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Protein

Peptide chain release factor 1, mitochondrial

Gene

MTRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • translation release factor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptide chain release factor 1, mitochondrial
Short name:
MRF-1
Short name:
MtRF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTRF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000120662.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7469 MTRF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604601 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75570

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9617

Open Targets

More...
OpenTargetsi
ENSG00000120662

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31273

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MTRF1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000030333? – 445Peptide chain release factor 1, mitochondrial
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei313N5-methylglutamineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75570

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75570

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75570

PeptideAtlas

More...
PeptideAtlasi
O75570

PRoteomics IDEntifications database

More...
PRIDEi
O75570

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50091

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75570

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75570

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O75570

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120662 Expressed in 202 organ(s), highest expression level in body of pancreas

CleanEx database of gene expression profiles

More...
CleanExi
HS_MTRF1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75570 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75570 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043316

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114978, 22 interactors

Protein interaction database and analysis system

More...
IntActi
O75570, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368790

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75570

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75570

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2726 Eukaryota
COG0216 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156877

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074815

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG017071

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75570

KEGG Orthology (KO)

More...
KOi
K02835

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLCGEKC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0O7T

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75570

TreeFam database of animal gene trees

More...
TreeFami
TF313720

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I_II

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00937 PCRF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00745 RF_PROK_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75570-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNRHLCVWLF RHPSLNGYLQ CHIQLHSHQF RQIHLDTRLQ VFRQNRNCIL
60 70 80 90 100
HLLSKNWSRR YCHQDTKMLW KHKALQKYME NLSKEYQTLE QCLQHIPVNE
110 120 130 140 150
ENRRSLNRRH AELAPLAAIY QEIQETEQAI EELESMCKSL NKQDEKQLQE
160 170 180 190 200
LALEERQTID QKINMLYNEL FQSLVPKEKY DKNDVILEVT AGRTTGGDIC
210 220 230 240 250
QQFTREIFDM YQNYSCYKHW QFELLNYTPA DYGGLHHAAA RISGDGVYKH
260 270 280 290 300
LKYEGGIHRV QRIPEVGLSS RMQRIHTGTM SVIVLPQPDE VDVKLDPKDL
310 320 330 340 350
RIDTFRAKGA GGQHVNKTDS AVRLVHIPTG LVVECQQERS QIKNKEIAFR
360 370 380 390 400
VLRARLYQQI IEKDKRQQQS ARKLQVGTRA QSERIRTYNF TQDRVSDHRI
410 420 430 440
AYEVRDIKEF LCGGKGLDQL IQRLLQSADE EAIAELLDEH LKSAK
Length:445
Mass (Da):52,306
Last modified:April 12, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3DC637D90F04C6F7
GO
Isoform 2 (identifier: O75570-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGNGEVVLFSDAEM
     409-445: EFLCGGKGLD...LLDEHLKSAK → AQSHSTGGSR...FYVVGRAWIS

Note: No experimental confirmation available.
Show »
Length:468
Mass (Da):54,622
Checksum:iC344E292BE468528
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RFD4X6RFD4_HUMAN
Peptide chain release factor 1, mit...
MTRF1
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ41A0A087WZ41_HUMAN
Peptide chain release factor 1, mit...
MTRF1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8N6Z2Q8N6Z2_HUMAN
MTRF1 protein
MTRF1 hCG_32761
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1S1A0A087X1S1_HUMAN
Peptide chain release factor 1, mit...
MTRF1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63H → L in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti71K → N in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti102N → S in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti123I → T in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti134E → G in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti143Q → R in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti149Q → L in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti224L → P in AAD12759 (PubMed:9838146).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0246032N → S. Corresponds to variant dbSNP:rs9532758Ensembl.1
Natural variantiVAR_034447324L → V. Corresponds to variant dbSNP:rs9566725Ensembl.1
Natural variantiVAR_051789407I → V. Corresponds to variant dbSNP:rs9315812Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0558581M → MGNGEVVLFSDAEM in isoform 2. 1 Publication1
Alternative sequenceiVSP_055859409 – 445EFLCG…LKSAK → AQSHSTGGSRDPAHSTFLSL DSVRSPGILIMTSSVRNFYV VGRAWIS in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF072934 mRNA Translation: AAD12759.1
AK294343 mRNA Translation: BAG57612.1
AL354696 Genomic DNA No translation available.
BC042196 mRNA Translation: AAH42196.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9378.1 [O75570-1]

