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UniProtKB - O75564 (JERKY_HUMAN)

Entry version 137 (12 Aug 2020)
Sequence version 3 (28 Mar 2018)
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Protein

Jerky protein homolog

Gene

JRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May bind DNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi38 – 58H-T-H motifPROSITE-ProRule annotationAdd BLAST21
DNA bindingi110 – 142H-T-H motifPROSITE-ProRule annotationAdd BLAST33

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: GO_Central
  • mRNA binding Source: Ensembl
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75564

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Jerky protein homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JRKImported
Synonyms:JH81 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000234616.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:6199, JRK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603210, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75564

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8629

MalaCards human disease database

More...MalaCardsi		JRK

Open Targets

More...OpenTargetsi		ENSG00000234616

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		64280, Childhood absence epilepsy
307, Juvenile myoclonic epilepsy

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75564, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		JRK

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001261281 – 556Jerky protein homologAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei414PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75564

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75564

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75564

PeptideAtlas

More...PeptideAtlasi		O75564

PRoteomics IDEntifications database

More...PRIDEi		O75564

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50087

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75564

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75564

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000234616, Expressed in sural nerve and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75564, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
O75564
With#Exp.IntAct
CTNNB1 [P35222]3EBI-8607681,EBI-491549
Lef1 [P27782] from Mus musculus.3EBI-8607681,EBI-984464
Isoform 2 [O75564-2]
With#Exp.IntAct
ALAS1 [P13196]3EBI-17181882,EBI-3905054
BYSL [Q13895]3EBI-17181882,EBI-358049
C2CD6 [Q53TS8]3EBI-17181882,EBI-739879
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-17181882,EBI-10961624
CDC37 [Q16543]3EBI-17181882,EBI-295634
CNKSR3 [Q6P9H4]3EBI-17181882,EBI-10253274
FAM161A [Q3B820]3EBI-17181882,EBI-719941
FBXO17 [Q96EF6]3EBI-17181882,EBI-2510157
GOLGA6L9 [A6NEM1]3EBI-17181882,EBI-5916454
HSF2BP [O75031]3EBI-17181882,EBI-7116203
IFRD2 - isoform 2 [Q12894-2]3EBI-17181882,EBI-14102882
KDM1A [O60341]3EBI-17181882,EBI-710124
KPNA6 [O60684]3EBI-17181882,EBI-359923
LDOC1 [O95751]3EBI-17181882,EBI-740738
LGALS14 [Q8TCE9]3EBI-17181882,EBI-10274069
MTUS2 - isoform 2 [Q5JR59-3]3EBI-17181882,EBI-11522433
PDZD4 [Q17RL8]3EBI-17181882,EBI-10239064
PICK1 [Q9NRD5]3EBI-17181882,EBI-79165
PRICKLE1 [Q96MT3]3EBI-17181882,EBI-2348662
TFIP11 [Q9UBB9]3EBI-17181882,EBI-1105213
TPM4 [P67936]3EBI-17181882,EBI-1642100
TRIM23 [P36406]3EBI-17181882,EBI-740098
TRIM41 [Q8WV44]3EBI-17181882,EBI-725997
TRIP10 - isoform 2 [Q15642-2]3EBI-17181882,EBI-6550597
TSGA10 [Q9BZW7]3EBI-17181882,EBI-744794
TXK [P42681]3EBI-17181882,EBI-7877438
USP2 [O75604]3EBI-17181882,EBI-743272
UTP14C [Q5TAP6]3EBI-17181882,EBI-11737646
ZBTB8A [Q96BR9]3EBI-17181882,EBI-742740
ZNF343 [Q6P1L6]3EBI-17181882,EBI-10252492
ZNF417 [Q8TAU3]3EBI-17181882,EBI-740727
ZNF620 [Q6ZNG0]3EBI-17181882,EBI-4395669
ZNF629 [Q9UEG4]3EBI-17181882,EBI-9977294
ZNF655 [Q8N720]3EBI-17181882,EBI-625509
ZRANB1 [Q9UGI0]3EBI-17181882,EBI-527853

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		O75564, 41 interactors

Molecular INTeraction database

More...MINTi		O75564

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000482410

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75564, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75564

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 62HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini77 – 149HTH CENPB-typePROSITE-ProRule annotationAdd BLAST73
Domaini213 – 382DDE-1Sequence analysisAdd BLAST170

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tigger transposable element derived protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3105, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162277

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75564

Identification of Orthologs from Complete Genome Data

More...OMAi		VACAWNA

Database of Orthologous Groups

More...OrthoDBi		1343623at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75564

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004875, DDE_SF_endonuclease_dom
IPR009057, Homeobox-like_sf
IPR006600, HTH_CenpB_DNA-bd_dom
IPR007889, HTH_Psq
IPR036388, WH-like_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04218, CENP-B_N, 1 hit
PF03184, DDE_1, 1 hit
PF03221, HTH_Tnp_Tc5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00674, CENPB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51253, HTH_CENPB, 1 hit
PS50960, HTH_PSQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75564-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASKPAAGKS RGEKRKRVVL TLKEKIDICT RLEKGESRKA LMQEYNVGMS 
        60         70         80         90        100
TLYDIRAHKA QLLRFFASSD SNKALEQRRT LHTPKLEHLD RVLYEWFLGK 
       110        120        130        140        150
RSEGVPVSGP MLIEKAKDFY EQMQLTEPCV FSGGWLWRFK ARHGIKKLDA 
       160        170        180        190        200
SSEKQSADHQ AAEQFCAFFR SLAAEHGLSA EQVYNADETG LFWRCLPNPT 
       210        220        230        240        250
PEGGAVPGPK QGKDRLTVLM CANATGSHRL KPLAIGKCSG PRAFKGIQHL 
       260        270        280        290        300
PVAYKAQGNA WVDKEIFSDW FHHIFVPSVR EHFRTIGLPE DSKAVLLLDS 
       310        320        330        340        350
SRAHPQEAEL VSSNVFTIFL PASVASLVQP MEQGIRRDFM RNFINPPVPL 
       360        370        380        390        400
QGPHARYNMN DAIFSVACAW NAVPSHVFRR AWRKLWPSVA FAEGSSSEEE 
       410        420        430        440        450
LEAECFPVKP HNKSFAHILE LVKEGSSCPG QLRQRQAASW GVAGREAEGG 
       460        470        480        490        500
RPPAATSPAE VVWSSEKTPK ADQDGRGDPG EGEEVAWEQA AVAFDAVLRF 
       510        520        530        540        550
AERQPCFSAQ EVGQLRALRA VFRSQQQETV GLEDVVVTSP EELAIPKCCL 

EASTET
Length:556
Mass (Da):61,815
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6D0E018C016335A
GO
Isoform 2 (identifier: O75564-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     528-556: ETVGLEDVVVTSPEELAIPKCCLEASTET → VRRRRGALGAVVKVEALQEGPGGCGATAQSPLPCSSTAGDN

Show »
Length:568
Mass (Da):62,789
Checksum:i53006397C52106DD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZD9A0A087WZD9_HUMAN
Jerky protein homolog
JRK
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti476R → G in AAC32353 (PubMed:9675132).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059375528 – 556ETVGL…ASTET → VRRRRGALGAVVKVEALQEG PGGCGATAQSPLPCSSTAGD N in isoform 2. Add BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC108002 Genomic DNA No translation available.
KC877375 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82315.1
CH471162 Genomic DNA Translation: EAW82316.1
CH471162 Genomic DNA Translation: EAW82317.1
BC043351 mRNA Translation: AAH43351.1
AF072467 mRNA Translation: AAC32352.1
AF072468 mRNA Translation: AAC32353.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS75796.1 [O75564-2]
CCDS75797.1 [O75564-1]

NCBI Reference Sequences

More...RefSeqi		NP_001070995.2, NM_001077527.2 [O75564-1]
NP_001266281.1, NM_001279352.1 [O75564-1]
NP_003715.3, NM_003724.3 [O75564-2]
XP_006716740.1, XM_006716677.3 [O75564-2]
XP_006716741.1, XM_006716678.3 [O75564-2]
XP_011515656.1, XM_011517354.1 [O75564-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000571961; ENSP00000461610; ENSG00000234616 [O75564-1]
ENST00000612905; ENSP00000482410; ENSG00000234616 [O75564-2]
ENST00000614134; ENSP00000485390; ENSG00000234616 [O75564-2]
ENST00000615982; ENSP00000483808; ENSG00000234616 [O75564-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8629

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8629

UCSC genome browser

More...UCSCi		uc033cbh.2, human
uc033cbj.1, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108002 Genomic DNA No translation available.
KC877375 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82315.1
CH471162 Genomic DNA Translation: EAW82316.1
CH471162 Genomic DNA Translation: EAW82317.1
BC043351 mRNA Translation: AAH43351.1
AF072467 mRNA Translation: AAC32352.1
AF072468 mRNA Translation: AAC32353.1
CCDSiCCDS75796.1 [O75564-2]
CCDS75797.1 [O75564-1]
RefSeqiNP_001070995.2, NM_001077527.2 [O75564-1]
NP_001266281.1, NM_001279352.1 [O75564-1]
NP_003715.3, NM_003724.3 [O75564-2]
XP_006716740.1, XM_006716677.3 [O75564-2]
XP_006716741.1, XM_006716678.3 [O75564-2]
XP_011515656.1, XM_011517354.1 [O75564-1]

3D structure databases

SMRiO75564
ModBaseiSearch...

Protein-protein interaction databases

IntActiO75564, 41 interactors
MINTiO75564
STRINGi9606.ENSP00000482410

PTM databases

iPTMnetiO75564
PhosphoSitePlusiO75564

Polymorphism and mutation databases

BioMutaiJRK

Proteomic databases

EPDiO75564
jPOSTiO75564
MassIVEiO75564
PeptideAtlasiO75564
PRIDEiO75564
ProteomicsDBi50087

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27777, 15 antibodies

Genome annotation databases

EnsembliENST00000571961; ENSP00000461610; ENSG00000234616 [O75564-1]
ENST00000612905; ENSP00000482410; ENSG00000234616 [O75564-2]
ENST00000614134; ENSP00000485390; ENSG00000234616 [O75564-2]
ENST00000615982; ENSP00000483808; ENSG00000234616 [O75564-1]
GeneIDi8629
KEGGihsa:8629
UCSCiuc033cbh.2, human
uc033cbj.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8629
DisGeNETi8629
EuPathDBiHostDB:ENSG00000234616.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		JRK
HGNCiHGNC:6199, JRK
MalaCardsiJRK
MIMi603210, gene
neXtProtiNX_O75564
OpenTargetsiENSG00000234616
Orphaneti64280, Childhood absence epilepsy
307, Juvenile myoclonic epilepsy

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3105, Eukaryota
GeneTreeiENSGT00940000162277
InParanoidiO75564
OMAiVACAWNA
OrthoDBi1343623at2759
PhylomeDBiO75564

Enzyme and pathway databases

PathwayCommonsiO75564

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8629, 4 hits in 87 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		JRK, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8629
PharosiO75564, Tbio

Protein Ontology

More...PROi		PR:O75564
RNActiO75564, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000234616, Expressed in sural nerve and 246 other tissues
ExpressionAtlasiO75564, baseline and differential

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR004875, DDE_SF_endonuclease_dom
IPR009057, Homeobox-like_sf
IPR006600, HTH_CenpB_DNA-bd_dom
IPR007889, HTH_Psq
IPR036388, WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF04218, CENP-B_N, 1 hit
PF03184, DDE_1, 1 hit
PF03221, HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674, CENPB, 1 hit
SUPFAMiSSF46689, SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51253, HTH_CENPB, 1 hit
PS50960, HTH_PSQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJERKY_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75564
Secondary accession number(s): D3DWI5, O75565, Q86XJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 28, 2018
Last modified: August 12, 2020
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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