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Protein

GSK-3-binding protein FRAT2

Gene

FRAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
SIGNORiO75474

Names & Taxonomyi

Protein namesi
Recommended name:
GSK-3-binding protein FRAT2
Alternative name(s):
Frequently rearranged in advanced T-cell lymphomas 2
Short name:
FRAT-2
Gene namesi
Name:FRAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000181274.6
HGNCiHGNC:16048 FRAT2
MIMi605006 gene
neXtProtiNX_O75474

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi23401
OpenTargetsiENSG00000181274
PharmGKBiPA28362

Polymorphism and mutation databases

BioMutaiFRAT2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873341 – 233GSK-3-binding protein FRAT2Add BLAST233

Proteomic databases

EPDiO75474
MaxQBiO75474
PaxDbiO75474
PeptideAtlasiO75474
PRIDEiO75474
ProteomicsDBi50036

PTM databases

iPTMnetiO75474
PhosphoSitePlusiO75474

Expressioni

Gene expression databases

BgeeiENSG00000181274 Expressed in 169 organ(s), highest expression level in blood
CleanExiHS_FRAT2
GenevisibleiO75474 HS

Organism-specific databases

HPAiHPA049763

Interactioni

Subunit structurei

Binds GSK-3 and prevents GSK-3-dependent phosphorylation.

Protein-protein interaction databases

BioGridi116974, 3 interactors
ComplexPortaliCPX-462 Nuclear export complex FRAT2-GSK3B
IntActiO75474, 13 interactors
MINTiO75474
STRINGi9606.ENSP00000360058

Structurei

3D structure databases

ProteinModelPortaliO75474
SMRiO75474
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni174 – 196Involved in GSK-3 bindingBy similarityAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 23Asp/Glu-rich (highly acidic)Add BLAST18
Compositional biasi6 – 10Poly-Glu5
Compositional biasi13 – 21Poly-Glu9

Sequence similaritiesi

Belongs to the GSK-3-binding protein family.Curated

Phylogenomic databases

eggNOGiENOG410J5HI Eukaryota
ENOG410ZA2I LUCA
GeneTreeiENSGT00390000007081
HOGENOMiHOG000112642
HOVERGENiHBG051660
InParanoidiO75474
KOiK03096
OMAiQRRWTQA
OrthoDBiEOG091G0PDL
PhylomeDBiO75474
TreeFamiTF330804

Family and domain databases

InterProiView protein in InterPro
IPR039202 FRAT2
IPR008014 GSK3-bd
PANTHERiPTHR35154 PTHR35154, 1 hit
PTHR35154:SF2 PTHR35154:SF2, 1 hit
PfamiView protein in Pfam
PF05350 GSK-3_bind, 1 hit

Sequencei

Sequence statusi: Complete.

O75474-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPCRREEEEE AGEEAEGEEE EDDSFLLLQQ SVTLGSSGEV DRLVAQIGET
60 70 80 90 100
LQLDAAQDSP ASPCAPPGVP LRAPGPLAAA VPADKARPPA VPLLLPPASA
110 120 130 140 150
ETVGPAPSGA LRCALGDRGR VRGRAAPYCV AEVAAGPSAL PGPCRRGWLR
160 170 180 190 200
DAVTSRRLQQ RRWTQAGARA GDDDPHRLLQ QLVLSGNLIK EAVRRLQRAV
210 220 230
AAVAATGPAS APGPGGGRSG PDRIALQPSG SLL
Length:233
Mass (Da):24,051
Last modified:March 7, 2006 - v3
Checksum:i01ACC1DEEAB4C16F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83A → T in AAH20165 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045118 mRNA Translation: BAB39165.1
AL355490 Genomic DNA No translation available.
BC020165 mRNA Translation: AAH20165.1
AF062739 mRNA Translation: AAC39786.1
CCDSiCCDS7456.1
PIRiJC7618
RefSeqiNP_036215.1, NM_012083.2
UniGeneiHs.140720

Genome annotation databases

EnsembliENST00000371019; ENSP00000360058; ENSG00000181274
GeneIDi23401
KEGGihsa:23401
UCSCiuc001knd.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045118 mRNA Translation: BAB39165.1
AL355490 Genomic DNA No translation available.
BC020165 mRNA Translation: AAH20165.1
AF062739 mRNA Translation: AAC39786.1
CCDSiCCDS7456.1
PIRiJC7618
RefSeqiNP_036215.1, NM_012083.2
UniGeneiHs.140720

3D structure databases

ProteinModelPortaliO75474
SMRiO75474
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116974, 3 interactors
ComplexPortaliCPX-462 Nuclear export complex FRAT2-GSK3B
IntActiO75474, 13 interactors
MINTiO75474
STRINGi9606.ENSP00000360058

PTM databases

iPTMnetiO75474
PhosphoSitePlusiO75474

Polymorphism and mutation databases

BioMutaiFRAT2

Proteomic databases

EPDiO75474
MaxQBiO75474
PaxDbiO75474
PeptideAtlasiO75474
PRIDEiO75474
ProteomicsDBi50036

Protocols and materials databases

DNASUi23401
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371019; ENSP00000360058; ENSG00000181274
GeneIDi23401
KEGGihsa:23401
UCSCiuc001knd.2 human

Organism-specific databases

CTDi23401
DisGeNETi23401
EuPathDBiHostDB:ENSG00000181274.6
GeneCardsiFRAT2
H-InvDBiHIX0009086
HGNCiHGNC:16048 FRAT2
HPAiHPA049763
MIMi605006 gene
neXtProtiNX_O75474
OpenTargetsiENSG00000181274
PharmGKBiPA28362
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J5HI Eukaryota
ENOG410ZA2I LUCA
GeneTreeiENSGT00390000007081
HOGENOMiHOG000112642
HOVERGENiHBG051660
InParanoidiO75474
KOiK03096
OMAiQRRWTQA
OrthoDBiEOG091G0PDL
PhylomeDBiO75474
TreeFamiTF330804

Enzyme and pathway databases

ReactomeiR-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
SIGNORiO75474

Miscellaneous databases

GeneWikiiFRAT2
GenomeRNAii23401
PROiPR:O75474
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181274 Expressed in 169 organ(s), highest expression level in blood
CleanExiHS_FRAT2
GenevisibleiO75474 HS

Family and domain databases

InterProiView protein in InterPro
IPR039202 FRAT2
IPR008014 GSK3-bd
PANTHERiPTHR35154 PTHR35154, 1 hit
PTHR35154:SF2 PTHR35154:SF2, 1 hit
PfamiView protein in Pfam
PF05350 GSK-3_bind, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRAT2_HUMAN
AccessioniPrimary (citable) accession number: O75474
Secondary accession number(s): Q5JTI0, Q8WUL9, Q9BYG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 7, 2006
Last modified: September 12, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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