UniProtKB - O75558 (STX11_HUMAN)
Protein
Syntaxin-11
Gene
STX11
Organism
Homo sapiens (Human)
Status
Functioni
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: GO_Central
GO - Biological processi
- exocytosis Source: GO_Central
- intracellular protein transport Source: GO_Central
- membrane fusion Source: ProtInc
- synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
- vesicle docking Source: GO_Central
- vesicle fusion Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | O75558 |
SIGNORi | O75558 |
Names & Taxonomyi
Protein namesi | Recommended name: Syntaxin-11 |
Gene namesi | Name:STX11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11429, STX11 |
MIMi | 605014, gene |
neXtProti | NX_O75558 |
VEuPathDBi | HostDB:ENSG00000135604.9 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane By similarity; Peripheral membrane protein By similarity
Other locations
- Membrane Curated; Peripheral membrane protein Curated
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
- presynaptic active zone membrane Source: GO_Central
- presynaptic membrane Source: GO_Central
Other locations
- endomembrane system Source: GO_Central
- integral component of membrane Source: GO_Central
- SNARE complex Source: GO_Central
- synaptic vesicle Source: GO_Central
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Involvement in diseasei
Hemophagocytic lymphohistiocytosis, familial, 4 (FHL4)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
Related information in OMIMKeywords - Diseasei
Familial hemophagocytic lymphohistiocytosisOrganism-specific databases
DisGeNETi | 8676 |
GeneReviewsi | STX11 |
MalaCardsi | STX11 |
MIMi | 603552, phenotype |
OpenTargetsi | ENSG00000135604 |
Orphaneti | 540, Familial hemophagocytic lymphohistiocytosis |
PharmGKBi | PA36229 |
Miscellaneous databases
Pharosi | O75558, Tbio |
Genetic variation databases
BioMutai | STX11 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210221 | 1 – 287 | Syntaxin-11Add BLAST | 287 |
Proteomic databases
EPDi | O75558 |
jPOSTi | O75558 |
MassIVEi | O75558 |
MaxQBi | O75558 |
PaxDbi | O75558 |
PeptideAtlasi | O75558 |
PRIDEi | O75558 |
ProteomicsDBi | 50085 |
2D gel databases
OGPi | O75558 |
PTM databases
iPTMneti | O75558 |
PhosphoSitePlusi | O75558 |
SwissPalmi | O75558 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135604, Expressed in monocyte and 127 other tissues |
Genevisiblei | O75558, HS |
Organism-specific databases
HPAi | ENSG00000135604, Tissue enhanced (blood, bone marrow, breast) |
Interactioni
Subunit structurei
Interacts with the SNARE proteins SNAP-23 and VAMP.
Binary interactionsi
O75558
GO - Molecular functioni
- SNARE binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114224, 139 interactors |
CORUMi | O75558 |
IntActi | O75558, 153 interactors |
MINTi | O75558 |
STRINGi | 9606.ENSP00000356540 |
Miscellaneous databases
RNActi | O75558, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 204 – 266 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 41 – 71 | Sequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the syntaxin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0810, Eukaryota |
GeneTreei | ENSGT01000000214380 |
HOGENOMi | CLU_042423_2_0_1 |
InParanoidi | O75558 |
OMAi | EYNQAEM |
OrthoDBi | 1033833at2759 |
PhylomeDBi | O75558 |
TreeFami | TF313763 |
Family and domain databases
CDDi | cd15878, SNARE_syntaxin11, 1 hit cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR028672, STX11 IPR006012, Syntaxin/epimorphin_CS IPR042781, Syntaxin11_SNARE IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957:SF30, PTHR19957:SF30, 1 hit |
Pfami | View protein in Pfam PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
i Sequence
Sequence statusi: Complete.
O75558-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD
60 70 80 90 100
IQDENQLLVA DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI
110 120 130 140 150
HCKLRAMKEL SEAAEAQHGP HSAVARISRA QYNALTLTFQ RAMHDYNQAE
160 170 180 190 200
MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM FEQGKWDVFS ENLLADVKGA
210 220 230 240 250
RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD TLNVIELNVQ
260 270 280
KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 | D → N in AAD02107 (PubMed:9571206).Curated | 1 | |
Sequence conflicti | 93 – 94 | IK → FR in AAC24031 (PubMed:9553086).Curated | 2 | |
Sequence conflicti | 96 – 97 | RG → PP in AAD02107 (PubMed:9571206).Curated | 2 | |
Sequence conflicti | 103 – 104 | KL → NV in AAD02107 (PubMed:9571206).Curated | 2 | |
Sequence conflicti | 121 – 126 | HSAVAR → ALGSGG in AAD02107 (PubMed:9571206).Curated | 6 | |
Sequence conflicti | 200 – 220 | ARAAL…RLESR → RGPPTTRSRAATANCCAWRA A in AAC24031 (PubMed:9553086).CuratedAdd BLAST | 21 | |
Sequence conflicti | 200 | A → V in AAD02107 (PubMed:9571206).Curated | 1 | |
Sequence conflicti | 215 | L → V in AAD02107 (PubMed:9571206).Curated | 1 | |
Sequence conflicti | 220 | R → A in AAD02107 (PubMed:9571206).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011995 | 31 | E → Q. Corresponds to variant dbSNP:rs1802414Ensembl. | 1 | |
Natural variantiVAR_029769 | 49 | R → Q. Corresponds to variant dbSNP:rs17073498EnsemblClinVar. | 1 | |
Natural variantiVAR_011996 | 204 | L → H. Corresponds to variant dbSNP:rs1133248Ensembl. | 1 | |
Natural variantiVAR_029770 | 277 | T → A. Corresponds to variant dbSNP:rs9496891EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038898 mRNA Translation: AAD02107.1 AF044309 mRNA Translation: AAC24031.1 AF071504 mRNA Translation: AAC24004.1 AL135917 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47849.1 CH471051 Genomic DNA Translation: EAW47850.1 BC033519 mRNA Translation: AAH33519.1 |
CCDSi | CCDS5205.1 |
PIRi | JE0094 |
RefSeqi | NP_003755.2, NM_003764.3 XP_011534516.1, XM_011536214.2 XP_011534519.1, XM_011536217.2 XP_011534520.1, XM_011536218.2 XP_016866889.1, XM_017011400.1 |
Genome annotation databases
Ensembli | ENST00000367568; ENSP00000356540; ENSG00000135604 |
GeneIDi | 8676 |
KEGGi | hsa:8676 |
UCSCi | uc003qks.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
STX11base STX11 mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038898 mRNA Translation: AAD02107.1 AF044309 mRNA Translation: AAC24031.1 AF071504 mRNA Translation: AAC24004.1 AL135917 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47849.1 CH471051 Genomic DNA Translation: EAW47850.1 BC033519 mRNA Translation: AAH33519.1 |
CCDSi | CCDS5205.1 |
PIRi | JE0094 |
RefSeqi | NP_003755.2, NM_003764.3 XP_011534516.1, XM_011536214.2 XP_011534519.1, XM_011536217.2 XP_011534520.1, XM_011536218.2 XP_016866889.1, XM_017011400.1 |
3D structure databases
SMRi | O75558 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114224, 139 interactors |
CORUMi | O75558 |
IntActi | O75558, 153 interactors |
MINTi | O75558 |
STRINGi | 9606.ENSP00000356540 |
PTM databases
iPTMneti | O75558 |
PhosphoSitePlusi | O75558 |
SwissPalmi | O75558 |
Genetic variation databases
BioMutai | STX11 |
2D gel databases
OGPi | O75558 |
Proteomic databases
EPDi | O75558 |
jPOSTi | O75558 |
MassIVEi | O75558 |
MaxQBi | O75558 |
PaxDbi | O75558 |
PeptideAtlasi | O75558 |
PRIDEi | O75558 |
ProteomicsDBi | 50085 |
Protocols and materials databases
Antibodypediai | 714, 177 antibodies |
DNASUi | 8676 |
Genome annotation databases
Ensembli | ENST00000367568; ENSP00000356540; ENSG00000135604 |
GeneIDi | 8676 |
KEGGi | hsa:8676 |
UCSCi | uc003qks.5, human |
Organism-specific databases
CTDi | 8676 |
DisGeNETi | 8676 |
GeneCardsi | STX11 |
GeneReviewsi | STX11 |
HGNCi | HGNC:11429, STX11 |
HPAi | ENSG00000135604, Tissue enhanced (blood, bone marrow, breast) |
MalaCardsi | STX11 |
MIMi | 603552, phenotype 605014, gene |
neXtProti | NX_O75558 |
OpenTargetsi | ENSG00000135604 |
Orphaneti | 540, Familial hemophagocytic lymphohistiocytosis |
PharmGKBi | PA36229 |
VEuPathDBi | HostDB:ENSG00000135604.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0810, Eukaryota |
GeneTreei | ENSGT01000000214380 |
HOGENOMi | CLU_042423_2_0_1 |
InParanoidi | O75558 |
OMAi | EYNQAEM |
OrthoDBi | 1033833at2759 |
PhylomeDBi | O75558 |
TreeFami | TF313763 |
Enzyme and pathway databases
PathwayCommonsi | O75558 |
SIGNORi | O75558 |
Miscellaneous databases
BioGRID-ORCSi | 8676, 4 hits in 875 CRISPR screens |
GeneWikii | STX11 |
GenomeRNAii | 8676 |
Pharosi | O75558, Tbio |
PROi | PR:O75558 |
RNActi | O75558, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135604, Expressed in monocyte and 127 other tissues |
Genevisiblei | O75558, HS |
Family and domain databases
CDDi | cd15878, SNARE_syntaxin11, 1 hit cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR028672, STX11 IPR006012, Syntaxin/epimorphin_CS IPR042781, Syntaxin11_SNARE IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957:SF30, PTHR19957:SF30, 1 hit |
Pfami | View protein in Pfam PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STX11_HUMAN | |
Accessioni | O75558Primary (citable) accession number: O75558 Secondary accession number(s): E1P598 Q5TCL6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families