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UniProtKB - O75494 (SRS10_HUMAN)

Entry version 202 (02 Dec 2020)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
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Protein

Serine/arginine-rich splicing factor 10

Gene

SRSF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75494

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-72163, mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 10
Alternative name(s):
40 kDa SR-repressor protein
Short name:
SRrp40
FUS-interacting serine-arginine-rich protein 1
Splicing factor SRp38
Splicing factor, arginine/serine-rich 13A
TLS-associated protein with Ser-Arg repeats
Short name:
TASR
Short name:
TLS-associated protein with SR repeats
TLS-associated serine-arginine protein
Short name:
TLS-associated SR protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRSF10
Synonyms:FUSIP1, FUSIP2, SFRS13A, TASR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000188529.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:16713, SRSF10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605221, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75494

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10772

Open Targets

More...OpenTargetsi		ENSG00000188529

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28427

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75494, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SRSF10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000815931 – 262Serine/arginine-rich splicing factor 10Add BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Isoform 4 (identifier: O75494-4)
Modified residuei158PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Isoform 3 (identifier: O75494-3)
Modified residuei168PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75494

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75494

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75494

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75494

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75494

PeptideAtlas

More...PeptideAtlasi		O75494

PRoteomics IDEntifications database

More...PRIDEi		O75494

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50048 [O75494-1]
50049 [O75494-2]
50050 [O75494-3]
50051 [O75494-4]
50052 [O75494-5]
63091

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O75494-1 [O75494-1]
O75494-2 [O75494-2]
O75494-3 [O75494-3]
O75494-4 [O75494-4]
O75494-5 [O75494-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75494

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75494

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O75494

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188529, Expressed in left lobe of thyroid gland and 242 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75494, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75494, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188529, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The phosphorylated but not the dephosphorylated form interacts with TRA2B/SFRS10 (PubMed:14765198). The dephosphorylated form interacts with SNRNP70 (PubMed:14765198).

Isoform 1 interacts with FUS C-terminus (PubMed:9774382).

Isoform 3 interacts with FUS C-terminus (PubMed:9774382).

Interacts with YTHDC1, leading to inhibit RNA-binding activity of SRSF10 (PubMed:26876937).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115990, 108 interactors

Protein interaction database and analysis system

More...IntActi		O75494, 58 interactors

Molecular INTeraction database

More...MINTi		O75494

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000420195

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75494, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75494

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 88RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi106 – 260Arg/Ser-rich (RS domain)Add BLAST155

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0118, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154450

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012062_10_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75494

Identification of Orthologs from Complete Genome Data

More...OMAi		YVQYTFE

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75494

TreeFam database of animal gene trees

More...TreeFami		TF351864

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034476, SRSF10

The PANTHER Classification System

More...PANTHERi		PTHR23147:SF87, PTHR23147:SF87, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076, RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75494-1) [UniParc]FASTAAdd to basket
Also known as: TASR-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRYLRPPNT SLFVRNVADD TRSEDLRREF GRYGPIVDVY VPLDFYTRRP 
        60         70         80         90        100
RGFAYVQFED VRDAEDALHN LDRKWICGRQ IEIQFAQGDR KTPNQMKAKE 
       110        120        130        140        150
GRNVYSSSRY DDYDRYRRSR SRSYERRRSR SRSFDYNYRR SYSPRNSRPT 
       160        170        180        190        200
GRPRRSRSHS DNDRFKHRNR SFSRSKSNSR SRSKSQPKKE MKAKSRSRSA 
       210        220        230        240        250
SHTKTRGTSK TDSKTHYKSG SRYEKESRKK EPPRSKSQSR SQSRSRSKSR 
       260 
SRSWTSPKSS GH
Length:262
Mass (Da):31,301
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i205F95D36CBBFAB4
GO
Isoform 2 (identifier: O75494-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-147: Missing.

Show »
Length:261
Mass (Da):31,213
Checksum:iA07499B11D4C7570
GO
Isoform 3 (identifier: O75494-3) [UniParc]FASTAAdd to basket
Also known as: TASR-2, SRp38-2

The sequence of this isoform differs from the canonical sequence as follows:
     165-183: FKHRNRSFSRSKSNSRSRS → PNCSWNTQYSSAYYTSRKI
     184-262: Missing.

Show »
Length:183
Mass (Da):22,222
Checksum:i4AA87CAA9B51A131
GO
Isoform 4 (identifier: O75494-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-173: RFKHRNRSFS → SQVSKKKNER
     174-183: Missing.
     184-262: Missing.

Show »
Length:173
Mass (Da):21,000
Checksum:i4AB40FBF24846495
GO
Isoform 5 (identifier: O75494-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-165: NSRPTGRPRRSRSHSDNDRF → KPNCSWNTQYSSAYYTSRKI
     166-173: Missing.
     174-183: Missing.
     184-262: Missing.

Show »
Length:165
Mass (Da):20,117
Checksum:i6CB98688C53A9F69
GO
Isoform 6 (identifier: O75494-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-147: Missing.
     165-183: FKHRNRSFSRSKSNSRSRS → PNCSWNTQYSSAYYTSRKI
     184-262: Missing.

Show »
Length:182
Mass (Da):22,135
Checksum:iF99356E1D895987D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JRI1Q5JRI1_HUMAN
Serine/arginine-rich-splicing facto...
SRSF10
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6IQ42Q6IQ42_HUMAN
FUSIP1 protein
SRSF10 FUSIP1
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMP8R4GMP8_HUMAN
Serine/arginine-rich splicing facto...
SRSF10
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043697146 – 165NSRPT…DNDRF → KPNCSWNTQYSSAYYTSRKI in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_010421147Missing in isoform 2 and isoform 6. 1 Publication1
Alternative sequenceiVSP_010422164 – 173RFKHRNRSFS → SQVSKKKNER in isoform 4. Curated10
Alternative sequenceiVSP_010424165 – 183FKHRN…SRSRS → PNCSWNTQYSSAYYTSRKI in isoform 3 and isoform 6. 4 PublicationsAdd BLAST19
Alternative sequenceiVSP_043698166 – 173Missing in isoform 5. 1 Publication8
Alternative sequenceiVSP_010423174 – 183Missing in isoform 4 and isoform 5. 1 Publication10
Alternative sequenceiVSP_010425184 – 262Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 4 PublicationsAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF047448 mRNA Translation: AAC70918.1
AF067730 mRNA Translation: AAC26727.1
AF449427 mRNA Translation: AAL57514.1
AY150180 mRNA Translation: AAN65380.1
AY150181 mRNA Translation: AAN65381.1
AF419331 mRNA Translation: AAL16665.1
AF419332 Genomic DNA Translation: AAL16666.1
AY048592 Genomic DNA Translation: AAL06098.1
AY048592 Genomic DNA Translation: AAL06099.1
AK001286 mRNA Translation: BAA91601.1
AK001656 mRNA Translation: BAG50956.1
AK296175 mRNA Translation: BAG58911.1
AL590609 Genomic DNA No translation available.
BC001107 mRNA Translation: AAH01107.1
BC005039 mRNA Translation: AAH05039.1
BC010074 mRNA Translation: AAH10074.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30629.1 [O75494-3]
CCDS30630.1 [O75494-1]
CCDS53280.1 [O75494-5]
CCDS53281.1 [O75494-6]
CCDS53282.1 [O75494-2]
CCDS53283.1 [O75494-4]

NCBI Reference Sequences

More...RefSeqi		NP_001177934.1, NM_001191005.2 [O75494-2]
NP_001177935.1, NM_001191006.2 [O75494-4]
NP_001177936.1, NM_001191007.2 [O75494-6]
NP_001177938.1, NM_001191009.2 [O75494-5]
NP_006616.1, NM_006625.5 [O75494-3]
NP_473357.1, NM_054016.3 [O75494-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000343255; ENSP00000344149; ENSG00000188529 [O75494-2]
ENST00000344989; ENSP00000342913; ENSG00000188529 [O75494-3]
ENST00000374452; ENSP00000363576; ENSG00000188529 [O75494-4]
ENST00000453840; ENSP00000388991; ENSG00000188529 [O75494-6]
ENST00000484146; ENSP00000419813; ENSG00000188529 [O75494-5]
ENST00000492112; ENSP00000420195; ENSG00000188529 [O75494-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10772

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10772

UCSC genome browser

More...UCSCi		uc057dhz.1, human [O75494-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047448 mRNA Translation: AAC70918.1
AF067730 mRNA Translation: AAC26727.1
AF449427 mRNA Translation: AAL57514.1
AY150180 mRNA Translation: AAN65380.1
AY150181 mRNA Translation: AAN65381.1
AF419331 mRNA Translation: AAL16665.1
AF419332 Genomic DNA Translation: AAL16666.1
AY048592 Genomic DNA Translation: AAL06098.1
AY048592 Genomic DNA Translation: AAL06099.1
AK001286 mRNA Translation: BAA91601.1
AK001656 mRNA Translation: BAG50956.1
AK296175 mRNA Translation: BAG58911.1
AL590609 Genomic DNA No translation available.
BC001107 mRNA Translation: AAH01107.1
BC005039 mRNA Translation: AAH05039.1
BC010074 mRNA Translation: AAH10074.1
CCDSiCCDS30629.1 [O75494-3]
CCDS30630.1 [O75494-1]
CCDS53280.1 [O75494-5]
CCDS53281.1 [O75494-6]
CCDS53282.1 [O75494-2]
CCDS53283.1 [O75494-4]
RefSeqiNP_001177934.1, NM_001191005.2 [O75494-2]
NP_001177935.1, NM_001191006.2 [O75494-4]
NP_001177936.1, NM_001191007.2 [O75494-6]
NP_001177938.1, NM_001191009.2 [O75494-5]
NP_006616.1, NM_006625.5 [O75494-3]
NP_473357.1, NM_054016.3 [O75494-1]

3D structure databases

SMRiO75494
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115990, 108 interactors
IntActiO75494, 58 interactors
MINTiO75494
STRINGi9606.ENSP00000420195

PTM databases

iPTMnetiO75494
PhosphoSitePlusiO75494
SwissPalmiO75494

Polymorphism and mutation databases

BioMutaiSRSF10

Proteomic databases

EPDiO75494
jPOSTiO75494
MassIVEiO75494
MaxQBiO75494
PaxDbiO75494
PeptideAtlasiO75494
PRIDEiO75494
ProteomicsDBi50048 [O75494-1]
50049 [O75494-2]
50050 [O75494-3]
50051 [O75494-4]
50052 [O75494-5]
63091
TopDownProteomicsiO75494-1 [O75494-1]
O75494-2 [O75494-2]
O75494-3 [O75494-3]
O75494-4 [O75494-4]
O75494-5 [O75494-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		60384, 244 antibodies

The DNASU plasmid repository

More...DNASUi		10772

Genome annotation databases

EnsembliENST00000343255; ENSP00000344149; ENSG00000188529 [O75494-2]
ENST00000344989; ENSP00000342913; ENSG00000188529 [O75494-3]
ENST00000374452; ENSP00000363576; ENSG00000188529 [O75494-4]
ENST00000453840; ENSP00000388991; ENSG00000188529 [O75494-6]
ENST00000484146; ENSP00000419813; ENSG00000188529 [O75494-5]
ENST00000492112; ENSP00000420195; ENSG00000188529 [O75494-1]
GeneIDi10772
KEGGihsa:10772
UCSCiuc057dhz.1, human [O75494-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10772
DisGeNETi10772
EuPathDBiHostDB:ENSG00000188529.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		SRSF10
HGNCiHGNC:16713, SRSF10
HPAiENSG00000188529, Low tissue specificity
MIMi605221, gene
neXtProtiNX_O75494
OpenTargetsiENSG00000188529
PharmGKBiPA28427

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0118, Eukaryota
GeneTreeiENSGT00940000154450
HOGENOMiCLU_012062_10_2_1
InParanoidiO75494
OMAiYVQYTFE
PhylomeDBiO75494
TreeFamiTF351864

Enzyme and pathway databases

PathwayCommonsiO75494
ReactomeiR-HSA-72163, mRNA Splicing - Major Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10772, 551 hits in 838 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SRSF10, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FUSIP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10772
PharosiO75494, Tbio

Protein Ontology

More...PROi		PR:O75494
RNActiO75494, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000188529, Expressed in left lobe of thyroid gland and 242 other tissues
ExpressionAtlasiO75494, baseline and differential
GenevisibleiO75494, HS

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034476, SRSF10
PANTHERiPTHR23147:SF87, PTHR23147:SF87, 1 hit
PfamiView protein in Pfam
PF00076, RRM_1, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRS10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75494
Secondary accession number(s): A6NFM6
, A6NI42, A6NIU7, B4DJP9, O60572, Q5JRH9, Q5JRI0, Q5JRI2, Q5JRI3, Q5JRI4, Q96G09, Q96P17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: November 1, 1998
Last modified: December 2, 2020
This is version 202 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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