UniProtKB - O75469 (NR1I2_HUMAN)
Nuclear receptor subfamily 1 group I member 2
NR1I2
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 247 | Agonist | 1 | |
Binding sitei | 285 | Agonist | 1 | |
Binding sitei | 288 | Agonist | 1 | |
Binding sitei | 299 | Agonist | 1 | |
Binding sitei | 407 | Agonist | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 38 – 107 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 70 | |
Zinc fingeri | 41 – 61 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 77 – 102 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- drug binding Source: UniProtKB
- nuclear receptor activity Source: UniProtKB
- nuclear receptor binding Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- zinc ion binding Source: InterPro
GO - Biological processi
- cell differentiation Source: GO_Central
- cholesterol homeostasis Source: GO_Central
- exogenous drug catabolic process Source: UniProtKB
- lipid homeostasis Source: GO_Central
- lipid metabolic process Source: GO_Central
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription, DNA-templated Source: GO_Central
- signal transduction Source: ProtInc
- steroid metabolic process Source: ProtInc
- transcription initiation from RNA polymerase II promoter Source: Reactome
- xenobiotic metabolic process Source: UniProtKB
- xenobiotic transport Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O75469 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors [O75469-1] |
SignaLinki | O75469 |
SIGNORi | O75469 |
Protein family/group databases
TCDBi | 9.B.208.1.3, the vitamin d3 receptor (vdr) family |
Chemistry databases
SwissLipidsi | SLP:000001583 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor subfamily 1 group I member 2Alternative name(s): Orphan nuclear receptor PAR1 Orphan nuclear receptor PXR Pregnane X receptor Steroid and xenobiotic receptor Short name: SXR |
Gene namesi | Name:NR1I2 Synonyms:PXR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000144852.16 |
HGNCi | HGNC:7968, NR1I2 |
MIMi | 603065, gene |
neXtProti | NX_O75469 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Cytoskeleton
- intermediate filament cytoskeleton Source: HPA
Nucleus
- nuclear body Source: HPA
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 66 – 67 | RR → AA: Abolishes nuclear localization; when associated with 91-A-A-92. 1 Publication | 2 | |
Mutagenesisi | 91 – 92 | RR → AA: Abolishes nuclear localization; when associated with 66-A-A-67. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 8856 |
OpenTargetsi | ENSG00000144852 |
PharmGKBi | PA378 |
Miscellaneous databases
Pharosi | O75469, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3401 |
DrugBanki | DB04468, Afimoxifene DB14001, alpha-Tocopherol succinate DB01393, Bezafibrate DB00564, Carbamazepine DB06777, Chenodeoxycholic acid DB01068, Clonazepam DB00257, Clotrimazole DB00531, Cyclophosphamide DB14002, D-alpha-Tocopherol acetate DB01234, Dexamethasone DB14649, Dexamethasone acetate DB00255, Diethylstilbestrol DB01248, Docetaxel DB05928, Dovitinib DB01127, Econazole DB00530, Erlotinib DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00977, Ethinylestradiol DB00754, Ethotoin DB01039, Fenofibrate DB13873, Fenofibric acid DB00499, Flutamide DB01645, Genistein DB07931, Hexestrol DB01892, Hyperforin DB01181, Ifosfamide DB01026, Ketoconazole DB00431, Lindane DB00532, Mephenytoin DB00849, Methylphenobarbital DB01110, Miconazole DB00834, Mifepristone DB11605, Myrrh DB01115, Nifedipine DB00239, Oxiconazole DB01229, Paclitaxel DB00312, Pentobarbital DB04930, Permethrin DB01174, Phenobarbital DB04824, Phenolphthalein DB00252, Phenytoin DB12582, Piperine DB01708, Prasterone DB02789, Pregnenolone DB11087, Pyrethrum extract DB04216, Quercetin DB02709, Resveratrol DB01045, Rifampicin DB01220, Rifaximin DB08864, Rilpivirine DB00503, Ritonavir DB00421, Spironolactone DB04466, SR12813 DB01138, Sulfinpyrazone DB00675, Tamoxifen DB07080, TO-901317 DB08604, Triclosan DB13179, Troleandomycin DB00163, Vitamin E DB00682, Warfarin |
DrugCentrali | O75469 |
GuidetoPHARMACOLOGYi | 606 |
Polymorphism and mutation databases
BioMutai | NR1I2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053547 | 1 – 434 | Nuclear receptor subfamily 1 group I member 2Add BLAST | 434 |
Proteomic databases
MassIVEi | O75469 |
PaxDbi | O75469 |
PeptideAtlasi | O75469 |
PRIDEi | O75469 |
ProteomicsDBi | 50027 [O75469-1] 50028 [O75469-2] 50029 [O75469-3] 50030 [O75469-4] 50031 [O75469-5] 50032 [O75469-6] 50033 [O75469-7] |
PTM databases
iPTMneti | O75469 |
PhosphoSitePlusi | O75469 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000144852, Expressed in right lobe of liver and 93 other tissues |
ExpressionAtlasi | O75469, baseline and differential |
Genevisiblei | O75469, HS |
Organism-specific databases
HPAi | ENSG00000144852, Group enriched (blood, intestine, liver) |
Interactioni
Subunit structurei
Heterodimer with RXR.
Interacts with NCOA1.
Interacts (via domain NR LBD) with CRY1 and CRY2 in a ligand-dependent manner (By similarity).
By similarity5 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- nuclear receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114380, 41 interactors |
ComplexPortali | CPX-496, RXRalpha-PXR nuclear receptor complex CPX-517, PXR-NCOA1 activated nuclear receptor complex |
IntActi | O75469, 11 interactors |
STRINGi | 9606.ENSP00000336528 |
Chemistry databases
BindingDBi | O75469 |
Miscellaneous databases
RNActi | O75469, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O75469 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O75469 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 146 – 433 | NR LBDPROSITE-ProRule annotationAdd BLAST | 288 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 108 – 145 | HingeAdd BLAST | 38 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 66 – 92 | Bipartite nuclear localization signalAdd BLAST | 27 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 41 – 61 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 77 – 102 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000161118 |
InParanoidi | O75469 |
OMAi | NGYHFNV |
OrthoDBi | 297114at2759 |
PhylomeDBi | O75469 |
TreeFami | TF316304 |
Family and domain databases
DisProti | DP00323 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00361 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG
60 70 80 90 100
YHFNVMTCEG CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR
110 120 130 140 150
KCLESGMKKE MIMSDEAVEE RRALIKRKKS ERTGTQPLGV QGLTEEQRMM
160 170 180 190 200
IRELMDAQMK TFDTTFSHFK NFRLPGVLSS GCELPESLQA PSREEAAKWS
210 220 230 240 250
QVRKDLCSLK VSLQLRGEDG SVWNYKPPAD SGGKEIFSLL PHMADMSTYM
260 270 280 290 300
FKGIISFAKV ISYFRDLPIE DQISLLKGAA FELCQLRFNT VFNAETGTWE
310 320 330 340 350
CGRLSYCLED TAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS
360 370 380 390 400
PDRPGVLQHR VVDQLQEQFA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL
410 420 430
RSINAQHTQR LLRIQDIHPF ATPLMQELFG ITGS
The sequence of this isoform differs from the canonical sequence as follows:
1-55: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MDPRGEVGAKNLPPNSPRGPEANL
The sequence of this isoform differs from the canonical sequence as follows:
174-210: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-55: Missing.
174-210: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MDPRGEVGAKNLPPNSPRGPEANL
174-210: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KPQ3 | J3KPQ3_HUMAN | Nuclear receptor subfamily 1 group ... | NR1I2 hCG_21777 | 434 | Annotation score: | ||
H0Y8E2 | H0Y8E2_HUMAN | Nuclear receptor subfamily 1 group ... | NR1I2 hCG_21777 | 397 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 109 | K → N in CAB55489 (Ref. 5) Curated | 1 | |
Sequence conflicti | 109 | K → N in CAB55490 (Ref. 5) Curated | 1 | |
Sequence conflicti | 109 | K → N in CAB55491 (Ref. 5) Curated | 1 | |
Sequence conflicti | 109 | K → N in CAB55492 (Ref. 5) Curated | 1 | |
Sequence conflicti | 109 | K → N in CAB55493 (Ref. 5) Curated | 1 | |
Sequence conflicti | 109 | K → N in CAB55494 (Ref. 5) Curated | 1 | |
Sequence conflicti | 174 | Missing in AAH17304 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050581 | 12 | A → T1 PublicationCorresponds to variant dbSNP:rs1063955Ensembl. | 1 | |
Natural variantiVAR_033237 | 18 | E → K1 PublicationCorresponds to variant dbSNP:rs59371185Ensembl. | 1 | |
Natural variantiVAR_012228 | 27 | P → S in allele PXR*2. 2 PublicationsCorresponds to variant dbSNP:rs12721613Ensembl. | 1 | |
Natural variantiVAR_012229 | 36 | G → R in allele PXR*3. 1 PublicationCorresponds to variant dbSNP:rs12721607Ensembl. | 1 | |
Natural variantiVAR_018340 | 98 | R → C1 PublicationCorresponds to variant dbSNP:rs72551371Ensembl. | 1 | |
Natural variantiVAR_012230 | 122 | R → Q in allele PXR*4; rare polymorphism. 1 PublicationCorresponds to variant dbSNP:rs12721608Ensembl. | 1 | |
Natural variantiVAR_018341 | 148 | R → Q1 PublicationCorresponds to variant dbSNP:rs72551373Ensembl. | 1 | |
Natural variantiVAR_033238 | 370 | A → T1 PublicationCorresponds to variant dbSNP:rs35761343Ensembl. | 1 | |
Natural variantiVAR_018342 | 381 | R → W1 PublicationCorresponds to variant dbSNP:rs72551375Ensembl. | 1 | |
Natural variantiVAR_018343 | 403 | I → V1 PublicationCorresponds to variant dbSNP:rs72551376Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003668 | 1 – 55 | Missing in isoform 1B and isoform 2B. 1 PublicationAdd BLAST | 55 | |
Alternative sequenceiVSP_003667 | 1 | M → MDPRGEVGAKNLPPNSPRGP EANL in isoform 1C and isoform 2C. 1 Publication | 1 | |
Alternative sequenceiVSP_026669 | 1 | M → MTVTRTHHFKEGSLRAPAIP LHSAAAELASNHPRGPEANL in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_003669 | 174 – 210 | Missing in isoform 2A, isoform 2B and isoform 2C. 1 PublicationAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY091855 mRNA Translation: AAM26736.1 AF061056 mRNA Translation: AAD05436.1 AF084644 mRNA Translation: AAC64557.1 AF084645 mRNA Translation: AAC64558.1 AF364606 Genomic DNA Translation: AAK38720.1 AF364606 Genomic DNA Translation: AAK38721.1 AF364606 Genomic DNA Translation: AAK38722.1 AJ009936 mRNA Translation: CAB55489.1 AJ009936 mRNA Translation: CAB55490.1 AJ009936 mRNA Translation: CAB55491.1 AJ009937 mRNA Translation: CAB55492.1 AJ009937 mRNA Translation: CAB55493.1 AJ009937 mRNA Translation: CAB55494.1 DQ911122 Genomic DNA Translation: ABJ52965.1 DQ923326 Genomic DNA Translation: ABJ52966.1 EF614253 Genomic DNA Translation: ABR09276.1 BC017304 mRNA Translation: AAH17304.2 |
CCDSi | CCDS2995.1 [O75469-7] CCDS43136.1 [O75469-1] CCDS54627.1 [O75469-4] |
RefSeqi | NP_003880.3, NM_003889.3 [O75469-1] NP_071285.1, NM_022002.2 [O75469-7] NP_148934.1, NM_033013.2 [O75469-4] |
Genome annotation databases
Ensembli | ENST00000337940; ENSP00000336528; ENSG00000144852 [O75469-7] |
GeneIDi | 8856 |
KEGGi | hsa:8856 |
UCSCi | uc003edk.3, human [O75469-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY091855 mRNA Translation: AAM26736.1 AF061056 mRNA Translation: AAD05436.1 AF084644 mRNA Translation: AAC64557.1 AF084645 mRNA Translation: AAC64558.1 AF364606 Genomic DNA Translation: AAK38720.1 AF364606 Genomic DNA Translation: AAK38721.1 AF364606 Genomic DNA Translation: AAK38722.1 AJ009936 mRNA Translation: CAB55489.1 AJ009936 mRNA Translation: CAB55490.1 AJ009936 mRNA Translation: CAB55491.1 AJ009937 mRNA Translation: CAB55492.1 AJ009937 mRNA Translation: CAB55493.1 AJ009937 mRNA Translation: CAB55494.1 DQ911122 Genomic DNA Translation: ABJ52965.1 DQ923326 Genomic DNA Translation: ABJ52966.1 EF614253 Genomic DNA Translation: ABR09276.1 BC017304 mRNA Translation: AAH17304.2 |
CCDSi | CCDS2995.1 [O75469-7] CCDS43136.1 [O75469-1] CCDS54627.1 [O75469-4] |
RefSeqi | NP_003880.3, NM_003889.3 [O75469-1] NP_071285.1, NM_022002.2 [O75469-7] NP_148934.1, NM_033013.2 [O75469-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ILG | X-ray | 2.52 | A | 130-434 | [»] | |
1ILH | X-ray | 2.76 | A | 130-434 | [»] | |
1M13 | X-ray | 2.15 | A | 130-434 | [»] | |
1NRL | X-ray | 2.00 | A/B | 130-434 | [»] | |
1SKX | X-ray | 2.80 | A | 130-431 | [»] | |
2O9I | X-ray | 2.80 | A/B | 142-434 | [»] | |
2QNV | X-ray | 2.80 | A | 130-434 | [»] | |
3CTB | X-ray | 2.00 | A/B | 130-434 | [»] | |
3HVL | X-ray | 2.10 | A/B | 130-434 | [»] | |
3R8D | X-ray | 2.80 | A | 130-434 | [»] | |
4J5W | X-ray | 2.80 | A/B | 130-434 | [»] | |
4J5X | X-ray | 2.80 | A/B | 130-434 | [»] | |
4NY9 | X-ray | 2.80 | A | 142-431 | [»] | |
4S0S | X-ray | 2.80 | A/B | 130-434 | [»] | |
4S0T | X-ray | 3.14 | A/B | 130-434 | [»] | |
4X1F | X-ray | 2.00 | A | 130-434 | [»] | |
4X1G | X-ray | 2.25 | A | 130-434 | [»] | |
4XAO | X-ray | 2.58 | A | 130-434 | [»] | |
4XHD | X-ray | 2.40 | A | 130-434 | [»] | |
5A86 | X-ray | 2.25 | A/B | 130-432 | [»] | |
5X0R | X-ray | 2.67 | A/B | 130-434 | [»] | |
6BNS | X-ray | 2.56 | A/B | 130-434 | [»] | |
6DUP | X-ray | 2.30 | A/B | 130-426 | [»] | |
6HJ2 | X-ray | 2.28 | A | 130-434 | [»] | |
6HTY | X-ray | 2.22 | A/B | 129-434 | [»] | |
6NX1 | X-ray | 2.27 | A/B | 130-434 | [»] | |
6P2B | X-ray | 2.30 | A/B | 130-434 | [»] | |
6S41 | X-ray | 2.70 | A/B | 138-434 | [»] | |
SMRi | O75469 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114380, 41 interactors |
ComplexPortali | CPX-496, RXRalpha-PXR nuclear receptor complex CPX-517, PXR-NCOA1 activated nuclear receptor complex |
IntActi | O75469, 11 interactors |
STRINGi | 9606.ENSP00000336528 |
Chemistry databases
BindingDBi | O75469 |
ChEMBLi | CHEMBL3401 |
DrugBanki | DB04468, Afimoxifene DB14001, alpha-Tocopherol succinate DB01393, Bezafibrate DB00564, Carbamazepine DB06777, Chenodeoxycholic acid DB01068, Clonazepam DB00257, Clotrimazole DB00531, Cyclophosphamide DB14002, D-alpha-Tocopherol acetate DB01234, Dexamethasone DB14649, Dexamethasone acetate DB00255, Diethylstilbestrol DB01248, Docetaxel DB05928, Dovitinib DB01127, Econazole DB00530, Erlotinib DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00977, Ethinylestradiol DB00754, Ethotoin DB01039, Fenofibrate DB13873, Fenofibric acid DB00499, Flutamide DB01645, Genistein DB07931, Hexestrol DB01892, Hyperforin DB01181, Ifosfamide DB01026, Ketoconazole DB00431, Lindane DB00532, Mephenytoin DB00849, Methylphenobarbital DB01110, Miconazole DB00834, Mifepristone DB11605, Myrrh DB01115, Nifedipine DB00239, Oxiconazole DB01229, Paclitaxel DB00312, Pentobarbital DB04930, Permethrin DB01174, Phenobarbital DB04824, Phenolphthalein DB00252, Phenytoin DB12582, Piperine DB01708, Prasterone DB02789, Pregnenolone DB11087, Pyrethrum extract DB04216, Quercetin DB02709, Resveratrol DB01045, Rifampicin DB01220, Rifaximin DB08864, Rilpivirine DB00503, Ritonavir DB00421, Spironolactone DB04466, SR12813 DB01138, Sulfinpyrazone DB00675, Tamoxifen DB07080, TO-901317 DB08604, Triclosan DB13179, Troleandomycin DB00163, Vitamin E DB00682, Warfarin |
DrugCentrali | O75469 |
GuidetoPHARMACOLOGYi | 606 |
SwissLipidsi | SLP:000001583 |
Protein family/group databases
TCDBi | 9.B.208.1.3, the vitamin d3 receptor (vdr) family |
PTM databases
iPTMneti | O75469 |
PhosphoSitePlusi | O75469 |
Polymorphism and mutation databases
BioMutai | NR1I2 |
Proteomic databases
MassIVEi | O75469 |
PaxDbi | O75469 |
PeptideAtlasi | O75469 |
PRIDEi | O75469 |
ProteomicsDBi | 50027 [O75469-1] 50028 [O75469-2] 50029 [O75469-3] 50030 [O75469-4] 50031 [O75469-5] 50032 [O75469-6] 50033 [O75469-7] |
Protocols and materials databases
Antibodypediai | 16619, 399 antibodies |
Genome annotation databases
Ensembli | ENST00000337940; ENSP00000336528; ENSG00000144852 [O75469-7] |
GeneIDi | 8856 |
KEGGi | hsa:8856 |
UCSCi | uc003edk.3, human [O75469-1] |
Organism-specific databases
CTDi | 8856 |
DisGeNETi | 8856 |
EuPathDBi | HostDB:ENSG00000144852.16 |
GeneCardsi | NR1I2 |
HGNCi | HGNC:7968, NR1I2 |
HPAi | ENSG00000144852, Group enriched (blood, intestine, liver) |
MIMi | 603065, gene |
neXtProti | NX_O75469 |
OpenTargetsi | ENSG00000144852 |
PharmGKBi | PA378 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000161118 |
InParanoidi | O75469 |
OMAi | NGYHFNV |
OrthoDBi | 297114at2759 |
PhylomeDBi | O75469 |
TreeFami | TF316304 |
Enzyme and pathway databases
PathwayCommonsi | O75469 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors [O75469-1] |
SignaLinki | O75469 |
SIGNORi | O75469 |
Miscellaneous databases
BioGRID-ORCSi | 8856, 1 hit in 866 CRISPR screens |
EvolutionaryTracei | O75469 |
GeneWikii | Pregnane_X_receptor |
GenomeRNAii | 8856 |
Pharosi | O75469, Tchem |
PROi | PR:O75469 |
RNActi | O75469, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144852, Expressed in right lobe of liver and 93 other tissues |
ExpressionAtlasi | O75469, baseline and differential |
Genevisiblei | O75469, HS |
Family and domain databases
DisProti | DP00323 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00361 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NR1I2_HUMAN | |
Accessioni | O75469Primary (citable) accession number: O75469 Secondary accession number(s): Q006P5 Q9UNW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 219 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations