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Entry version 171 (16 Oct 2019)
Sequence version 1 (01 Nov 1998)
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Protein

Syntaxin-11

Gene

STX11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syntaxin-11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STX11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11429 STX11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605014 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75558

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Familial hemophagocytic lymphohistiocytosis 4 (FHL4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
Related information in OMIM

Keywords - Diseasei

Familial hemophagocytic lymphohistiocytosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
8676

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
STX11

MalaCards human disease database

More...
MalaCardsi
STX11
MIMi603552 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000135604

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
540 Familial hemophagocytic lymphohistiocytosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36229

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75558

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STX11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002102211 – 287Syntaxin-11Add BLAST287

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75558

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75558

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O75558

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75558

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75558

PeptideAtlas

More...
PeptideAtlasi
O75558

PRoteomics IDEntifications database

More...
PRIDEi
O75558

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50085

2D gel databases

USC-OGP 2-DE database

More...
OGPi
O75558

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75558

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75558

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O75558

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135604 Expressed in 107 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75558 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007992
HPA076253

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the SNARE proteins SNAP-23 and VAMP.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
AXIN1A0A0S2Z4M13EBI-714135,EBI-16429430
AXIN1O151693EBI-714135,EBI-710484
BLOC1S6Q9UL455EBI-714135,EBI-465781
BYSLQ138957EBI-714135,EBI-358049
C1orf109Q9NX045EBI-714135,EBI-8643161
CARD9Q9H2573EBI-714135,EBI-751319
CCBE1Q6UXH83EBI-714135,EBI-3923278
CCDC184Q52MB25EBI-714135,EBI-10179526
CDCA7LQ96GN53EBI-714135,EBI-5278764
CRYBA4P536733EBI-714135,EBI-7519711
CWF19L2Q2TBE03EBI-714135,EBI-5453285
DISC1Q9NRI5-23EBI-714135,EBI-11988027
EIF1ADQ8N9N85EBI-714135,EBI-750700
FAM110AQ9BQ893EBI-714135,EBI-1752811
FAM161AQ3B8203EBI-714135,EBI-719941
FAM74A6Q5TZK33EBI-714135,EBI-10247271
FAM90A1Q86YD73EBI-714135,EBI-6658203
FARS2O953633EBI-714135,EBI-2513774
GOLGA8DPQ0D2H93EBI-714135,EBI-10181276
GOLGA8GQ08AF83EBI-714135,EBI-10181260
HAUS1Q96CS23EBI-714135,EBI-2514791
HGSO149643EBI-714135,EBI-740220
IKZF3Q9UKT93EBI-714135,EBI-747204
KAT5Q929935EBI-714135,EBI-399080
KCTD9Q7L2733EBI-714135,EBI-4397613
KIFC3Q9BVG8-56EBI-714135,EBI-14069005
KLC3Q6P5973EBI-714135,EBI-1643885
LENG1Q96BZ83EBI-714135,EBI-726510
LONRF1Q17RB83EBI-714135,EBI-2341787
MBIPQ9NS73-53EBI-714135,EBI-10182361
MEOX2P502223EBI-714135,EBI-748397
MFAP1P550813EBI-714135,EBI-1048159
MID2Q9UJV3-23EBI-714135,EBI-10172526
NDC80O147773EBI-714135,EBI-715849
PPP1R18Q6NYC85EBI-714135,EBI-2557469
PRKAB2O437414EBI-714135,EBI-1053424
PRPF31Q8WWY36EBI-714135,EBI-1567797
RNF6A0A0S2Z4G93EBI-714135,EBI-16428950
RNF8O760644EBI-714135,EBI-373337
RUNX1T1Q06455-43EBI-714135,EBI-10224192
SH2D4AQ9H7883EBI-714135,EBI-747035
SMARCE1Q969G33EBI-714135,EBI-455078
SNAP23A8K2873EBI-714135,EBI-10188497
SNAP23O001617EBI-714135,EBI-745000
STXBP1P617646EBI-714135,EBI-960169
TCF4P158843EBI-714135,EBI-533224
TLE5Q081173EBI-714135,EBI-717810
USHBP1Q8N6Y03EBI-714135,EBI-739895
VPS52Q8N1B43EBI-714135,EBI-2799833
WDYHV1Q96HA83EBI-714135,EBI-741158
ZCCHC10Q8TBK64EBI-714135,EBI-597063
ZNF417Q8TAU35EBI-714135,EBI-740727
ZNF587Q96SQ55EBI-714135,EBI-6427977

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114224, 109 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O75558

Protein interaction database and analysis system

More...
IntActi
O75558, 136 interactors

Molecular INTeraction database

More...
MINTi
O75558

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356540

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75558

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini204 – 266t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili41 – 71Sequence analysisAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0810 Eukaryota
COG5074 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182652

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000286023

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75558

KEGG Orthology (KO)

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KOi
K08487

Identification of Orthologs from Complete Genome Data

More...
OMAi
ENCKIRI

Database of Orthologous Groups

More...
OrthoDBi
1033833at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75558

TreeFam database of animal gene trees

More...
TreeFami
TF313763

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00179 SynN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010989 SNARE
IPR028672 STX11
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom

The PANTHER Classification System

More...
PANTHERi
PTHR19957:SF30 PTHR19957:SF30, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00804 Syntaxin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47661 SSF47661, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O75558-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD
60 70 80 90 100
IQDENQLLVA DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI
110 120 130 140 150
HCKLRAMKEL SEAAEAQHGP HSAVARISRA QYNALTLTFQ RAMHDYNQAE
160 170 180 190 200
MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM FEQGKWDVFS ENLLADVKGA
210 220 230 240 250
RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD TLNVIELNVQ
260 270 280
KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK
Length:287
Mass (Da):33,196
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18E8B43BA987D891
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61D → N in AAD02107 (PubMed:9571206).Curated1
Sequence conflicti93 – 94IK → FR in AAC24031 (PubMed:9553086).Curated2
Sequence conflicti96 – 97RG → PP in AAD02107 (PubMed:9571206).Curated2
Sequence conflicti103 – 104KL → NV in AAD02107 (PubMed:9571206).Curated2
Sequence conflicti121 – 126HSAVAR → ALGSGG in AAD02107 (PubMed:9571206).Curated6
Sequence conflicti200 – 220ARAAL…RLESR → RGPPTTRSRAATANCCAWRA A in AAC24031 (PubMed:9553086).CuratedAdd BLAST21
Sequence conflicti200A → V in AAD02107 (PubMed:9571206).Curated1
Sequence conflicti215L → V in AAD02107 (PubMed:9571206).Curated1
Sequence conflicti220R → A in AAD02107 (PubMed:9571206).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01199531E → Q. Corresponds to variant dbSNP:rs1802414Ensembl.1
Natural variantiVAR_02976949R → Q. Corresponds to variant dbSNP:rs17073498EnsemblClinVar.1
Natural variantiVAR_011996204L → H. Corresponds to variant dbSNP:rs1133248Ensembl.1
Natural variantiVAR_029770277T → A. Corresponds to variant dbSNP:rs9496891EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF038898 mRNA Translation: AAD02107.1
AF044309 mRNA Translation: AAC24031.1
AF071504 mRNA Translation: AAC24004.1
AL135917 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47849.1
CH471051 Genomic DNA Translation: EAW47850.1
BC033519 mRNA Translation: AAH33519.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5205.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JE0094

NCBI Reference Sequences

More...
RefSeqi
NP_003755.2, NM_003764.3
XP_011534516.1, XM_011536214.2
XP_011534519.1, XM_011536217.2
XP_011534520.1, XM_011536218.2
XP_016866889.1, XM_017011400.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367568; ENSP00000356540; ENSG00000135604

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8676

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8676

UCSC genome browser

More...
UCSCi
uc003qks.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

STX11base

STX11 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038898 mRNA Translation: AAD02107.1
AF044309 mRNA Translation: AAC24031.1
AF071504 mRNA Translation: AAC24004.1
AL135917 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47849.1
CH471051 Genomic DNA Translation: EAW47850.1
BC033519 mRNA Translation: AAH33519.1
CCDSiCCDS5205.1
PIRiJE0094
RefSeqiNP_003755.2, NM_003764.3
XP_011534516.1, XM_011536214.2
XP_011534519.1, XM_011536217.2
XP_011534520.1, XM_011536218.2
XP_016866889.1, XM_017011400.1

3D structure databases

SMRiO75558
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114224, 109 interactors
CORUMiO75558
IntActiO75558, 136 interactors
MINTiO75558
STRINGi9606.ENSP00000356540

PTM databases

iPTMnetiO75558
PhosphoSitePlusiO75558
SwissPalmiO75558

Polymorphism and mutation databases

BioMutaiSTX11

2D gel databases

OGPiO75558

Proteomic databases

EPDiO75558
jPOSTiO75558
MassIVEiO75558
MaxQBiO75558
PaxDbiO75558
PeptideAtlasiO75558
PRIDEiO75558
ProteomicsDBi50085

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8676

Genome annotation databases

EnsembliENST00000367568; ENSP00000356540; ENSG00000135604
GeneIDi8676
KEGGihsa:8676
UCSCiuc003qks.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8676
DisGeNETi8676

GeneCards: human genes, protein and diseases

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GeneCardsi
STX11
GeneReviewsiSTX11
HGNCiHGNC:11429 STX11
HPAiHPA007992
HPA076253
MalaCardsiSTX11
MIMi603552 phenotype
605014 gene
neXtProtiNX_O75558
OpenTargetsiENSG00000135604
Orphaneti540 Familial hemophagocytic lymphohistiocytosis
PharmGKBiPA36229

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00950000182652
HOGENOMiHOG000286023
InParanoidiO75558
KOiK08487
OMAiENCKIRI
OrthoDBi1033833at2759
PhylomeDBiO75558
TreeFamiTF313763

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
STX11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8676
PharosiO75558

Protein Ontology

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PROi
PR:O75558

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000135604 Expressed in 107 organ(s), highest expression level in blood
GenevisibleiO75558 HS

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR028672 STX11
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF30 PTHR19957:SF30, 1 hit
PfamiView protein in Pfam
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTX11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75558
Secondary accession number(s): E1P598
, O75378, O95148, Q5TCL6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: October 16, 2019
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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