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Protein

Polycomb protein EED

Gene

EED

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.10 Publications

Caution

Two variants of the PRC2 complex have been described, termed PRC3 and PRC4. Each of the three complexes may include a different complement of EED isoforms, although the precise sequences of the isoforms in each complex have not been determined. The PRC2 and PRC4 complexes may also methylate 'Lys-26' of histone H1 in addition to 'Lys-27' of histone H3 (PubMed:15099518 and PubMed:15684044), although other studies have demonstrated no methylation of 'Lys-26' of histone H1 by PRC2 (PubMed:16431907).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • histone methyltransferase activity Source: MGI
  • identical protein binding Source: IntAct
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8953750 Transcriptional Regulation by E2F6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
O75530

SIGNOR Signaling Network Open Resource

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SIGNORi
O75530

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycomb protein EEDCurated
Short name:
hEED
Alternative name(s):
Embryonic ectoderm development protein1 Publication
WD protein associating with integrin cytoplasmic tails 1
Short name:
WAIT-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EEDImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000074266.17

Human Gene Nomenclature Database

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HGNCi
HGNC:3188 EED

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605984 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O75530

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cohen-Gibson syndrome (COGIS)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant overgrowth disorder characterized by accelerated osseous maturation, advanced bone age, skeletal abnormalities including flaring of the metaphyses of the long bones, large hands with long fingers and camptodactyly, scoliosis, cervical spine anomalies, dysmorphic facial features, and variable intellectual disability.
See also OMIM:617561
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079255194N → S in COGIS. 1 Publication1
Natural variantiVAR_079256236R → G in COGIS. 1 Publication1
Natural variantiVAR_078316236R → T in COGIS; decreased trimethylation of 'Lys-27' of histone H3; no effect on interaction with EZH2. 1 PublicationCorresponds to variant dbSNP:rs1131692176Ensembl.1
Natural variantiVAR_079257258H → Y in COGIS. 1 PublicationCorresponds to variant dbSNP:rs1131692174Ensembl.1
Natural variantiVAR_079258302R → G in COGIS. 1 PublicationCorresponds to variant dbSNP:rs1131692175Ensembl.1
Natural variantiVAR_078317302R → S in COGIS; decreased trimethylation of 'Lys-27' of histone H3. 2 PublicationsCorresponds to variant dbSNP:rs1131692173Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi97F → A: Abolishes binding to H3K27me3. 1 Publication1
Mutagenesisi148Y → A: Abolishes binding to H3K27me3. 1 Publication1
Mutagenesisi193I → N: Impairs interaction with EZH2. 1 Publication1
Mutagenesisi196L → P: Impairs interaction with EZH2. 1 Publication1
Mutagenesisi300 – 301ST → AA: Impairs interaction with the matrix protein MA of HIV-1. 1 Publication2
Mutagenesisi305 – 308HRNY → AAAA: Impairs interaction with the matrix protein MA of HIV-1. 1 Publication4
Mutagenesisi364W → A: Abolishes binding to H3K27me3. 1 Publication1
Mutagenesisi364W → L: Abolishes binding to H3K27me3. 1 Publication1
Mutagenesisi365Y → A: Abolishes binding to H3K27me3. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
8726

MalaCards human disease database

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MalaCardsi
EED
MIMi617561 phenotype

Open Targets

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OpenTargetsi
ENSG00000074266

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
3447 Weaver syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27624

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2189117

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2487

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
EED

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003437252 – 441Polycomb protein EEDAdd BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei34PhosphoserineBy similarity1
Modified residuei55PhosphothreonineCombined sources1
Modified residuei66N6,N6,N6-trimethyllysine; alternate1 Publication1
Modified residuei66N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei66N6-methyllysine; alternate1 Publication1
Modified residuei197N6,N6,N6-trimethyllysine; alternate1 Publication1
Modified residuei197N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei197N6-methyllysine; alternate1 Publication1
Modified residuei268N6,N6,N6-trimethyllysine; alternate1 Publication1
Modified residuei268N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei268N6-methyllysine; alternate1 Publication1
Modified residuei284N6,N6,N6-trimethyllysine; alternate1 Publication1
Modified residuei284N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei284N6-methyllysine; alternate1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated. Binding to histone H1 'Lys-26' promotes mono-, di-, and trimethylation of internal lysines.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75530

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75530

MaxQB - The MaxQuant DataBase

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MaxQBi
O75530

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O75530

PeptideAtlas

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PeptideAtlasi
O75530

PRoteomics IDEntifications database

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PRIDEi
O75530

ProteomicsDB human proteome resource

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ProteomicsDBi
50068
50069 [O75530-2]
50070 [O75530-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75530

