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Entry version 175 (13 Feb 2019)
Sequence version 1 (01 Nov 1998)
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Protein

Interferon-inducible double-stranded RNA-dependent protein kinase activator A

Gene

PRKRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • double-stranded RNA binding Source: BHF-UCL
  • enzyme activator activity Source: ProtInc
  • enzyme binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • pre-miRNA binding Source: BHF-UCL
  • protein homodimerization activity Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, RNA-mediated gene silencing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-426486 Small interfering RNA (siRNA) biogenesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O75569

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Alternative name(s):
PKR-associated protein X
PKR-associating protein X
Protein activator of the interferon-induced protein kinase
Protein kinase, interferon-inducible double-stranded RNA-dependent activator
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRKRA
Synonyms:PACT, RAX
ORF Names:HSD-14, HSD14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000180228.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9438 PRKRA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603424 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75569

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dystonia 16 (DYT16)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn early-onset dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT16 patients have progressive, generalized dystonia with axial muscle involvement, oro-mandibular (sardonic smile) and laryngeal dystonia and, in some cases, parkinsonian features.
See also OMIM:612067
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046213222P → L in DYT16. 1 PublicationCorresponds to variant dbSNP:rs121434410EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18S → A: No effect on apoptosis induction under conditions of stress. 1 Publication1
Mutagenesisi18S → D: Does not induce apoptosis. 1 Publication1
Mutagenesisi243Q → A: Abrogates apoptosis induction under conditions of stress. 1 Publication1
Mutagenesisi246S → A: Abrogates apoptosis induction under conditions of stress and binding to EIF2AK2. Prevents activation of EIF2AK2 in stressed cells; when associated with A-287. 1 Publication1
Mutagenesisi246S → D: Induces activation of EIF2AK2 and apoptosis in unstressed cells; when associated with D-287. 1 Publication1
Mutagenesisi260D → A: Abrogates apoptosis induction under conditions of stress. 1 Publication1
Mutagenesisi262D → A: Abrogates apoptosis induction under conditions of stress. 1 Publication1
Mutagenesisi265S → A: Abrogates apoptosis induction under conditions of stress. 1 Publication1
Mutagenesisi271Q → A: Abrogates apoptosis induction under conditions of stress. 1 Publication1
Mutagenesisi279S → A: Abrogates apoptosis induction under conditions of stress. 1 Publication1
Mutagenesisi287S → A: Abrogates apoptosis induction under conditions of stress. Prevents activation of EIF2AK2 in stressed cells; when associated with A-246. 1 Publication1
Mutagenesisi287S → D: Induces activation of EIF2AK2 and apoptosis in unstressed cells; when associated with D-246. 1 Publication1
Mutagenesisi288G → A: Abrogates apoptosis induction under conditions of stress. 1 Publication1
Mutagenesisi291C → A: Abrogates apoptosis induction under conditions of stress. 1 Publication1
Mutagenesisi298 – 299AA → KK: Abrogates interaction with DICER1 but does not affect interaction with AGO2. 1 Publication2

Keywords - Diseasei

Disease mutation, Dystonia, Parkinsonism

Organism-specific databases

DisGeNET

More...
DisGeNETi
8575

MalaCards human disease database

More...
MalaCardsi
PRKRA
MIMi612067 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000180228

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
210571 Dystonia 16

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33780

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRKRA

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002236091 – 313Interferon-inducible double-stranded RNA-dependent protein kinase activator AAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei246Phosphoserine1 Publication1
Modified residuei287Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-246 in unstressed cells and at Ser-287 in stressed cells. Phosphorylation at Ser-246 appears to be a prerequisite for subsequent phosphorylation at Ser-287. Phosphorylation at Ser-246 and Ser-287 are necessary for activation of EIF2AK2/PKR under conditions of stress.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75569

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75569

MaxQB - The MaxQuant DataBase

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MaxQBi
O75569

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75569

PeptideAtlas

More...
PeptideAtlasi
O75569

PRoteomics IDEntifications database

More...
PRIDEi
O75569

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50088
50089 [O75569-2]
50090 [O75569-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75569

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75569

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000180228 Expressed in 231 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75569 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75569 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004648
HPA034996
HPA034997

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with EIF2AK2/PKR through its DRBM domains. Interacts with DICER1, AGO2 and TARBP2. Also able to interact with dsRNA. Interacts with UBC9 (By similarity). Forms a complex with UBC9 and p53/TP53 (By similarity). Interacts with DUS2L (via DRBM domain). Interacts with DDX58.By similarity8 Publications
(Microbial infection) Interacts with ebolavirus protein VP35; this interaction inhibits the interaction between DDX58 and PRKRA. In addition, this interaction disrupts the interaction between VP35 and the viral polymerase L. So the VP35-PRKRA interaction plays a critical role in determining the outcome of ebolavirus infection.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114143, 70 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1072 RISC-loading complex, PRKRA variant

Database of interacting proteins

More...
DIPi
DIP-41809N

Protein interaction database and analysis system

More...
IntActi
O75569, 48 interactors

Molecular INTeraction database

More...
MINTi
O75569

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000318176

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIXNMR-A33-103[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75569

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75569

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O75569

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 101DRBM 1PROSITE-ProRule annotationAdd BLAST68
Domaini126 – 194DRBM 2PROSITE-ProRule annotationAdd BLAST69
Domaini240 – 308DRBM 3PROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 103Sufficient for self-association and interaction with TARBP2Add BLAST103
Regioni102 – 195Sufficient for self-association and interaction with TARBP2Add BLAST94
Regioni195 – 313Sufficient for self-association and interaction with TARBP2Add BLAST119

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Self-association may occur via interactions between DRBM domains as follows: DRBM 1/DRBM 1, DRBM 1/DRBM 2, DRBM 2/DRBM 2 or DRBM 3/DRBM3.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRKRA family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3732 Eukaryota
ENOG410XSCK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157618

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231919

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001700

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75569

Identification of Orthologs from Complete Genome Data

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OMAi
VTVCHGT

Database of Orthologous Groups

More...
OrthoDBi
1093169at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75569

TreeFam database of animal gene trees

More...
TreeFami
TF315953

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048 DSRM, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014720 dsRBD_dom
IPR033363 PRKRA
IPR032478 Staufen_C

The PANTHER Classification System

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PANTHERi
PTHR10910:SF8 PTHR10910:SF8, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00035 dsrm, 2 hits
PF16482 Staufen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00358 DSRM, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50137 DS_RBD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75569-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQSRHRAEA PPLEREDSGT FSLGKMITAK PGKTPIQVLH EYGMKTKNIP
60 70 80 90 100
VYECERSDVQ IHVPTFTFRV TVGDITCTGE GTSKKLAKHR AAEAAINILK
110 120 130 140 150
ANASICFAVP DPLMPDPSKQ PKNQLNPIGS LQELAIHHGW RLPEYTLSQE
160 170 180 190 200
GGPAHKREYT TICRLESFME TGKGASKKQA KRNAAEKFLA KFSNISPENH
210 220 230 240 250
ISLTNVVGHS LGCTWHSLRN SPGEKINLLK RSLLSIPNTD YIQLLSEIAK
260 270 280 290 300
EQGFNITYLD IDELSANGQY QCLAELSTSP ITVCHGSGIS CGNAQSDAAH
310
NALQYLKIIA ERK
Length:313
Mass (Da):34,404
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B01637E6194827E
GO
Isoform 2 (identifier: O75569-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MSQSRHRAEAPPLEREDSGTF → MQSTPFCGFC

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):33,123
Checksum:i1A1002362E1095D5
GO
Isoform 3 (identifier: O75569-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Note: No experimental confirmation available.
Show »
Length:288
Mass (Da):31,635
Checksum:iE663866BAB6DF0BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9Q4G5E9Q4_HUMAN
Interferon-inducible double-strande...
PRKRA hCG_43233
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEG8F8WEG8_HUMAN
Interferon-inducible double-strande...
PRKRA
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JMM3C9JMM3_HUMAN
Interferon-inducible double-strande...
PRKRA
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti282T → A in BAD96827 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046213222P → L in DYT16. 1 PublicationCorresponds to variant dbSNP:rs121434410EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0172821 – 25Missing in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0172831 – 21MSQSR…DSGTF → MQSTPFCGFC in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF072860 mRNA Translation: AAC25672.1
AF083033 mRNA Translation: AAD33099.1
AY251164 mRNA Translation: AAP20061.1
AL136615 mRNA Translation: CAB66550.1
AL833867 Transcribed RNA Translation: CAD38725.1
BT007243 mRNA Translation: AAP35907.1
AK290601 mRNA Translation: BAF83290.1
CR533525 mRNA Translation: CAG38556.1
AK223107 mRNA Translation: BAD96827.1
AC009948 Genomic DNA Translation: AAX88882.1
CH471058 Genomic DNA Translation: EAX11036.1
BC009470 mRNA Translation: AAH09470.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2279.1 [O75569-1]
CCDS46460.1 [O75569-2]
CCDS46461.1 [O75569-3]

