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Protein

Cytokine receptor-like factor 1

Gene

CRLF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine binding Source: HGNC
  • cytokine receptor activity Source: GO_Central
  • protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
1.1.1.105 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
R-HSA-9020956 Interleukin-27 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
O75462

SIGNOR Signaling Network Open Resource

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SIGNORi
O75462

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytokine receptor-like factor 1
Alternative name(s):
Cytokine-like factor 1
Short name:
CLF-1
ZcytoR5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRLF1
ORF Names:UNQ288/PRO327
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000006016.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2364 CRLF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604237 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75462

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Crisponi/Cold-induced sweating syndrome 1 (CISS1)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Patients manifest, in the neonatal period, orofacial weakness with impaired sucking and swallowing, resulting in poor feeding. Affected infants show a tendency to startle, with contractions of the facial muscles in response to tactile stimuli or during crying, trismus, abundant salivation, and opisthotonus. These features are referred to as Crisponi syndrome and can result in early death in infancy. Patients who survive into childhood have hyperhidrosis, mainly of the upper body, in response to cold temperatures, and sweat very little with heat. Additional abnormalities include a high-arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis.
See also OMIM:272430
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07081774L → P in CISS1. 1 PublicationCorresponds to variant dbSNP:rs1295488778Ensembl.1
Natural variantiVAR_07081875Y → D in CISS1. 1 Publication1
Natural variantiVAR_03311376W → G in CISS1. 2 PublicationsCorresponds to variant dbSNP:rs137853143EnsemblClinVar.1
Natural variantiVAR_01786581R → H in CISS1. 1 PublicationCorresponds to variant dbSNP:rs104894670EnsemblClinVar.1
Natural variantiVAR_070819113N → I in CISS1; together with P-114. 1 Publication1
Natural variantiVAR_070820114L → P in CISS1; together with I-113. 1 PublicationCorresponds to variant dbSNP:rs774359694Ensembl.1
Natural variantiVAR_070821138P → L in CISS1. 1 PublicationCorresponds to variant dbSNP:rs137853930EnsemblClinVar.1
Natural variantiVAR_070822145S → P in CISS1. 1 Publication1
Natural variantiVAR_070823216R → C in CISS1. 1 PublicationCorresponds to variant dbSNP:rs556029569Ensembl.1
Natural variantiVAR_070824268F → S in CISS1. 1 PublicationCorresponds to variant dbSNP:rs761982168Ensembl.1
Natural variantiVAR_070825284W → C in CISS1. 1 PublicationCorresponds to variant dbSNP:rs137853927EnsemblClinVar.1
Natural variantiVAR_070826312R → P in CISS1. 1 PublicationCorresponds to variant dbSNP:rs137853933Ensembl.1
Natural variantiVAR_070827340R → C in CISS1. 1 PublicationCorresponds to variant dbSNP:rs771459625Ensembl.1
Natural variantiVAR_017866374L → R in CISS1. 1 PublicationCorresponds to variant dbSNP:rs104894668EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
9244

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
CRLF1

MalaCards human disease database

More...
MalaCardsi
CRLF1
MIMi272430 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000006016

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
157820 Cold-induced sweating syndrome
1545 Crisponi syndrome
930 Idiopathic achalasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26882

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CRLF1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 371 PublicationAdd BLAST37
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001103938 – 422Cytokine receptor-like factor 1Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi143 ↔ 153By similarity
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi184 ↔ 195By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei219PhosphoserineBy similarity1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75462

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75462

MaxQB - The MaxQuant DataBase

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MaxQBi
O75462

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O75462

PeptideAtlas

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PeptideAtlasi
O75462

PRoteomics IDEntifications database

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PRIDEi
O75462

ProteomicsDB human proteome resource

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ProteomicsDBi
50025

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1167

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75462

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75462

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in fibroblast primary cell cultures under stimulation by IFNG/IFN-gamma, TNF and IL6/interleukin-6.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000006016 Expressed in 172 organ(s), highest expression level in right coronary artery

CleanEx database of gene expression profiles

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CleanExi
HS_CRLF1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75462 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75462 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA041493
HPA041793

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms covalently linked di- and tetramers. Forms a heteromeric complex with cardiotrophin-like cytokine (CLC); the CRLF1/CLC complex is a ligand for the ciliary neurotrophic factor receptor (CNTFR).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114670, 5 interactors

Database of interacting proteins

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DIPi
DIP-61205N

Protein interaction database and analysis system

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IntActi
O75462, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000376188

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75462

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75462

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 131Ig-like C2-typeAdd BLAST94
Domaini137 – 232Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini237 – 341Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST105

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi327 – 331WSXWS motif5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IV7Y Eukaryota
ENOG410Z87J LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156569

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000111972

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051119

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75462

Identification of Orthologs from Complete Genome Data

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OMAi
HKTRNQA

Database of Orthologous Groups

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OrthoDBi
702827at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75462

TreeFam database of animal gene trees

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TreeFami
TF106501

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00060 FN3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O75462-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAGRRGPAA QSARRPPPLL PLLLLLCVLG APRAGSGAHT AVISPQDPTL
60 70 80 90 100
LIGSSLLATC SVHGDPPGAT AEGLYWTLNG RRLPPELSRV LNASTLALAL
110 120 130 140 150
ANLNGSRQRS GDNLVCHARD GSILAGSCLY VGLPPEKPVN ISCWSKNMKD
160 170 180 190 200
LTCRWTPGAH GETFLHTNYS LKYKLRWYGQ DNTCEEYHTV GPHSCHIPKD
210 220 230 240 250
LALFTPYEIW VEATNRLGSA RSDVLTLDIL DVVTTDPPPD VHVSRVGGLE
260 270 280 290 300
DQLSVRWVSP PALKDFLFQA KYQIRYRVED SVDWKVVDDV SNQTSCRLAG
310 320 330 340 350
LKPGTVYFVQ VRCNPFGIYG SKKAGIWSEW SHPTAASTPR SERPGPGGGA
360 370 380 390 400
CEPRGGEPSS GPVRRELKQF LGWLKKHAYC SNLSFRLYDQ WRAWMQKSHK
410 420
TRNQDEGILP SGRRGTARGP AR
Length:422
Mass (Da):46,302
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD9DEFCB01B84228
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZL6M0QZL6_HUMAN
Cytokine receptor-like factor 1
CRLF1
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti240D → E in AAD54385 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07081774L → P in CISS1. 1 PublicationCorresponds to variant dbSNP:rs1295488778Ensembl.1
Natural variantiVAR_07081875Y → D in CISS1. 1 Publication1
Natural variantiVAR_03311376W → G in CISS1. 2 PublicationsCorresponds to variant dbSNP:rs137853143EnsemblClinVar.1
Natural variantiVAR_01786581R → H in CISS1. 1 PublicationCorresponds to variant dbSNP:rs104894670EnsemblClinVar.1
Natural variantiVAR_070819113N → I in CISS1; together with P-114. 1 Publication1
Natural variantiVAR_070820114L → P in CISS1; together with I-113. 1 PublicationCorresponds to variant dbSNP:rs774359694Ensembl.1
Natural variantiVAR_070821138P → L in CISS1. 1 PublicationCorresponds to variant dbSNP:rs137853930EnsemblClinVar.1
Natural variantiVAR_070822145S → P in CISS1. 1 Publication1
Natural variantiVAR_028355176R → K. Corresponds to variant dbSNP:rs11672248Ensembl.1
Natural variantiVAR_070823216R → C in CISS1. 1 PublicationCorresponds to variant dbSNP:rs556029569Ensembl.1
Natural variantiVAR_070824268F → S in CISS1. 1 PublicationCorresponds to variant dbSNP:rs761982168Ensembl.1
Natural variantiVAR_070825284W → C in CISS1. 1 PublicationCorresponds to variant dbSNP:rs137853927EnsemblClinVar.1
Natural variantiVAR_070826312R → P in CISS1. 1 PublicationCorresponds to variant dbSNP:rs137853933Ensembl.1
Natural variantiVAR_070827340R → C in CISS1. 1 PublicationCorresponds to variant dbSNP:rs771459625Ensembl.1
Natural variantiVAR_017866374L → R in CISS1. 1 PublicationCorresponds to variant dbSNP:rs104894668EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF059293 mRNA Translation: AAC28335.1
AF073515 mRNA Translation: AAD39681.1
AF178684 mRNA Translation: AAD54385.1
AY358291 mRNA Translation: AAQ88658.1
BC044634 mRNA Translation: AAH44634.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32962.1

NCBI Reference Sequences

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RefSeqi
NP_004741.1, NM_004750.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.114948

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000392386; ENSP00000376188; ENSG00000006016

Database of genes from NCBI RefSeq genomes

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GeneIDi
9244

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9244

UCSC genome browser

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UCSCi
uc010ebt.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059293 mRNA Translation: AAC28335.1
AF073515 mRNA Translation: AAD39681.1
AF178684 mRNA Translation: AAD54385.1
AY358291 mRNA Translation: AAQ88658.1
BC044634 mRNA Translation: AAH44634.1
CCDSiCCDS32962.1
RefSeqiNP_004741.1, NM_004750.4
UniGeneiHs.114948

3D structure databases

ProteinModelPortaliO75462
SMRiO75462
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114670, 5 interactors
DIPiDIP-61205N
IntActiO75462, 1 interactor
STRINGi9606.ENSP00000376188

PTM databases

GlyConnecti1167
iPTMnetiO75462
PhosphoSitePlusiO75462

Polymorphism and mutation databases

BioMutaiCRLF1

Proteomic databases

EPDiO75462
jPOSTiO75462
MaxQBiO75462
PaxDbiO75462
PeptideAtlasiO75462
PRIDEiO75462
ProteomicsDBi50025

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9244
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392386; ENSP00000376188; ENSG00000006016
GeneIDi9244
KEGGihsa:9244
UCSCiuc010ebt.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9244
DisGeNETi9244
EuPathDBiHostDB:ENSG00000006016.10

GeneCards: human genes, protein and diseases

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GeneCardsi
CRLF1
GeneReviewsiCRLF1
HGNCiHGNC:2364 CRLF1
HPAiHPA041493
HPA041793
MalaCardsiCRLF1
MIMi272430 phenotype
604237 gene
neXtProtiNX_O75462
OpenTargetsiENSG00000006016
Orphaneti157820 Cold-induced sweating syndrome
1545 Crisponi syndrome
930 Idiopathic achalasia
PharmGKBiPA26882

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IV7Y Eukaryota
ENOG410Z87J LUCA
GeneTreeiENSGT00940000156569
HOGENOMiHOG000111972
HOVERGENiHBG051119
InParanoidiO75462
OMAiHKTRNQA
OrthoDBi702827at2759
PhylomeDBiO75462
TreeFamiTF106501

Enzyme and pathway databases

BRENDAi1.1.1.105 2681
ReactomeiR-HSA-6788467 IL-6-type cytokine receptor ligand interactions
R-HSA-9020956 Interleukin-27 signaling
SignaLinkiO75462
SIGNORiO75462

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CRLF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9244

Protein Ontology

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PROi
PR:O75462

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000006016 Expressed in 172 organ(s), highest expression level in right coronary artery
CleanExiHS_CRLF1
ExpressionAtlasiO75462 baseline and differential
GenevisibleiO75462 HS

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRLF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75462
Secondary accession number(s): Q9UHH5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: November 1, 1998
Last modified: January 16, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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