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Protein

Carbonic anhydrase-related protein 11

Gene

CA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not have a catalytic activity.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase-related protein 11
Alternative name(s):
CA-RP XI
Short name:
CA-XI
Short name:
CARP XI
Carbonic anhydrase-related protein 2
Short name:
CA-RP II
Short name:
CARP-2
Gene namesi
Name:CA11
Synonyms:CARP2
ORF Names:UNQ211/PRO237
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000063180.8
HGNCiHGNC:1370 CA11
MIMi604644 gene
neXtProtiNX_O75493

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi770
OpenTargetsiENSG00000063180
PharmGKBiPA25986

Chemistry databases

ChEMBLiCHEMBL2420
DrugBankiDB00909 Zonisamide

Polymorphism and mutation databases

BioMutaiCA11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000424524 – 328Carbonic anhydrase-related protein 11Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75493
PeptideAtlasiO75493
PRIDEiO75493
ProteomicsDBi50047

PTM databases

iPTMnetiO75493
PhosphoSitePlusiO75493

Expressioni

Tissue specificityi

Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.

Gene expression databases

BgeeiENSG00000063180 Expressed in 205 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_CA11
ExpressionAtlasiO75493 baseline and differential
GenevisibleiO75493 HS

Organism-specific databases

HPAiHPA041778

Interactioni

Protein-protein interaction databases

BioGridi107224, 6 interactors
STRINGi9606.ENSP00000084798

Structurei

3D structure databases

ProteinModelPortaliO75493
SMRiO75493
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 303Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST271

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00920000149072
HOGENOMiHOG000019899
HOVERGENiHBG097666
InParanoidiO75493
OMAiAVSWEEW
OrthoDBiEOG091G0T4J
PhylomeDBiO75493
TreeFamiTF352926

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O75493-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAAARLSAP RALVLWAALG AAAHIGPAPD PEDWWSYKDN LQGNFVPGPP
60 70 80 90 100
FWGLVNAAWS LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL
110 120 130 140 150
YNTGRHVSFL PAPRPVVNVS GGPLLYSHRL SELRLLFGAR DGAGSEHQIN
160 170 180 190 200
HQGFSAEVQL IHFNQELYGN FSAASRGPNG LAILSLFVNV ASTSNPFLSR
210 220 230 240 250
LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS LSTPPCSETV
260 270 280 290 300
TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNSRP LQPLAHRALR
310 320
GNRDPRHPER RCRGPNYRLH VDGVPHGR
Length:328
Mass (Da):36,238
Last modified:December 1, 2000 - v2
Checksum:iA4FC408718B2E857
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXK8M0QXK8_HUMAN
Carbonic anhydrase-related protein ...
CA11
113Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23 – 24AH → GN in BAA36840 (PubMed:10350627).Curated2
Sequence conflicti75L → V in AAC99689 (PubMed:9878543).Curated1
Sequence conflicti280I → M in AAD08802 (PubMed:9878252).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067662 mRNA Translation: AAC99689.1
AB018195 mRNA Translation: BAA36840.1
AY358967 mRNA Translation: AAQ89326.1
CR541772 mRNA Translation: CAG46571.1
BT007265 mRNA Translation: AAP35929.1
BC002662 mRNA Translation: AAH02662.1
AF050106 mRNA Translation: AAD08802.1
CCDSiCCDS12729.1
PIRiJE0375
RefSeqiNP_001208.2, NM_001217.4
UniGeneiHs.428446

Genome annotation databases

EnsembliENST00000084798; ENSP00000084798; ENSG00000063180
GeneIDi770
KEGGihsa:770
UCSCiuc002pjz.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067662 mRNA Translation: AAC99689.1
AB018195 mRNA Translation: BAA36840.1
AY358967 mRNA Translation: AAQ89326.1
CR541772 mRNA Translation: CAG46571.1
BT007265 mRNA Translation: AAP35929.1
BC002662 mRNA Translation: AAH02662.1
AF050106 mRNA Translation: AAD08802.1
CCDSiCCDS12729.1
PIRiJE0375
RefSeqiNP_001208.2, NM_001217.4
UniGeneiHs.428446

3D structure databases

ProteinModelPortaliO75493
SMRiO75493
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107224, 6 interactors
STRINGi9606.ENSP00000084798

Chemistry databases

ChEMBLiCHEMBL2420
DrugBankiDB00909 Zonisamide

PTM databases

iPTMnetiO75493
PhosphoSitePlusiO75493

Polymorphism and mutation databases

BioMutaiCA11

Proteomic databases

PaxDbiO75493
PeptideAtlasiO75493
PRIDEiO75493
ProteomicsDBi50047

Protocols and materials databases

DNASUi770
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000084798; ENSP00000084798; ENSG00000063180
GeneIDi770
KEGGihsa:770
UCSCiuc002pjz.2 human

Organism-specific databases

CTDi770
DisGeNETi770
EuPathDBiHostDB:ENSG00000063180.8
GeneCardsiCA11
HGNCiHGNC:1370 CA11
HPAiHPA041778
MIMi604644 gene
neXtProtiNX_O75493
OpenTargetsiENSG00000063180
PharmGKBiPA25986
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00920000149072
HOGENOMiHOG000019899
HOVERGENiHBG097666
InParanoidiO75493
OMAiAVSWEEW
OrthoDBiEOG091G0T4J
PhylomeDBiO75493
TreeFamiTF352926

Miscellaneous databases

ChiTaRSiCA11 human
GeneWikiiCA11
GenomeRNAii770
PROiPR:O75493
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000063180 Expressed in 205 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_CA11
ExpressionAtlasiO75493 baseline and differential
GenevisibleiO75493 HS

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAH11_HUMAN
AccessioniPrimary (citable) accession number: O75493
Secondary accession number(s): O60596, Q6FHI1, Q9UEC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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