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75530

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer.5 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression peaks at the G1/S phase boundary.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced by E2F1, E2F2 and E2F3.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000074266 Expressed in 107 organ(s), highest expression level in endocervix

CleanEx database of gene expression profiles

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CleanExi
HS_EED

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75530 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75530 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB012211
HPA060089
HPA061140

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with HDAC, HDAC2, histone H1 and YY1. May interact with ITGA4, ITGAE and ITGB7. Interacts with CDYL. Interacts with ARNTL/BMAL1. Interacts with KMT2A/MLL1 (By similarity).By similarity14 Publications
(Microbial infection) May interact with the MA protein of HIV-1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114265, 492 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O75530

Database of interacting proteins

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DIPi
DIP-36673N

Protein interaction database and analysis system

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IntActi
O75530, 70 interactors

Molecular INTeraction database

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MINTi
O75530

STRING: functional protein association networks

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STRINGi
9606.ENSP00000263360

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
O75530

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1441
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IIWX-ray1.80A77-441[»]
3IIYX-ray2.65A77-441[»]
3IJ0X-ray2.45A77-441[»]
3IJ1X-ray2.10A77-441[»]
3IJCX-ray1.95A77-441[»]
3JPXX-ray2.05A40-441[»]
3JZGX-ray2.10A40-441[»]
3JZHX-ray2.05A40-441[»]
3JZNX-ray2.60A76-441[»]
3K26X-ray1.58A76-441[»]
3K27X-ray1.76A76-441[»]
4W2RX-ray2.81E/F81-441[»]
4X3EX-ray2.30A77-441[»]
5GSAX-ray2.49A/B76-441[»]
5H13X-ray1.90A76-441[»]
5H14X-ray1.90A/B76-441[»]
5H15X-ray2.27A/B76-441[»]
5H17X-ray2.30A76-441[»]
5H19X-ray1.90A76-441[»]
5H24X-ray2.50A/B76-441[»]
5H25X-ray2.88A/B76-441[»]
5HYNX-ray2.95B/G/L/R77-441[»]
5IJ7X-ray2.62E/F81-441[»]
5IJ8X-ray2.99E/F81-441[»]
5K0MX-ray1.83A77-441[»]
5LS6X-ray3.47B/E/H/K77-441[»]
5TTWX-ray1.74A/C76-441[»]
5U5HX-ray1.80A76-441[»]
5U5KX-ray2.33A76-441[»]
5U5TX-ray1.60A/B76-441[»]
5U62X-ray1.90A/B76-441[»]
5U69X-ray1.28A77-441[»]
5U6DX-ray1.64A77-441[»]
5U8AX-ray1.45A77-441[»]
5U8FX-ray1.34A77-441[»]
5WG6X-ray3.90B/D2-441[»]
5WP3X-ray2.55A75-441[»]
5WUKX-ray2.03A76-441[»]
6B3WX-ray3.05E/F81-441[»]
6C23electron microscopy3.90L1-441[»]
6C24electron microscopy3.50L1-441[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75530

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75530

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O75530

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati91 – 134WD 1Add BLAST44
Repeati142 – 185WD 2Add BLAST44
Repeati188 – 228WD 3Add BLAST41
Repeati234 – 275WD 4Add BLAST42
Repeati304 – 341WD 5Add BLAST38
Repeati359 – 399WD 6Add BLAST41
Repeati408 – 441WD 7Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni81 – 441Interaction with EZH2By similarityAdd BLAST361
Regioni149 – 303Required for interaction with the matrix protein MA of HIV-1Add BLAST155
Regioni301 – 441Required for interaction with the matrix protein MA of HIV-1Add BLAST141

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WD repeat domain mediates recognition of trimethylated histone peptides at the consensus sequence Ala-Arg-Lys-Ser. This is achieved through an aromatic cage encircling the methyllysine, and involving Phe-97, Tyr-148 and Tyr-365.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat ESC family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1034 Eukaryota
ENOG410XRQI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000047334

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052708

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75530

KEGG Orthology (KO)

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KOi
K11462

Identification of Orthologs from Complete Genome Data

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OMAi
CTTLTHP

Database of Orthologous Groups

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OrthoDBi
1339129at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75530

TreeFam database of animal gene trees

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TreeFami
TF314451

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR037352 Polycomb_EED
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR10253 PTHR10253, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket
Note: Additional isoforms may be produced by alternative initiation, both from non-canonical start codons upstream of the initiator methionine displayed and from other canonical start codons downstream of that displayed (PubMed:15099518 and PubMed:15684044). The precise sites of translation initiation have not been unambiguously identified.

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75530-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT
60 70 80 90 100
ERPDTPTNTP NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ
110 120 130 140 150
FNWHSKEGDP LVFATVGSNR VTLYECHSQG EIRLLQSYVD ADADENFYTC
160 170 180 190 200
AWTYDSNTSH PLLAVAGSRG IIRIINPITM QCIKHYVGHG NAINELKFHP
210 220 230 240 250
RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL SADYDLLGEK
260 270 280 290 300
IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS
310 320 330 340 350
TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV
360 370 380 390 400
TILGRFDYSQ CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK
410 420 430 440
CTTLTHHKCG AAIRQTSFSR DSSILIAVCD DASIWRWDRL R
Length:441
Mass (Da):50,198
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2E0A5BA27C0499A
GO
Isoform 2 (identifier: O75530-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-322: K → KSGRAILHSHQQCMRDPVSPNLRQHL

Show »
Length:466
Mass (Da):53,061
Checksum:i614B2E31B2A9D41F
GO
Isoform 3 (identifier: O75530-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-441: Missing.

Show »
Length:400
Mass (Da):45,524
Checksum:i45DD879776FF83D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJK2E9PJK2_HUMAN
Polycomb protein EED
EED
361Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMU3E9PMU3_HUMAN
Polycomb protein EED
EED
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEL4H0YEL4_HUMAN
Polycomb protein EED
EED
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC23685 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC68675 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32D → E in AAC68675 (PubMed:9765275).Curated1
Sequence conflicti74K → S in AAD08714 (PubMed:9880543).Curated1
Sequence conflicti74K → S in AAD08815 (PubMed:9880543).Curated1
Sequence conflicti337E → K in AAD08714 (PubMed:9880543).Curated1
Sequence conflicti337E → K in AAD08815 (PubMed:9880543).Curated1
Sequence conflicti417S → G in BAF84809 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079255194N → S in COGIS. 1 Publication1
Natural variantiVAR_079256236R → G in COGIS. 1 Publication1
Natural variantiVAR_078316236R → T in COGIS; decreased trimethylation of 'Lys-27' of histone H3; no effect on interaction with EZH2. 1 PublicationCorresponds to variant dbSNP:rs1131692176Ensembl.1
Natural variantiVAR_079257258H → Y in COGIS. 1 PublicationCorresponds to variant dbSNP:rs1131692174Ensembl.1
Natural variantiVAR_079258302R → G in COGIS. 1 PublicationCorresponds to variant dbSNP:rs1131692175Ensembl.1
Natural variantiVAR_078317302R → S in COGIS; decreased trimethylation of 'Lys-27' of histone H3. 2 PublicationsCorresponds to variant dbSNP:rs1131692173Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034691322K → KSGRAILHSHQQCMRDPVSP NLRQHL in isoform 2. 1 Publication1
Alternative sequenceiVSP_034692401 – 441Missing in isoform 3. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF080227 mRNA Translation: AAC95144.1
AF070418 mRNA Translation: AAC23685.1 Different initiation.
U90651 mRNA Translation: AAD08714.1
AF099032 mRNA Translation: AAD08815.1
AK292120 mRNA Translation: BAF84809.1
AP003084 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75129.1
CH471076 Genomic DNA Translation: EAW75130.1
BC047672 mRNA Translation: AAH47672.1
BC068995 mRNA Translation: AAH68995.1
AF078933 mRNA Translation: AAC68675.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS76463.1 [O75530-2]
CCDS8273.1 [O75530-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001294936.1, NM_001308007.1 [O75530-2]
NP_003788.2, NM_003797.4 [O75530-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.503510
Hs.528103

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263360; ENSP00000263360; ENSG00000074266 [O75530-1]
ENST00000327320; ENSP00000315587; ENSG00000074266 [O75530-3]
ENST00000351625; ENSP00000338186; ENSG00000074266 [O75530-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8726

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8726

UCSC genome browser

More...
UCSCi
uc001pbp.4 human [O75530-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080227 mRNA Translation: AAC95144.1
AF070418 mRNA Translation: AAC23685.1 Different initiation.
U90651 mRNA Translation: AAD08714.1
AF099032 mRNA Translation: AAD08815.1
AK292120 mRNA Translation: BAF84809.1
AP003084 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75129.1
CH471076 Genomic DNA Translation: EAW75130.1
BC047672 mRNA Translation: AAH47672.1
BC068995 mRNA Translation: AAH68995.1
AF078933 mRNA Translation: AAC68675.1 Different initiation.
CCDSiCCDS76463.1 [O75530-2]
CCDS8273.1 [O75530-1]
RefSeqiNP_001294936.1, NM_001308007.1 [O75530-2]
NP_003788.2, NM_003797.4 [O75530-1]
UniGeneiHs.503510
Hs.528103

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IIWX-ray1.80A77-441[»]
3IIYX-ray2.65A77-441[»]
3IJ0X-ray2.45A77-441[»]
3IJ1X-ray2.10A77-441[»]
3IJCX-ray1.95A77-441[»]
3JPXX-ray2.05A40-441[»]
3JZGX-ray2.10A40-441[»]
3JZHX-ray2.05A40-441[»]
3JZNX-ray2.60A76-441[»]
3K26X-ray1.58A76-441[»]
3K27X-ray1.76A76-441[»]
4W2RX-ray2.81E/F81-441[»]
4X3EX-ray2.30A77-441[»]
5GSAX-ray2.49A/B76-441[»]
5H13X-ray1.90A76-441[»]
5H14X-ray1.90A/B76-441[»]
5H15X-ray2.27A/B76-441[»]
5H17X-ray2.30A76-441[»]
5H19X-ray1.90A76-441[»]
5H24X-ray2.50A/B76-441[»]
5H25X-ray2.88A/B76-441[»]
5HYNX-ray2.95B/G/L/R77-441[»]
5IJ7X-ray2.62E/F81-441[»]
5IJ8X-ray2.99E/F81-441[»]
5K0MX-ray1.83A77-441[»]
5LS6X-ray3.47B/E/H/K77-441[»]
5TTWX-ray1.74A/C76-441[»]
5U5HX-ray1.80A76-441[»]
5U5KX-ray2.33A76-441[»]
5U5TX-ray1.60A/B76-441[»]
5U62X-ray1.90A/B76-441[»]
5U69X-ray1.28A77-441[»]
5U6DX-ray1.64A77-441[»]
5U8AX-ray1.45A77-441[»]
5U8FX-ray1.34A77-441[»]
5WG6X-ray3.90B/D2-441[»]
5WP3X-ray2.55A75-441[»]
5WUKX-ray2.03A76-441[»]
6B3WX-ray3.05E/F81-441[»]
6C23electron microscopy3.90L1-441[»]
6C24electron microscopy3.50L1-441[»]
ProteinModelPortaliO75530
SMRiO75530
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114265, 492 interactors
CORUMiO75530
DIPiDIP-36673N
IntActiO75530, 70 interactors
MINTiO75530
STRINGi9606.ENSP00000263360

Chemistry databases

BindingDBiO75530
ChEMBLiCHEMBL2189117
GuidetoPHARMACOLOGYi2487

PTM databases

iPTMnetiO75530
PhosphoSitePlusiO75530

Polymorphism and mutation databases

BioMutaiEED

Proteomic databases

EPDiO75530
jPOSTiO75530
MaxQBiO75530
PaxDbiO75530
PeptideAtlasiO75530
PRIDEiO75530
ProteomicsDBi50068
50069 [O75530-2]
50070 [O75530-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8726
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263360; ENSP00000263360; ENSG00000074266 [O75530-1]
ENST00000327320; ENSP00000315587; ENSG00000074266 [O75530-3]
ENST00000351625; ENSP00000338186; ENSG00000074266 [O75530-2]
GeneIDi8726
KEGGihsa:8726
UCSCiuc001pbp.4 human [O75530-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8726
DisGeNETi8726
EuPathDBiHostDB:ENSG00000074266.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EED
HGNCiHGNC:3188 EED
HPAiCAB012211
HPA060089
HPA061140
MalaCardsiEED
MIMi605984 gene
617561 phenotype
neXtProtiNX_O75530
OpenTargetsiENSG00000074266
Orphaneti3447 Weaver syndrome
PharmGKBiPA27624

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1034 Eukaryota
ENOG410XRQI LUCA
GeneTreeiENSGT00510000047334
HOVERGENiHBG052708
InParanoidiO75530
KOiK11462
OMAiCTTLTHP
OrthoDBi1339129at2759
PhylomeDBiO75530
TreeFamiTF314451

Enzyme and pathway databases

ReactomeiR-HSA-212300 PRC2 methylates histones and DNA
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8953750 Transcriptional Regulation by E2F6
SignaLinkiO75530
SIGNORiO75530

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EED human
EvolutionaryTraceiO75530

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
EED

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8726

Protein Ontology

More...
PROi
PR:O75530

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000074266 Expressed in 107 organ(s), highest expression level in endocervix
CleanExiHS_EED
ExpressionAtlasiO75530 baseline and differential
GenevisibleiO75530 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR037352 Polycomb_EED
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10253 PTHR10253, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEED_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75530
Secondary accession number(s): A8K7V5
, O00149, Q6NTH2, Q7LDA5, Q7LDG8, Q86VV2, Q9UNY7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: January 16, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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