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UniProtKB - O75558 (STX11_HUMAN)

Entry version 180 (10 Feb 2021)
Sequence version 1 (01 Nov 1998)
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Protein

Syntaxin-11

Gene

STX11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75558

SIGNOR Signaling Network Open Resource

More...SIGNORi		O75558

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syntaxin-11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STX11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11429, STX11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605014, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75558

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000135604.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hemophagocytic lymphohistiocytosis, familial, 4 (FHL4)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
Related information in OMIM

Keywords - Diseasei

Familial hemophagocytic lymphohistiocytosis

Organism-specific databases

DisGeNET

More...DisGeNETi		8676

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		STX11

MalaCards human disease database

More...MalaCardsi		STX11
MIMi603552, phenotype

Open Targets

More...OpenTargetsi		ENSG00000135604

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		540, Familial hemophagocytic lymphohistiocytosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36229

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75558, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STX11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002102211 – 287Syntaxin-11Add BLAST287

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75558

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75558

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75558

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75558

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75558

PeptideAtlas

More...PeptideAtlasi		O75558

PRoteomics IDEntifications database

More...PRIDEi		O75558

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50085

2D gel databases

USC-OGP 2-DE database

More...OGPi		O75558

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75558

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75558

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O75558

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135604, Expressed in monocyte and 127 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75558, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000135604, Tissue enhanced (blood, bone marrow, breast)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the SNARE proteins SNAP-23 and VAMP.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O75558
With#Exp.IntAct
A2M [P01023]3EBI-714135,EBI-640741
ATN1 [Q86V38]3EBI-714135,EBI-11954292
AXIN1 [A0A0S2Z4M1]3EBI-714135,EBI-16429430
AXIN1 [O15169]3EBI-714135,EBI-710484
AXIN2 [Q9Y2T1]3EBI-714135,EBI-4400025
BACE2 [Q9Y5Z0]3EBI-714135,EBI-11282723
BLOC1S6 [Q9UL45]6EBI-714135,EBI-465781
BYSL [Q13895]8EBI-714135,EBI-358049
C1orf109 [Q9NX04]6EBI-714135,EBI-8643161
CARD9 [Q9H257]3EBI-714135,EBI-751319
CCBE1 [Q6UXH8]3EBI-714135,EBI-3923278
CCDC120 [Q96HB5]3EBI-714135,EBI-744556
CCDC125 [Q86Z20]3EBI-714135,EBI-11977221
CCDC184 [Q52MB2]6EBI-714135,EBI-10179526
CCDC196 [A0A1B0GWI1]3EBI-714135,EBI-10181422
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-714135,EBI-10175300
CDCA7L [Q96GN5]3EBI-714135,EBI-5278764
CDR2L [Q86X02]3EBI-714135,EBI-11063830
COL26A1 - isoform 2 [Q96A83-2]3EBI-714135,EBI-21553822
CRYAA2 [A0A140G945]3EBI-714135,EBI-25838900
CRYBA4 [P53673]3EBI-714135,EBI-7519711
CWF19L2 [Q2TBE0]3EBI-714135,EBI-5453285
DISC1 - isoform 2 [Q9NRI5-2]4EBI-714135,EBI-11988027
DNAJB6 - isoform B [O75190-2]3EBI-714135,EBI-12593112
DNM2 - isoform 2 [P50570-2]3EBI-714135,EBI-10968534
DUPD1 [Q68J44]3EBI-714135,EBI-1054321
EIF1AD [Q8N9N8]6EBI-714135,EBI-750700
EIF2B5 [Q13144]3EBI-714135,EBI-4401110
FAM110A [Q9BQ89]3EBI-714135,EBI-1752811
FAM161A [Q3B820]3EBI-714135,EBI-719941
FAM161B [Q96MY7]3EBI-714135,EBI-7225287
FAM74A6 [Q5TZK3]3EBI-714135,EBI-10247271
FAM90A1 [Q86YD7]3EBI-714135,EBI-6658203
FARS2 [O95363]3EBI-714135,EBI-2513774
GIPC1 - isoform 2 [O14908-2]3EBI-714135,EBI-25913156
GLE1 [Q53GS7]3EBI-714135,EBI-1955541
GOLGA8DP [Q0D2H9]3EBI-714135,EBI-10181276
GOLGA8G [Q08AF8]3EBI-714135,EBI-10181260
HAUS1 [Q96CS2]3EBI-714135,EBI-2514791
HGS [O14964]3EBI-714135,EBI-740220
HOXA1 [P49639]3EBI-714135,EBI-740785
IKZF3 [Q9UKT9]3EBI-714135,EBI-747204
KAT5 [Q92993]6EBI-714135,EBI-399080
KCTD9 [Q7L273]3EBI-714135,EBI-4397613
KIFC3 - isoform 4 [Q9BVG8-5]7EBI-714135,EBI-14069005
KLC3 [Q6P597]3EBI-714135,EBI-1643885
KLF11 [O14901]3EBI-714135,EBI-948266
KLK6 [Q92876]3EBI-714135,EBI-2432309
KRT75 [O95678]3EBI-714135,EBI-2949715
LENG1 [Q96BZ8]3EBI-714135,EBI-726510
LONRF1 [Q17RB8]3EBI-714135,EBI-2341787
MAGOHB [Q96A72]3EBI-714135,EBI-746778
MBD3L1 [Q8WWY6]3EBI-714135,EBI-12516603
MBIP - isoform 4 [Q9NS73-5]3EBI-714135,EBI-10182361
MECP2 [P51608]3EBI-714135,EBI-1189067
MEOX2 [P50222]3EBI-714135,EBI-748397
MFAP1 [P55081]3EBI-714135,EBI-1048159
MID2 - isoform 2 [Q9UJV3-2]3EBI-714135,EBI-10172526
MIS18A [Q9NYP9]3EBI-714135,EBI-1104552
NDC80 [O14777]3EBI-714135,EBI-715849
NTAQ1 [Q96HA8]3EBI-714135,EBI-741158
PAK1 [Q13153]3EBI-714135,EBI-1307
PKN1 [Q16512]3EBI-714135,EBI-602382
PMP22 [D3DTS7]3EBI-714135,EBI-25882629
PPP1R18 [Q6NYC8]6EBI-714135,EBI-2557469
PRKAB2 [O43741]4EBI-714135,EBI-1053424
PRPF18 [Q99633]3EBI-714135,EBI-2798416
PRPF31 [Q8WWY3]6EBI-714135,EBI-1567797
RAD51D [O75771]3EBI-714135,EBI-1055693
RNF6 [A0A0S2Z4G9]3EBI-714135,EBI-16428950
RNF8 [O76064]6EBI-714135,EBI-373337
RNPS1 [Q15287]3EBI-714135,EBI-395959
RUNX1T1 - isoform 4 [Q06455-4]3EBI-714135,EBI-10224192
SCNM1 [Q9BWG6]5EBI-714135,EBI-748391
SH2D4A [Q9H788]3EBI-714135,EBI-747035
SHC3 [Q92529]3EBI-714135,EBI-79084
SIKE1 [Q9BRV8]3EBI-714135,EBI-1773646
SMARCE1 [Q969G3]3EBI-714135,EBI-455078
SNAP23 [A8K287]3EBI-714135,EBI-10188497
SNAP23 [O00161]10EBI-714135,EBI-745000
SNAP25 - isoform 2 [P60880-2]3EBI-714135,EBI-12177361
SOGA1 - isoform 4 [O94964-4]3EBI-714135,EBI-14083835
SPRED1 [Q7Z699]3EBI-714135,EBI-5235340
STX1A [Q16623]3EBI-714135,EBI-712466
STX4 [Q12846]3EBI-714135,EBI-744942
STXBP1 [P61764]6EBI-714135,EBI-960169
TADA3 [O75528]3EBI-714135,EBI-473249
TCEA2 [Q15560]3EBI-714135,EBI-710310
TCF4 [P15884]3EBI-714135,EBI-533224
TLE5 [Q08117]3EBI-714135,EBI-717810
TLE5 - isoform 2 [Q08117-2]3EBI-714135,EBI-11741437
TOR1A - isoform 2 [O14656-2]3EBI-714135,EBI-25847109
TRIM41 [Q8WV44]3EBI-714135,EBI-725997
TSGA10IP [Q3SY00]3EBI-714135,EBI-10241197
UBASH3A - isoform 2 [P57075-2]3EBI-714135,EBI-7353612
USHBP1 [Q8N6Y0]3EBI-714135,EBI-739895
VPS52 [Q8N1B4]3EBI-714135,EBI-2799833
ZCCHC10 [Q8TBK6]4EBI-714135,EBI-597063
ZNF19 [P17023]3EBI-714135,EBI-12884200
ZNF417 [Q8TAU3]6EBI-714135,EBI-740727
ZNF587 [Q96SQ5]8EBI-714135,EBI-6427977

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114224, 139 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O75558

Protein interaction database and analysis system

More...IntActi		O75558, 153 interactors

Molecular INTeraction database

More...MINTi		O75558

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356540

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75558, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75558

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini204 – 266t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili41 – 71Sequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0810, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214380

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_042423_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75558

Identification of Orthologs from Complete Genome Data

More...OMAi		EYNQAEM

Database of Orthologous Groups

More...OrthoDBi		1033833at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75558

TreeFam database of animal gene trees

More...TreeFami		TF313763

Family and domain databases

Conserved Domains Database

More...CDDi		cd15878, SNARE_syntaxin11, 1 hit
cd00179, SynN, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010989, SNARE
IPR028672, STX11
IPR006012, Syntaxin/epimorphin_CS
IPR042781, Syntaxin11_SNARE
IPR006011, Syntaxin_N
IPR000727, T_SNARE_dom

The PANTHER Classification System

More...PANTHERi		PTHR19957:SF30, PTHR19957:SF30, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00804, Syntaxin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00503, SynN, 1 hit
SM00397, t_SNARE, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47661, SSF47661, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00914, SYNTAXIN, 1 hit
PS50192, T_SNARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O75558-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD 
        60         70         80         90        100
IQDENQLLVA DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI 
       110        120        130        140        150
HCKLRAMKEL SEAAEAQHGP HSAVARISRA QYNALTLTFQ RAMHDYNQAE 
       160        170        180        190        200
MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM FEQGKWDVFS ENLLADVKGA 
       210        220        230        240        250
RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD TLNVIELNVQ 
       260        270        280 
KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK
Length:287
Mass (Da):33,196
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18E8B43BA987D891
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61D → N in AAD02107 (PubMed:9571206).Curated1
Sequence conflicti93 – 94IK → FR in AAC24031 (PubMed:9553086).Curated2
Sequence conflicti96 – 97RG → PP in AAD02107 (PubMed:9571206).Curated2
Sequence conflicti103 – 104KL → NV in AAD02107 (PubMed:9571206).Curated2
Sequence conflicti121 – 126HSAVAR → ALGSGG in AAD02107 (PubMed:9571206).Curated6
Sequence conflicti200 – 220ARAAL…RLESR → RGPPTTRSRAATANCCAWRA A in AAC24031 (PubMed:9553086).CuratedAdd BLAST21
Sequence conflicti200A → V in AAD02107 (PubMed:9571206).Curated1
Sequence conflicti215L → V in AAD02107 (PubMed:9571206).Curated1
Sequence conflicti220R → A in AAD02107 (PubMed:9571206).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01199531E → Q. Corresponds to variant dbSNP:rs1802414Ensembl.1
Natural variantiVAR_02976949R → Q. Corresponds to variant dbSNP:rs17073498EnsemblClinVar.1
Natural variantiVAR_011996204L → H. Corresponds to variant dbSNP:rs1133248Ensembl.1
Natural variantiVAR_029770277T → A. Corresponds to variant dbSNP:rs9496891EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF038898 mRNA Translation: AAD02107.1
AF044309 mRNA Translation: AAC24031.1
AF071504 mRNA Translation: AAC24004.1
AL135917 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47849.1
CH471051 Genomic DNA Translation: EAW47850.1
BC033519 mRNA Translation: AAH33519.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5205.1