NCBI Reference Sequences

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RefSeqi
NP_001132989.1, NM_001139517.1 [O75569-2]
NP_001132990.1, NM_001139518.1 [O75569-3]
NP_003681.1, NM_003690.4 [O75569-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.570274

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000325748; ENSP00000318176; ENSG00000180228 [O75569-1]
ENST00000432031; ENSP00000393883; ENSG00000180228 [O75569-2]
ENST00000487082; ENSP00000430604; ENSG00000180228 [O75569-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8575

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8575

UCSC genome browser

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UCSCi
uc002umd.4 human [O75569-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072860 mRNA Translation: AAC25672.1
AF083033 mRNA Translation: AAD33099.1
AY251164 mRNA Translation: AAP20061.1
AL136615 mRNA Translation: CAB66550.1
AL833867 Transcribed RNA Translation: CAD38725.1
BT007243 mRNA Translation: AAP35907.1
AK290601 mRNA Translation: BAF83290.1
CR533525 mRNA Translation: CAG38556.1
AK223107 mRNA Translation: BAD96827.1
AC009948 Genomic DNA Translation: AAX88882.1
CH471058 Genomic DNA Translation: EAX11036.1
BC009470 mRNA Translation: AAH09470.1
CCDSiCCDS2279.1 [O75569-1]
CCDS46460.1 [O75569-2]
CCDS46461.1 [O75569-3]
RefSeqiNP_001132989.1, NM_001139517.1 [O75569-2]
NP_001132990.1, NM_001139518.1 [O75569-3]
NP_003681.1, NM_003690.4 [O75569-1]
UniGeneiHs.570274

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIXNMR-A33-103[»]
ProteinModelPortaliO75569
SMRiO75569
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114143, 70 interactors
ComplexPortaliCPX-1072 RISC-loading complex, PRKRA variant
DIPiDIP-41809N
IntActiO75569, 48 interactors
MINTiO75569
STRINGi9606.ENSP00000318176

PTM databases

iPTMnetiO75569
PhosphoSitePlusiO75569

Polymorphism and mutation databases

BioMutaiPRKRA

Proteomic databases

EPDiO75569
jPOSTiO75569
MaxQBiO75569
PaxDbiO75569
PeptideAtlasiO75569
PRIDEiO75569
ProteomicsDBi50088
50089 [O75569-2]
50090 [O75569-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8575
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325748; ENSP00000318176; ENSG00000180228 [O75569-1]
ENST00000432031; ENSP00000393883; ENSG00000180228 [O75569-2]
ENST00000487082; ENSP00000430604; ENSG00000180228 [O75569-3]
GeneIDi8575
KEGGihsa:8575
UCSCiuc002umd.4 human [O75569-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8575
DisGeNETi8575
EuPathDBiHostDB:ENSG00000180228.12

GeneCards: human genes, protein and diseases

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GeneCardsi
PRKRA
HGNCiHGNC:9438 PRKRA
HPAiCAB004648
HPA034996
HPA034997
MalaCardsiPRKRA
MIMi603424 gene
612067 phenotype
neXtProtiNX_O75569
OpenTargetsiENSG00000180228
Orphaneti210571 Dystonia 16
PharmGKBiPA33780

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3732 Eukaryota
ENOG410XSCK LUCA
GeneTreeiENSGT00940000157618
HOGENOMiHOG000231919
HOVERGENiHBG001700
InParanoidiO75569
OMAiVTVCHGT
OrthoDBi1093169at2759
PhylomeDBiO75569
TreeFamiTF315953

Enzyme and pathway databases

ReactomeiR-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-426486 Small interfering RNA (siRNA) biogenesis
SIGNORiO75569

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PRKRA human
EvolutionaryTraceiO75569

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PRKRA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8575

Protein Ontology

More...
PROi
PR:O75569

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000180228 Expressed in 231 organ(s), highest expression level in sperm
ExpressionAtlasiO75569 baseline and differential
GenevisibleiO75569 HS

Family and domain databases

CDDicd00048 DSRM, 3 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR033363 PRKRA
IPR032478 Staufen_C
PANTHERiPTHR10910:SF8 PTHR10910:SF8, 1 hit
PfamiView protein in Pfam
PF00035 dsrm, 2 hits
PF16482 Staufen_C, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 3 hits
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRKRA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75569
Secondary accession number(s): A8K3I6
, Q53G24, Q6X7T5, Q8NDK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 1, 1998
Last modified: February 13, 2019
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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