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Entry version 190 (07 Apr 2021)
Sequence version 1 (01 Nov 1998)
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Protein

PC4 and SFRS1-interacting protein

Gene

PSIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
O75475

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-162592, Integration of provirus
R-HSA-164843, 2-LTR circle formation
R-HSA-175567, Integration of viral DNA into host genomic DNA
R-HSA-177539, Autointegration results in viral DNA circles
R-HSA-180689, APOBEC3G mediated resistance to HIV-1 infection
R-HSA-180910, Vpr-mediated nuclear import of PICs

SIGNOR Signaling Network Open Resource

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SIGNORi
O75475

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PC4 and SFRS1-interacting protein
Alternative name(s):
CLL-associated antigen KW-7
Dense fine speckles 70 kDa protein
Short name:
DFS 70
Lens epithelium-derived growth factor
Transcriptional coactivator p75/p52
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSIP1
Synonyms:DFS70, LEDGF, PSIP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9527, PSIP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603620, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O75475

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000164985.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1 exon 4.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi360K → A: Reduced interaction with POGZ, CDCA7L and human HIV-1 integrase. 1 Publication1
Mutagenesisi365I → A: Loss of interaction with human HIV-1 integrase; reduced interaction with POGZ and CDCA7L. 2 Publications1
Mutagenesisi366D → A: Loss of interaction with human HIV-1 integrase; no effect on interaction with CDCA7L and POGZ. 1 Publication1
Mutagenesisi366D → N: Loss of interaction with human HIV-1 integrase; no effect on interaction with KMT2A. 2 Publications1
Mutagenesisi368L → A: Reduced interaction with KMT2A. Significant loss of interaction with KMT2A; when associated with D-407. 1 Publication1
Mutagenesisi370V → A: Reduced interaction with POGZ, CDCA7L and human HIV-1 integrase. 1 Publication1
Mutagenesisi404R → D: Significant loss of interaction with KMT2A; when associated with D-405. 1 Publication1
Mutagenesisi405R → D: Significant loss of interaction with KMT2A; when associated with D-404. 1 Publication1
Mutagenesisi406F → A: Loss of interaction with human HIV-1 integrase and POGZ; reduced interaction with CDCA7L. 2 Publications1
Mutagenesisi407K → D: Reduced interaction with KMT2A. Significant loss of interaction with KMT2A; when associated with A-368. 1 Publication1
Mutagenesisi408V → A: Reduced interaction with human HIV-1 integrase; no effect on interaction with POGZ and CDCA7L. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
11168

Open Targets

More...
OpenTargetsi
ENSG00000164985

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33872

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75475, Tbio

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
2120, Hom s DSF70

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3988590

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PSIP1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001917081 – 530PC4 and SFRS1-interacting proteinAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki75Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei102PhosphoserineBy similarity1
Modified residuei105PhosphoserineBy similarity1
Modified residuei106PhosphoserineCombined sources1
Modified residuei115PhosphothreonineBy similarity1
Modified residuei122PhosphothreonineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei141PhosphothreonineCombined sources1
Modified residuei167PhosphothreonineCombined sources1
Modified residuei177PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei271PhosphoserineCombined sources1
Modified residuei272PhosphothreonineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei437PhosphothreonineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei514PhosphoserineCombined sources1
Modified residuei517CitrullineBy similarity1
Modified residuei522PhosphoserineCombined sources1
Modified residuei527PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75475

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75475

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O75475

MaxQB - The MaxQuant DataBase

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MaxQBi
O75475

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75475

PeptideAtlas

More...
PeptideAtlasi
O75475

PRoteomics IDEntifications database

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PRIDEi
O75475

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
50037 [O75475-1]
50038 [O75475-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
O75475-1 [O75475-1]
O75475-2 [O75475-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
O75475, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75475

MetOSite database of methionine sulfoxide sites

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MetOSitei
O75475

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75475

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O75475

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164985, Expressed in ventricular zone and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75475, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75475, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164985, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:15895093).

Interacts with IFRD1/PC4 (PubMed:9822615).

Isoform 2 interacts with SFRS1 (PubMed:9885563). Isoform 1 interacts (via IBD domain) with POGZ (via IBM motif) and CDCA7L (via IBM motifs) (PubMed:19244240, PubMed:25082813, PubMed:29997176).

Interacts (via IBD domain) with KMT2A (via IBM motifs) with a moderate affinity whereas interacts with the KMT2A-MEN1 complex with a greater affinity; MEN1 enhances interaction of KMT2A with PSIP1 (PubMed:22327296, PubMed:25305204, PubMed:25082813, PubMed:29997176).

Interacts with fusion protein KMT2A-MLLT3 (PubMed:25305204).

Interacts (via IBD domain) with IWS1 (via IBM motif), MED1 (via IBM motif) and DBF4 (via IBM motifs) (PubMed:29997176).

9 Publications

(Microbial infection) Interacts (via IBD domain) with human HIV-1 integrase protein (HIV-1 IN), determining its nuclear localization, its tight association with chromatin and its protection from the proteasome.

7 Publications

(Microbial infection) Interacts with HIV-2 IN.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116339, 100 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O75475

Database of interacting proteins

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DIPi
DIP-46656N

Protein interaction database and analysis system

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IntActi
O75475, 39 interactors

Molecular INTeraction database

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MINTi
O75475

STRING: functional protein association networks

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STRINGi
9606.ENSP00000370109

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
O75475

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
O75475, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1530
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

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BMRBi
O75475

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75475

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O75475

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 64PWWPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni340 – 417Integrase-binding domain (IBD)1 PublicationAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili306 – 334Sequence analysisAdd BLAST29
Coiled coili371 – 395Sequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi146 – 156Nuclear localization signal1 PublicationAdd BLAST11

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HDGF family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1904, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000154706

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_034054_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75475

Identification of Orthologs from Complete Genome Data

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OMAi
NLRVGMN

Database of Orthologous Groups

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OrthoDBi
530959at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75475

TreeFam database of animal gene trees

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TreeFami
TF105385

Family and domain databases

Conserved Domains Database

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CDDi
cd05834, HDGF_related, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.930.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00408

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035496, HDGF-rel_PWWP
IPR036218, HIVI-bd_sf
IPR021567, LEDGF_IBD
IPR000313, PWWP_dom
IPR035441, TFIIS/LEDGF_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11467, LEDGF, 1 hit
PF00855, PWWP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00293, PWWP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140576, SSF140576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50812, PWWP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75475-1) [UniParc]FASTAAdd to basket
Also known as: p75, PSIP1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET
60 70 80 90 100
AFLGPKDIFP YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQAATK
110 120 130 140 150
QSNASSDVEV EEKETSVSKE DTDHEEKASN EDVTKAVDIT TPKAARRGRK
160 170 180 190 200
RKAEKQVETE EAGVVTTATA SVNLKVSPKR GRPAATEVKI PKPRGRPKMV
210 220 230 240 250
KQPCPSESDI ITEEDKSKKK GQEEKQPKKQ PKKDEEGQKE EDKPRKEPDK
260 270 280 290 300
KEGKKEVESK RKNLAKTGVT STSDSEEEGD DQEGEKKRKG GRNFQTAHRR
310 320 330 340 350
NMLKGQHEKE AADRKRKQEE QMETEQQNKD EGKKPEVKKV EKKRETSMDS
360 370 380 390 400
RLQRIHAEIK NSLKIDNLDV NRCIEALDEL ASLQVTMQQA QKHTEMITTL
410 420 430 440 450
KKIRRFKVSQ VIMEKSTMLY NKFKNMFLVG EGDSVITQVL NKSLAEQRQH
460 470 480 490 500
EEANKTKDQG KKGPNKKLEK EQTGSKTLNG GSDAQDGNQP QHNGESNEDS
510 520 530
KDNHEASTKK KPSSEERETE ISLKDSTLDN
Note: Less active than isoform 2 as transcriptional coactivator, but more abundant in cells.
Length:530
Mass (Da):60,103
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B653D02B1D0E174
GO
Isoform 2 (identifier: O75475-2) [UniParc]FASTAAdd to basket
Also known as: p52, PSIP2

The sequence of this isoform differs from the canonical sequence as follows:
     326-333: QQNKDEGK → HQTTCNLQ
     334-530: Missing.

Show »
Length:333
Mass (Da):37,725
Checksum:iDAFEC8F815C06FCD
GO
Isoform 3 (identifier: O75475-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-530: QQNKDEGKKP...ISLKDSTLDN → HFAL

Show »
Length:329
Mass (Da):37,268
Checksum:iF35C00DDD27E9BAE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYT7V9GYT7_HUMAN
PC4 and SFRS1-interacting protein
PSIP1
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti153 – 161Missing in AAH64135 (PubMed:15489334).Curated9
Sequence conflicti224E → G in AAC97946 (PubMed:9822615).Curated1
Sequence conflicti224E → G in AAC97945 (PubMed:9822615).Curated1
Sequence conflicti272T → P in AAB52589 (PubMed:10856157).Curated1
Sequence conflicti420Y → F in AAC97946 (PubMed:9822615).Curated1
Sequence conflicti420Y → F in AAB52589 (PubMed:10856157).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044435326 – 530QQNKD…STLDN → HFAL in isoform 3. 1 PublicationAdd BLAST205
Alternative sequenceiVSP_014297326 – 333QQNKDEGK → HQTTCNLQ in isoform 2. 2 Publications8
Alternative sequenceiVSP_014298334 – 530Missing in isoform 2. 2 PublicationsAdd BLAST197

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF098483 mRNA Translation: AAC97946.1
AF098482 mRNA Translation: AAC97945.1
AF063020 mRNA Translation: AAC25167.1
AF199339 Genomic DNA Translation: AAF25870.1
AF199339 Genomic DNA Translation: AAF25871.1
AF432220 mRNA Translation: AAL99926.1
AL359998 Genomic DNA No translation available.
AL441925 Genomic DNA No translation available.
AL513423 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58677.1
CH471071 Genomic DNA Translation: EAW58678.1
CH471071 Genomic DNA Translation: EAW58679.1
BC044568 mRNA Translation: AAH44568.2
BC064135 mRNA Translation: AAH64135.1
U94319 mRNA Translation: AAB52589.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6479.1 [O75475-1]
CCDS6480.1 [O75475-2]
CCDS83348.1 [O75475-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7168

NCBI Reference Sequences

More...
RefSeqi
NP_001121689.1, NM_001128217.2 [O75475-1]
NP_001304827.1, NM_001317898.1 [O75475-3]
NP_001304829.1, NM_001317900.1
NP_066967.3, NM_021144.3 [O75475-2]
NP_150091.2, NM_033222.4 [O75475-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380715; ENSP00000370091; ENSG00000164985 [O75475-3]
ENST00000380716; ENSP00000370092; ENSG00000164985 [O75475-2]
ENST00000380733; ENSP00000370109; ENSG00000164985 [O75475-1]
ENST00000380738; ENSP00000370114; ENSG00000164985 [O75475-1]
ENST00000397519; ENSP00000380653; ENSG00000164985 [O75475-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11168

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11168

UCSC genome browser

More...
UCSCi
uc003zlv.6, human [O75475-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098483 mRNA Translation: AAC97946.1
AF098482 mRNA Translation: AAC97945.1
AF063020 mRNA Translation: AAC25167.1
AF199339 Genomic DNA Translation: AAF25870.1
AF199339 Genomic DNA Translation: AAF25871.1
AF432220 mRNA Translation: AAL99926.1
AL359998 Genomic DNA No translation available.
AL441925 Genomic DNA No translation available.
AL513423 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58677.1
CH471071 Genomic DNA Translation: EAW58678.1
CH471071 Genomic DNA Translation: EAW58679.1
BC044568 mRNA Translation: AAH44568.2
BC064135 mRNA Translation: AAH64135.1
U94319 mRNA Translation: AAB52589.1
CCDSiCCDS6479.1 [O75475-1]
CCDS6480.1 [O75475-2]
CCDS83348.1 [O75475-3]
PIRiJC7168
RefSeqiNP_001121689.1, NM_001128217.2 [O75475-1]
NP_001304827.1, NM_001317898.1 [O75475-3]
NP_001304829.1, NM_001317900.1
NP_066967.3, NM_021144.3 [O75475-2]
NP_150091.2, NM_033222.4 [O75475-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z9ENMR-A347-471[»]
2B4JX-ray2.02C/D347-442[»]
2M16NMR-A1-93[»]
2MSRNMR-B344-426[»]
2MTNNMR-A337-442[»]
2N3ANMR-B348-426[»]
3F9KX-ray3.20C/G/K/O/S/W/a/e/i/m/q/u347-435[»]
3HPGX-ray3.28G/H/I/J/K/L347-435[»]
3HPHX-ray2.64E/F/G/H348-435[»]
3U88X-ray3.00C/D347-435[»]
3ZEHNMR-A3-100[»]
4FU6X-ray2.10A1-135[»]
5N88X-ray1.70D347-425[»]
E347-424[»]
5OYMX-ray2.05A/B/C/D/E/F/G/H345-431[»]
5YI9NMR-A345-442[»]
6EMONMR-A345-442[»]
6EMPNMR-A345-442[»]
6EMQNMR-A345-443[»]
6EMRNMR-A345-442[»]
6S01electron microscopy3.20K1-530[»]
6TRJX-ray1.30A345-430[»]
6TVMNMR-A/B345-467[»]
6Z2Yelectron microscopy3.34C/F1-324[»]
BMRBiO75475
SMRiO75475
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116339, 100 interactors
CORUMiO75475
DIPiDIP-46656N
IntActiO75475, 39 interactors
MINTiO75475
STRINGi9606.ENSP00000370109

Chemistry databases

BindingDBiO75475
ChEMBLiCHEMBL3988590

Protein family/group databases

Allergomei2120, Hom s DSF70

PTM databases

GlyGeniO75475, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO75475
MetOSiteiO75475
PhosphoSitePlusiO75475
SwissPalmiO75475

Genetic variation databases

BioMutaiPSIP1

Proteomic databases

EPDiO75475
jPOSTiO75475
MassIVEiO75475
MaxQBiO75475
PaxDbiO75475
PeptideAtlasiO75475
PRIDEiO75475
ProteomicsDBi50037 [O75475-1]
50038 [O75475-2]
TopDownProteomicsiO75475-1 [O75475-1]
O75475-2 [O75475-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
O75475, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4436, 230 antibodies

The DNASU plasmid repository

More...
DNASUi
11168

Genome annotation databases

EnsembliENST00000380715; ENSP00000370091; ENSG00000164985 [O75475-3]
ENST00000380716; ENSP00000370092; ENSG00000164985 [O75475-2]
ENST00000380733; ENSP00000370109; ENSG00000164985 [O75475-1]
ENST00000380738; ENSP00000370114; ENSG00000164985 [O75475-1]
ENST00000397519; ENSP00000380653; ENSG00000164985 [O75475-2]
GeneIDi11168
KEGGihsa:11168
UCSCiuc003zlv.6, human [O75475-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11168
DisGeNETi11168

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PSIP1
HGNCiHGNC:9527, PSIP1
HPAiENSG00000164985, Low tissue specificity
MIMi603620, gene
neXtProtiNX_O75475
OpenTargetsiENSG00000164985
PharmGKBiPA33872
VEuPathDBiHostDB:ENSG00000164985.14

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1904, Eukaryota
GeneTreeiENSGT00940000154706
HOGENOMiCLU_034054_1_0_1
InParanoidiO75475
OMAiNLRVGMN
OrthoDBi530959at2759
PhylomeDBiO75475
TreeFamiTF105385

Enzyme and pathway databases

PathwayCommonsiO75475
ReactomeiR-HSA-162592, Integration of provirus
R-HSA-164843, 2-LTR circle formation
R-HSA-175567, Integration of viral DNA into host genomic DNA
R-HSA-177539, Autointegration results in viral DNA circles
R-HSA-180689, APOBEC3G mediated resistance to HIV-1 infection
R-HSA-180910, Vpr-mediated nuclear import of PICs
SIGNORiO75475

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11168, 25 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PSIP1, human
EvolutionaryTraceiO75475

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PSIP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11168
PharosiO75475, Tbio

Protein Ontology

More...
PROi
PR:O75475
RNActiO75475, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164985, Expressed in ventricular zone and 245 other tissues
ExpressionAtlasiO75475, baseline and differential
GenevisibleiO75475, HS

Family and domain databases

CDDicd05834, HDGF_related, 1 hit
Gene3Di1.20.930.10, 1 hit
IDEALiIID00408
InterProiView protein in InterPro
IPR035496, HDGF-rel_PWWP
IPR036218, HIVI-bd_sf
IPR021567, LEDGF_IBD
IPR000313, PWWP_dom
IPR035441, TFIIS/LEDGF_dom_sf
PfamiView protein in Pfam
PF11467, LEDGF, 1 hit
PF00855, PWWP, 1 hit
SMARTiView protein in SMART
SM00293, PWWP, 1 hit
SUPFAMiSSF140576, SSF140576, 1 hit
PROSITEiView protein in PROSITE
PS50812, PWWP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSIP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75475
Secondary accession number(s): D3DRI9
, O00256, O95368, Q6P391, Q86YB9, Q9NZI3, Q9UER6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1998
Last modified: April 7, 2021
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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