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Protein

Geminin

Gene

GMNN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: CAFA
  • histone deacetylase binding Source: UniProtKB
  • repressing transcription factor binding Source: Ensembl
  • transcription corepressor activity Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA replication inhibitor
Biological processCell cycle

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68962 Activation of the pre-replicative complex

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Geminin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GMNN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000112312.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17493 GMNN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602842 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75496

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Meier-Gorlin syndrome 6 (MGORS6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Meier-Gorlin syndrome, a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
See also OMIM:616835
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07617217K → R in MGORS6. 1 PublicationCorresponds to variant dbSNP:rs864309488EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
51053

MalaCards human disease database

More...
MalaCardsi
GMNN
MIMi616835 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000112312

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2554 Ear-patella-short stature syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38455

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1293278

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GMNN

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001487291 – 209GemininAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei27N6-acetyllysineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei184Phosphoserine; by CK21 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated during mitosis. Phosphorylation at Ser-184 by CK2 results in enhanced binding to Hox proteins and more potent inhibitory effect on Hox transcriptional activity.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75496

MaxQB - The MaxQuant DataBase

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MaxQBi
O75496

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O75496

PeptideAtlas

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PeptideAtlasi
O75496

PRoteomics IDEntifications database

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PRIDEi
O75496

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50053

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75496

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75496

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
O75496

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Absent during G1 phase, accumulates during S, G2, and M phases, and disappears at the time of the metaphase-anaphase transition.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000112312 Expressed in 216 organ(s), highest expression level in body of pancreas

CleanEx database of gene expression profiles

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CleanExi
HS_GMNN

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75496 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75496 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB011458
CAB047327
CAB047328
HPA049977
HPA054597

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. Interacts with CDT1; this inhibits binding of the MCM complex to origins of replication. The complex with CDT1 exists in two forms, a "permissive" heterotrimer and an "inhibitory" heterohexamer. Interacts (via coiled-coil domain) with IDAS (via coiled-coil domain); this targets GMNN to the nucleus. The heterodimer formed by GMNN and MCIDAS has much lower affinity for CDT1 than the GMNN homodimer. Interacts with a subset of Hox proteins, affinity increasing from anterior to posterior types, the strongest interaction being with HOXB1, HOXC9 and HOXD10. Interacts with LRWD1 from G1/S to mitosis.9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119246, 71 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O75496

Database of interacting proteins

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DIPi
DIP-31088N

Protein interaction database and analysis system

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IntActi
O75496, 27 interactors

Molecular INTeraction database

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MINTi
O75496

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000230056

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

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DisProti
DP00901

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75496

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75496

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O75496

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni82 – 161Necessary and sufficient for interaction with IDAS and CDT11 PublicationAdd BLAST80
Regioni170 – 190Homeodomain bindingAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili94 – 1444 PublicationsAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the geminin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG0B Eukaryota
ENOG410XZS9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153270

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112711

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002965

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75496

KEGG Orthology (KO)

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KOi
K10749

Identification of Orthologs from Complete Genome Data

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OMAi
VPEHSEN

Database of Orthologous Groups

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OrthoDBi
EOG091G19OS

Database for complete collections of gene phylogenies

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PhylomeDBi
O75496

TreeFam database of animal gene trees

More...
TreeFami
TF101171

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029697 Geminin
IPR022786 Geminin/Multicilin

The PANTHER Classification System

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PANTHERi
PTHR13372:SF4 PTHR13372:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07412 Geminin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O75496-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPSMKQKQE EIKENIKNSS VPRRTLKMIQ PSASGSLVGR ENELSAGLSK
60 70 80 90 100
RKHRNDHLTS TTSSPGVIVP ESSENKNLGG VTQESFDLMI KENPSSQYWK
110 120 130 140 150
EVAEKRRKAL YEALKENEKL HKEIEQKDNE IARLKKENKE LAEVAEHVQY
160 170 180 190 200
MAELIERLNG EPLDNFESLD NQEFDSEEET VEDSLVEDSE IGTCAEGTVS

SSTDAKPCI
Length:209
Mass (Da):23,565
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BABE60F6F5AC252
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E2QRF9E2QRF9_HUMAN
Geminin
GMNN
179Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C608H7C608_HUMAN
Geminin
GMNN
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0U5C9K0U5_HUMAN
Geminin
GMNN
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03395915N → H. Corresponds to variant dbSNP:rs34891389Ensembl.1
Natural variantiVAR_07617217K → R in MGORS6. 1 PublicationCorresponds to variant dbSNP:rs864309488EnsemblClinVar.1
Natural variantiVAR_02423318N → T1 PublicationCorresponds to variant dbSNP:rs1923185Ensembl.1
Natural variantiVAR_03396048L → F. Corresponds to variant dbSNP:rs2307307Ensembl.1
Natural variantiVAR_03396154R → W. Corresponds to variant dbSNP:rs2307306Ensembl.1
Natural variantiVAR_05310760S → P. Corresponds to variant dbSNP:rs2307302Ensembl.1
Natural variantiVAR_053108203T → M. Corresponds to variant dbSNP:rs2307303Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF067855 mRNA Translation: AAC39787.1
AK021685 mRNA Translation: BAG51040.1
AL133264 Genomic DNA No translation available.
BC005185 mRNA Translation: AAH05185.1
BC005389 mRNA Translation: AAH05389.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4560.1

