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UniProtKB - O75558 (STX11_HUMAN)

Protein

Syntaxin-11

Gene

STX11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-11
Gene namesi
Name:STX11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000135604.9
HGNCiHGNC:11429 STX11
MIMi605014 gene
neXtProtiNX_O75558

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Familial hemophagocytic lymphohistiocytosis 4 (FHL4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
See also OMIM:603552

Keywords - Diseasei

Familial hemophagocytic lymphohistiocytosis

Organism-specific databases

DisGeNETi8676
GeneReviewsiSTX11
MalaCardsiSTX11
MIMi603552 phenotype
OpenTargetsiENSG00000135604
Orphaneti540 Familial hemophagocytic lymphohistiocytosis
PharmGKBiPA36229

Polymorphism and mutation databases

BioMutaiSTX11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102211 – 287Syntaxin-11Add BLAST287

Proteomic databases

EPDiO75558
MaxQBiO75558
PaxDbiO75558
PeptideAtlasiO75558
PRIDEiO75558
ProteomicsDBi50085

2D gel databases

OGPiO75558

PTM databases

iPTMnetiO75558
PhosphoSitePlusiO75558
SwissPalmiO75558

Expressioni

Gene expression databases

BgeeiENSG00000135604 Expressed in 107 organ(s), highest expression level in blood
CleanExiHS_STX11
GenevisibleiO75558 HS

Organism-specific databases

HPAiHPA007992
HPA076253

Interactioni

Subunit structurei

Interacts with the SNARE proteins SNAP-23 and VAMP.

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-714135,EBI-717810
AXIN1A0A0S2Z4M13EBI-714135,EBI-16429430
AXIN1O151693EBI-714135,EBI-710484
BLOC1S6Q9UL455EBI-714135,EBI-465781
BYSLQ138957EBI-714135,EBI-358049
C1orf109Q9NX045EBI-714135,EBI-8643161
CARD9Q9H2573EBI-714135,EBI-751319
CCBE1Q6UXH83EBI-714135,EBI-3923278
CCDC184Q52MB25EBI-714135,EBI-10179526
CDCA7LQ96GN53EBI-714135,EBI-5278764
CRYBA4P536733EBI-714135,EBI-7519711
CWF19L2Q2TBE03EBI-714135,EBI-5453285
EIF1ADQ8N9N85EBI-714135,EBI-750700
FAM110AQ9BQ893EBI-714135,EBI-1752811
FAM161AQ3B8203EBI-714135,EBI-719941
FAM74A6Q5TZK33EBI-714135,EBI-10247271
FAM90A1Q86YD73EBI-714135,EBI-6658203
FARS2O953633EBI-714135,EBI-2513774
GOLGA8DPQ0D2H93EBI-714135,EBI-10181276
GOLGA8GQ08AF83EBI-714135,EBI-10181260
HAUS1Q96CS23EBI-714135,EBI-2514791
HGSO149643EBI-714135,EBI-740220
IKZF3Q9UKT93EBI-714135,EBI-747204
KAT5Q929935EBI-714135,EBI-399080
KCTD9Q7L2733EBI-714135,EBI-4397613
KLC3Q6P5973EBI-714135,EBI-1643885
LENG1Q96BZ83EBI-714135,EBI-726510
LONRF1Q17RB83EBI-714135,EBI-2341787
MBIPQ9NS73-53EBI-714135,EBI-10182361
MEOX2P502223EBI-714135,EBI-748397
MFAP1P550813EBI-714135,EBI-1048159
MID2Q9UJV3-23EBI-714135,EBI-10172526
NDC80O147773EBI-714135,EBI-715849
PPP1R18Q6NYC85EBI-714135,EBI-2557469
PRKAB2O437413EBI-714135,EBI-1053424
PRPF31Q8WWY36EBI-714135,EBI-1567797
RNF6A0A0S2Z4G93EBI-714135,EBI-16428950
RNF8O760644EBI-714135,EBI-373337
RUNX1T1Q06455-43EBI-714135,EBI-10224192
SH2D4AQ9H7883EBI-714135,EBI-747035
SMARCE1Q969G33EBI-714135,EBI-455078
SNAP23A8K2873EBI-714135,EBI-10188497
SNAP23O001617EBI-714135,EBI-745000
STXBP1P617646EBI-714135,EBI-960169
TCF4P158843EBI-714135,EBI-533224
USHBP1Q8N6Y03EBI-714135,EBI-739895
VPS52Q8N1B43EBI-714135,EBI-2799833
WDYHV1Q96HA83EBI-714135,EBI-741158
ZCCHC10Q8TBK64EBI-714135,EBI-597063
ZNF417Q8TAU35EBI-714135,EBI-740727
ZNF587Q96SQ55EBI-714135,EBI-6427977

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi114224, 104 interactors
CORUMiO75558
IntActiO75558, 97 interactors
MINTiO75558
STRINGi9606.ENSP00000356540

Structurei

3D structure databases

ProteinModelPortaliO75558
SMRiO75558
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini204 – 266t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 71Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00760000119200
HOGENOMiHOG000286023
HOVERGENiHBG099780
InParanoidiO75558
KOiK08487
OMAiEYNQAEM
OrthoDBiEOG091G0K4L
PhylomeDBiO75558
TreeFamiTF313763

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR028672 STX11
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF30 PTHR19957:SF30, 1 hit
PfamiView protein in Pfam
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

