Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Enoyl-CoA delta isomerase 2, mitochondrial

Gene

ECI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei92Acyl-CoABy similarity1
Binding sitei111Acyl-CoABy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei280Important for catalytic activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dodecenoyl-CoA delta-isomerase activity Source: UniProtKB
  • fatty-acyl-CoA binding Source: InterPro
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS03615-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390247 Beta-oxidation of very long chain fatty acids
R-HSA-9033241 Peroxisomal protein import

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001195 [O75521-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Enoyl-CoA delta isomerase 2, mitochondrial (EC:5.3.3.8)
Alternative name(s):
DRS-1
Delta(3),delta(2)-enoyl-CoA isomerase
Short name:
D3,D2-enoyl-CoA isomerase
Diazepam-binding inhibitor-related protein 1
Short name:
DBI-related protein 1
Dodecenoyl-CoA isomerase
Hepatocellular carcinoma-associated antigen 88
Peroxisomal 3,2-trans-enoyl-CoA isomerase
Short name:
pECI
Renal carcinoma antigen NY-REN-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ECI2
Synonyms:DRS1, HCA88, PECI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198721.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14601 ECI2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608024 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75521

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10455

Open Targets

More...
OpenTargetsi
ENSG00000198721

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33168

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB08231 MYRISTIC ACID

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ECI2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 38MitochondrionSequence analysisAdd BLAST38
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000021402739 – 394Enoyl-CoA delta isomerase 2, mitochondrialAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei51N6-acetyllysine; alternateCombined sources1
Modified residuei51N6-succinyllysine; alternateBy similarity1
Modified residuei55N6-succinyllysineBy similarity1
Modified residuei62N6-acetyllysine; alternateBy similarity1
Modified residuei62N6-succinyllysine; alternateBy similarity1
Modified residuei70N6-succinyllysineBy similarity1
Modified residuei81N6-succinyllysineBy similarity1
Modified residuei90N6-succinyllysineBy similarity1
Modified residuei92N6-acetyllysine; alternateCombined sources1
Modified residuei92N6-succinyllysine; alternateBy similarity1
Modified residuei101PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei161N6-succinyllysineBy similarity1
Modified residuei289N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75521

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75521

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75521

PeptideAtlas

More...
PeptideAtlasi
O75521

PRoteomics IDEntifications database

More...
PRIDEi
O75521

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50059
50060 [O75521-2]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00419263

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
O75521

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75521

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75521

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O75521

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in heart, skeletal muscle and liver. Expressed in CD34+ T-cells and CD34+ bone marrow cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198721 Expressed in 220 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75521 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75521 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022130
HPA031626

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115718, 41 interactors

Protein interaction database and analysis system

More...
IntActi
O75521, 65 interactors

Molecular INTeraction database

More...
MINTi
O75521

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369461

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1394
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75521

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75521

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O75521

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 124ACBPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 70Acyl-CoA bindingBy similarity5
Regioni151 – 322ECH-likeAdd BLAST172
Regioni198 – 202Substrate bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi392 – 394Microbody targeting signalSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0016 Eukaryota
KOG0817 Eukaryota
COG1024 LUCA
COG4281 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155105

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006723

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75521

KEGG Orthology (KO)

More...
KOi
K13239

Identification of Orthologs from Complete Genome Data

More...
OMAi
SYMLPLI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0T5I

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75521

TreeFam database of animal gene trees

More...
TreeFami
TF313375

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.12.10, 1 hit
1.20.80.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR029045 ClpP/crotonase-like_dom_sf
IPR001753 Enoyl-CoA_hydra/iso
IPR014748 Enoyl-CoA_hydra_C
IPR014352 FERM/acyl-CoA-bd_prot_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00887 ACBP, 1 hit
PF00378 ECH_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00689 ACOABINDINGP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47027 SSF47027, 1 hit
SSF52096 SSF52096, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75521-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMAYLAWRL ARRSCPSSLQ VTSFPVVQLH MNRTAMRASQ KDFENSMNQV
60 70 80 90 100
KLLKKDPGNE VKLKLYALYK QATEGPCNMP KPGVFDLINK AKWDAWNALG
110 120 130 140 150
SLPKEAARQN YVDLVSSLSP SLESSSQVEP GTDRKSTGFE TLVVTSEDGI
160 170 180 190 200
TKIMFNRPKK KNAINTEMYH EIMRALKAAS KDDSIITVLT GNGDYYSSGN
210 220 230 240 250
DLTNFTDIPP GGVEEKAKNN AVLLREFVGC FIDFPKPLIA VVNGPAVGIS
260 270 280 290 300
VTLLGLFDAV YASDRATFHT PFSHLGQSPE GCSSYTFPKI MSPAKATEML
310 320 330 340 350
IFGKKLTAGE ACAQGLVTEV FPDSTFQKEV WTRLKAFAKL PPNALRISKE
360 370 380 390
VIRKREREKL HAVNAEECNV LQGRWLSDEC TNAVVNFLSR KSKL
Length:394
Mass (Da):43,585
Last modified:September 1, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AC633D43A320102
GO
Isoform 2 (identifier: O75521-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:359
Mass (Da):39,609
Checksum:iB9EC60A0D445C9F0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGA2A0A0C4DGA2_HUMAN
Enoyl-CoA delta isomerase 2, mitoch...
ECI2
364Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LLU7F1LLU7_HUMAN
Enoyl-CoA delta isomerase 2, mitoch...
ECI2
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JB63C9JB63_HUMAN
Enoyl-CoA delta isomerase 2, mitoch...
ECI2
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAW4F8WAW4_HUMAN
Enoyl-CoA delta isomerase 2, mitoch...
ECI2
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W6J1F8W6J1_HUMAN
Enoyl-CoA delta isomerase 2, mitoch...
ECI2
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC19317 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAD34173 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF66247 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH02668 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH16781 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH17474 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH33841 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH34702 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG52068 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119S → C in CAB66577 (PubMed:11230166).Curated1
Sequence conflicti195Y → C in AAC19317 (PubMed:10354522).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05849347M → I. Corresponds to variant dbSNP:rs3177253Ensembl.1
Natural variantiVAR_058494344A → V2 PublicationsCorresponds to variant dbSNP:rs7166Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0378541 – 35Missing in isoform 2. 3 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF069301 mRNA Translation: AAC19317.1 Different initiation.
AL136642 mRNA Translation: CAB66577.1
AK075108 mRNA Translation: BAG52068.1 Different initiation.
AL033383 Genomic DNA No translation available.
BC002668 mRNA Translation: AAH02668.3 Different initiation.
BC016781 mRNA Translation: AAH16781.1 Different initiation.
BC017474 mRNA Translation: AAH17474.1 Different initiation.
BC033841 mRNA Translation: AAH33841.3 Different initiation.
BC034702 mRNA Translation: AAH34702.1 Different initiation.
AF153612 mRNA Translation: AAD34173.1 Different initiation.
AF244138 mRNA Translation: AAF66247.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43420.2 [O75521-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001159482.1, NM_001166010.1
NP_006108.2, NM_006117.2
NP_996667.2, NM_206836.2 [O75521-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.15250

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380118; ENSP00000369461; ENSG00000198721 [O75521-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10455

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10455

UCSC genome browser

More...
UCSCi
uc003mwd.4 human [O75521-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069301 mRNA Translation: AAC19317.1 Different initiation.
AL136642 mRNA Translation: CAB66577.1
AK075108 mRNA Translation: BAG52068.1 Different initiation.
AL033383 Genomic DNA No translation available.
BC002668 mRNA Translation: AAH02668.3 Different initiation.
BC016781 mRNA Translation: AAH16781.1 Different initiation.
BC017474 mRNA Translation: AAH17474.1 Different initiation.
BC033841 mRNA Translation: AAH33841.3 Different initiation.
BC034702 mRNA Translation: AAH34702.1 Different initiation.
AF153612 mRNA Translation: AAD34173.1 Different initiation.
AF244138 mRNA Translation: AAF66247.1 Different initiation.
CCDSiCCDS43420.2 [O75521-1]
RefSeqiNP_001159482.1, NM_001166010.1
NP_006108.2, NM_006117.2
NP_996667.2, NM_206836.2 [O75521-1]
UniGeneiHs.15250

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQUNMR-A31-133[»]
2F6QX-ray1.95A/B/C138-394[»]
4U18X-ray2.64A/B/C138-390[»]
4U19X-ray1.88A/B/C138-390[»]
4U1AX-ray2.85A/B/C138-384[»]
ProteinModelPortaliO75521
SMRiO75521
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115718, 41 interactors
IntActiO75521, 65 interactors
MINTiO75521
STRINGi9606.ENSP00000369461

Chemistry databases

DrugBankiDB08231 MYRISTIC ACID
SwissLipidsiSLP:000001195 [O75521-2]

PTM databases

iPTMnetiO75521
PhosphoSitePlusiO75521
SwissPalmiO75521

Polymorphism and mutation databases

BioMutaiECI2

2D gel databases

REPRODUCTION-2DPAGEiIPI00419263
UCD-2DPAGEiO75521

Proteomic databases

EPDiO75521
MaxQBiO75521
PaxDbiO75521
PeptideAtlasiO75521
PRIDEiO75521
ProteomicsDBi50059
50060 [O75521-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10455
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380118; ENSP00000369461; ENSG00000198721 [O75521-1]
GeneIDi10455
KEGGihsa:10455
UCSCiuc003mwd.4 human [O75521-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10455
DisGeNETi10455
EuPathDBiHostDB:ENSG00000198721.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ECI2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0025043
HGNCiHGNC:14601 ECI2
HPAiHPA022130
HPA031626
MIMi608024 gene
neXtProtiNX_O75521
OpenTargetsiENSG00000198721
PharmGKBiPA33168

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0016 Eukaryota
KOG0817 Eukaryota
COG1024 LUCA
COG4281 LUCA
GeneTreeiENSGT00940000155105
HOVERGENiHBG006723
InParanoidiO75521
KOiK13239
OMAiSYMLPLI
OrthoDBiEOG091G0T5I
PhylomeDBiO75521
TreeFamiTF313375

Enzyme and pathway databases

BioCyciMetaCyc:HS03615-MONOMER
ReactomeiR-HSA-390247 Beta-oxidation of very long chain fatty acids
R-HSA-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ECI2 human
EvolutionaryTraceiO75521

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PECI_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10455

Protein Ontology

More...
PROi
PR:O75521

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198721 Expressed in 220 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiO75521 baseline and differential
GenevisibleiO75521 HS

Family and domain databases

Gene3Di1.10.12.10, 1 hit
1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR029045 ClpP/crotonase-like_dom_sf
IPR001753 Enoyl-CoA_hydra/iso
IPR014748 Enoyl-CoA_hydra_C
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PF00378 ECH_1, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
SSF52096 SSF52096, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECI2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75521
Secondary accession number(s): Q5JYK5
, Q5JYK7, Q7L124, Q8N0X0, Q9BUE9, Q9H0T9, Q9NQH1, Q9NYH7, Q9UN55
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: September 1, 2009
Last modified: December 5, 2018
This is version 192 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again