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Protein

Leucine-rich repeat-containing G-protein coupled receptor 5

Gene

LGR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.5 Publications

Miscellaneous

LGR5 is used as a marker of adult tissue stem cells in the intestine, stomach, hair follicle, and mammary epithelium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled peptide receptor activity Source: GO_Central
  • G protein-coupled receptor activity Source: ProtInc
  • protein-hormone receptor activity Source: InterPro
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-4641263 Regulation of FZD by ubiquitination

SIGNOR Signaling Network Open Resource

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SIGNORi
O75473

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing G-protein coupled receptor 5
Alternative name(s):
G-protein coupled receptor 49
G-protein coupled receptor 67
G-protein coupled receptor HG38
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LGR5
Synonyms:GPR49, GPR67
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000139292.12

Human Gene Nomenclature Database

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HGNCi
HGNC:4504 LGR5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606667 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75473

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 561ExtracellularSequence analysisAdd BLAST540
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei562 – 582Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini583 – 593CytoplasmicSequence analysisAdd BLAST11
Transmembranei594 – 614Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini615 – 638ExtracellularSequence analysisAdd BLAST24
Transmembranei639 – 659Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini660 – 682CytoplasmicSequence analysisAdd BLAST23
Transmembranei683 – 703Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini704 – 722ExtracellularSequence analysisAdd BLAST19
Transmembranei723 – 743Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini744 – 767CytoplasmicSequence analysisAdd BLAST24
Transmembranei768 – 788Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini789 – 802ExtracellularSequence analysisAdd BLAST14
Transmembranei803 – 823Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini824 – 907CytoplasmicSequence analysisAdd BLAST84

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi146D → F: Abolishes activation of Wnt signaling. 1 Publication1
Mutagenesisi170D → F: Abolishes activation of Wnt signaling. 1 Publication1
Mutagenesisi190A → D: Abolishes activation of Wnt signaling. 1 Publication1
Mutagenesisi861S → A: Impaired internalization to the trans-Golgi network; when associated with A-864. 1 Publication1
Mutagenesisi864S → A: Impaired internalization to the trans-Golgi network; when associated with A-861. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8549

Open Targets

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OpenTargetsi
ENSG00000139292

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28894

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
148

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LGR5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001279422 – 907Leucine-rich repeat-containing G-protein coupled receptor 5Add BLAST886

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 40
Disulfide bondi38 ↔ 52
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi348 ↔ 373
Disulfide bondi479 ↔ 541
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi637 ↔ 712PROSITE-ProRule annotation
Glycosylationi792N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75473

MaxQB - The MaxQuant DataBase

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MaxQBi
O75473

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O75473

PeptideAtlas

More...
PeptideAtlasi
O75473

PRoteomics IDEntifications database

More...
PRIDEi
O75473

ProteomicsDB human proteome resource

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ProteomicsDBi
50034
50035 [O75473-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75473

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75473

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139292 Expressed in 162 organ(s), highest expression level in endometrium

CleanEx database of gene expression profiles

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CleanExi
HS_LGR5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75473 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75473 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA012530

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a complex composed of RNF43, LGR5 and RSPO1 (PubMed:21909076, PubMed:21727895, PubMed:21693646, PubMed:22815884, PubMed:23809763, PubMed:23756651). Also interacts with other R-spondin ligands, including RSPO2, RSPO3 and RSPO4 (PubMed:21909076, PubMed:21727895, PubMed:21693646, PubMed:29769720).7 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114119, 7 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O75473

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000266674

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1907
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BSRX-ray3.20A/B22-543[»]
4BSSX-ray3.20A/B/E/F22-543[»]
4BSTX-ray4.30A/B22-543[»]
4BSUX-ray3.20A/B/E/F22-543[»]
4KNGX-ray2.50A/B32-557[»]
4UFRX-ray2.20A/C32-486[»]
A/C538-544[»]
4UFSX-ray4.80A32-486[»]
A538-544[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75473

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75473

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 66LRRNTAdd BLAST42
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati67 – 90LRR 1Add BLAST24
Repeati91 – 112LRR 2Add BLAST22
Repeati115 – 136LRR 3Add BLAST22
Repeati139 – 160LRR 4Add BLAST22
Repeati163 – 184LRR 5Add BLAST22
Repeati187 – 208LRR 6Add BLAST22
Repeati211 – 232LRR 7Add BLAST22
Repeati235 – 256LRR 8Add BLAST22
Repeati258 – 279LRR 9Add BLAST22
Repeati282 – 303LRR 10Add BLAST22
Repeati306 – 328LRR 11Add BLAST23
Repeati329 – 350LRR 12Add BLAST22
Repeati353 – 374LRR 13Add BLAST22
Repeati375 – 396LRR 14Add BLAST22
Repeati399 – 420LRR 15Add BLAST22
Repeati423 – 446LRR 16Add BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
KOG2087 Eukaryota
COG4886 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231829

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG031675

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75473

KEGG Orthology (KO)

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KOi
K04308

Identification of Orthologs from Complete Genome Data

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OMAi
KCSAKFE

Database of Orthologous Groups

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OrthoDBi
340670at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75473

TreeFam database of animal gene trees

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TreeFami
TF316814

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002131 Gphrmn_rcpt_fam
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 4 hits
PF01462 LRRNT, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00373 GLYCHORMONER
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 15 hits
SM00013 LRRNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS51450 LRR, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O75473-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTSRLGVLL SLPVLLQLAT GGSSPRSGVL LRGCPTHCHC EPDGRMLLRV
60 70 80 90 100
DCSDLGLSEL PSNLSVFTSY LDLSMNNISQ LLPNPLPSLR FLEELRLAGN
110 120 130 140 150
ALTYIPKGAF TGLYSLKVLM LQNNQLRHVP TEALQNLRSL QSLRLDANHI
160 170 180 190 200
SYVPPSCFSG LHSLRHLWLD DNALTEIPVQ AFRSLSALQA MTLALNKIHH
210 220 230 240 250
IPDYAFGNLS SLVVLHLHNN RIHSLGKKCF DGLHSLETLD LNYNNLDEFP
260 270 280 290 300
TAIRTLSNLK ELGFHSNNIR SIPEKAFVGN PSLITIHFYD NPIQFVGRSA
310 320 330 340 350
FQHLPELRTL TLNGASQITE FPDLTGTANL ESLTLTGAQI SSLPQTVCNQ
360 370 380 390 400
LPNLQVLDLS YNLLEDLPSF SVCQKLQKID LRHNEIYEIK VDTFQQLLSL
410 420 430 440 450
RSLNLAWNKI AIIHPNAFST LPSLIKLDLS SNLLSSFPIT GLHGLTHLKL
460 470 480 490 500
TGNHALQSLI SSENFPELKV IEMPYAYQCC AFGVCENAYK ISNQWNKGDN
510 520 530 540 550
SSMDDLHKKD AGMFQAQDER DLEDFLLDFE EDLKALHSVQ CSPSPGPFKP
560 570 580 590 600
CEHLLDGWLI RIGVWTIAVL ALTCNALVTS TVFRSPLYIS PIKLLIGVIA
610 620 630 640 650
AVNMLTGVSS AVLAGVDAFT FGSFARHGAW WENGVGCHVI GFLSIFASES
660 670 680 690 700
SVFLLTLAAL ERGFSVKYSA KFETKAPFSS LKVIILLCAL LALTMAAVPL
710 720 730 740 750
LGGSKYGASP LCLPLPFGEP STMGYMVALI LLNSLCFLMM TIAYTKLYCN
760 770 780 790 800
LDKGDLENIW DCSMVKHIAL LLFTNCILNC PVAFLSFSSL INLTFISPEV
810 820 830 840 850
IKFILLVVVP LPACLNPLLY ILFNPHFKED LVSLRKQTYV WTRSKHPSLM
860 870 880 890 900
SINSDDVEKQ SCDSTQALVT FTSSSITYDL PPSSVPSPAY PVTESCHLSS

VAFVPCL
Length:907
Mass (Da):99,998
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i822D5C5E6F0D9092
GO
Isoform 2 (identifier: O75473-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-286: Missing.

Show »
Length:883
Mass (Da):97,404
Checksum:i50B293FCFCAED440
GO
Isoform 3 (identifier: O75473-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-214: Missing.

Show »
Length:835
Mass (Da):92,006
Checksum:i352096C4523C1E2F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti90R → H in AAC77911 (PubMed:9849958).Curated1
Sequence conflicti212L → W in AAC77911 (PubMed:9849958).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049411383H → R. Corresponds to variant dbSNP:rs12303775Ensembl.1
Natural variantiVAR_049412666V → A1 PublicationCorresponds to variant dbSNP:rs17109924Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054782143 – 214Missing in isoform 3. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_037746263 – 286Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF062006 mRNA Translation: AAC28019.1
AF061444 mRNA Translation: AAC77911.1
FN820440 mRNA Translation: CBL95002.2
AC078860 Genomic DNA No translation available.
AC090116 Genomic DNA No translation available.
BC096324 mRNA Translation: AAH96324.1
BC096325 mRNA Translation: AAH96325.1
BC096326 mRNA Translation: AAH96326.1
BC099650 mRNA Translation: AAH99650.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS61194.1 [O75473-2]
CCDS61195.1 [O75473-3]
CCDS9000.1 [O75473-1]

Protein sequence database of the Protein Information Resource

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PIRi
JE0176

NCBI Reference Sequences

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RefSeqi
NP_001264155.1, NM_001277226.1 [O75473-2]
NP_001264156.1, NM_001277227.1 [O75473-3]
NP_003658.1, NM_003667.3 [O75473-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.658889

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000266674; ENSP00000266674; ENSG00000139292 [O75473-1]
ENST00000536515; ENSP00000443033; ENSG00000139292 [O75473-3]
ENST00000540815; ENSP00000441035; ENSG00000139292 [O75473-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8549

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8549

UCSC genome browser

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UCSCi
uc001swl.5 human [O75473-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062006 mRNA Translation: AAC28019.1
AF061444 mRNA Translation: AAC77911.1
FN820440 mRNA Translation: CBL95002.2
AC078860 Genomic DNA No translation available.
AC090116 Genomic DNA No translation available.
BC096324 mRNA Translation: AAH96324.1
BC096325 mRNA Translation: AAH96325.1
BC096326 mRNA Translation: AAH96326.1
BC099650 mRNA Translation: AAH99650.1
CCDSiCCDS61194.1 [O75473-2]
CCDS61195.1 [O75473-3]
CCDS9000.1 [O75473-1]
PIRiJE0176
RefSeqiNP_001264155.1, NM_001277226.1 [O75473-2]
NP_001264156.1, NM_001277227.1 [O75473-3]
NP_003658.1, NM_003667.3 [O75473-1]
UniGeneiHs.658889

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BSRX-ray3.20A/B22-543[»]
4BSSX-ray3.20A/B/E/F22-543[»]
4BSTX-ray4.30A/B22-543[»]
4BSUX-ray3.20A/B/E/F22-543[»]
4KNGX-ray2.50A/B32-557[»]
4UFRX-ray2.20A/C32-486[»]
A/C538-544[»]
4UFSX-ray4.80A32-486[»]
A538-544[»]
ProteinModelPortaliO75473
SMRiO75473
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114119, 7 interactors
CORUMiO75473
STRINGi9606.ENSP00000266674

Chemistry databases

GuidetoPHARMACOLOGYi148

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiO75473
PhosphoSitePlusiO75473

Polymorphism and mutation databases

BioMutaiLGR5

Proteomic databases

jPOSTiO75473
MaxQBiO75473
PaxDbiO75473
PeptideAtlasiO75473
PRIDEiO75473
ProteomicsDBi50034
50035 [O75473-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266674; ENSP00000266674; ENSG00000139292 [O75473-1]
ENST00000536515; ENSP00000443033; ENSG00000139292 [O75473-3]
ENST00000540815; ENSP00000441035; ENSG00000139292 [O75473-2]
GeneIDi8549
KEGGihsa:8549
UCSCiuc001swl.5 human [O75473-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8549
DisGeNETi8549
EuPathDBiHostDB:ENSG00000139292.12

GeneCards: human genes, protein and diseases

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GeneCardsi
LGR5
HGNCiHGNC:4504 LGR5
HPAiHPA012530
MIMi606667 gene
neXtProtiNX_O75473
OpenTargetsiENSG00000139292
PharmGKBiPA28894

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG2087 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000160214
HOGENOMiHOG000231829
HOVERGENiHBG031675
InParanoidiO75473
KOiK04308
OMAiKCSAKFE
OrthoDBi340670at2759
PhylomeDBiO75473
TreeFamiTF316814

Enzyme and pathway databases

ReactomeiR-HSA-4641263 Regulation of FZD by ubiquitination
SIGNORiO75473

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LGR5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LGR5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8549

Protein Ontology

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PROi
PR:O75473

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000139292 Expressed in 162 organ(s), highest expression level in endometrium
CleanExiHS_LGR5
ExpressionAtlasiO75473 baseline and differential
GenevisibleiO75473 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002131 Gphrmn_rcpt_fam
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 4 hits
PF01462 LRRNT, 1 hit
PRINTSiPR00373 GLYCHORMONER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM00369 LRR_TYP, 15 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS51450 LRR, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLGR5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75473
Secondary accession number(s): D8MCT0
, Q4VAM0, Q4VAM2, Q9UP75
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: January 16, 2019
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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