DAB1

Functionⁱ

Adapter molecule functioning in neural development. May regulate SIAH1 activity.By similarity

GO - Molecular functionⁱ

phosphatidylinositol 3-kinase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult walking behavior Source: Ensembl
axon guidance Source: Reactome
cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration Source: Ensembl
cerebellum structural organization Source: Ensembl
dendrite development Source: Ensembl
Golgi localization Source: Ensembl
lateral motor column neuron migration Source: Ensembl
midgut development Source: Ensembl
negative regulation of astrocyte differentiation Source: Ensembl
negative regulation of axonogenesis Source: Ensembl
negative regulation of cell adhesion Source: Ensembl
negative regulation of JAK-STAT cascade Source: Ensembl
positive regulation of neuron differentiation Source: Ensembl
positive regulation of protein kinase activity Source: Ensembl
radial glia guided migration of Purkinje cell Source: Ensembl
response to drug Source: Ensembl
small GTPase mediated signal transduction Source: Ensembl
ventral spinal cord development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation, Neurogenesis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8866376 Reelin signalling pathway
SignaLinkⁱ	O75553
SIGNORⁱ	O75553

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Disabled homolog 1
Gene namesⁱ	Name:DAB1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173406.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2661 DAB1
MIMⁱ	603448 gene
neXtProtⁱ	NX_O75553

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Spinocerebellar ataxia 37 (SCA37)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA37 is an autosomal dominant form characterized by adult-onset of slowly progressive gait instability, frequent falls, and dysarthria associated with cerebellar atrophy on brain imaging.

Keywords - Diseaseⁱ

Neurodegeneration, Spinocerebellar ataxia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1600
MalaCards human disease database More...MalaCardsⁱ	DAB1
MIMⁱ	615945 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000173406
Orphanetⁱ	363710 Spinocerebellar ataxia type 37
PharmGKBⁱ	PA27131

Polymorphism and mutation databases

BioMutaⁱ	DAB1

BioMutaⁱ

DAB1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079767	1 – 588	Disabled homolog 1Add BLAST		588

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	198	PhosphotyrosineBy similarity	1
Modified residueⁱ	220	PhosphotyrosineBy similarity	1
Modified residueⁱ	232	PhosphotyrosineBy similarity	1
Modified residueⁱ	524	Phosphoserine; by CDK5By similarity	1

Post-translational modificationⁱ

Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O75553
PeptideAtlas More...PeptideAtlasⁱ	O75553
PRIDEⁱ	O75553
ProteomicsDBⁱ	50077 50078 [O75553-2] 50079 [O75553-3] 50080 [O75553-4] 50081 [O75553-5] 50082 [O75553-6]

PTM databases

iPTMnetⁱ	O75553
PhosphoSitePlusⁱ	O75553

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173406 Expressed in 120 organ(s), highest expression level in frontal cortex
ExpressionAtlasⁱ	O75553 baseline and differential
Genevisibleⁱ	O75553 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB032329 HPA052033 HPA067495

HPAⁱ

CAB032329
HPA052033
HPA067495

Interactionⁱ

Subunit structureⁱ

Associates with the SH2 domains of SRC, FYN and ABL (By similarity). Interacts (phosphorylated on tyrosine residues) with CRK and CRKL (via respective SH2 domain) (By similarity). Interacts with SIAH1, LRP8 and VLDLR (By similarity). Interacts with LRP1 (PubMed:15272003). Interacts with APLP1 (via NPXY motif) (By similarity). Interacts with DAB2IP (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
	Q9H9I0	3	EBI-7875264,EBI-10309771
BHLHE40	O14503	3	EBI-7875264,EBI-711810
C1orf94	Q6P1W5	3	EBI-7875264,EBI-946029
CIART	Q8N365	3	EBI-7875264,EBI-10265133
DAZAP2	Q15038	3	EBI-7875264,EBI-724310
FAM168A	Q92567	3	EBI-7875264,EBI-7957930
hCG_2003792	A0A024R5S0	3	EBI-7875264,EBI-10188461
HMBOX1	Q6NT76	3	EBI-7875264,EBI-2549423
HNRNPLL	Q8WVV9	3	EBI-7875264,EBI-535849
HYAL3	O43820	3	EBI-7875264,EBI-3913399
KRTAP19-5	Q3LI72	3	EBI-7875264,EBI-1048945
KRTAP19-7	Q3SYF9	3	EBI-7875264,EBI-10241353
KRTAP8-1	Q8IUC2	3	EBI-7875264,EBI-10261141
LGALS9B	Q3B8N2	3	EBI-7875264,EBI-10240775
LGALS9C	Q6DKI2	3	EBI-7875264,EBI-9088829
LNX1	Q8TBB1	3	EBI-7875264,EBI-739832
MAGED1	Q9Y5V3	3	EBI-7875264,EBI-716006
MBNL1	Q86VM6	3	EBI-7875264,EBI-10225084
MBNL1	Q9NR56	3	EBI-7875264,EBI-2805004
MBNL3	Q9NUK0	3	EBI-7875264,EBI-6661142
NAF1	Q96HR8	3	EBI-7875264,EBI-2515597
PIN1	Q13526	3	EBI-7875264,EBI-714158
POGZ	Q7Z3K3	3	EBI-7875264,EBI-1389308
PPIG	Q13427	3	EBI-7875264,EBI-396072
PRR20C	P86479	3	EBI-7875264,EBI-10172814
RAMMET	Q9BTL3	3	EBI-7875264,EBI-744023
RBFOX2	O43251	3	EBI-7875264,EBI-746056
RHOXF2	Q9BQY4	3	EBI-7875264,EBI-372094
ROR2	A1L4F5	3	EBI-7875264,EBI-10172778
SIRPB1	O00241-2	3	EBI-7875264,EBI-10179231
SMAP2	Q8WU79	3	EBI-7875264,EBI-2822515
SNRPB	P14678-2	3	EBI-7875264,EBI-372475
STRBP	Q96SI9	3	EBI-7875264,EBI-740355
TCEA2	Q15560	3	EBI-7875264,EBI-710310
TCEA2	Q86VL0	3	EBI-7875264,EBI-10259904
TCEANC	Q8N8B7	3	EBI-7875264,EBI-954696
TMTC3	Q6ZXV5	3	EBI-7875264,EBI-10188441
TOLLIP	Q6FIE9	3	EBI-7875264,EBI-10249783
TOLLIP	Q9H0E2	3	EBI-7875264,EBI-74615
VENTX	O95231	3	EBI-7875264,EBI-10191303
WDYHV1	Q96HA8	3	EBI-7875264,EBI-741158
ZBTB32	A0A0C4DGF1	3	EBI-7875264,EBI-10188476
ZC3H10	Q96K80	3	EBI-7875264,EBI-742550
ZCCHC10	Q8TBK6	3	EBI-7875264,EBI-597063
ZNF488	Q96MN9	3	EBI-7875264,EBI-948288

GO - Molecular functionⁱ

phosphatidylinositol 3-kinase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107970, 66 interactors
ELMⁱ	O75553
IntActⁱ	O75553, 49 interactors
Molecular INTeraction database More...MINTⁱ	O75553

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75553
SMRⁱ	O75553
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	36 – 189	PIDPROSITE-ProRule annotationAdd BLAST		154

Domainⁱ

The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00520000055585
HOVERGENⁱ	HBG018945
InParanoidⁱ	O75553
KEGG Orthology (KO) More...KOⁱ	K20054
OMAⁱ	DQPSLSC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0382
PhylomeDBⁱ	O75553
TreeFamⁱ	TF316724

