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Protein

Zinc finger protein 821

Gene

ZNF821

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri116 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri150 – 172C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 821
Gene namesi
Name:ZNF821
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000102984.14
HGNCiHGNC:28043 ZNF821
neXtProtiNX_O75541

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55565
OpenTargetsiENSG00000102984
PharmGKBiPA162410689

Polymorphism and mutation databases

BioMutaiZNF821

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172891 – 412Zinc finger protein 821Add BLAST412

Proteomic databases

EPDiO75541
PaxDbiO75541
PeptideAtlasiO75541
PRIDEiO75541
ProteomicsDBi50075
50076 [O75541-2]

PTM databases

iPTMnetiO75541
PhosphoSitePlusiO75541

Expressioni

Gene expression databases

BgeeiENSG00000102984 Expressed in 127 organ(s), highest expression level in testis
CleanExiHS_ZNF821
ExpressionAtlasiO75541 baseline and differential
GenevisibleiO75541 HS

Organism-specific databases

HPAiHPA036372
HPA042742

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120720, 5 interactors
IntActiO75541, 7 interactors
MINTiO75541
STRINGi9606.ENSP00000398089

Structurei

3D structure databases

ProteinModelPortaliO75541
SMRiO75541
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili257 – 366Sequence analysisAdd BLAST110

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri116 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri150 – 172C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITHI Eukaryota
ENOG410Z0QD LUCA
GeneTreeiENSGT00910000144301
HOGENOMiHOG000069989
HOVERGENiHBG053151
InParanoidiO75541
OMAiCPLCQLE
OrthoDBiEOG091G0IJN
PhylomeDBiO75541
TreeFamiTF326851

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: O75541-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRRKQTNPN KVHWDQVFAG LEEQARQAMM KTDFPGDLGS QRQAIQQLRD
60 70 80 90 100
QDSSSSDSEG DEEETTQDEV SSHTSEEDGG VVKVEKELEN TEQPVGGNEV
110 120 130 140 150
VEHEVTGNLN SDPLLELCQC PLCQLDCGSR EQLIAHVYQH TAAVVSAKSY
160 170 180 190 200
MCPVCGRALS SPGSLGRHLL IHSEDQRSNC AVCGARFTSH ATFNSEKLPE
210 220 230 240 250
VLNMESLPTV HNEGPSSAEG KDIAFSPPVY PAGILLVCNN CAAYRKLLEA
260 270 280 290 300
QTPSVRKWAL RRQNEPLEVR LQRLERERTA KKSRRDNETP EEREVRRMRD
310 320 330 340 350
REAKRLQRMQ ETDEQRARRL QRDREAMRLK RANETPEKRQ ARLIREREAK
360 370 380 390 400
RLKRRLEKMD MMLRAQFGQD PSAMAALAAE MNFFQLPVSG VELDSQLLGK
410
MAFEEQNSSS LH
Note: No experimental confirmation available.
Length:412
Mass (Da):46,794
Last modified:May 16, 2012 - v3
Checksum:iB3C953147F1C4E5C
GO
Isoform 2 (identifier: O75541-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-57: Missing.

Show »
Length:370
Mass (Da):42,140
Checksum:i383D2D7EFAC1BEB5
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DH12A0A0C4DH12_HUMAN
Zinc finger protein 821
ZNF821
370Annotation score:
H3BS68H3BS68_HUMAN
Zinc finger protein 821
ZNF821
403Annotation score:
H3BRD6H3BRD6_HUMAN
Zinc finger protein 821
ZNF821
250Annotation score:
H3BVG7H3BVG7_HUMAN
Zinc finger protein 821
ZNF821
212Annotation score:
H3BPS7H3BPS7_HUMAN
Zinc finger protein 821
ZNF821 LOC55565, hCG_33012
62Annotation score:
H3BR59H3BR59_HUMAN
Zinc finger protein 821
ZNF821 LOC55565, hCG_33012
66Annotation score:
A0A087WXX1A0A087WXX1_HUMAN
Zinc finger protein 821
ZNF821
139Annotation score:
H3BQE4H3BQE4_HUMAN
Zinc finger protein 821
ZNF821
138Annotation score:
H3BTZ4H3BTZ4_HUMAN
Zinc finger protein 821
ZNF821
62Annotation score:
H3BR75H3BR75_HUMAN
Zinc finger protein 821
ZNF821
105Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03093316 – 57Missing in isoform 2. 2 PublicationsAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070588 mRNA Translation: AAC28648.1
AK296603 mRNA Translation: BAG59216.1
AC009127 Genomic DNA No translation available.
AC010653 Genomic DNA No translation available.
CH471166 Genomic DNA Translation: EAW59211.1
CH471166 Genomic DNA Translation: EAW59213.1
CH471166 Genomic DNA Translation: EAW59214.1
CH471166 Genomic DNA Translation: EAW59219.1
BC012116 mRNA Translation: AAH12116.1
CCDSiCCDS32481.1 [O75541-2]
CCDS56006.1 [O75541-1]
RefSeqiNP_001188481.1, NM_001201552.1 [O75541-1]
NP_001188482.1, NM_001201553.1 [O75541-1]
NP_001188483.1, NM_001201554.1
NP_001188485.1, NM_001201556.1
NP_060000.1, NM_017530.2
XP_005256090.1, XM_005256033.2 [O75541-1]
XP_006721296.1, XM_006721233.1 [O75541-1]
XP_011521513.1, XM_011523211.2 [O75541-1]
XP_016878898.1, XM_017023409.1 [O75541-1]
XP_016878899.1, XM_017023410.1 [O75541-1]
XP_016878900.1, XM_017023411.1 [O75541-1]
XP_016878901.1, XM_017023412.1 [O75541-1]
XP_016878903.1, XM_017023414.1
UniGeneiHs.744055

Genome annotation databases

EnsembliENST00000425432; ENSP00000398089; ENSG00000102984 [O75541-1]
ENST00000565601; ENSP00000455648; ENSG00000102984 [O75541-1]
GeneIDi55565
KEGGihsa:55565
UCSCiuc002fbf.4 human [O75541-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070588 mRNA Translation: AAC28648.1
AK296603 mRNA Translation: BAG59216.1
AC009127 Genomic DNA No translation available.
AC010653 Genomic DNA No translation available.
CH471166 Genomic DNA Translation: EAW59211.1
CH471166 Genomic DNA Translation: EAW59213.1
CH471166 Genomic DNA Translation: EAW59214.1
CH471166 Genomic DNA Translation: EAW59219.1
BC012116 mRNA Translation: AAH12116.1
CCDSiCCDS32481.1 [O75541-2]
CCDS56006.1 [O75541-1]
RefSeqiNP_001188481.1, NM_001201552.1 [O75541-1]
NP_001188482.1, NM_001201553.1 [O75541-1]
NP_001188483.1, NM_001201554.1
NP_001188485.1, NM_001201556.1
NP_060000.1, NM_017530.2
XP_005256090.1, XM_005256033.2 [O75541-1]
XP_006721296.1, XM_006721233.1 [O75541-1]
XP_011521513.1, XM_011523211.2 [O75541-1]
XP_016878898.1, XM_017023409.1 [O75541-1]
XP_016878899.1, XM_017023410.1 [O75541-1]
XP_016878900.1, XM_017023411.1 [O75541-1]
XP_016878901.1, XM_017023412.1 [O75541-1]
XP_016878903.1, XM_017023414.1
UniGeneiHs.744055

3D structure databases

ProteinModelPortaliO75541
SMRiO75541
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120720, 5 interactors
IntActiO75541, 7 interactors
MINTiO75541
STRINGi9606.ENSP00000398089

PTM databases

iPTMnetiO75541
PhosphoSitePlusiO75541

Polymorphism and mutation databases

BioMutaiZNF821

Proteomic databases

EPDiO75541
PaxDbiO75541
PeptideAtlasiO75541
PRIDEiO75541
ProteomicsDBi50075
50076 [O75541-2]

Protocols and materials databases

DNASUi55565
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000425432; ENSP00000398089; ENSG00000102984 [O75541-1]
ENST00000565601; ENSP00000455648; ENSG00000102984 [O75541-1]
GeneIDi55565
KEGGihsa:55565
UCSCiuc002fbf.4 human [O75541-1]

Organism-specific databases

CTDi55565
DisGeNETi55565
EuPathDBiHostDB:ENSG00000102984.14
GeneCardsiZNF821
HGNCiHGNC:28043 ZNF821
HPAiHPA036372
HPA042742
neXtProtiNX_O75541
OpenTargetsiENSG00000102984
PharmGKBiPA162410689
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITHI Eukaryota
ENOG410Z0QD LUCA
GeneTreeiENSGT00910000144301
HOGENOMiHOG000069989
HOVERGENiHBG053151
InParanoidiO75541
OMAiCPLCQLE
OrthoDBiEOG091G0IJN
PhylomeDBiO75541
TreeFamiTF326851

Miscellaneous databases

GenomeRNAii55565
PROiPR:O75541

Gene expression databases

BgeeiENSG00000102984 Expressed in 127 organ(s), highest expression level in testis
CleanExiHS_ZNF821
ExpressionAtlasiO75541 baseline and differential
GenevisibleiO75541 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZN821_HUMAN
AccessioniPrimary (citable) accession number: O75541
Secondary accession number(s): A6NK48, B4DKK4, D3DWS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 16, 2012
Last modified: September 12, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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