UniProtKB - O75533 (SF3B1_HUMAN)
Splicing factor 3B subunit 1
SF3B1
Functioni
GO - Molecular functioni
- mRNA binding Source: GO_Central
- RNA binding Source: UniProtKB
- splicing factor binding Source: UniProtKB
GO - Biological processi
- mRNA splicing, via spliceosome Source: UniProtKB
- positive regulation of gene expression, epigenetic Source: Reactome
- RNA splicing Source: UniProtKB
- RNA splicing, via transesterification reactions Source: UniProtKB
- spliceosomal complex assembly Source: GO_Central
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | O75533 |
Reactomei | R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72165, mRNA Splicing - Minor Pathway |
SIGNORi | O75533 |
Names & Taxonomyi
Protein namesi | Recommended name: Splicing factor 3B subunit 1Alternative name(s): Pre-mRNA-splicing factor SF3b 155 kDa subunit Short name: SF3b155 Spliceosome-associated protein 155 Short name: SAP 155 |
Gene namesi | Name:SF3B1 Synonyms:SAP155 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10768, SF3B1 |
MIMi | 605590, gene |
neXtProti | NX_O75533 |
VEuPathDBi | HostDB:ENSG00000115524.15 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
- Nucleus speckle
Note: During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.
Nucleus
- catalytic step 2 spliceosome Source: UniProtKB
- nuclear speck Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- spliceosomal complex Source: UniProtKB
- U11/U12 snRNP Source: MGI
- U12-type spliceosomal complex Source: UniProtKB
- U2 snRNP Source: MGI
- U2-type precatalytic spliceosome Source: UniProtKB
- U2-type prespliceosome Source: GO_Central
Keywords - Cellular componenti
Nucleus, SpliceosomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 200 | W → A: Abolishes interaction with RBM39; when associated with A-218; A-232; A-254; A-293; A-310 and A-338. 1 Publication | 1 | |
Mutagenesisi | 218 | W → A: Abolishes interaction with RBM39; when associated with A-200; A-232; A-254; A-293; A-310 and A-338. 1 Publication | 1 | |
Mutagenesisi | 223 | T → A: No effect on interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 227 | T → A: No effect on interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 232 | W → A: Abolishes interaction with RBM39; when associated with A-200; A-218; A-254; A-293; A-310 and A-338. 1 Publication | 1 | |
Mutagenesisi | 235 | T → A: No effect on interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 244 | T → A: Slight inhibition of interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 248 | T → A: Slight inhibition of interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 254 | W → A: Abolishes interaction with RBM39; when associated with A-200; A-218; A-232; A-293; A-310 and A-338. 1 Publication | 1 | |
Mutagenesisi | 257 | T → A: No effect on interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 261 | T → A: Slight inhibition of interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 267 | T → A: No effect on interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 273 | T → A: No effect on interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 278 | T → A: No effect on interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 293 | W → A: Abolishes interaction with RBM39; when associated with A-200; A-218; A-232; A-254; A-310 and A-338. 1 Publication | 1 | |
Mutagenesisi | 296 | T → A: No effect on interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 303 | T → A: No effect on interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 310 | W → A: Abolishes interaction with RBM39; when associated with A-200; A-218; A-232; A-254; A-293 and A-338. 1 Publication | 1 | |
Mutagenesisi | 313 | T → A: No effect on interaction with PPP1R8. 1 Publication | 1 | |
Mutagenesisi | 338 | W → A: Abolishes interaction with RBM39; when associated with A-200; A-218; A-232; A-254; A-293 and A-310. 1 Publication | 1 | |
