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Protein

Claudin-11

Gene

CLDN11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-11
Alternative name(s):
Oligodendrocyte-specific protein
Gene namesi
Name:CLDN11
Synonyms:OSP, OTM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000013297.10
HGNCiHGNC:8514 CLDN11
MIMi601326 gene
neXtProtiNX_O75508

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1CytoplasmicSequence analysis1
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 82ExtracellularSequence analysisAdd BLAST60
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 122CytoplasmicSequence analysisAdd BLAST19
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 157ExtracellularSequence analysisAdd BLAST14
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 207CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi5010
OpenTargetsiENSG00000013297
PharmGKBiPA26559

Polymorphism and mutation databases

BioMutaiCLDN11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447601 – 207Claudin-11Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei197PhosphoserineBy similarity1
Modified residuei198PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO75508
PeptideAtlasiO75508
PRIDEiO75508
ProteomicsDBi50057

PTM databases

iPTMnetiO75508
PhosphoSitePlusiO75508
SwissPalmiO75508

Expressioni

Gene expression databases

BgeeiENSG00000013297 Expressed in 192 organ(s), highest expression level in globus pallidus
CleanExiHS_CLDN11
GenevisibleiO75508 HS

Organism-specific databases

HPAiCAB009789
HPA013166

Interactioni

Subunit structurei

Interacts with tetraspanin-3/TSPAN3 (By similarity). Interacts with OCLN (PubMed:20375010).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO75508, 10 interactors
STRINGi9606.ENSP00000064724

Structurei

3D structure databases

ProteinModelPortaliO75508
SMRiO75508
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEXU Eukaryota
ENOG41101XN LUCA
GeneTreeiENSGT00890000139496
HOGENOMiHOG000220937
HOVERGENiHBG102313
InParanoidiO75508
KOiK06087
OMAiYSLYTGW
OrthoDBiEOG091G0MX2
PhylomeDBiO75508
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003555 Claudin11
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF6 PTHR12002:SF6, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01384 CLAUDIN11
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

O75508-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVATCLQVVG FVTSFVGWIG VIVTTSTNDW VVTCGYTIPT CRKLDELGSK
60 70 80 90 100
GLWADCVMAT GLYHCKPLVD ILILPGYVQA CRALMIAASV LGLPAILLLL
110 120 130 140 150
TVLPCIRMGQ EPGVAKYRRA QLAGVLLILL ALCALVATIW FPVCAHRETT
160 170 180 190 200
IVSFGYSLYA GWIGAVLCLV GGCVILCCAG DAQAFGENRF YYTAGSSSPT

HAKSAHV
Length:207
Mass (Da):21,993
Last modified:May 30, 2000 - v2
Checksum:i4FF79C676FCAFA47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160A → T in AAV38209 (Ref. 3) Curated1
Sequence conflicti160A → T in AAV38210 (Ref. 3) Curated1
Sequence conflicti189 – 207RFYYT…KSAHV → VSTTLRALAPRLMRRVPTYK RAARLPTEVL in AAC25187 (PubMed:10700007).CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068863 mRNA Translation: AAC25187.1
AJ245901 mRNA Translation: CAB55487.1
BT019402 mRNA Translation: AAV38209.1
BT019403 mRNA Translation: AAV38210.1
AK312923 mRNA Translation: BAG35768.1
CH471052 Genomic DNA Translation: EAW78505.1
CH471052 Genomic DNA Translation: EAW78509.1
BC013577 mRNA Translation: AAH13577.1
CCDSiCCDS3213.1
RefSeqiNP_005593.2, NM_005602.5
UniGeneiHs.31595

Genome annotation databases

EnsembliENST00000064724; ENSP00000064724; ENSG00000013297
GeneIDi5010
KEGGihsa:5010
UCSCiuc003fgx.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068863 mRNA Translation: AAC25187.1
AJ245901 mRNA Translation: CAB55487.1
BT019402 mRNA Translation: AAV38209.1
BT019403 mRNA Translation: AAV38210.1
AK312923 mRNA Translation: BAG35768.1
CH471052 Genomic DNA Translation: EAW78505.1
CH471052 Genomic DNA Translation: EAW78509.1
BC013577 mRNA Translation: AAH13577.1
CCDSiCCDS3213.1
RefSeqiNP_005593.2, NM_005602.5
UniGeneiHs.31595

3D structure databases

ProteinModelPortaliO75508
SMRiO75508
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO75508, 10 interactors
STRINGi9606.ENSP00000064724

PTM databases

iPTMnetiO75508
PhosphoSitePlusiO75508
SwissPalmiO75508

Polymorphism and mutation databases

BioMutaiCLDN11

Proteomic databases

PaxDbiO75508
PeptideAtlasiO75508
PRIDEiO75508
ProteomicsDBi50057

Protocols and materials databases

DNASUi5010
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000064724; ENSP00000064724; ENSG00000013297
GeneIDi5010
KEGGihsa:5010
UCSCiuc003fgx.4 human

Organism-specific databases

CTDi5010
DisGeNETi5010
EuPathDBiHostDB:ENSG00000013297.10
GeneCardsiCLDN11
HGNCiHGNC:8514 CLDN11
HPAiCAB009789
HPA013166
MIMi601326 gene
neXtProtiNX_O75508
OpenTargetsiENSG00000013297
PharmGKBiPA26559
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEXU Eukaryota
ENOG41101XN LUCA
GeneTreeiENSGT00890000139496
HOGENOMiHOG000220937
HOVERGENiHBG102313
InParanoidiO75508
KOiK06087
OMAiYSLYTGW
OrthoDBiEOG091G0MX2
PhylomeDBiO75508
TreeFamiTF331936

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Miscellaneous databases

ChiTaRSiCLDN11 human
GeneWikiiCLDN11
GenomeRNAii5010
PROiPR:O75508
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000013297 Expressed in 192 organ(s), highest expression level in globus pallidus
CleanExiHS_CLDN11
GenevisibleiO75508 HS

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003555 Claudin11
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF6 PTHR12002:SF6, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01384 CLAUDIN11
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD11_HUMAN
AccessioniPrimary (citable) accession number: O75508
Secondary accession number(s): B2R7C1, D3DNQ5, Q5U0P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: October 10, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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