S1_HUMAN	Peptide chain release factor 1, mit... Peptide chain release factor 1, mitochondrial	MTRF1	153	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	63	H → L in AAD12759 (PubMed:9838146).Curated	1
Sequence conflictⁱ	71	K → N in AAD12759 (PubMed:9838146).Curated	1
Sequence conflictⁱ	102	N → S in AAD12759 (PubMed:9838146).Curated	1
Sequence conflictⁱ	123	I → T in AAD12759 (PubMed:9838146).Curated	1
Sequence conflictⁱ	134	E → G in AAD12759 (PubMed:9838146).Curated	1
Sequence conflictⁱ	143	Q → R in AAD12759 (PubMed:9838146).Curated	1
Sequence conflictⁱ	149	Q → L in AAD12759 (PubMed:9838146).Curated	1
Sequence conflictⁱ	224	L → P in AAD12759 (PubMed:9838146).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024603	2	N → S. Corresponds to variant dbSNP:rs9532758Ensembl.	1
Natural variantⁱVAR_034447	324	L → V. Corresponds to variant dbSNP:rs9566725Ensembl.	1
Natural variantⁱVAR_051789	407	I → V. Corresponds to variant dbSNP:rs9315812Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055858	1	M → MGNGEVVLFSDAEM in isoform 2. 1 Publication		1
Alternative sequenceⁱVSP_055859	409 – 445	EFLCG…LKSAK → AQSHSTGGSRDPAHSTFLSL DSVRSPGILIMTSSVRNFYV VGRAWIS in isoform 2. 1 PublicationAdd BLAST		37

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF072934 mRNA Translation: AAD12759.1 AK294343 mRNA Translation: BAG57612.1 AL354696 Genomic DNA No translation available. BC042196 mRNA Translation: AAH42196.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9378.1 [O75570-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_004285.2, NM_004294.2 [O75570-1] XP_005266656.1, XM_005266599.2 XP_006719960.1, XM_006719897.2 XP_006719961.1, XM_006719898.2 [O75570-1] XP_006719963.1, XM_006719900.2 [O75570-1] XP_011533620.1, XM_011535318.2 [O75570-1] XP_011533622.1, XM_011535320.2 [O75570-1] XP_011533623.1, XM_011535321.2 [O75570-1] XP_011533625.1, XM_011535323.2 [O75570-1] XP_011533627.1, XM_011535325.2 [O75570-1] XP_016876351.1, XM_017020862.1 XP_016876352.1, XM_017020863.1 XP_016876353.1, XM_017020864.1 XP_016876354.1, XM_017020865.1 [O75570-1] XP_016876355.1, XM_017020866.1 [O75570-1] XP_016876356.1, XM_017020867.1 [O75570-1] XP_016876357.1, XM_017020868.1 [O75570-1] XP_016876358.1, XM_017020869.1 [O75570-1] XP_016876362.1, XM_017020873.1 XP_016876363.1, XM_017020874.1 [O75570-1] XP_016876364.1, XM_017020875.1 [O75570-1]
UniGeneⁱ	Hs.382176

Genome annotation databases

Ensemblⁱ	ENST00000379477; ENSP00000368790; ENSG00000120662 [O75570-1] ENST00000379480; ENSP00000368793; ENSG00000120662 [O75570-1]
GeneIDⁱ	9617
KEGGⁱ	hsa:9617
UCSC genome browser More...UCSCⁱ	uc001uxx.4 human [O75570-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75570	Peptide chain release factor 1, mitochondrial (Fragment)		HUMAN		226	UniRef100_O75570
MTRF1 isoform 5 (Fragment)		PANTR		226
Uncharacterized protein		PANPA		445
Mitochondrial translational release factor 1, isoform CRA_a		HUMAN		445
MTRF1 isoform 1		PANTR		445
+2

Protein	Similar proteins		Species	Score	Length	Source
O75570	Peptide chain release factor 1, mitochondrial (Fragment)		HUMAN		226	UniRef90_O75570
MTRF1 isoform 5 (Fragment)		PANTR		226
Uncharacterized protein		PANPA		445
Uncharacterized protein		Cebus capucinus imitator		448
Peptide chain release factor 1, mitochondrial		CALJA		446
+48

Protein	Similar proteins		Species	Score	Length	Source
O75570	Peptide chain release factor 1, mitochondrial (Fragment)		HUMAN		226	UniRef50_O75570
MTRF1 isoform 5 (Fragment)		PANTR		226
Uncharacterized protein		PANPA		445
Uncharacterized protein		Cebus capucinus imitator		448
Peptide chain release factor 1, mitochondrial		CALJA		446
+125

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF072934 mRNA Translation: AAD12759.1 AK294343 mRNA Translation: BAG57612.1 AL354696 Genomic DNA No translation available. BC042196 mRNA Translation: AAH42196.1
CCDSⁱ	CCDS9378.1 [O75570-1]
RefSeqⁱ	NP_004285.2, NM_004294.2 [O75570-1] XP_005266656.1, XM_005266599.2 XP_006719960.1, XM_006719897.2 XP_006719961.1, XM_006719898.2 [O75570-1] XP_006719963.1, XM_006719900.2 [O75570-1] XP_011533620.1, XM_011535318.2 [O75570-1] XP_011533622.1, XM_011535320.2 [O75570-1] XP_011533623.1, XM_011535321.2 [O75570-1] XP_011533625.1, XM_011535323.2 [O75570-1] XP_011533627.1, XM_011535325.2 [O75570-1] XP_016876351.1, XM_017020862.1 XP_016876352.1, XM_017020863.1 XP_016876353.1, XM_017020864.1 XP_016876354.1, XM_017020865.1 [O75570-1] XP_016876355.1, XM_017020866.1 [O75570-1] XP_016876356.1, XM_017020867.1 [O75570-1] XP_016876357.1, XM_017020868.1 [O75570-1] XP_016876358.1, XM_017020869.1 [O75570-1] XP_016876362.1, XM_017020873.1 XP_016876363.1, XM_017020874.1 [O75570-1] XP_016876364.1, XM_017020875.1 [O75570-1]
UniGeneⁱ	Hs.382176

3D structure databases

ProteinModelPortalⁱ	O75570
SMRⁱ	O75570
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114978, 22 interactors
IntActⁱ	O75570, 2 interactors
STRINGⁱ	9606.ENSP00000368790

PTM databases

iPTMnetⁱ	O75570
PhosphoSitePlusⁱ	O75570
SwissPalmⁱ	O75570

Polymorphism and mutation databases

BioMutaⁱ	MTRF1

BioMutaⁱ

MTRF1

Proteomic databases

EPDⁱ	O75570
MaxQBⁱ	O75570
PaxDbⁱ	O75570
PeptideAtlasⁱ	O75570
PRIDEⁱ	O75570
ProteomicsDBⁱ	50091

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000379477; ENSP00000368790; ENSG00000120662 [O75570-1] ENST00000379480; ENSP00000368793; ENSG00000120662 [O75570-1]
GeneIDⁱ	9617
KEGGⁱ	hsa:9617
UCSCⁱ	uc001uxx.4 human [O75570-1]

Organism-specific databases

CTDⁱ	9617
DisGeNETⁱ	9617
EuPathDBⁱ	HostDB:ENSG00000120662.15
GeneCardsⁱ	MTRF1
HGNCⁱ	HGNC:7469 MTRF1
HPAⁱ	HPA043316
MIMⁱ	604601 gene
neXtProtⁱ	NX_O75570
OpenTargetsⁱ	ENSG00000120662
PharmGKBⁱ	PA31273
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2726 Eukaryota COG0216 LUCA
GeneTreeⁱ	ENSGT00390000011879
HOGENOMⁱ	HOG000074815
HOVERGENⁱ	HBG017071
InParanoidⁱ	O75570
KOⁱ	K02835
OMAⁱ	FLCGEKC
OrthoDBⁱ	EOG091G0O7T
PhylomeDBⁱ	O75570
TreeFamⁱ	TF313720

Miscellaneous databases

GeneWikiⁱ	MTRF1
GenomeRNAiⁱ	9617
Protein Ontology More...PROⁱ	PR:O75570
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000120662 Expressed in 202 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_MTRF1
ExpressionAtlasⁱ	O75570 baseline and differential
Genevisibleⁱ	O75570 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR005139 PCRF IPR000352 Pep_chain_release_fac_I_II
Pfamⁱ	View protein in Pfam PF03462 PCRF, 1 hit PF00472 RF-1, 1 hit
SMARTⁱ	View protein in SMART SM00937 PCRF, 1 hit
PROSITEⁱ	View protein in PROSITE PS00745 RF_PROK_I, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RF1M_HUMAN
Accessionⁱ	O75570Primary (citable) accession number: O75570 Secondary accession number(s): B4DG01, Q5T6Y5, Q8IUQ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	April 12, 2005
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM

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UniProtKB - O75570 (RF1M_HUMAN)

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Peptide chain release factor 1, mitochondrial

MTRF1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