UniProtKB - O75564 (JERKY_HUMAN)
Protein
Jerky protein homolog
Gene
JRK
Organism
Homo sapiens (Human)
Status
Functioni
May bind DNA.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 38 – 58 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 21 | |
DNA bindingi | 110 – 142 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 33 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- mRNA binding Source: Ensembl
GO - Biological processi
- positive regulation of canonical Wnt signaling pathway Source: FlyBase
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Jerky protein homologCurated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000234616.8 |
HGNCi | HGNC:6199 JRK |
MIMi | 603210 gene |
neXtProti | NX_O75564 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: Ensembl
- ribonucleoprotein complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 8629 |
MalaCardsi | JRK |
OpenTargetsi | ENSG00000234616 |
Orphaneti | 64280 Childhood absence epilepsy 307 Juvenile myoclonic epilepsy |
Polymorphism and mutation databases
BioMutai | JRK |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000126128 | 1 – 556 | Jerky protein homologAdd BLAST | 556 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 414 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O75564 |
jPOSTi | O75564 |
PeptideAtlasi | O75564 |
PRIDEi | O75564 |
ProteomicsDBi | 50087 |
PTM databases
iPTMneti | O75564 |
PhosphoSitePlusi | O75564 |
Expressioni
Tissue specificityi
Expressed ubiquitously.1 Publication
Gene expression databases
Bgeei | ENSG00000234616 Expressed in 234 organ(s), highest expression level in epithelium of bronchus |
ExpressionAtlasi | O75564 baseline and differential |
Organism-specific databases
HPAi | HPA052675 |
Interactioni
Binary interactionsi
Protein-protein interaction databases
IntActi | O75564, 38 interactors |
MINTi | O75564 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 62 | HTH psq-typePROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 77 – 149 | HTH CENPB-typePROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 213 – 382 | DDE-1Sequence analysisAdd BLAST | 170 |
Sequence similaritiesi
Belongs to the tigger transposable element derived protein family.Curated
Phylogenomic databases
GeneTreei | ENSGT00940000162277 |
HOVERGENi | HBG052163 |
InParanoidi | O75564 |
OMAi | GMSTLYD |
OrthoDBi | 856254at2759 |
PhylomeDBi | O75564 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR004875 DDE_SF_endonuclease_dom IPR009057 Homeobox-like_sf IPR006600 HTH_CenpB_DNA-bd_dom IPR007889 HTH_Psq IPR036388 WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF04218 CENP-B_N, 1 hit PF03184 DDE_1, 1 hit PF03221 HTH_Tnp_Tc5, 1 hit |
SMARTi | View protein in SMART SM00674 CENPB, 1 hit |
SUPFAMi | SSF46689 SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51253 HTH_CENPB, 1 hit PS50960 HTH_PSQ, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O75564-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MASKPAAGKS RGEKRKRVVL TLKEKIDICT RLEKGESRKA LMQEYNVGMS
60 70 80 90 100
TLYDIRAHKA QLLRFFASSD SNKALEQRRT LHTPKLEHLD RVLYEWFLGK
110 120 130 140 150
RSEGVPVSGP MLIEKAKDFY EQMQLTEPCV FSGGWLWRFK ARHGIKKLDA
160 170 180 190 200
SSEKQSADHQ AAEQFCAFFR SLAAEHGLSA EQVYNADETG LFWRCLPNPT
210 220 230 240 250
PEGGAVPGPK QGKDRLTVLM CANATGSHRL KPLAIGKCSG PRAFKGIQHL
260 270 280 290 300
PVAYKAQGNA WVDKEIFSDW FHHIFVPSVR EHFRTIGLPE DSKAVLLLDS
310 320 330 340 350
SRAHPQEAEL VSSNVFTIFL PASVASLVQP MEQGIRRDFM RNFINPPVPL
360 370 380 390 400
QGPHARYNMN DAIFSVACAW NAVPSHVFRR AWRKLWPSVA FAEGSSSEEE
410 420 430 440 450
LEAECFPVKP HNKSFAHILE LVKEGSSCPG QLRQRQAASW GVAGREAEGG
460 470 480 490 500
RPPAATSPAE VVWSSEKTPK ADQDGRGDPG EGEEVAWEQA AVAFDAVLRF
510 520 530 540 550
AERQPCFSAQ EVGQLRALRA VFRSQQQETV GLEDVVVTSP EELAIPKCCL
EASTET
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZD9 | A0A087WZD9_HUMAN | Jerky protein homolog | JRK | 25 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 476 | R → G in AAC32353 (PubMed:9675132).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059375 | 528 – 556 | ETVGL…ASTET → VRRRRGALGAVVKVEALQEG PGGCGATAQSPLPCSSTAGD N in isoform 2. Add BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC108002 Genomic DNA No translation available. KC877375 Genomic DNA No translation available. CH471162 Genomic DNA Translation: EAW82315.1 CH471162 Genomic DNA Translation: EAW82316.1 CH471162 Genomic DNA Translation: EAW82317.1 BC043351 mRNA Translation: AAH43351.1 AF072467 mRNA Translation: AAC32352.1 AF072468 mRNA Translation: AAC32353.1 |