NCBI Reference Sequences

More...
RefSeqi
NP_001238918.1, NM_001251989.1
NP_001238919.1, NM_001251990.1
NP_001238920.1, NM_001251991.1
NP_056979.1, NM_015895.4
XP_005249216.1, XM_005249159.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.234896

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000230056; ENSP00000230056; ENSG00000112312
ENST00000356509; ENSP00000348902; ENSG00000112312
ENST00000620958; ENSP00000477506; ENSG00000112312

Database of genes from NCBI RefSeq genomes

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GeneIDi
51053

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51053

UCSC genome browser

More...
UCSCi
uc003nem.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067855 mRNA Translation: AAC39787.1
AK021685 mRNA Translation: BAG51040.1
AL133264 Genomic DNA No translation available.
BC005185 mRNA Translation: AAH05185.1
BC005389 mRNA Translation: AAH05389.1
CCDSiCCDS4560.1
RefSeqiNP_001238918.1, NM_001251989.1
NP_001238919.1, NM_001251990.1
NP_001238920.1, NM_001251991.1
NP_056979.1, NM_015895.4
XP_005249216.1, XM_005249159.1
UniGeneiHs.234896

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T6FX-ray1.47A/B109-145[»]
1UIIX-ray2.00A/B70-152[»]
2LP0NMR-B171-190[»]
2WVRX-ray3.30A/B1-209[»]
4BRYX-ray2.89A83-160[»]
DisProtiDP00901
ProteinModelPortaliO75496
SMRiO75496
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119246, 71 interactors
CORUMiO75496
DIPiDIP-31088N
IntActiO75496, 27 interactors
MINTiO75496
STRINGi9606.ENSP00000230056

Chemistry databases

ChEMBLiCHEMBL1293278

PTM databases

iPTMnetiO75496
PhosphoSitePlusiO75496

Polymorphism and mutation databases

BioMutaiGMNN

Proteomic databases

EPDiO75496
MaxQBiO75496
PaxDbiO75496
PeptideAtlasiO75496
PRIDEiO75496
ProteomicsDBi50053

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51053
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230056; ENSP00000230056; ENSG00000112312
ENST00000356509; ENSP00000348902; ENSG00000112312
ENST00000620958; ENSP00000477506; ENSG00000112312
GeneIDi51053
KEGGihsa:51053
UCSCiuc003nem.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51053
DisGeNETi51053
EuPathDBiHostDB:ENSG00000112312.9

GeneCards: human genes, protein and diseases

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GeneCardsi
GMNN
HGNCiHGNC:17493 GMNN
HPAiCAB011458
CAB047327
CAB047328
HPA049977
HPA054597
MalaCardsiGMNN
MIMi602842 gene
616835 phenotype
neXtProtiNX_O75496
OpenTargetsiENSG00000112312
Orphaneti2554 Ear-patella-short stature syndrome
PharmGKBiPA38455

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IG0B Eukaryota
ENOG410XZS9 LUCA
GeneTreeiENSGT00940000153270
HOGENOMiHOG000112711
HOVERGENiHBG002965
InParanoidiO75496
KOiK10749
OMAiVPEHSEN
OrthoDBiEOG091G19OS
PhylomeDBiO75496
TreeFamiTF101171

Enzyme and pathway databases

ReactomeiR-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68962 Activation of the pre-replicative complex

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GMNN human
EvolutionaryTraceiO75496

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Geminin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51053
PMAP-CutDBiO75496

Protein Ontology

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PROi
PR:O75496

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000112312 Expressed in 216 organ(s), highest expression level in body of pancreas
CleanExiHS_GMNN
ExpressionAtlasiO75496 baseline and differential
GenevisibleiO75496 HS

Family and domain databases

InterProiView protein in InterPro
IPR029697 Geminin
IPR022786 Geminin/Multicilin
PANTHERiPTHR13372:SF4 PTHR13372:SF4, 1 hit
PfamiView protein in Pfam
PF07412 Geminin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGEMI_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75496
Secondary accession number(s): B3KMM8, Q9H1Z1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1998
Last modified: December 5, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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