NCBI Reference Sequences

More...
RefSeqi
NP_004285.2, NM_004294.2 [O75570-1]
XP_005266656.1, XM_005266599.2
XP_006719960.1, XM_006719897.2
XP_006719961.1, XM_006719898.2 [O75570-1]
XP_006719963.1, XM_006719900.2 [O75570-1]
XP_011533620.1, XM_011535318.2 [O75570-1]
XP_011533622.1, XM_011535320.2 [O75570-1]
XP_011533623.1, XM_011535321.2 [O75570-1]
XP_011533625.1, XM_011535323.2 [O75570-1]
XP_011533627.1, XM_011535325.2 [O75570-1]
XP_016876351.1, XM_017020862.1
XP_016876352.1, XM_017020863.1
XP_016876353.1, XM_017020864.1
XP_016876354.1, XM_017020865.1 [O75570-1]
XP_016876355.1, XM_017020866.1 [O75570-1]
XP_016876356.1, XM_017020867.1 [O75570-1]
XP_016876357.1, XM_017020868.1 [O75570-1]
XP_016876358.1, XM_017020869.1 [O75570-1]
XP_016876362.1, XM_017020873.1
XP_016876363.1, XM_017020874.1 [O75570-1]
XP_016876364.1, XM_017020875.1 [O75570-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.382176

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379477; ENSP00000368790; ENSG00000120662 [O75570-1]
ENST00000379480; ENSP00000368793; ENSG00000120662 [O75570-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9617

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9617

UCSC genome browser

More...
UCSCi
uc001uxx.4 human [O75570-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072934 mRNA Translation: AAD12759.1
AK294343 mRNA Translation: BAG57612.1
AL354696 Genomic DNA No translation available.
BC042196 mRNA Translation: AAH42196.1
CCDSiCCDS9378.1 [O75570-1]
RefSeqiNP_004285.2, NM_004294.2 [O75570-1]
XP_005266656.1, XM_005266599.2
XP_006719960.1, XM_006719897.2
XP_006719961.1, XM_006719898.2 [O75570-1]
XP_006719963.1, XM_006719900.2 [O75570-1]
XP_011533620.1, XM_011535318.2 [O75570-1]
XP_011533622.1, XM_011535320.2 [O75570-1]
XP_011533623.1, XM_011535321.2 [O75570-1]
XP_011533625.1, XM_011535323.2 [O75570-1]
XP_011533627.1, XM_011535325.2 [O75570-1]
XP_016876351.1, XM_017020862.1
XP_016876352.1, XM_017020863.1
XP_016876353.1, XM_017020864.1
XP_016876354.1, XM_017020865.1 [O75570-1]
XP_016876355.1, XM_017020866.1 [O75570-1]
XP_016876356.1, XM_017020867.1 [O75570-1]
XP_016876357.1, XM_017020868.1 [O75570-1]
XP_016876358.1, XM_017020869.1 [O75570-1]
XP_016876362.1, XM_017020873.1
XP_016876363.1, XM_017020874.1 [O75570-1]
XP_016876364.1, XM_017020875.1 [O75570-1]
UniGeneiHs.382176

3D structure databases

ProteinModelPortaliO75570
SMRiO75570
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114978, 22 interactors
IntActiO75570, 2 interactors
STRINGi9606.ENSP00000368790

PTM databases

iPTMnetiO75570
PhosphoSitePlusiO75570
SwissPalmiO75570

Polymorphism and mutation databases

BioMutaiMTRF1

Proteomic databases

EPDiO75570
MaxQBiO75570
PaxDbiO75570
PeptideAtlasiO75570
PRIDEiO75570
ProteomicsDBi50091

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379477; ENSP00000368790; ENSG00000120662 [O75570-1]
ENST00000379480; ENSP00000368793; ENSG00000120662 [O75570-1]
GeneIDi9617
KEGGihsa:9617
UCSCiuc001uxx.4 human [O75570-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9617
DisGeNETi9617
EuPathDBiHostDB:ENSG00000120662.15

GeneCards: human genes, protein and diseases

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GeneCardsi
MTRF1
HGNCiHGNC:7469 MTRF1
HPAiHPA043316
MIMi604601 gene
neXtProtiNX_O75570
OpenTargetsiENSG00000120662
PharmGKBiPA31273

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2726 Eukaryota
COG0216 LUCA
GeneTreeiENSGT00940000156877
HOGENOMiHOG000074815
HOVERGENiHBG017071
InParanoidiO75570
KOiK02835
OMAiFLCGEKC
OrthoDBiEOG091G0O7T
PhylomeDBiO75570
TreeFamiTF313720

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MTRF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9617

Protein Ontology

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PROi
PR:O75570

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000120662 Expressed in 202 organ(s), highest expression level in body of pancreas
CleanExiHS_MTRF1
ExpressionAtlasiO75570 baseline and differential
GenevisibleiO75570 HS

Family and domain databases

InterProiView protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I_II
PfamiView protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit
SMARTiView protein in SMART
SM00937 PCRF, 1 hit
PROSITEiView protein in PROSITE
PS00745 RF_PROK_I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRF1M_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75570
Secondary accession number(s): B4DG01, Q5T6Y5, Q8IUQ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 12, 2005
Last modified: December 5, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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