CCDSi | CCDS75796.1 [O75564-2] CCDS75797.1 [O75564-1] |
RefSeqi | NP_001070995.2, NM_001077527.2 [O75564-1] NP_001266281.1, NM_001279352.1 [O75564-1] NP_003715.3, NM_003724.3 [O75564-2] XP_006716740.1, XM_006716677.3 [O75564-2] XP_006716741.1, XM_006716678.3 [O75564-2] XP_011515656.1, XM_011517354.1 [O75564-1] |
UniGenei | Hs.535903 Hs.683465 |
Genome annotation databases
Ensembli | ENST00000571961; ENSP00000461610; ENSG00000234616 [O75564-1] ENST00000612905; ENSP00000482410; ENSG00000234616 [O75564-2] ENST00000614134; ENSP00000485390; ENSG00000234616 [O75564-2] ENST00000615982; ENSP00000483808; ENSG00000234616 [O75564-1] |
GeneIDi | 8629 |
KEGGi | hsa:8629 |
UCSCi | uc033cbh.2 human uc033cbj.1 human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC108002 Genomic DNA No translation available. KC877375 Genomic DNA No translation available. CH471162 Genomic DNA Translation: EAW82315.1 CH471162 Genomic DNA Translation: EAW82316.1 CH471162 Genomic DNA Translation: EAW82317.1 BC043351 mRNA Translation: AAH43351.1 AF072467 mRNA Translation: AAC32352.1 AF072468 mRNA Translation: AAC32353.1 |
CCDSi | CCDS75796.1 [O75564-2] CCDS75797.1 [O75564-1] |
RefSeqi | NP_001070995.2, NM_001077527.2 [O75564-1] NP_001266281.1, NM_001279352.1 [O75564-1] NP_003715.3, NM_003724.3 [O75564-2] XP_006716740.1, XM_006716677.3 [O75564-2] XP_006716741.1, XM_006716678.3 [O75564-2] XP_011515656.1, XM_011517354.1 [O75564-1] |
UniGenei | Hs.535903 Hs.683465 |
3D structure databases
ProteinModelPortali | O75564 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | O75564, 38 interactors |
MINTi | O75564 |
PTM databases
iPTMneti | O75564 |
PhosphoSitePlusi | O75564 |
Polymorphism and mutation databases
BioMutai | JRK |
Proteomic databases
EPDi | O75564 |
jPOSTi | O75564 |
PeptideAtlasi | O75564 |
PRIDEi | O75564 |
ProteomicsDBi | 50087 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000571961; ENSP00000461610; ENSG00000234616 [O75564-1] ENST00000612905; ENSP00000482410; ENSG00000234616 [O75564-2] ENST00000614134; ENSP00000485390; ENSG00000234616 [O75564-2] ENST00000615982; ENSP00000483808; ENSG00000234616 [O75564-1] |
GeneIDi | 8629 |
KEGGi | hsa:8629 |
UCSCi | uc033cbh.2 human uc033cbj.1 human |
Organism-specific databases
CTDi | 8629 |
DisGeNETi | 8629 |
EuPathDBi | HostDB:ENSG00000234616.8 |
GeneCardsi | JRK |
HGNCi | HGNC:6199 JRK |
HPAi | HPA052675 |
MalaCardsi | JRK |
MIMi | 603210 gene |
neXtProti | NX_O75564 |
OpenTargetsi | ENSG00000234616 |
Orphaneti | 64280 Childhood absence epilepsy 307 Juvenile myoclonic epilepsy |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000162277 |
HOVERGENi | HBG052163 |
InParanoidi | O75564 |
OMAi | GMSTLYD |
OrthoDBi | 856254at2759 |
PhylomeDBi | O75564 |
Miscellaneous databases
GenomeRNAii | 8629 |
PROi | PR:O75564 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000234616 Expressed in 234 organ(s), highest expression level in epithelium of bronchus |
ExpressionAtlasi | O75564 baseline and differential |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR004875 DDE_SF_endonuclease_dom IPR009057 Homeobox-like_sf IPR006600 HTH_CenpB_DNA-bd_dom IPR007889 HTH_Psq IPR036388 WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF04218 CENP-B_N, 1 hit PF03184 DDE_1, 1 hit PF03221 HTH_Tnp_Tc5, 1 hit |
SMARTi | View protein in SMART SM00674 CENPB, 1 hit |
SUPFAMi | SSF46689 SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51253 HTH_CENPB, 1 hit PS50960 HTH_PSQ, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | JERKY_HUMAN | |
Accessioni | O75564Primary (citable) accession number: O75564 Secondary accession number(s): D3DWI5, O75565, Q86XJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 17, 2003 |
Last sequence update: | March 28, 2018 | |
Last modified: | February 13, 2019 | |
This is version 128 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot