NDUFS3

Functionⁱ

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityⁱ

NADH + ubiquinone + 5 H⁺(In) = NAD⁺ + ubiquinol + 4 H⁺(Out).

NADH + acceptor = NAD⁺ + reduced acceptor.

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial electron transport, NADH to ubiquinone
Source: UniProtKB
Non-traceable author statementⁱ
- 9647766
- 9878551
mitochondrial respiratory chain complex I assembly Source: Reactome
negative regulation of cell growth
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16826196
negative regulation of intrinsic apoptotic signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16826196
reactive oxygen species metabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16826196
substantia nigra development
Source: UniProtKB
Inferred from high throughput expression patternⁱ
- 22926577

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase, Translocase
Biological process	Electron transport, Respiratory chain, Transport
Ligand	NAD, Ubiquinone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-611105 Respiratory electron transport R-HSA-6799198 Complex I biogenesis

Reactomeⁱ

R-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC:1.6.99.3, EC:7.1.1.2) Alternative name(s): Complex I-30kD Short name: CI-30kD NADH-ubiquinone oxidoreductase 30 kDa subunit
Gene namesⁱ	Name:NDUFS3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000213619.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7710 NDUFS3
MIMⁱ	603846 gene
neXtProtⁱ	NX_O75489

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4722
MalaCards human disease database More...MalaCardsⁱ	NDUFS3
Open Targets More...OpenTargetsⁱ	ENSG00000213619
Orphanetⁱ	2609 Isolated complex I deficiency 255241 Leigh syndrome with leukodystrophy
PharmGKBⁱ	PA31520

Chemistry databases

ChEMBLⁱ	CHEMBL2363065
Drug and drug target database More...DrugBankⁱ	DB00997 Doxorubicin DB00157 NADH

Polymorphism and mutation databases

BioMutaⁱ	NDUFS3

BioMutaⁱ

NDUFS3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 36	Mitochondrion1 PublicationAdd BLAST		36
ChainⁱPRO_0000019998	37 – 264	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialAdd BLAST		228

Proteomic databases

EPDⁱ	O75489
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75489
PaxDbⁱ	O75489
PeptideAtlas More...PeptideAtlasⁱ	O75489
PRIDEⁱ	O75489
ProteomicsDBⁱ	50046
TopDownProteomicsⁱ	O75489-1 [O75489-1]

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00025796 O75489

REPRODUCTION-2DPAGEⁱ

IPI00025796
O75489

PTM databases

CarbonylDBⁱ	O75489
iPTMnetⁱ	O75489
PhosphoSitePlusⁱ	O75489
SwissPalmⁱ	O75489

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000213619 Expressed in 234 organ(s), highest expression level in muscle of leg
CleanExⁱ	HS_NDUFS3
ExpressionAtlasⁱ	O75489 baseline and differential
Genevisibleⁱ	O75489 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA004484

HPAⁱ

HPA004484

Interactionⁱ

Subunit structureⁱ

Mammalian complex I is composed of 45 different subunits. Interacts with NDUFAF3.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NDUFA5	Q16718	3	EBI-1224896,EBI-746417
NDUFS2	O75306	6	EBI-1224896,EBI-1224806

Protein-protein interaction databases

BioGridⁱ	110801, 161 interactors
ComplexPortalⁱ	CPX-577 Mitochondrial respiratory chain complex I
CORUMⁱ	O75489
IntActⁱ	O75489, 83 interactors
Molecular INTeraction database More...MINTⁱ	O75489
STRINGⁱ	9606.ENSP00000263774

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	45 – 47	Combined sources	3
Helixⁱ	52 – 68	Combined sources	17
Turnⁱ	70 – 72	Combined sources	3
Beta strandⁱ	76 – 78	Combined sources	3
Beta strandⁱ	84 – 87	Combined sources	4
Helixⁱ	90 – 92	Combined sources	3
Helixⁱ	93 – 101	Combined sources	9
Beta strandⁱ	113 – 115	Combined sources	3
Beta strandⁱ	120 – 124	Combined sources	5
Beta strandⁱ	129 – 134	Combined sources	6
Turnⁱ	135 – 138	Combined sources	4
Beta strandⁱ	139 – 144	Combined sources	6
Turnⁱ	156 – 160	Combined sources	5
Helixⁱ	162 – 164	Combined sources	3
Helixⁱ	165 – 172	Combined sources	8
Beta strandⁱ	178 – 180	Combined sources	3
Beta strandⁱ	187 – 189	Combined sources	3
Beta strandⁱ	207 – 213	Combined sources	7
Turnⁱ	214 – 217	Combined sources	4
Beta strandⁱ	218 – 223	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	O75489
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the complex I 30 kDa subunit family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1713 Eukaryota COG0852 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017480
HOGENOMⁱ	HOG000009797
HOVERGENⁱ	HBG000450
InParanoidⁱ	O75489
KEGG Orthology (KO) More...KOⁱ	K03936
OMAⁱ	HHQAQFT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AFP
PhylomeDBⁱ	O75489
TreeFamⁱ	TF314794

Family and domain databases

Gene3Dⁱ	3.30.460.80, 1 hit
HAMAPⁱ	MF_01357 NDH1_NuoC, 1 hit
InterProⁱ	View protein in InterPro IPR010218 NADH_DH_suC IPR037232 NADH_quin_OxRdtase_su_C/D-like IPR001268 NADH_UbQ_OxRdtase_30kDa_su IPR020396 NADH_UbQ_OxRdtase_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00329 Complex1_30kDa, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD001581 NADH_UbQ_OxRdtase_30kDa_su, 1 hit
SUPFAMⁱ	SSF143243 SSF143243, 1 hit
TIGRFAMsⁱ	TIGR01961 NuoC_fam, 1 hit
PROSITEⁱ	View protein in PROSITE PS00542 COMPLEX1_30K, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O75489-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAVARLW WRGILGASAL TRGTGRPSVL LLPVRRESAG ADTRPTVRPR 
        60         70         80         90        100
NDVAHKQLSA FGEYVAEILP KYVQQVQVSC FNELEVCIHP DGVIPVLTFL 
       110        120        130        140        150
RDHTNAQFKS LVDLTAVDVP TRQNRFEIVY NLLSLRFNSR IRVKTYTDEL 
       160        170        180        190        200
TPIESAVSVF KAANWYEREI WDMFGVFFAN HPDLRRILTD YGFEGHPFRK 
       210        220        230        240        250
DFPLSGYVEL RYDDEVKRVV AEPVELAQEF RKFDLNSPWE AFPVYRQPPE 
       260 
SLKLEAGDKK PDAK

Length:264

Mass (Da):30,242

Last modified:November 1, 1998 - v1

Checksum:ⁱC058D62779BEF17B

GO

Isoform 2 (identifier: O75489-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
128-132: IVYNL → VSWEI
133-264: Missing.

« Hide

        10         20         30         40         50
MAAAAVARLW WRGILGASAL TRGTGRPSVL LLPVRRESAG ADTRPTVRPR 
        60         70         80         90        100
NDVAHKQLSA FGEYVAEILP KYVQQVQVSC FNELEVCIHP DGVIPVLTFL 
       110        120        130 
RDHTNAQFKS LVDLTAVDVP TRQNRFEVSW EI

Note: No experimental confirmation available.

Show »

Length:132

Mass (Da):14,679

Checksum:ⁱF56D4EA3021A11EF

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PS48	E9PS48_HUMAN	NADH dehydrogenase [ubiquinone] iro... NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	161	Annotation score:
E9PKL8	E9PKL8_HUMAN	NADH dehydrogenase [ubiquinone] iro... NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	77	Annotation score:
E9PJE7	E9PJE7_HUMAN	NADH dehydrogenase [ubiquinone] iro... NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	67	Annotation score:
G3V194	G3V194_HUMAN	NADH dehydrogenase (Ubiquinone) Fe-... NADH dehydrogenase (Ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase), isoform CRA_c (NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial)	NDUFS3 hCG_25184	121	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1 – 7	MAAAAVA → MAAGRY (PubMed:10931946).Curated		7

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_012036	249	P → Q. Corresponds to variant dbSNP:rs9600Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057065	128 – 132	IVYNL → VSWEI in isoform 2. 1 Publication		5
Alternative sequenceⁱVSP_057066	133 – 264	Missing in isoform 2. 1 PublicationAdd BLAST		132

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF067139 mRNA Translation: AAC27451.1 AF200954 Genomic DNA Translation: AAG17541.1 AF100743 mRNA Translation: AAD40386.1 AK294167 mRNA Translation: BAG57489.1 AK313802 mRNA Translation: BAG36538.1 AC090559 Genomic DNA No translation available. AC104942 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW67895.1 BC000617 mRNA Translation: AAH00617.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7941.1 [O75489-1]
PIRⁱ	JE0195
NCBI Reference Sequences More...RefSeqⁱ	NP_004542.1, NM_004551.2 [O75489-1]
UniGeneⁱ	Hs.502528

Genome annotation databases

Ensemblⁱ	ENST00000263774; ENSP00000263774; ENSG00000213619 [O75489-1] ENST00000534716; ENSP00000434970; ENSG00000213619 [O75489-2] ENST00000645714; ENSP00000496383; ENSG00000285387 [O75489-1] ENST00000646736; ENSP00000494074; ENSG00000285387 [O75489-2]
GeneIDⁱ	4722
KEGGⁱ	hsa:4722
UCSC genome browser More...UCSCⁱ	uc001nga.3 human [O75489-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75489	Uncharacterized protein DKFZp586K0821 (Fragment)		HUMAN		190	UniRef100_O75489
O75489-2	NDUFS3 isoform 8		PANTR		132	UniRef100_A0A2J8LGR6

Protein	Similar proteins		Species	Score	Length	Source
O75489	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	)	BOVIN		266	UniRef90_O75489
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial		PANTR		264
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial		PONPY		263
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial		GORGO		263
Uncharacterized protein DKFZp586K0821 (Fragment)		HUMAN		190
+100
O75489-2	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial		HUMAN		161	UniRef90_E9PS48
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial		PANTR		161
Uncharacterized protein		PANPA		161
Uncharacterized protein		COLAP		165
Uncharacterized protein		RHIBE		164
+11

Protein	Similar proteins		Species	Score	Length	Source
O75489	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	)	BOVIN		266	UniRef50_O75489
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial		PANTR		264
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial		PONPY		263
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial		GORGO		263
Uncharacterized protein DKFZp586K0821 (Fragment)		HUMAN		190
+172
O75489-2	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial		HUMAN		161	UniRef50_E9PS48
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial		PANTR		161
Uncharacterized protein		PANPA		161
Uncharacterized protein		COLAP		165
Uncharacterized protein		RHIBE		164
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF067139 mRNA Translation: AAC27451.1 AF200954 Genomic DNA Translation: AAG17541.1 AF100743 mRNA Translation: AAD40386.1 AK294167 mRNA Translation: BAG57489.1 AK313802 mRNA Translation: BAG36538.1 AC090559 Genomic DNA No translation available. AC104942 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW67895.1 BC000617 mRNA Translation: AAH00617.1
CCDSⁱ	CCDS7941.1 [O75489-1]
PIRⁱ	JE0195
RefSeqⁱ	NP_004542.1, NM_004551.2 [O75489-1]
UniGeneⁱ	Hs.502528

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5XTB	electron microscopy	3.40	P	43-250	[»]
	5XTD	electron microscopy	3.70	P	43-250	[»]
	5XTH	electron microscopy	3.90	P	43-250	[»]
	5XTI	electron microscopy	17.40	BP/P	43-250	[»]
ProteinModelPortalⁱ	O75489
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110801, 161 interactors
ComplexPortalⁱ	CPX-577 Mitochondrial respiratory chain complex I
CORUMⁱ	O75489
IntActⁱ	O75489, 83 interactors
MINTⁱ	O75489
STRINGⁱ	9606.ENSP00000263774

Chemistry databases

ChEMBLⁱ	CHEMBL2363065
DrugBankⁱ	DB00997 Doxorubicin DB00157 NADH

PTM databases

CarbonylDBⁱ	O75489
iPTMnetⁱ	O75489
PhosphoSitePlusⁱ	O75489
SwissPalmⁱ	O75489

Polymorphism and mutation databases

BioMutaⁱ	NDUFS3

BioMutaⁱ

NDUFS3

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00025796 O75489

REPRODUCTION-2DPAGEⁱ

IPI00025796
O75489

Proteomic databases

EPDⁱ	O75489
MaxQBⁱ	O75489
PaxDbⁱ	O75489
PeptideAtlasⁱ	O75489
PRIDEⁱ	O75489
ProteomicsDBⁱ	50046
TopDownProteomicsⁱ	O75489-1 [O75489-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4722
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000263774; ENSP00000263774; ENSG00000213619 [O75489-1] ENST00000534716; ENSP00000434970; ENSG00000213619 [O75489-2] ENST00000645714; ENSP00000496383; ENSG00000285387 [O75489-1] ENST00000646736; ENSP00000494074; ENSG00000285387 [O75489-2]
GeneIDⁱ	4722
KEGGⁱ	hsa:4722
UCSCⁱ	uc001nga.3 human [O75489-1]

Organism-specific databases

CTDⁱ	4722
DisGeNETⁱ	4722
EuPathDBⁱ	HostDB:ENSG00000213619.9
GeneCardsⁱ	NDUFS3
HGNCⁱ	HGNC:7710 NDUFS3
HPAⁱ	HPA004484
MalaCardsⁱ	NDUFS3
MIMⁱ	603846 gene
neXtProtⁱ	NX_O75489
OpenTargetsⁱ	ENSG00000213619
Orphanetⁱ	2609 Isolated complex I deficiency 255241 Leigh syndrome with leukodystrophy
PharmGKBⁱ	PA31520
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1713 Eukaryota COG0852 LUCA
GeneTreeⁱ	ENSGT00390000017480
HOGENOMⁱ	HOG000009797
HOVERGENⁱ	HBG000450
InParanoidⁱ	O75489
KOⁱ	K03936
OMAⁱ	HHQAQFT
OrthoDBⁱ	EOG091G0AFP
PhylomeDBⁱ	O75489
TreeFamⁱ	TF314794

Enzyme and pathway databases

Reactomeⁱ	R-HSA-611105 Respiratory electron transport R-HSA-6799198 Complex I biogenesis

Reactomeⁱ

R-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Miscellaneous databases

ChiTaRSⁱ	NDUFS3 human
GeneWikiⁱ	NDUFS3
GenomeRNAiⁱ	4722
Protein Ontology More...PROⁱ	PR:O75489
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000213619 Expressed in 234 organ(s), highest expression level in muscle of leg
CleanExⁱ	HS_NDUFS3
ExpressionAtlasⁱ	O75489 baseline and differential
Genevisibleⁱ	O75489 HS

Family and domain databases

Gene3Dⁱ	3.30.460.80, 1 hit
HAMAPⁱ	MF_01357 NDH1_NuoC, 1 hit
InterProⁱ	View protein in InterPro IPR010218 NADH_DH_suC IPR037232 NADH_quin_OxRdtase_su_C/D-like IPR001268 NADH_UbQ_OxRdtase_30kDa_su IPR020396 NADH_UbQ_OxRdtase_CS
Pfamⁱ	View protein in Pfam PF00329 Complex1_30kDa, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD001581 NADH_UbQ_OxRdtase_30kDa_su, 1 hit
SUPFAMⁱ	SSF143243 SSF143243, 1 hit
TIGRFAMsⁱ	TIGR01961 NuoC_fam, 1 hit
PROSITEⁱ	View protein in PROSITE PS00542 COMPLEX1_30K, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NDUS3_HUMAN
Accessionⁱ	O75489Primary (citable) accession number: O75489 Secondary accession number(s): B2R9J1, B4DFM8, Q9UNQ8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 185 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - O75489 (NDUS3_HUMAN)

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NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