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Protein

Glypican-4

Gene

GPC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928 HS-GAG biosynthesis
R-HSA-2024096 HS-GAG degradation
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3656237 Defective EXT2 causes exostoses 2
R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-975634 Retinoid metabolism and transport
SIGNORiO75487

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-4
Alternative name(s):
K-glypican
Cleaved into the following chain:
Gene namesi
Name:GPC4
ORF Names:UNQ474/PRO937
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000076716.8
HGNCiHGNC:4452 GPC4
MIMi300168 gene
neXtProtiNX_O75487

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2239
GeneReviewsiGPC4
MalaCardsiGPC4
OpenTargetsiENSG00000076716
Orphaneti373 Simpson-Golabi-Behmel syndrome
PharmGKBiPA28833

Polymorphism and mutation databases

BioMutaiGPC4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001231519 – 529Glypican-4Add BLAST511
ChainiPRO_000033384719 – ?Secreted glypican-4
PropeptideiPRO_0000012316530 – 556Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei357PhosphoserineCombined sources1
Glycosylationi494O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi498O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi500O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi529GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

EPDiO75487
MaxQBiO75487
PaxDbiO75487
PeptideAtlasiO75487
PRIDEiO75487
ProteomicsDBi50045

PTM databases

iPTMnetiO75487
PhosphoSitePlusiO75487

Expressioni

Gene expression databases

BgeeiENSG00000076716 Expressed in 177 organ(s), highest expression level in lower esophagus
CleanExiHS_GPC4
GenevisibleiO75487 HS

Organism-specific databases

HPAiHPA030836

Interactioni

Protein-protein interaction databases

BioGridi108530, 24 interactors
IntActiO75487, 13 interactors
MINTiO75487
STRINGi9606.ENSP00000359864

Structurei

3D structure databases

ProteinModelPortaliO75487
SMRiO75487
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821 Eukaryota
ENOG410XST2 LUCA
GeneTreeiENSGT00550000074430
HOVERGENiHBG003464
InParanoidiO75487
KOiK08110
OMAiQCPSEFE
OrthoDBiEOG091G06T6
PhylomeDBiO75487
TreeFamiTF105317

Family and domain databases

InterProiView protein in InterPro
IPR001863 Glypican
IPR031180 Glypican-4
IPR019803 Glypican_CS
PANTHERiPTHR10822 PTHR10822, 1 hit
PTHR10822:SF25 PTHR10822:SF25, 1 hit
PfamiView protein in Pfam
PF01153 Glypican, 1 hit
PROSITEiView protein in PROSITE
PS01207 GLYPICAN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O75487-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARFGLPALL CTLAVLSAAL LAAELKSKSC SEVRRLYVSK GFNKNDAPLH
60 70 80 90 100
EINGDHLKIC PQGSTCCSQE MEEKYSLQSK DDFKSVVSEQ CNHLQAVFAS
110 120 130 140 150
RYKKFDEFFK ELLENAEKSL NDMFVKTYGH LYMQNSELFK DLFVELKRYY
160 170 180 190 200
VVGNVNLEEM LNDFWARLLE RMFRLVNSQY HFTDEYLECV SKYTEQLKPF
210 220 230 240 250
GDVPRKLKLQ VTRAFVAART FAQGLAVAGD VVSKVSVVNP TAQCTHALLK
260 270 280 290 300
MIYCSHCRGL VTVKPCYNYC SNIMRGCLAN QGDLDFEWNN FIDAMLMVAE
310 320 330 340 350
RLEGPFNIES VMDPIDVKIS DAIMNMQDNS VQVSQKVFQG CGPPKPLPAG
360 370 380 390 400
RISRSISESA FSARFRPHHP EERPTTAAGT SLDRLVTDVK EKLKQAKKFW
410 420 430 440 450
SSLPSNVCND ERMAAGNGNE DDCWNGKGKS RYLFAVTGNG LANQGNNPEV
460 470 480 490 500
QVDTSKPDIL ILRQIMALRV MTSKMKNAYN GNDVDFFDIS DESSGEGSGS
510 520 530 540 550
GCEYQQCPSE FDYNATDHAG KSANEKADSA GVRPGAQAYL LTVFCILFLV

MQREWR
Length:556
Mass (Da):62,412
Last modified:May 16, 2003 - v4
Checksum:i827E07FAA0BD8188
GO
Isoform 2 (identifier: O75487-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Note: No experimental confirmation available.
Show »
Length:486
Mass (Da):54,910
Checksum:iB83D796B5B026A96
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016191391E → D4 PublicationsCorresponds to variant dbSNP:rs1129980Ensembl.1
Natural variantiVAR_016192442A → V3 PublicationsCorresponds to variant dbSNP:rs1048369Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565701 – 70Missing in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030186 mRNA Translation: AAC69991.1
AF064826 mRNA Translation: AAC31899.1
AY358507 mRNA Translation: AAQ88871.1
AY052833 mRNA Translation: AAL11018.1
AK304207 mRNA Translation: BAG65082.1
AK312605 mRNA Translation: BAG35494.1
AL034400 Genomic DNA No translation available.
AL109623 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11772.1
BC017166 mRNA Translation: AAH17166.1
CCDSiCCDS14637.1 [O75487-1]
RefSeqiNP_001439.2, NM_001448.2 [O75487-1]
UniGeneiHs.58367

Genome annotation databases

EnsembliENST00000370828; ENSP00000359864; ENSG00000076716 [O75487-1]
GeneIDi2239
KEGGihsa:2239
UCSCiuc004exc.2 human [O75487-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030186 mRNA Translation: AAC69991.1
AF064826 mRNA Translation: AAC31899.1
AY358507 mRNA Translation: AAQ88871.1
AY052833 mRNA Translation: AAL11018.1
AK304207 mRNA Translation: BAG65082.1
AK312605 mRNA Translation: BAG35494.1
AL034400 Genomic DNA No translation available.
AL109623 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11772.1
BC017166 mRNA Translation: AAH17166.1
CCDSiCCDS14637.1 [O75487-1]
RefSeqiNP_001439.2, NM_001448.2 [O75487-1]
UniGeneiHs.58367

3D structure databases

ProteinModelPortaliO75487
SMRiO75487
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108530, 24 interactors
IntActiO75487, 13 interactors
MINTiO75487
STRINGi9606.ENSP00000359864

PTM databases

iPTMnetiO75487
PhosphoSitePlusiO75487

Polymorphism and mutation databases

BioMutaiGPC4

Proteomic databases

EPDiO75487
MaxQBiO75487
PaxDbiO75487
PeptideAtlasiO75487
PRIDEiO75487
ProteomicsDBi50045

Protocols and materials databases

DNASUi2239
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370828; ENSP00000359864; ENSG00000076716 [O75487-1]
GeneIDi2239
KEGGihsa:2239
UCSCiuc004exc.2 human [O75487-1]

Organism-specific databases

CTDi2239
DisGeNETi2239
EuPathDBiHostDB:ENSG00000076716.8
GeneCardsiGPC4
GeneReviewsiGPC4
HGNCiHGNC:4452 GPC4
HPAiHPA030836
MalaCardsiGPC4
MIMi300168 gene
neXtProtiNX_O75487
OpenTargetsiENSG00000076716
Orphaneti373 Simpson-Golabi-Behmel syndrome
PharmGKBiPA28833
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3821 Eukaryota
ENOG410XST2 LUCA
GeneTreeiENSGT00550000074430
HOVERGENiHBG003464
InParanoidiO75487
KOiK08110
OMAiQCPSEFE
OrthoDBiEOG091G06T6
PhylomeDBiO75487
TreeFamiTF105317

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928 HS-GAG biosynthesis
R-HSA-2024096 HS-GAG degradation
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3656237 Defective EXT2 causes exostoses 2
R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-975634 Retinoid metabolism and transport
SIGNORiO75487

Miscellaneous databases

ChiTaRSiGPC4 human
GeneWikiiGlypican_4
GenomeRNAii2239
PROiPR:O75487
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000076716 Expressed in 177 organ(s), highest expression level in lower esophagus
CleanExiHS_GPC4
GenevisibleiO75487 HS

Family and domain databases

InterProiView protein in InterPro
IPR001863 Glypican
IPR031180 Glypican-4
IPR019803 Glypican_CS
PANTHERiPTHR10822 PTHR10822, 1 hit
PTHR10822:SF25 PTHR10822:SF25, 1 hit
PfamiView protein in Pfam
PF01153 Glypican, 1 hit
PROSITEiView protein in PROSITE
PS01207 GLYPICAN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPC4_HUMAN
AccessioniPrimary (citable) accession number: O75487
Secondary accession number(s): B2R6J7
, B4E2C0, Q6ZMA6, Q96L43, Q9NU08, Q9UJN1, Q9UPD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 16, 2003
Last modified: October 10, 2018
This is version 166 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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