Protein sequence database of the Protein Information Resource

More...PIRi		JE0094

NCBI Reference Sequences

More...RefSeqi		NP_003755.2, NM_003764.3
XP_011534516.1, XM_011536214.2
XP_011534519.1, XM_011536217.2
XP_011534520.1, XM_011536218.2
XP_016866889.1, XM_017011400.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367568; ENSP00000356540; ENSG00000135604

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8676

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8676

UCSC genome browser

More...UCSCi		uc003qks.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

STX11base

STX11 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038898 mRNA Translation: AAD02107.1
AF044309 mRNA Translation: AAC24031.1
AF071504 mRNA Translation: AAC24004.1
AL135917 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47849.1
CH471051 Genomic DNA Translation: EAW47850.1
BC033519 mRNA Translation: AAH33519.1
CCDSiCCDS5205.1
PIRiJE0094
RefSeqiNP_003755.2, NM_003764.3
XP_011534516.1, XM_011536214.2
XP_011534519.1, XM_011536217.2
XP_011534520.1, XM_011536218.2
XP_016866889.1, XM_017011400.1

3D structure databases

SMRiO75558
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114224, 139 interactors
CORUMiO75558
IntActiO75558, 153 interactors
MINTiO75558
STRINGi9606.ENSP00000356540

PTM databases

iPTMnetiO75558
PhosphoSitePlusiO75558
SwissPalmiO75558

Genetic variation databases

BioMutaiSTX11

2D gel databases

OGPiO75558

Proteomic databases

EPDiO75558
jPOSTiO75558
MassIVEiO75558
MaxQBiO75558
PaxDbiO75558
PeptideAtlasiO75558
PRIDEiO75558
ProteomicsDBi50085

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		714, 177 antibodies

The DNASU plasmid repository

More...DNASUi		8676

Genome annotation databases

EnsembliENST00000367568; ENSP00000356540; ENSG00000135604
GeneIDi8676
KEGGihsa:8676
UCSCiuc003qks.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8676
DisGeNETi8676

GeneCards: human genes, protein and diseases

More...GeneCardsi		STX11
GeneReviewsiSTX11
HGNCiHGNC:11429, STX11
HPAiENSG00000135604, Tissue enhanced (blood, bone marrow, breast)
MalaCardsiSTX11
MIMi603552, phenotype
605014, gene
neXtProtiNX_O75558
OpenTargetsiENSG00000135604
Orphaneti540, Familial hemophagocytic lymphohistiocytosis
PharmGKBiPA36229
VEuPathDBiHostDB:ENSG00000135604.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0810, Eukaryota
GeneTreeiENSGT01000000214380
HOGENOMiCLU_042423_2_0_1
InParanoidiO75558
OMAiEYNQAEM
OrthoDBi1033833at2759
PhylomeDBiO75558
TreeFamiTF313763

Enzyme and pathway databases

PathwayCommonsiO75558
SIGNORiO75558

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8676, 4 hits in 875 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		STX11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8676
PharosiO75558, Tbio

Protein Ontology

More...PROi		PR:O75558
RNActiO75558, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135604, Expressed in monocyte and 127 other tissues
GenevisibleiO75558, HS

Family and domain databases

CDDicd15878, SNARE_syntaxin11, 1 hit
cd00179, SynN, 1 hit
InterProiView protein in InterPro
IPR010989, SNARE
IPR028672, STX11
IPR006012, Syntaxin/epimorphin_CS
IPR042781, Syntaxin11_SNARE
IPR006011, Syntaxin_N
IPR000727, T_SNARE_dom
PANTHERiPTHR19957:SF30, PTHR19957:SF30, 1 hit
PfamiView protein in Pfam
PF00804, Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503, SynN, 1 hit
SM00397, t_SNARE, 1 hit
SUPFAMiSSF47661, SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914, SYNTAXIN, 1 hit
PS50192, T_SNARE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTX11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75558
Secondary accession number(s): E1P598
, O75378, O95148, Q5TCL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: February 10, 2021
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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