O75558-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD 
        60         70         80         90        100
IQDENQLLVA DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI 
       110        120        130        140        150
HCKLRAMKEL SEAAEAQHGP HSAVARISRA QYNALTLTFQ RAMHDYNQAE 
       160        170        180        190        200
MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM FEQGKWDVFS ENLLADVKGA 
       210        220        230        240        250
RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD TLNVIELNVQ 
       260        270        280 
KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK
Length:287
Mass (Da):33,196
Last modified:November 1, 1998 - v1
Checksum:i18E8B43BA987D891
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61D → N in AAD02107 (PubMed:9571206).Curated1
Sequence conflicti93 – 94IK → FR in AAC24031 (PubMed:9553086).Curated2
Sequence conflicti96 – 97RG → PP in AAD02107 (PubMed:9571206).Curated2
Sequence conflicti103 – 104KL → NV in AAD02107 (PubMed:9571206).Curated2
Sequence conflicti121 – 126HSAVAR → ALGSGG in AAD02107 (PubMed:9571206).Curated6
Sequence conflicti200 – 220ARAAL…RLESR → RGPPTTRSRAATANCCAWRA A in AAC24031 (PubMed:9553086).CuratedAdd BLAST21
Sequence conflicti200A → V in AAD02107 (PubMed:9571206).Curated1
Sequence conflicti215L → V in AAD02107 (PubMed:9571206).Curated1
Sequence conflicti220R → A in AAD02107 (PubMed:9571206).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01199531E → Q. Corresponds to variant dbSNP:rs1802414Ensembl.1
Natural variantiVAR_02976949R → Q. Corresponds to variant dbSNP:rs17073498EnsemblClinVar.1
Natural variantiVAR_011996204L → H. Corresponds to variant dbSNP:rs1133248Ensembl.1
Natural variantiVAR_029770277T → A. Corresponds to variant dbSNP:rs9496891EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038898 mRNA Translation: AAD02107.1
AF044309 mRNA Translation: AAC24031.1
AF071504 mRNA Translation: AAC24004.1
AL135917 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47849.1
CH471051 Genomic DNA Translation: EAW47850.1
BC033519 mRNA Translation: AAH33519.1
CCDSiCCDS5205.1
PIRiJE0094
RefSeqiNP_003755.2, NM_003764.3
XP_011534516.1, XM_011536214.2
XP_011534519.1, XM_011536217.2
XP_011534520.1, XM_011536218.2
XP_016866889.1, XM_017011400.1
UniGeneiHs.118958

Genome annotation databases

EnsembliENST00000367568; ENSP00000356540; ENSG00000135604
GeneIDi8676
KEGGihsa:8676
UCSCiuc003qks.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

STX11base

STX11 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038898 mRNA Translation: AAD02107.1
AF044309 mRNA Translation: AAC24031.1
AF071504 mRNA Translation: AAC24004.1
AL135917 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47849.1
CH471051 Genomic DNA Translation: EAW47850.1
BC033519 mRNA Translation: AAH33519.1
CCDSiCCDS5205.1
PIRiJE0094
RefSeqiNP_003755.2, NM_003764.3
XP_011534516.1, XM_011536214.2
XP_011534519.1, XM_011536217.2
XP_011534520.1, XM_011536218.2
XP_016866889.1, XM_017011400.1
UniGeneiHs.118958

3D structure databases

ProteinModelPortaliO75558
SMRiO75558
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114224, 104 interactors
CORUMiO75558
IntActiO75558, 97 interactors
MINTiO75558
STRINGi9606.ENSP00000356540

PTM databases

iPTMnetiO75558
PhosphoSitePlusiO75558
SwissPalmiO75558

Polymorphism and mutation databases

BioMutaiSTX11

2D gel databases

OGPiO75558

Proteomic databases

EPDiO75558
MaxQBiO75558
PaxDbiO75558
PeptideAtlasiO75558
PRIDEiO75558
ProteomicsDBi50085

Protocols and materials databases

DNASUi8676
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367568; ENSP00000356540; ENSG00000135604
GeneIDi8676
KEGGihsa:8676
UCSCiuc003qks.5 human

Organism-specific databases

CTDi8676
DisGeNETi8676
EuPathDBiHostDB:ENSG00000135604.9
GeneCardsiSTX11
GeneReviewsiSTX11
HGNCiHGNC:11429 STX11
HPAiHPA007992
HPA076253
MalaCardsiSTX11
MIMi603552 phenotype
605014 gene
neXtProtiNX_O75558
OpenTargetsiENSG00000135604
Orphaneti540 Familial hemophagocytic lymphohistiocytosis
PharmGKBiPA36229
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00760000119200
HOGENOMiHOG000286023
HOVERGENiHBG099780
InParanoidiO75558
KOiK08487
OMAiEYNQAEM
OrthoDBiEOG091G0K4L
PhylomeDBiO75558
TreeFamiTF313763

Miscellaneous databases

ChiTaRSiSTX11 human
GeneWikiiSTX11
GenomeRNAii8676
PROiPR:O75558
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135604 Expressed in 107 organ(s), highest expression level in blood
CleanExiHS_STX11
GenevisibleiO75558 HS

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR028672 STX11
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF30 PTHR19957:SF30, 1 hit
PfamiView protein in Pfam
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTX11_HUMAN
AccessioniPrimary (citable) accession number: O75558
Secondary accession number(s): E1P598
, O75378, O95148, Q5TCL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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