Mutagenesisi | 700 | K → E: Does not affect the stability of the SF3B complex interaction with U2AF65. Does not decrease the affinity to RNA. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23451 |
MalaCardsi | SF3B1 |
OpenTargetsi | ENSG00000115524 |
Orphaneti | 75564, Acquired idiopathic sideroblastic anemia 39044, Uveal melanoma |
PharmGKBi | PA35686 |
Miscellaneous databases
Pharosi | O75533, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1229013 |
DrugBanki | DB14017, H3B-8800 |
Genetic variation databases
BioMutai | SF3B1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000174323 | 1 – 1304 | Splicing factor 3B subunit 1Add BLAST | 1304 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 125 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 129 | PhosphoserineCombined sources | 1 | |
Modified residuei | 141 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 142 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 157 | CitrullineBy similarity | 1 | |
Modified residuei | 194 | PhosphoserineCombined sources | 1 | |
Modified residuei | 203 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 207 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 211 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 214 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 214 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 223 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 227 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 229 | PhosphoserineBy similarity | 1 | |
Modified residuei | 235 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 244 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 248 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 257 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 261 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 267 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 273 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 278 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 287 | PhosphoserineCombined sources | 1 | |
Modified residuei | 296 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 299 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 303 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 313 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 322 | PhosphoserineCombined sources | 1 | |
Modified residuei | 326 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 328 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 332 | PhosphoserineCombined sources | 1 | |
Modified residuei | 341 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 344 | PhosphoserineCombined sources | 1 | |
Modified residuei | 349 | PhosphoserineCombined sources | 1 | |
Modified residuei | 350 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 354 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 400 | PhosphoserineCombined sources | 1 | |
Cross-linki | 413 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 413 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 426 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 430 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 434 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 436 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 488 | PhosphoserineCombined sources | 1 | |
Modified residuei | 554 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 562 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O75533 |
jPOSTi | O75533 |
MassIVEi | O75533 |
MaxQBi | O75533 |
PaxDbi | O75533 |
PeptideAtlasi | O75533 |
PRIDEi | O75533 |
ProteomicsDBi | 19445 50072 [O75533-1] |
PTM databases
iPTMneti | O75533 |
MetOSitei | O75533 |
PhosphoSitePlusi | O75533 |
SwissPalmi | O75533 |
Expressioni
Gene expression databases
Bgeei | ENSG00000115524, Expressed in small intestine Peyer's patch and 242 other tissues |
ExpressionAtlasi | O75533, baseline and differential |
Genevisiblei | O75533, HS |
Organism-specific databases
HPAi | ENSG00000115524, Low tissue specificity |
Interactioni
Subunit structurei
Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (PubMed:16603771). Identified in the spliceosome C complex (PubMed:11991638).
Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077).
Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A and DDX42 (PubMed:12234937, PubMed:12738865, PubMed:28541300, PubMed:27720643). SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP).
Interacts directly with the splicing factor U2AF (PubMed:12234937). Within the SF3B complex interacts directly (via HEAT domain) with SF3B3, SF3B5 and (via HEAT domain) with PHF5A (PubMed:27720643).
Interacts directly with SF3B6 (PubMed:16432215, Ref. 36, PubMed:21062891). The SF3B complex composed of SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6 and PHF5A interacts with U2AF2 (PubMed:27720643). Phosphorylated form interacts with PPP1R8 (PubMed:12105215).
Interacts with PQBP1 (PubMed:23512658).
Interacts with RBM17 (PubMed:17589525).
Interacts with RBM39 (PubMed:24795046).
Interacts with SETX (PubMed:21700224).
Interacts with RBM15 (PubMed:26575292).
16 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 469 | Interaction with RNA1 Publication | 1 | |
Sitei | 587 | Interaction with RNA1 Publication | 1 | |
Sitei | 592 | Interaction with PHF5A1 Publication | 1 | |
Sitei | 602 | Interaction with SF3B31 Publication | 1 | |
Sitei | 677 | Interaction with SF3B31 Publication | 1 | |
Sitei | 1035 | Interaction with RNA1 Publication | 1 | |
Sitei | 1049 | Interaction with RNA1 Publication | 1 | |
Sitei | 1141 | Interaction with RNA1 Publication | 1 | |
Sitei | 1205 | Interaction with SF3B31 Publication | 1 |
Binary interactionsi
Hide detailsO75533
With | #Exp. | IntAct |
---|---|---|
RBM17 [Q96I25] | 3 | EBI-876542,EBI-740272 |
Isoform 1 [O75533-1]
With | #Exp. | IntAct |
---|---|---|
RBM17 [Q96I25] | 3 | EBI-15565798,EBI-740272 |
SF3B6 [Q9Y3B4] | 3 | EBI-15565798,EBI-1046261 |
GO - Molecular functioni
- splicing factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 117017, 336 interactors |
ComplexPortali | CPX-1099, B-WICH chromatin remodelling complex |
CORUMi | O75533 |
DIPi | DIP-29411N |
ELMi | O75533 |
IntActi | O75533, 102 interactors |
MINTi | O75533 |
STRINGi | 9606.ENSP00000335321 |
Miscellaneous databases
RNActi | O75533, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | O75533 |
SMRi | O75533 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O75533 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 529 – 568 | HEAT 1Add BLAST | 40 | |
Repeati | 569 – 603 | HEAT 2Add BLAST | 35 | |
Repeati | 604 – 641 | HEAT 3Add BLAST | 38 | |
Repeati | 643 – 677 | HEAT 4Add BLAST | 35 | |
Repeati | 680 – 718 | HEAT 5Add BLAST | 39 | |
Repeati | 763 – 801 | HEAT 6Add BLAST | 39 | |
Repeati | 843 – 881 | HEAT 7Add BLAST | 39 | |
Repeati | 1010 – 1048 | HEAT 8Add BLAST | 39 | |
Repeati | 1052 – 1090 | HEAT 9Add BLAST | 39 | |
Repeati | 1122 – 1160 | HEAT 10Add BLAST | 39 | |
Repeati | 1163 – 1201 | HEAT 11Add BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 190 – 342 | U2AF homology region; mediates interaction with RBM391 PublicationAdd BLAST | 153 | |
Regioni | 223 – 491 | Interaction with PPP1R81 PublicationAdd BLAST | 269 | |
Regioni | 529 – 568 | Interaction with SF3B14Add BLAST | 40 | |
Regioni | 547 – 550 | Interaction with PHF5A1 Publication | 4 | |
Regioni | 1156 – 1157 | Interaction with PHF5A1 Publication | 2 | |
Regioni | 1248 – 1304 | Interaction with SF3B3 and SF3B51 PublicationAdd BLAST | 57 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0213, Eukaryota |
GeneTreei | ENSGT00390000018393 |
HOGENOMi | CLU_002242_0_0_1 |
InParanoidi | O75533 |
OMAi | RSRWDAT |
PhylomeDBi | O75533 |
TreeFami | TF105680 |
Family and domain databases
DisProti | DP01863 |
Gene3Di | 1.25.10.10, 2 hits |
IDEALi | IID00190 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015016, SF3b_su1 IPR038737, SF3b_su1-like |
PANTHERi | PTHR12097, PTHR12097, 2 hits |
Pfami | View protein in Pfam PF08920, SF3b1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKIAKTHED IEAQIREIQG KKAALDEAQG VGLDSTGYYD QEIYGGSDSR
60 70 80 90 100
FAGYVTSIAA TELEDDDDDY SSSTSLLGQK KPGYHAPVAL LNDIPQSTEQ
110 120 130 140 150
YDPFAEHRPP KIADREDEYK KHRRTMIISP ERLDPFADGG KTPDPKMNAR
160 170 180 190 200
TYMDVMREQH LTKEEREIRQ QLAEKAKAGE LKVVNGAAAS QPPSKRKRRW
210 220 230 240 250
DQTADQTPGA TPKKLSSWDQ AETPGHTPSL RWDETPGRAK GSETPGATPG
260 270 280 290 300
SKIWDPTPSH TPAGAATPGR GDTPGHATPG HGGATSSARK NRWDETPKTE
310 320 330 340 350
RDTPGHGSGW AETPRTDRGG DSIGETPTPG ASKRKSRWDE TPASQMGGST
360 370 380 390 400
PVLTPGKTPI GTPAMNMATP TPGHIMSMTP EQLQAWRWER EIDERNRPLS
410 420 430 440 450
DEELDAMFPE GYKVLPPPAG YVPIRTPARK LTATPTPLGG MTGFHMQTED
460 470 480 490 500
RTMKSVNDQP SGNLPFLKPD DIQYFDKLLV DVDESTLSPE EQKERKIMKL
510 520 530 540 550
LLKIKNGTPP MRKAALRQIT DKAREFGAGP LFNQILPLLM SPTLEDQERH
560 570 580 590 600
LLVKVIDRIL YKLDDLVRPY VHKILVVIEP LLIDEDYYAR VEGREIISNL
610 620 630 640 650
AKAAGLATMI STMRPDIDNM DEYVRNTTAR AFAVVASALG IPSLLPFLKA
660 670 680 690 700
VCKSKKSWQA RHTGIKIVQQ IAILMGCAIL PHLRSLVEII EHGLVDEQQK
710 720 730 740 750
VRTISALAIA ALAEAATPYG IESFDSVLKP LWKGIRQHRG KGLAAFLKAI
760 770 780 790 800
GYLIPLMDAE YANYYTREVM LILIREFQSP DEEMKKIVLK VVKQCCGTDG
810 820 830 840 850
VEANYIKTEI LPPFFKHFWQ HRMALDRRNY RQLVDTTVEL ANKVGAAEII
860 870 880 890 900
SRIVDDLKDE AEQYRKMVME TIEKIMGNLG AADIDHKLEE QLIDGILYAF
910 920 930 940 950
QEQTTEDSVM LNGFGTVVNA LGKRVKPYLP QICGTVLWRL NNKSAKVRQQ
960 970 980 990 1000
AADLISRTAV VMKTCQEEKL MGHLGVVLYE YLGEEYPEVL GSILGALKAI
1010 1020 1030 1040 1050
VNVIGMHKMT PPIKDLLPRL TPILKNRHEK VQENCIDLVG RIADRGAEYV
1060 1070 1080 1090 1100
SAREWMRICF ELLELLKAHK KAIRRATVNT FGYIAKAIGP HDVLATLLNN
1110 1120 1130 1140 1150
LKVQERQNRV CTTVAIAIVA ETCSPFTVLP ALMNEYRVPE LNVQNGVLKS
1160 1170 1180 1190 1200
LSFLFEYIGE MGKDYIYAVT PLLEDALMDR DLVHRQTASA VVQHMSLGVY
1210 1220 1230 1240 1250
GFGCEDSLNH LLNYVWPNVF ETSPHVIQAV MGALEGLRVA IGPCRMLQYC
1260 1270 1280 1290 1300
LQGLFHPARK VRDVYWKIYN SIYIGSQDAL IAHYPRIYND DKNTYIRYEL
DYIL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C341 | H7C341_HUMAN | Splicing factor 3B subunit 1 | SF3B1 | 241 | Annotation score: | ||
B4DGZ4 | B4DGZ4_HUMAN | Splicing factor 3B subunit 1 | SF3B1 | 154 | Annotation score: | ||
F8WC19 | F8WC19_HUMAN | Splicing factor 3B subunit 1 | SF3B1 | 37 | Annotation score: | ||
A0A494C1M2 | A0A494C1M2_HUMAN | Splicing factor 3B subunit 1 | SF3B1 | 161 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 149 | A → V in AAC97189 (PubMed:9585501).Curated | 1 | |
Sequence conflicti | 594 | R → L in AAC97189 (PubMed:9585501).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046182 | 140 – 144 | GKTPD → FYSAA in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_046183 | 145 – 1304 | Missing in isoform 2. 1 PublicationAdd BLAST | 1160 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF054284 mRNA Translation: AAC97189.1 AF086296 mRNA No translation available. AC010746 Genomic DNA No translation available. AF070540 mRNA Translation: AAC28633.1 |
CCDSi | CCDS33356.1 [O75533-1] CCDS46479.1 [O75533-2] |
RefSeqi | NP_036565.2, NM_012433.3 [O75533-1] |
Genome annotation databases
Ensembli | ENST00000335508; ENSP00000335321; ENSG00000115524 [O75533-1] ENST00000409915; ENSP00000428820; ENSG00000115524 [O75533-2] ENST00000414963; ENSP00000402997; ENSG00000115524 [O75533-2] |
GeneIDi | 23451 |
KEGGi | hsa:23451 |
UCSCi | uc002uue.4, human [O75533-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF054284 mRNA Translation: AAC97189.1 AF086296 mRNA No translation available. AC010746 Genomic DNA No translation available. AF070540 mRNA Translation: AAC28633.1 |
CCDSi | CCDS33356.1 [O75533-1] CCDS46479.1 [O75533-2] |
RefSeqi | NP_036565.2, NM_012433.3 [O75533-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2F9D | X-ray | 2.50 | P/Q | 373-415 | [»] | |
2F9J | X-ray | 3.00 | P/Q | 380-415 | [»] | |
2FHO | NMR | - | A | 379-424 | [»] | |
2PEH | X-ray | 2.11 | C/D | 333-342 | [»] | |
3LQV | X-ray | 2.38 | P/Q | 377-415 | [»] | |
4OZ1 | X-ray | 1.74 | C | 333-342 | [»] | |
5IFE | X-ray | 3.10 | C | 1-1304 | [»] | |
5O9Z | electron microscopy | 4.50 | v | 1-1304 | [»] | |
5Z56 | electron microscopy | 5.10 | 1 | 1-1304 | [»] | |
5Z57 | electron microscopy | 6.50 | 1 | 1-1304 | [»] | |
5Z58 | electron microscopy | 4.90 | 1 | 1-1304 | [»] | |
5ZYA | electron microscopy | 3.95 | C | 1-1304 | [»] | |
6AH0 | electron microscopy | 5.70 | 1 | 1-1304 | [»] | |
6EN4 | X-ray | 3.08 | C | 453-1304 | [»] | |
6FF4 | electron microscopy | 16.00 | u | 1-1304 | [»] | |
6FF7 | electron microscopy | 4.50 | u | 1-1304 | [»] | |
6N3E | X-ray | 1.89 | B | 291-297 | [»] | |
6QX9 | electron microscopy | 3.28 | B1 | 1-1304 | [»] | |
6Y50 | electron microscopy | 4.10 | u | 1-1304 | [»] | |
6Y53 | electron microscopy | 7.10 | u | 1-1304 | [»] | |
6Y5Q | electron microscopy | 7.10 | u | 1-1304 | [»] | |
BMRBi | O75533 | |||||
SMRi | O75533 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117017, 336 interactors |
ComplexPortali | CPX-1099, B-WICH chromatin remodelling complex |
CORUMi | O75533 |
DIPi | DIP-29411N |
ELMi | O75533 |
IntActi | O75533, 102 interactors |
MINTi | O75533 |
STRINGi | 9606.ENSP00000335321 |
Chemistry databases
ChEMBLi | CHEMBL1229013 |
DrugBanki | DB14017, H3B-8800 |
PTM databases
iPTMneti | O75533 |
MetOSitei | O75533 |
PhosphoSitePlusi | O75533 |
SwissPalmi | O75533 |
Genetic variation databases
BioMutai | SF3B1 |
Proteomic databases
EPDi | O75533 |
jPOSTi | O75533 |
MassIVEi | O75533 |
MaxQBi | O75533 |
PaxDbi | O75533 |
PeptideAtlasi | O75533 |
PRIDEi | O75533 |
ProteomicsDBi | 19445 50072 [O75533-1] |
Protocols and materials databases
Antibodypediai | 19893, 255 antibodies |
Genome annotation databases
Ensembli | ENST00000335508; ENSP00000335321; ENSG00000115524 [O75533-1] ENST00000409915; ENSP00000428820; ENSG00000115524 [O75533-2] ENST00000414963; ENSP00000402997; ENSG00000115524 [O75533-2] |
GeneIDi | 23451 |
KEGGi | hsa:23451 |
UCSCi | uc002uue.4, human [O75533-1] |
Organism-specific databases
CTDi | 23451 |
DisGeNETi | 23451 |
GeneCardsi | SF3B1 |
HGNCi | HGNC:10768, SF3B1 |
HPAi | ENSG00000115524, Low tissue specificity |
MalaCardsi | SF3B1 |
MIMi | 605590, gene |
neXtProti | NX_O75533 |
OpenTargetsi | ENSG00000115524 |
Orphaneti | 75564, Acquired idiopathic sideroblastic anemia 39044, Uveal melanoma |
PharmGKBi | PA35686 |
VEuPathDBi | HostDB:ENSG00000115524.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0213, Eukaryota |
GeneTreei | ENSGT00390000018393 |
HOGENOMi | CLU_002242_0_0_1 |
InParanoidi | O75533 |
OMAi | RSRWDAT |
PhylomeDBi | O75533 |
TreeFami | TF105680 |
Enzyme and pathway databases
PathwayCommonsi | O75533 |
Reactomei | R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72165, mRNA Splicing - Minor Pathway |
SIGNORi | O75533 |
Miscellaneous databases
BioGRID-ORCSi | 23451, 648 hits in 877 CRISPR screens |
ChiTaRSi | SF3B1, human |
EvolutionaryTracei | O75533 |
GeneWikii | SF3B1 |
GenomeRNAii | 23451 |
Pharosi | O75533, Tbio |
PROi | PR:O75533 |
RNActi | O75533, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115524, Expressed in small intestine Peyer's patch and 242 other tissues |
ExpressionAtlasi | O75533, baseline and differential |
Genevisiblei | O75533, HS |
Family and domain databases
DisProti | DP01863 |
Gene3Di | 1.25.10.10, 2 hits |
IDEALi | IID00190 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015016, SF3b_su1 IPR038737, SF3b_su1-like |
PANTHERi | PTHR12097, PTHR12097, 2 hits |
Pfami | View protein in Pfam PF08920, SF3b1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SF3B1_HUMAN | |
Accessioni | O75533Primary (citable) accession number: O75533 Secondary accession number(s): E9PCH3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 14, 2001 |
Last sequence update: | November 24, 2009 | |
Last modified: | February 10, 2021 | |
This is version 202 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM