UniProtKB - O75541 (ZN821_HUMAN)
Protein
Zinc finger protein 821
Gene
ZNF821
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 116 – 140 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 150 – 172 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O75541 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 821 |
Gene namesi | Name:ZNF821 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000102984.14 |
HGNCi | HGNC:28043, ZNF821 |
neXtProti | NX_O75541 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55565 |
OpenTargetsi | ENSG00000102984 |
PharmGKBi | PA162410689 |
Miscellaneous databases
Pharosi | O75541, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF821 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317289 | 1 – 412 | Zinc finger protein 821Add BLAST | 412 |
Proteomic databases
MassIVEi | O75541 |
PaxDbi | O75541 |
PeptideAtlasi | O75541 |
PRIDEi | O75541 |
ProteomicsDBi | 50075 [O75541-1] 50076 [O75541-2] |
PTM databases
GlyGeni | O75541, 1 site, 2 N-linked glycans (1 site) |
iPTMneti | O75541 |
PhosphoSitePlusi | O75541 |
Expressioni
Gene expression databases
Bgeei | ENSG00000102984, Expressed in cortical plate and 145 other tissues |
ExpressionAtlasi | O75541, baseline and differential |
Genevisiblei | O75541, HS |
Organism-specific databases
HPAi | ENSG00000102984, Tissue enhanced (brain, testis) |
Interactioni
Binary interactionsi
Hide detailsO75541
With | #Exp. | IntAct |
---|---|---|
CDCA7L [Q96GN5] | 3 | EBI-740865,EBI-5278764 |
PIM2 [Q9P1W9] | 3 | EBI-740865,EBI-720425 |
Isoform 2 [O75541-2]
With | #Exp. | IntAct |
---|---|---|
DVL3 [Q92997] | 3 | EBI-14544035,EBI-739789 |
RUNDC3A - isoform 3 [Q59EK9-3] | 3 | EBI-14544035,EBI-11957366 |
Protein-protein interaction databases
BioGRIDi | 120720, 7 interactors |
IntActi | O75541, 7 interactors |
MINTi | O75541 |
STRINGi | 9606.ENSP00000398089 |
Miscellaneous databases
RNActi | O75541, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 257 – 366 | Sequence analysisAdd BLAST | 110 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 116 – 140 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 150 – 172 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159421 |
InParanoidi | O75541 |
OMAi | NPPVYPA |
OrthoDBi | 901424at2759 |
PhylomeDBi | O75541 |
TreeFami | TF326851 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O75541-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRRKQTNPN KVHWDQVFAG LEEQARQAMM KTDFPGDLGS QRQAIQQLRD
60 70 80 90 100
QDSSSSDSEG DEEETTQDEV SSHTSEEDGG VVKVEKELEN TEQPVGGNEV
110 120 130 140 150
VEHEVTGNLN SDPLLELCQC PLCQLDCGSR EQLIAHVYQH TAAVVSAKSY
160 170 180 190 200
MCPVCGRALS SPGSLGRHLL IHSEDQRSNC AVCGARFTSH ATFNSEKLPE
210 220 230 240 250
VLNMESLPTV HNEGPSSAEG KDIAFSPPVY PAGILLVCNN CAAYRKLLEA
260 270 280 290 300
QTPSVRKWAL RRQNEPLEVR LQRLERERTA KKSRRDNETP EEREVRRMRD
310 320 330 340 350
REAKRLQRMQ ETDEQRARRL QRDREAMRLK RANETPEKRQ ARLIREREAK
360 370 380 390 400
RLKRRLEKMD MMLRAQFGQD PSAMAALAAE MNFFQLPVSG VELDSQLLGK
410
MAFEEQNSSS LH
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DH12 | A0A0C4DH12_HUMAN | Zinc finger protein 821 | ZNF821 | 370 | Annotation score: | ||
H3BS68 | H3BS68_HUMAN | Zinc finger protein 821 | ZNF821 | 403 | Annotation score: | ||
H3BPS7 | H3BPS7_HUMAN | Zinc finger protein 821 | ZNF821 LOC55565, hCG_33012 | 62 | Annotation score: | ||
A0A087WXX1 | A0A087WXX1_HUMAN | Zinc finger protein 821 | ZNF821 | 139 | Annotation score: | ||
H3BVG7 | H3BVG7_HUMAN | Zinc finger protein 821 | ZNF821 | 212 | Annotation score: | ||
H3BRD6 | H3BRD6_HUMAN | Zinc finger protein 821 | ZNF821 | 250 | Annotation score: | ||
H3BQE4 | H3BQE4_HUMAN | Zinc finger protein 821 | ZNF821 | 138 | Annotation score: | ||
H3BR75 | H3BR75_HUMAN | Zinc finger protein 821 | ZNF821 | 105 | Annotation score: | ||
H3BR59 | H3BR59_HUMAN | Zinc finger protein 821 | ZNF821 LOC55565, hCG_33012 | 66 | Annotation score: | ||
H3BTZ4 | H3BTZ4_HUMAN | Zinc finger protein 821 | ZNF821 | 62 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030933 | 16 – 57 | Missing in isoform 2. 2 PublicationsAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF070588 mRNA Translation: AAC28648.1 AK296603 mRNA Translation: BAG59216.1 AC009127 Genomic DNA No translation available. AC010653 Genomic DNA No translation available. CH471166 Genomic DNA Translation: EAW59211.1 CH471166 Genomic DNA Translation: EAW59213.1 CH471166 Genomic DNA Translation: EAW59214.1 CH471166 Genomic DNA Translation: EAW59219.1 BC012116 mRNA Translation: AAH12116.1 |
CCDSi | CCDS32481.1 [O75541-2] CCDS56006.1 [O75541-1] |
RefSeqi | NP_001188481.1, NM_001201552.1 [O75541-1] NP_001188482.1, NM_001201553.1 [O75541-1] NP_001188483.1, NM_001201554.1 NP_001188485.1, NM_001201556.1 NP_060000.1, NM_017530.2 XP_005256090.1, XM_005256033.2 XP_006721296.1, XM_006721233.1 XP_011521513.1, XM_011523211.2 [O75541-1] XP_016878898.1, XM_017023409.1 XP_016878899.1, XM_017023410.1 [O75541-1] XP_016878900.1, XM_017023411.1 [O75541-1] XP_016878901.1, XM_017023412.1 [O75541-1] XP_016878903.1, XM_017023414.1 |
Genome annotation databases
Ensembli | ENST00000425432; ENSP00000398089; ENSG00000102984 [O75541-1] ENST00000565601; ENSP00000455648; ENSG00000102984 [O75541-1] |
GeneIDi | 55565 |
KEGGi | hsa:55565 |
UCSCi | uc002fbf.4, human [O75541-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF070588 mRNA Translation: AAC28648.1 AK296603 mRNA Translation: BAG59216.1 AC009127 Genomic DNA No translation available. AC010653 Genomic DNA No translation available. CH471166 Genomic DNA Translation: EAW59211.1 CH471166 Genomic DNA Translation: EAW59213.1 CH471166 Genomic DNA Translation: EAW59214.1 CH471166 Genomic DNA Translation: EAW59219.1 BC012116 mRNA Translation: AAH12116.1 |
CCDSi | CCDS32481.1 [O75541-2] CCDS56006.1 [O75541-1] |
RefSeqi | NP_001188481.1, NM_001201552.1 [O75541-1] NP_001188482.1, NM_001201553.1 [O75541-1] NP_001188483.1, NM_001201554.1 NP_001188485.1, NM_001201556.1 NP_060000.1, NM_017530.2 XP_005256090.1, XM_005256033.2 XP_006721296.1, XM_006721233.1 XP_011521513.1, XM_011523211.2 [O75541-1] XP_016878898.1, XM_017023409.1 XP_016878899.1, XM_017023410.1 [O75541-1] XP_016878900.1, XM_017023411.1 [O75541-1] XP_016878901.1, XM_017023412.1 [O75541-1] XP_016878903.1, XM_017023414.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120720, 7 interactors |
IntActi | O75541, 7 interactors |
MINTi | O75541 |
STRINGi | 9606.ENSP00000398089 |
PTM databases
GlyGeni | O75541, 1 site, 2 N-linked glycans (1 site) |
iPTMneti | O75541 |
PhosphoSitePlusi | O75541 |
Polymorphism and mutation databases
BioMutai | ZNF821 |
Proteomic databases
MassIVEi | O75541 |
PaxDbi | O75541 |
PeptideAtlasi | O75541 |
PRIDEi | O75541 |
ProteomicsDBi | 50075 [O75541-1] 50076 [O75541-2] |
Protocols and materials databases
Antibodypediai | 16662, 91 antibodies |
DNASUi | 55565 |
Genome annotation databases
Ensembli | ENST00000425432; ENSP00000398089; ENSG00000102984 [O75541-1] ENST00000565601; ENSP00000455648; ENSG00000102984 [O75541-1] |
GeneIDi | 55565 |
KEGGi | hsa:55565 |
UCSCi | uc002fbf.4, human [O75541-1] |
Organism-specific databases
CTDi | 55565 |
DisGeNETi | 55565 |
EuPathDBi | HostDB:ENSG00000102984.14 |
GeneCardsi | ZNF821 |
HGNCi | HGNC:28043, ZNF821 |
HPAi | ENSG00000102984, Tissue enhanced (brain, testis) |
neXtProti | NX_O75541 |
OpenTargetsi | ENSG00000102984 |
PharmGKBi | PA162410689 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159421 |
InParanoidi | O75541 |
OMAi | NPPVYPA |
OrthoDBi | 901424at2759 |
PhylomeDBi | O75541 |
TreeFami | TF326851 |
Enzyme and pathway databases
PathwayCommonsi | O75541 |
Miscellaneous databases
BioGRID-ORCSi | 55565, 1 hit in 865 CRISPR screens |
ChiTaRSi | ZNF821, human |
GenomeRNAii | 55565 |
Pharosi | O75541, Tdark |
PROi | PR:O75541 |
RNActi | O75541, protein |
Gene expression databases
Bgeei | ENSG00000102984, Expressed in cortical plate and 145 other tissues |
ExpressionAtlasi | O75541, baseline and differential |
Genevisiblei | O75541, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN821_HUMAN | |
Accessioni | O75541Primary (citable) accession number: O75541 Secondary accession number(s): A6NK48, B4DKK4, D3DWS3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | May 16, 2012 | |
Last modified: | December 2, 2020 | |
This is version 174 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM