UniProtKB - O75461 (E2F6_HUMAN)
Transcription factor E2F6
E2F6
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 50 – 129 | Sequence analysisAdd BLAST | 80 |
GO - Molecular functioni
- DNA binding Source: GO_Central
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- protein dimerization activity Source: InterPro
- sequence-specific DNA binding Source: GO_Central
- transcription factor binding Source: GO_Central
GO - Biological processi
- negative regulation of G0 to G1 transition Source: Reactome
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of cell cycle Source: GO_Central
- regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Cell cycle, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O75461 |
Reactomei | R-HSA-69205, G1/S-Specific Transcription R-HSA-8953750, Transcriptional Regulation by E2F6 |
SignaLinki | O75461 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor E2F6Short name: E2F-6 |
Gene namesi | Name:E2F6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169016.16 |
HGNCi | HGNC:3120, E2F6 |
MIMi | 602944, gene |
neXtProti | NX_O75461 |
Subcellular locationi
Nucleus
Nucleus
- MLL1 complex Source: UniProtKB
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: MGI
Other locations
- RNA polymerase II transcription regulator complex Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 68 | L → E: Reduction in repressor activity, little effect on S-phase entry. | 1 |
Organism-specific databases
DisGeNETi | 1876 |
OpenTargetsi | ENSG00000169016 |
PharmGKBi | PA27578 |
Miscellaneous databases
Pharosi | O75461, Tbio |
Polymorphism and mutation databases
BioMutai | E2F6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219472 | 1 – 281 | Transcription factor E2F6Add BLAST | 281 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 9 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | O75461 |
jPOSTi | O75461 |
MassIVEi | O75461 |
MaxQBi | O75461 |
PaxDbi | O75461 |
PeptideAtlasi | O75461 |
PRIDEi | O75461 |
ProteomicsDBi | 33817 50023 [O75461-1] 50024 [O75461-2] |
PTM databases
iPTMneti | O75461 |
PhosphoSitePlusi | O75461 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000169016, Expressed in gastrocnemius and 116 other tissues |
ExpressionAtlasi | O75461, baseline and differential |
Genevisiblei | O75461, HS |
Organism-specific databases
HPAi | ENSG00000169016, Low tissue specificity |
Interactioni
Subunit structurei
Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2.
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.
2 PublicationsBinary interactionsi
Hide detailsO75461
GO - Molecular functioni
- protein dimerization activity Source: InterPro
- transcription factor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 108208, 93 interactors |
CORUMi | O75461 |
DIPi | DIP-41699N |
IntActi | O75461, 55 interactors |
MINTi | O75461 |
STRINGi | 9606.ENSP00000370936 |
Miscellaneous databases
RNActi | O75461, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 130 – 222 | DimerizationSequence analysisAdd BLAST | 93 | |
Regioni | 143 – 164 | Leucine-zipperAdd BLAST | 22 | |
Regioni | 173 – 281 | Transcription repressionAdd BLAST | 109 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 95 – 129 | DEF boxAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 265 – 268 | Poly-Glu | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2577, Eukaryota |
GeneTreei | ENSGT00940000155734 |
HOGENOMi | CLU_032091_4_0_1 |
InParanoidi | O75461 |
OMAi | VEQNHSN |
OrthoDBi | 1087250at2759 |
PhylomeDBi | O75461 |
TreeFami | TF105566 |
Family and domain databases
CDDi | cd14660, E2F_DD, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR015633, E2F IPR037241, E2F-DP_heterodim IPR032198, E2F_CC-MB IPR003316, E2F_WHTH_DNA-bd_dom IPR015635, Transcription_factor_E2F6 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12081, PTHR12081, 1 hit PTHR12081:SF19, PTHR12081:SF19, 1 hit |
Pfami | View protein in Pfam PF16421, E2F_CC-MB, 1 hit PF02319, E2F_TDP, 1 hit |
SMARTi | View protein in SMART SM01372, E2F_TDP, 1 hit |
SUPFAMi | SSF144074, SSF144074, 1 hit SSF46785, SSF46785, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSQQRPARKL PSLLLDPTEE TVRRRCRDPI NVEGLLPSKI RINLEDNVQY
60 70 80 90 100
VSMRKALKVK RPRFDVSLVY LTRKFMDLVR SAPGGILDLN KVATKLGVRK
110 120 130 140 150
RRVYDITNVL DGIDLVEKKS KNHIRWIGSD LSNFGAVPQQ KKLQEELSDL
160 170 180 190 200
SAMEDALDEL IKDCAQQLFE LTDDKENERL AYVTYQDIHS IQAFHEQIVI
210 220 230 240 250
AVKAPAETRL DVPAPREDSI TVHIRSTNGP IDVYLCEVEQ GQTSNKRSEG
260 270 280
VGTSSSESTH PEGPEEEENP QQSEELLEVS N
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WEZ5 | F8WEZ5_HUMAN | Transcription factor E2F6 | E2F6 | 63 | Annotation score: | ||
F8WC40 | F8WC40_HUMAN | Transcription factor E2F6 | E2F6 | 55 | Annotation score: | ||
Q2Z197 | Q2Z197_HUMAN | Putative truncated transcription fa... | E2F6 | 50 | Annotation score: | ||
Q2Z196 | Q2Z196_HUMAN | E2F transcription factor 6 isoform ... | E2F6 | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 – 8 | AR → HE in AAC14694 (PubMed:9501179).Curated | 2 | |
Sequence conflicti | 66 | V → A in AAT02637 (PubMed:15081404).Curated | 1 | |
Sequence conflicti | 220 | I → V in AAC14694 (PubMed:9501179).Curated | 1 | |
Sequence conflicti | 229 | G → E in AAC14694 (PubMed:9501179).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008771 | 1 – 75 | Missing in isoform 2. 1 PublicationAdd BLAST | 75 | |
Alternative sequenceiVSP_054754 | 1 – 36 | MSQQR…VEGLL → MNPS in isoform 3. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF059292 mRNA Translation: AAC31426.1 AY083996 mRNA Translation: AAM10783.1 AY083997 Genomic DNA Translation: AAM10784.1 AY083997 Genomic DNA Translation: AAM10785.1 AY551347 mRNA Translation: AAT02637.1 AJ493061 Genomic DNA Translation: CAD37950.1 AK290413 mRNA Translation: BAF83102.1 AC099344 Genomic DNA Translation: AAY14826.1 CH471053 Genomic DNA Translation: EAX00931.1 BC008348 mRNA Translation: AAH08348.1 BC107740 mRNA Translation: AAI07741.1 AF041381 mRNA Translation: AAC14694.1 |
CCDSi | CCDS1680.2 [O75461-1] CCDS62858.1 [O75461-2] CCDS62859.1 [O75461-3] |
RefSeqi | NP_001265204.1, NM_001278275.1 [O75461-3] NP_001265205.1, NM_001278276.1 [O75461-2] NP_001265206.1, NM_001278277.1 [O75461-2] NP_001265207.1, NM_001278278.1 [O75461-2] NP_937987.2, NM_198256.3 [O75461-1] |
Genome annotation databases
Ensembli | ENST00000307236; ENSP00000302159; ENSG00000169016 [O75461-3] ENST00000381525; ENSP00000370936; ENSG00000169016 [O75461-1] ENST00000542100; ENSP00000446315; ENSG00000169016 [O75461-2] ENST00000546212; ENSP00000438864; ENSG00000169016 [O75461-2] |
GeneIDi | 1876 |
KEGGi | hsa:1876 |
UCSCi | uc002rbf.4, human [O75461-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF059292 mRNA Translation: AAC31426.1 AY083996 mRNA Translation: AAM10783.1 AY083997 Genomic DNA Translation: AAM10784.1 AY083997 Genomic DNA Translation: AAM10785.1 AY551347 mRNA Translation: AAT02637.1 AJ493061 Genomic DNA Translation: CAD37950.1 AK290413 mRNA Translation: BAF83102.1 AC099344 Genomic DNA Translation: AAY14826.1 CH471053 Genomic DNA Translation: EAX00931.1 BC008348 mRNA Translation: AAH08348.1 BC107740 mRNA Translation: AAI07741.1 AF041381 mRNA Translation: AAC14694.1 |
CCDSi | CCDS1680.2 [O75461-1] CCDS62858.1 [O75461-2] CCDS62859.1 [O75461-3] |
RefSeqi | NP_001265204.1, NM_001278275.1 [O75461-3] NP_001265205.1, NM_001278276.1 [O75461-2] NP_001265206.1, NM_001278277.1 [O75461-2] NP_001265207.1, NM_001278278.1 [O75461-2] NP_937987.2, NM_198256.3 [O75461-1] |
3D structure databases
SMRi | O75461 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108208, 93 interactors |
CORUMi | O75461 |
DIPi | DIP-41699N |
IntActi | O75461, 55 interactors |
MINTi | O75461 |
STRINGi | 9606.ENSP00000370936 |
PTM databases
iPTMneti | O75461 |
PhosphoSitePlusi | O75461 |
Polymorphism and mutation databases
BioMutai | E2F6 |
Proteomic databases
EPDi | O75461 |
jPOSTi | O75461 |
MassIVEi | O75461 |
MaxQBi | O75461 |
PaxDbi | O75461 |
PeptideAtlasi | O75461 |
PRIDEi | O75461 |
ProteomicsDBi | 33817 50023 [O75461-1] 50024 [O75461-2] |
Protocols and materials databases
Antibodypediai | 12671, 316 antibodies |
DNASUi | 1876 |
Genome annotation databases
Ensembli | ENST00000307236; ENSP00000302159; ENSG00000169016 [O75461-3] ENST00000381525; ENSP00000370936; ENSG00000169016 [O75461-1] ENST00000542100; ENSP00000446315; ENSG00000169016 [O75461-2] ENST00000546212; ENSP00000438864; ENSG00000169016 [O75461-2] |
GeneIDi | 1876 |
KEGGi | hsa:1876 |
UCSCi | uc002rbf.4, human [O75461-1] |
Organism-specific databases
CTDi | 1876 |
DisGeNETi | 1876 |
EuPathDBi | HostDB:ENSG00000169016.16 |
GeneCardsi | E2F6 |
HGNCi | HGNC:3120, E2F6 |
HPAi | ENSG00000169016, Low tissue specificity |
MIMi | 602944, gene |
neXtProti | NX_O75461 |
OpenTargetsi | ENSG00000169016 |
PharmGKBi | PA27578 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2577, Eukaryota |
GeneTreei | ENSGT00940000155734 |
HOGENOMi | CLU_032091_4_0_1 |
InParanoidi | O75461 |
OMAi | VEQNHSN |
OrthoDBi | 1087250at2759 |
PhylomeDBi | O75461 |
TreeFami | TF105566 |
Enzyme and pathway databases
PathwayCommonsi | O75461 |
Reactomei | R-HSA-69205, G1/S-Specific Transcription R-HSA-8953750, Transcriptional Regulation by E2F6 |
SignaLinki | O75461 |
Miscellaneous databases
BioGRID-ORCSi | 1876, 169 hits in 866 CRISPR screens |
GenomeRNAii | 1876 |
Pharosi | O75461, Tbio |
PROi | PR:O75461 |
RNActi | O75461, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169016, Expressed in gastrocnemius and 116 other tissues |
ExpressionAtlasi | O75461, baseline and differential |
Genevisiblei | O75461, HS |
Family and domain databases
CDDi | cd14660, E2F_DD, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR015633, E2F IPR037241, E2F-DP_heterodim IPR032198, E2F_CC-MB IPR003316, E2F_WHTH_DNA-bd_dom IPR015635, Transcription_factor_E2F6 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12081, PTHR12081, 1 hit PTHR12081:SF19, PTHR12081:SF19, 1 hit |
Pfami | View protein in Pfam PF16421, E2F_CC-MB, 1 hit PF02319, E2F_TDP, 1 hit |
SMARTi | View protein in SMART SM01372, E2F_TDP, 1 hit |
SUPFAMi | SSF144074, SSF144074, 1 hit SSF46785, SSF46785, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E2F6_HUMAN | |
Accessioni | O75461Primary (citable) accession number: O75461 Secondary accession number(s): A8K2Z8 Q7Z2H6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM