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Protein

P antigen family member 1

Gene

PAGE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

GO - Biological processi

  • cellular defense response Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
P antigen family member 1
Short name:
PAGE-1
Alternative name(s):
AL5
G antigen 9
Short name:
GAGE-9
G antigen family B member 1
Prostate-associated gene 1 protein
Gene namesi
Name:PAGE1
Synonyms:GAGE9, GAGEB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000068985.4
HGNCiHGNC:4107 PAGE1
MIMi300288 gene
neXtProtiNX_O75459

Pathology & Biotechi

Organism-specific databases

DisGeNETi8712
OpenTargetsiENSG00000068985
PharmGKBiPA28522

Polymorphism and mutation databases

BioMutaiPAGE1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483471 – 146P antigen family member 1Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75459
MaxQBiO75459
PaxDbiO75459
PeptideAtlasiO75459
PRIDEiO75459
ProteomicsDBi50020

PTM databases

iPTMnetiO75459
PhosphoSitePlusiO75459

Expressioni

Tissue specificityi

Isolated from prostate cancer cell lines; expression associated with progression to androgen insensitive phenotype. Expressed in normal testis and at lower level in normal placenta.

Gene expression databases

BgeeiENSG00000068985 Expressed in 27 organ(s), highest expression level in right testis
CleanExiHS_PAGE1
GenevisibleiO75459 HS

Organism-specific databases

HPAiHPA003473

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-2559100,EBI-10175124

Protein-protein interaction databases

BioGridi114254, 27 interactors
IntActiO75459, 7 interactors
STRINGi9606.ENSP00000365320

Structurei

3D structure databases

ProteinModelPortaliO75459
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410IUTE Eukaryota
ENOG4110PV5 LUCA
GeneTreeiENSGT00900000141202
HOGENOMiHOG000237345
HOVERGENiHBG056227
InParanoidiO75459
OMAiKTGCELG
OrthoDBiEOG091G0UGV
PhylomeDBiO75459
TreeFamiTF340669

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 2 hits
PfamiView protein in Pfam
PF05831 GAGE, 2 hits
SMARTiView protein in SMART
SM01379 GAGE, 2 hits

Sequencei

Sequence statusi: Complete.

O75459-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFLRRLIYR RRPMIYVESS EESSDEQPDE VESPTQSQDS TPAEEREDEG
60 70 80 90 100
ASAAQGQEPE ADSQELVQPK TGCELGDGPD TKRVCLRNEE QMKLPAEGPE
110 120 130 140
PEADSQEQVH PKTGCERGDG PDVQELGLPN PEEVKTPEED EGQSQP
Length:146
Mass (Da):16,150
Last modified:October 3, 2006 - v2
Checksum:iE6C7BA94D898DCB2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02776775L → P1 PublicationCorresponds to variant dbSNP:rs1055197Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058989 mRNA Translation: AAC25990.1
CR542084 mRNA Translation: CAG46881.1
AC231643 Genomic DNA No translation available.
BC004861 mRNA Translation: AAH04861.1
CCDSiCCDS14327.1
RefSeqiNP_003776.2, NM_003785.3
XP_011542300.1, XM_011543998.2
UniGeneiHs.128231

Genome annotation databases

EnsembliENST00000376150; ENSP00000365320; ENSG00000068985
GeneIDi8712
KEGGihsa:8712
UCSCiuc004dom.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058989 mRNA Translation: AAC25990.1
CR542084 mRNA Translation: CAG46881.1
AC231643 Genomic DNA No translation available.
BC004861 mRNA Translation: AAH04861.1
CCDSiCCDS14327.1
RefSeqiNP_003776.2, NM_003785.3
XP_011542300.1, XM_011543998.2
UniGeneiHs.128231

3D structure databases

ProteinModelPortaliO75459
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114254, 27 interactors
IntActiO75459, 7 interactors
STRINGi9606.ENSP00000365320

PTM databases

iPTMnetiO75459
PhosphoSitePlusiO75459

Polymorphism and mutation databases

BioMutaiPAGE1

Proteomic databases

EPDiO75459
MaxQBiO75459
PaxDbiO75459
PeptideAtlasiO75459
PRIDEiO75459
ProteomicsDBi50020

Protocols and materials databases

DNASUi8712
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376150; ENSP00000365320; ENSG00000068985
GeneIDi8712
KEGGihsa:8712
UCSCiuc004dom.4 human

Organism-specific databases

CTDi8712
DisGeNETi8712
EuPathDBiHostDB:ENSG00000068985.4
GeneCardsiPAGE1
HGNCiHGNC:4107 PAGE1
HPAiHPA003473
MIMi300288 gene
neXtProtiNX_O75459
OpenTargetsiENSG00000068985
PharmGKBiPA28522
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUTE Eukaryota
ENOG4110PV5 LUCA
GeneTreeiENSGT00900000141202
HOGENOMiHOG000237345
HOVERGENiHBG056227
InParanoidiO75459
OMAiKTGCELG
OrthoDBiEOG091G0UGV
PhylomeDBiO75459
TreeFamiTF340669

Miscellaneous databases

GenomeRNAii8712
PROiPR:O75459
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000068985 Expressed in 27 organ(s), highest expression level in right testis
CleanExiHS_PAGE1
GenevisibleiO75459 HS

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 2 hits
PfamiView protein in Pfam
PF05831 GAGE, 2 hits
SMARTiView protein in SMART
SM01379 GAGE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPAGE1_HUMAN
AccessioniPrimary (citable) accession number: O75459
Secondary accession number(s): Q6FGM3, Q9BSS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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