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00640 PID, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform DAB588 (identifier: O75553-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID 
        60         70         80         90        100
EVSAARGDKL CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK 
       110        120        130        140        150
TGALQHHHAV HEISYIAKDI TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV 
       160        170        180        190        200
ILDLRDLFQL IYELKQREEL EKKAQKDKQC EQAVYQTILE EDVEDPVYQY 
       210        220        230        240        250
IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPV SNGYSFEDFE 
       260        270        280        290        300
ERFAAATPNR NLPTDFDEIF EATKAVTQLE LFGDMSTPPD ITSPPTPATP 
       310        320        330        340        350
GDAFIPSSSQ TLPASADVFS SVPFGTAAVP SGYVAMGAVL PSFWGQQPLV 
       360        370        380        390        400
QQQMVMGAQP PVAQVMPGAQ PIAWGQPGLF PATQQPWPTV AGQFPPAAFM 
       410        420        430        440        450
PTQTVMPLPA AMFQGPLTPL ATVPGTSDST RSSPQTDKPR QKMGKETFKD 
       460        470        480        490        500
FQMAQPPPVP SRKPDQPSLT CTSEAFSSYF NKVGVAQDTD DCDDFDISQL 
       510        520        530        540        550
NLTPVTSTTP STNSPPTPAP RQSSPSKSSA SHASDPTTDD IFEEGFESPS 
       560        570        580 
KSEEQEAPDG SQASSNSDPF GEPSGEPSGD NISPQAGS

Note: No experimental confirmation available.

Length:588

Mass (Da):63,775

Last modified:June 26, 2007 - v3

Checksum:ⁱDAD4024364113AC5

GO

Isoform DAB213 (identifier: O75553-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
200-213: YIVFEAGHEPIRDP → VISETSRGFRFKSD
214-588: Missing.

« Hide

        10         20         30         40         50
MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID 
        60         70         80         90        100
EVSAARGDKL CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK 
       110        120        130        140        150
TGALQHHHAV HEISYIAKDI TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV 
       160        170        180        190        200
ILDLRDLFQL IYELKQREEL EKKAQKDKQC EQAVYQTILE EDVEDPVYQV 
       210 
ISETSRGFRF KSD

Note: No experimental confirmation available.

Show »

Length:213

Mass (Da):24,091

Checksum:ⁱ9A3ADE86341D96E1

GO

Isoform DAB469 (identifier: O75553-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
103-221: Missing.

« Hide

        10         20         30         40         50
MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID 
        60         70         80         90        100
EVSAARGDKL CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK 
       110        120        130        140        150
TGVPTSQKKE GVYDVPKSQP VSNGYSFEDF EERFAAATPN RNLPTDFDEI 
       160        170        180        190        200
FEATKAVTQL ELFGDMSTPP DITSPPTPAT PGDAFIPSSS QTLPASADVF 
       210        220        230        240        250
SSVPFGTAAV PSGYVAMGAV LPSFWGQQPL VQQQMVMGAQ PPVAQVMPGA 
       260        270        280        290        300
QPIAWGQPGL FPATQQPWPT VAGQFPPAAF MPTQTVMPLP AAMFQGPLTP 
       310        320        330        340        350
LATVPGTSDS TRSSPQTDKP RQKMGKETFK DFQMAQPPPV PSRKPDQPSL 
       360        370        380        390        400
TCTSEAFSSY FNKVGVAQDT DDCDDFDISQ LNLTPVTSTT PSTNSPPTPA 
       410        420        430        440        450
PRQSSPSKSS ASHASDPTTD DIFEEGFESP SKSEEQEAPD GSQASSNSDP 
       460 
FGEPSGEPSG DNISPQAGS

Note: No experimental confirmation available.

Show »

Length:469

Mass (Da):49,856

Checksum:ⁱ5A03F93BDB4BAF42

GO

Isoform DAB537 (identifier: O75553-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
185-219: Missing.
259-274: Missing.

« Hide

        10         20         30         40         50
MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID 
        60         70         80         90        100
EVSAARGDKL CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK 
       110        120        130        140        150
TGALQHHHAV HEISYIAKDI TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV 
       160        170        180        190        200
ILDLRDLFQL IYELKQREEL EKKAQKDKQC EQAVYQVPTS QKKEGVYDVP 
       210        220        230        240        250
KSQPVSNGYS FEDFEERFAA ATPAVTQLEL FGDMSTPPDI TSPPTPATPG 
       260        270        280        290        300
DAFIPSSSQT LPASADVFSS VPFGTAAVPS GYVAMGAVLP SFWGQQPLVQ 
       310        320        330        340        350
QQMVMGAQPP VAQVMPGAQP IAWGQPGLFP ATQQPWPTVA GQFPPAAFMP 
       360        370        380        390        400
TQTVMPLPAA MFQGPLTPLA TVPGTSDSTR SSPQTDKPRQ KMGKETFKDF 
       410        420        430        440        450
QMAQPPPVPS RKPDQPSLTC TSEAFSSYFN KVGVAQDTDD CDDFDISQLN 
       460        470        480        490        500
LTPVTSTTPS TNSPPTPAPR QSSPSKSSAS HASDPTTDDI FEEGFESPSK 
       510        520        530 
SEEQEAPDGS QASSNSDPFG EPSGEPSGDN ISPQAGS

Note: No experimental confirmation available.

Show »

Length:537

Mass (Da):57,720

Checksum:ⁱ6626BD99FE7C098C

GO

Isoform DAB553 (identifier: O75553-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
185-219: Missing.

« Hide

        10         20         30         40         50
MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID 
        60         70         80         90        100
EVSAARGDKL CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK 
       110        120        130        140        150
TGALQHHHAV HEISYIAKDI TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV 
       160        170        180        190        200
ILDLRDLFQL IYELKQREEL EKKAQKDKQC EQAVYQVPTS QKKEGVYDVP 
       210        220        230        240        250
KSQPVSNGYS FEDFEERFAA ATPNRNLPTD FDEIFEATKA VTQLELFGDM 
       260        270        280        290        300
STPPDITSPP TPATPGDAFI PSSSQTLPAS ADVFSSVPFG TAAVPSGYVA 
       310        320        330        340        350
MGAVLPSFWG QQPLVQQQMV MGAQPPVAQV MPGAQPIAWG QPGLFPATQQ 
       360        370        380        390        400
PWPTVAGQFP PAAFMPTQTV MPLPAAMFQG PLTPLATVPG TSDSTRSSPQ 
       410        420        430        440        450
TDKPRQKMGK ETFKDFQMAQ PPPVPSRKPD QPSLTCTSEA FSSYFNKVGV 
       460        470        480        490        500
AQDTDDCDDF DISQLNLTPV TSTTPSTNSP PTPAPRQSSP SKSSASHASD 
       510        520        530        540        550
PTTDDIFEEG FESPSKSEEQ EAPDGSQASS NSDPFGEPSG EPSGDNISPQ 

AGS

Note: No experimental confirmation available.

Show »

Length:553

Mass (Da):59,612

Checksum:ⁱ59BC5E84DEF5F583

GO

Isoform DAB555 (identifier: O75553-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
242-274: Missing.

« Hide

        10         20         30         40         50
MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID 
        60         70         80         90        100
EVSAARGDKL CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK 
       110        120        130        140        150
TGALQHHHAV HEISYIAKDI TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV 
       160        170        180        190        200
ILDLRDLFQL IYELKQREEL EKKAQKDKQC EQAVYQTILE EDVEDPVYQY 
       210        220        230        240        250
IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPV SAVTQLELFG 
       260        270        280        290        300
DMSTPPDITS PPTPATPGDA FIPSSSQTLP ASADVFSSVP FGTAAVPSGY 
       310        320        330        340        350
VAMGAVLPSF WGQQPLVQQQ MVMGAQPPVA QVMPGAQPIA WGQPGLFPAT 
       360        370        380        390        400
QQPWPTVAGQ FPPAAFMPTQ TVMPLPAAMF QGPLTPLATV PGTSDSTRSS 
       410        420        430        440        450
PQTDKPRQKM GKETFKDFQM AQPPPVPSRK PDQPSLTCTS EAFSSYFNKV 
       460        470        480        490        500
GVAQDTDDCD DFDISQLNLT PVTSTTPSTN SPPTPAPRQS SPSKSSASHA 
       510        520        530        540        550
SDPTTDDIFE EGFESPSKSE EQEAPDGSQA SSNSDPFGEP SGEPSGDNIS 

PQAGS

Show »

Length:555

Mass (Da):59,950

Checksum:ⁱ9EB4FC3D31BBF8CB

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

X6R4J9	X6R4J9_HUMAN	Disabled homolog 1 Disabled homolog 1	DAB1	204	Annotation score:
A0A075B6G7	A0A075B6G7_HUMAN	Disabled homolog 1 Disabled homolog 1	DAB1	239	Annotation score:

Sequence cautionⁱ

The sequence BAE06094 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	15	A → T in AAI12939 (PubMed:15489334).Curated	1
Sequence conflictⁱ	59	K → M in AAH67447 (PubMed:15489334).Curated	1
Sequence conflictⁱ	86	F → L in AAF73058 (Ref. 2) Curated	1
Sequence conflictⁱ	295	P → S in AAH67447 (PubMed:15489334).Curated	1
Sequence conflictⁱ	324	F → L in AAC70068 (PubMed:9790777).Curated	1
Sequence conflictⁱ	331	S → P in AAC70068 (PubMed:9790777).Curated	1
Sequence conflictⁱ	359	Q → H in AAC70068 (PubMed:9790777).Curated	1
Sequence conflictⁱ	368	G → R in AAF73058 (Ref. 2) Curated	1
Sequence conflictⁱ	412	M → V in AAF73058 (Ref. 2) Curated	1
Sequence conflictⁱ	586	A → D in AAC70068 (PubMed:9790777).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_056857	71	V → I. Corresponds to variant dbSNP:rs1855377Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_026166	103 – 221	Missing in isoform DAB469. 1 PublicationAdd BLAST	119
Alternative sequenceⁱVSP_026167	185 – 219	Missing in isoform DAB553 and isoform DAB537. 1 PublicationAdd BLAST	35
Alternative sequenceⁱVSP_026168	200 – 213	YIVFE…PIRDP → VISETSRGFRFKSD in isoform DAB213. CuratedAdd BLAST	14
Alternative sequenceⁱVSP_026169	214 – 588	Missing in isoform DAB213. CuratedAdd BLAST	375
Alternative sequenceⁱVSP_026170	242 – 274	Missing in isoform DAB555. 3 PublicationsAdd BLAST	33
Alternative sequenceⁱVSP_026171	259 – 274	Missing in isoform DAB537. 1 PublicationAdd BLAST	16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF071062 mRNA Translation: AAC70068.1 AF263547 mRNA Translation: AAF73058.1 AL139219 Genomic DNA No translation available. AL161740 Genomic DNA No translation available. AL354883 Genomic DNA No translation available. AK095513 mRNA Translation: BAG53075.1 AB210012 mRNA Translation: BAE06094.1 Different initiation. CH471059 Genomic DNA Translation: EAX06637.1 BC067445 mRNA Translation: AAH67445.1 BC067446 mRNA Translation: AAH67446.1 BC067447 mRNA Translation: AAH67447.1 BC112938 mRNA Translation: AAI12939.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS607.1 [O75553-6]
NCBI Reference Sequences More...RefSeqⁱ	NP_066566.3, NM_021080.3 [O75553-6]
UniGeneⁱ	Hs.477370

Genome annotation databases

Ensemblⁱ	ENST00000371230; ENSP00000360274; ENSG00000173406 [O75553-2] ENST00000371231; ENSP00000360275; ENSG00000173406 [O75553-1] ENST00000371236; ENSP00000360280; ENSG00000173406 [O75553-6] ENST00000414851; ENSP00000387581; ENSG00000173406 [O75553-6] ENST00000420954; ENSP00000395296; ENSG00000173406 [O75553-5]
GeneIDⁱ	1600
KEGGⁱ	hsa:1600
UCSC genome browser More...UCSCⁱ	uc001cyq.2 human [O75553-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O75553	DAB1 isoform 10		PANTR		588	UniRef100_O75553
Uncharacterized protein		PANPA		588
DAB1 (Fragment)		HUMAN		33
O75553-2	DAB1 isoform 3		PANTR		213	UniRef100_O75553-2
O75553-3	Disabled homolog 1 (Fragment)		HUMAN		239	UniRef100_O75553-3
DAB1 isoform 9 (Fragment)		PANTR		239
O75553-5	DAB1 isoform 7		PANTR		553	UniRef100_O75553-5
Uncharacterized protein		PANPA		553
O75553-6	DAB1 isoform 4		PANTR		555	UniRef100_O75553-6
Uncharacterized protein		PANPA		555
DAB1, reelin adaptor protein		GORGO		555

Protein	Similar proteins		Species	Score	Length	Source
O75553	Disabled homolog 1	)	MOUSE		588	UniRef90_O75553
DAB1 isoform 10		PANTR		588
Uncharacterized protein		PANPA		588
DAB1 (Fragment)		HUMAN		33
DAB1, reelin adaptor protein		LOXAF		592
+117
O75553-2	DAB1 isoform 3		PANTR		213	UniRef90_O75553-2
Isoform DAB217 of Disabled homolog 1		MOUSE		217
DAB1 isoform 8		PONAB		213
DAB1, reelin adaptor protein		SAIBB		212
Uncharacterized protein		Cebus capucinus imitator		212
+7
O75553-3	Disabled homolog 1 (Fragment)		HUMAN		239	UniRef90_O75553-3
DAB1 isoform 9 (Fragment)		PANTR		239
disabled homolog 1 isoform X2		ERIEU		469
disabled homolog 1 isoform X3		DIPOR		469
disabled homolog 1 isoform X5		LIPVE		465
+12
O75553-4	Isoform DAB553 of Disabled homolog 1		HUMAN		553	UniRef90_O75553-5
DAB1 isoform 7		PANTR		553
Uncharacterized protein		PANPA		553
Uncharacterized protein		CALJA		553
disabled homolog 1 isoform X1		ERIEU		553
+100
O75553-5	DAB1 isoform 7		PANTR		553	UniRef90_O75553-5
Uncharacterized protein		PANPA		553
Uncharacterized protein		CALJA		553
disabled homolog 1 isoform X1		ERIEU		553
DAB1 isoform 4		PONAB		553
+100
O75553-6	Disabled homolog 1		MACFA		555	UniRef90_O75553-6
DAB1 isoform 4		PANTR		555
Uncharacterized protein		PANPA		555
DAB1, reelin adaptor protein		GORGO		555
LOW QUALITY PROTEIN: disabled homolog 1		Florida manatee		561
+93

Protein	Similar proteins		Species	Score	Length	Source
O75553	Disabled homolog 1	)	MOUSE		588	UniRef50_O75553
Disabled homolog 1		MACFA		555
Disabled homolog 1		RAT		555
DAB1 isoform 10		PANTR		588
Uncharacterized protein		PANPA		588
+468
O75553-2	DAB1 isoform 3		PANTR		213	UniRef50_O75553-2
Isoform DAB217 of Disabled homolog 1		MOUSE		217
DAB1 isoform 8		PONAB		213
Uncharacterized protein		CALJA		212
DAB1, reelin adaptor protein		SAIBB		212
+14
O75553-3	Disabled homolog 1 (Fragment)		HUMAN		239	UniRef50_O75553-3
DAB1 isoform 9 (Fragment)		PANTR		239
disabled homolog 1 isoform X2		ERIEU		469
disabled homolog 1 isoform X3		DIPOR		469
disabled homolog 1 isoform X5		TURTR		465
+16
O75553-4	Isoform DAB553 of Disabled homolog 1		HUMAN		553	UniRef50_O75553-5
DAB1 isoform 7		PANTR		553
Uncharacterized protein		PANPA		553
Uncharacterized protein		PIG		553
disabled homolog 1 isoform X2		DIPOR		553
+256
O75553-5	DAB1 isoform 7		PANTR		553	UniRef50_O75553-5
Uncharacterized protein		PANPA		553
Uncharacterized protein		PIG		553
disabled homolog 1 isoform X2		DIPOR		553
DAB1, reelin adaptor protein		GORGO		553
+256

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF071062 mRNA Translation: AAC70068.1 AF263547 mRNA Translation: AAF73058.1 AL139219 Genomic DNA No translation available. AL161740 Genomic DNA No translation available. AL354883 Genomic DNA No translation available. AK095513 mRNA Translation: BAG53075.1 AB210012 mRNA Translation: BAE06094.1 Different initiation. CH471059 Genomic DNA Translation: EAX06637.1 BC067445 mRNA Translation: AAH67445.1 BC067446 mRNA Translation: AAH67446.1 BC067447 mRNA Translation: AAH67447.1 BC112938 mRNA Translation: AAI12939.1
CCDSⁱ	CCDS607.1 [O75553-6]
RefSeqⁱ	NP_066566.3, NM_021080.3 [O75553-6]
UniGeneⁱ	Hs.477370

3D structure databases

ProteinModelPortalⁱ	O75553
SMRⁱ	O75553
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107970, 66 interactors
ELMⁱ	O75553
IntActⁱ	O75553, 49 interactors
MINTⁱ	O75553

PTM databases

iPTMnetⁱ	O75553
PhosphoSitePlusⁱ	O75553

Polymorphism and mutation databases

BioMutaⁱ	DAB1

BioMutaⁱ

DAB1

Proteomic databases

EPDⁱ	O75553
PeptideAtlasⁱ	O75553
PRIDEⁱ	O75553
ProteomicsDBⁱ	50077 50078 [O75553-2] 50079 [O75553-3] 50080 [O75553-4] 50081 [O75553-5] 50082 [O75553-6]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000371230; ENSP00000360274; ENSG00000173406 [O75553-2] ENST00000371231; ENSP00000360275; ENSG00000173406 [O75553-1] ENST00000371236; ENSP00000360280; ENSG00000173406 [O75553-6] ENST00000414851; ENSP00000387581; ENSG00000173406 [O75553-6] ENST00000420954; ENSP00000395296; ENSG00000173406 [O75553-5]
GeneIDⁱ	1600
KEGGⁱ	hsa:1600
UCSCⁱ	uc001cyq.2 human [O75553-1]

Organism-specific databases

CTDⁱ	1600
DisGeNETⁱ	1600
EuPathDBⁱ	HostDB:ENSG00000173406.15
GeneCardsⁱ	DAB1
HGNCⁱ	HGNC:2661 DAB1
HPAⁱ	CAB032329 HPA052033 HPA067495
MalaCardsⁱ	DAB1
MIMⁱ	603448 gene 615945 phenotype
neXtProtⁱ	NX_O75553
OpenTargetsⁱ	ENSG00000173406
Orphanetⁱ	363710 Spinocerebellar ataxia type 37
PharmGKBⁱ	PA27131
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00520000055585
HOVERGENⁱ	HBG018945
InParanoidⁱ	O75553
KOⁱ	K20054
OMAⁱ	DQPSLSC
OrthoDBⁱ	EOG091G0382
PhylomeDBⁱ	O75553
TreeFamⁱ	TF316724

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8866376 Reelin signalling pathway
SignaLinkⁱ	O75553
SIGNORⁱ	O75553

Miscellaneous databases

ChiTaRSⁱ	DAB1 human
GeneWikiⁱ	DAB1
GenomeRNAiⁱ	1600
Protein Ontology More...PROⁱ	PR:O75553
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173406 Expressed in 120 organ(s), highest expression level in frontal cortex
ExpressionAtlasⁱ	O75553 baseline and differential
Genevisibleⁱ	O75553 HS

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom
Pfamⁱ	View protein in Pfam PF00640 PID, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DAB1_HUMAN
Accessionⁱ	O75553Primary (citable) accession number: O75553 Secondary accession number(s): A4FU90 Q9NYA8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
	Last sequence update:	June 26, 2007
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - O75553 (DAB1_HUMAN)

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Disabled homolog 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

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Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Proteomic databases

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Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