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Entry version 147 (02 Jun 2021)
Sequence version 3 (07 Mar 2006)
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Protein

GSK-3-binding protein FRAT2

Gene

FRAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O75474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196299, Beta-catenin phosphorylation cascade
R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O75474

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GSK-3-binding protein FRAT2
Alternative name(s):
Frequently rearranged in advanced T-cell lymphomas 2
Short name:
FRAT-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRAT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16048, FRAT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605006, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75474

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000181274.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23401

Open Targets

More...
OpenTargetsi
ENSG00000181274

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28362

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75474, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FRAT2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000873341 – 233GSK-3-binding protein FRAT2Add BLAST233

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75474

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75474

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O75474

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75474

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75474

PeptideAtlas

More...
PeptideAtlasi
O75474

PRoteomics IDEntifications database

More...
PRIDEi
O75474

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50036

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75474

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75474

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000181274, Expressed in blood and 182 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75474, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000181274, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds GSK-3 and prevents GSK-3-dependent phosphorylation.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116974, 14 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-462, Nuclear export complex FRAT2-GSK3B

Protein interaction database and analysis system

More...
IntActi
O75474, 13 interactors

Molecular INTeraction database

More...
MINTi
O75474

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360058

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O75474, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75474

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni174 – 196Involved in GSK-3 bindingBy similarityAdd BLAST23
Regioni204 – 233DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 24Acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GSK-3-binding protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S0IC, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007081

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_101225_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75474

Identification of Orthologs from Complete Genome Data

More...
OMAi
TLPGPCR

Database of Orthologous Groups

More...
OrthoDBi
1477860at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75474

TreeFam database of animal gene trees

More...
TreeFami
TF330804

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039202, FRAT2
IPR008014, GSK3-bd

The PANTHER Classification System

More...
PANTHERi
PTHR35154, PTHR35154, 1 hit
PTHR35154:SF2, PTHR35154:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05350, GSK-3_bind, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O75474-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPCRREEEEE AGEEAEGEEE EDDSFLLLQQ SVTLGSSGEV DRLVAQIGET
60 70 80 90 100
LQLDAAQDSP ASPCAPPGVP LRAPGPLAAA VPADKARPPA VPLLLPPASA
110 120 130 140 150
ETVGPAPSGA LRCALGDRGR VRGRAAPYCV AEVAAGPSAL PGPCRRGWLR
160 170 180 190 200
DAVTSRRLQQ RRWTQAGARA GDDDPHRLLQ QLVLSGNLIK EAVRRLQRAV
210 220 230
AAVAATGPAS APGPGGGRSG PDRIALQPSG SLL
Length:233
Mass (Da):24,051
Last modified:March 7, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01ACC1DEEAB4C16F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83A → T in AAH20165 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB045118 mRNA Translation: BAB39165.1
AL355490 Genomic DNA No translation available.
BC020165 mRNA Translation: AAH20165.1
AF062739 mRNA Translation: AAC39786.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7456.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7618

NCBI Reference Sequences

More...
RefSeqi
NP_036215.1, NM_012083.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371019; ENSP00000360058; ENSG00000181274

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23401

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23401

UCSC genome browser

More...
UCSCi
uc001knd.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045118 mRNA Translation: BAB39165.1
AL355490 Genomic DNA No translation available.
BC020165 mRNA Translation: AAH20165.1
AF062739 mRNA Translation: AAC39786.1
CCDSiCCDS7456.1
PIRiJC7618
RefSeqiNP_036215.1, NM_012083.2

3D structure databases

SMRiO75474
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116974, 14 interactors
ComplexPortaliCPX-462, Nuclear export complex FRAT2-GSK3B
IntActiO75474, 13 interactors
MINTiO75474
STRINGi9606.ENSP00000360058

PTM databases

iPTMnetiO75474
PhosphoSitePlusiO75474

Genetic variation databases

BioMutaiFRAT2

Proteomic databases

EPDiO75474
jPOSTiO75474
MassIVEiO75474
MaxQBiO75474
PaxDbiO75474
PeptideAtlasiO75474
PRIDEiO75474
ProteomicsDBi50036

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30842, 138 antibodies

The DNASU plasmid repository

More...
DNASUi
23401

Genome annotation databases

EnsembliENST00000371019; ENSP00000360058; ENSG00000181274
GeneIDi23401
KEGGihsa:23401
UCSCiuc001knd.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23401
DisGeNETi23401

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FRAT2
HGNCiHGNC:16048, FRAT2
HPAiENSG00000181274, Low tissue specificity
MIMi605006, gene
neXtProtiNX_O75474
OpenTargetsiENSG00000181274
PharmGKBiPA28362
VEuPathDBiHostDB:ENSG00000181274.6

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S0IC, Eukaryota
GeneTreeiENSGT00390000007081
HOGENOMiCLU_101225_1_0_1
InParanoidiO75474
OMAiTLPGPCR
OrthoDBi1477860at2759
PhylomeDBiO75474
TreeFamiTF330804

Enzyme and pathway databases

PathwayCommonsiO75474
ReactomeiR-HSA-196299, Beta-catenin phosphorylation cascade
R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane
SIGNORiO75474

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23401, 7 hits in 996 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FRAT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23401
PharosiO75474, Tdark

Protein Ontology

More...
PROi
PR:O75474
RNActiO75474, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000181274, Expressed in blood and 182 other tissues
GenevisibleiO75474, HS

Family and domain databases

InterProiView protein in InterPro
IPR039202, FRAT2
IPR008014, GSK3-bd
PANTHERiPTHR35154, PTHR35154, 1 hit
PTHR35154:SF2, PTHR35154:SF2, 1 hit
PfamiView protein in Pfam
PF05350, GSK-3_bind, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRAT2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75474
Secondary accession number(s): Q5JTI0, Q8WUL9, Q9BYG2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 7, 2006
Last modified: June 2, 2021
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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