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Protein

Mammaglobin-B

Gene

SCGB2A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Mammaglobin-B
Alternative name(s):
Lacryglobin
Lipophilin-C
Mammaglobin-2
Secretoglobin family 2A member 1
Gene namesi
Name:SCGB2A1
Synonyms:LIPHC, MGB2, UGB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000124939.5
HGNCiHGNC:7051 SCGB2A1
MIMi604398 gene
neXtProtiNX_O75556

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4246
OpenTargetsiENSG00000124939
PharmGKBiPA34992

Polymorphism and mutation databases

BioMutaiSCGB2A1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 183 PublicationsAdd BLAST18
ChainiPRO_000003637319 – 95Mammaglobin-BAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75556
PeptideAtlasiO75556
PRIDEiO75556
ProteomicsDBi50084

PTM databases

GlyConnecti1487
iPTMnetiO75556
PhosphoSitePlusiO75556

Expressioni

Tissue specificityi

Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.

Gene expression databases

BgeeiENSG00000124939 Expressed in 103 organ(s), highest expression level in corpus epididymis
CleanExiHS_SCGB2A1
GenevisibleiO75556 HS

Organism-specific databases

HPAiHPA034584

Interactioni

Subunit structurei

Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110402, 19 interactors
IntActiO75556, 7 interactors
STRINGi9606.ENSP00000244930

Structurei

3D structure databases

ProteinModelPortaliO75556
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEU0 Eukaryota
ENOG4111A32 LUCA
GeneTreeiENSGT00390000013802
HOGENOMiHOG000294150
HOVERGENiHBG005021
InParanoidiO75556
OMAiDSIWCNM
OrthoDBiEOG091G16OV
PhylomeDBiO75556
TreeFamiTF338521

Family and domain databases

CDDicd00633 Secretoglobin, 1 hit
InterProiView protein in InterPro
IPR016126 Secretoglobin
IPR035960 Secretoglobin_sf
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit
SUPFAMiSSF48201 SSF48201, 1 hit
PROSITEiView protein in PROSITE
PS51311 SCGB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75556-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLMVLMLA ALLLHCYADS GCKLLEDMVE KTINSDISIP EYKELLQEFI
60 70 80 90
DSDAAAEAMG KFKQCFLNQS HRTLKNFGLM MHTVYDSIWC NMKSN
Length:95
Mass (Da):10,884
Last modified:November 1, 1998 - v1
Checksum:i0719738289F89F8D
GO

Mass spectrometryi

Molecular mass is 8854.94 Da from positions 19 - 95. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071219 mRNA Translation: AAC79996.1
AJ224173 mRNA Translation: CAA11865.1
BC062218 mRNA Translation: AAH62218.1
CCDSiCCDS8016.1
RefSeqiNP_002398.1, NM_002407.2
UniGeneiHs.97644

Genome annotation databases

EnsembliENST00000244930; ENSP00000244930; ENSG00000124939
GeneIDi4246
KEGGihsa:4246
UCSCiuc001nta.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071219 mRNA Translation: AAC79996.1
AJ224173 mRNA Translation: CAA11865.1
BC062218 mRNA Translation: AAH62218.1
CCDSiCCDS8016.1
RefSeqiNP_002398.1, NM_002407.2
UniGeneiHs.97644

3D structure databases

ProteinModelPortaliO75556
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110402, 19 interactors
IntActiO75556, 7 interactors
STRINGi9606.ENSP00000244930

PTM databases

GlyConnecti1487
iPTMnetiO75556
PhosphoSitePlusiO75556

Polymorphism and mutation databases

BioMutaiSCGB2A1

Proteomic databases

PaxDbiO75556
PeptideAtlasiO75556
PRIDEiO75556
ProteomicsDBi50084

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244930; ENSP00000244930; ENSG00000124939
GeneIDi4246
KEGGihsa:4246
UCSCiuc001nta.2 human

Organism-specific databases

CTDi4246
DisGeNETi4246
EuPathDBiHostDB:ENSG00000124939.5
GeneCardsiSCGB2A1
HGNCiHGNC:7051 SCGB2A1
HPAiHPA034584
MIMi604398 gene
neXtProtiNX_O75556
OpenTargetsiENSG00000124939
PharmGKBiPA34992
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEU0 Eukaryota
ENOG4111A32 LUCA
GeneTreeiENSGT00390000013802
HOGENOMiHOG000294150
HOVERGENiHBG005021
InParanoidiO75556
OMAiDSIWCNM
OrthoDBiEOG091G16OV
PhylomeDBiO75556
TreeFamiTF338521

Miscellaneous databases

ChiTaRSiSCGB2A1 human
GeneWikiiMammaglobin-B
GenomeRNAii4246
PROiPR:O75556
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124939 Expressed in 103 organ(s), highest expression level in corpus epididymis
CleanExiHS_SCGB2A1
GenevisibleiO75556 HS

Family and domain databases

CDDicd00633 Secretoglobin, 1 hit
InterProiView protein in InterPro
IPR016126 Secretoglobin
IPR035960 Secretoglobin_sf
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit
SUPFAMiSSF48201 SSF48201, 1 hit
PROSITEiView protein in PROSITE
PS51311 SCGB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSG2A1_HUMAN
AccessioniPrimary (citable) accession number: O75556
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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